1. Vitamin D Related/Nuclear Receptor
  2. Androgen Receptor
  3. JNJ-26146900

JNJ-26146900 is a potent and orally active androgen receptor antagonist with a Ki value of 400nM for rat AR. JNJ-26146900 is a nonsteroidal androgen receptor (AR) ligand. JNJ-26146900 reduces prostate tumor size and prevents bone loss. JNJ-26146900 can be used in research of cancer.

For research use only. We do not sell to patients.

JNJ-26146900 Chemical Structure

JNJ-26146900 Chemical Structure

CAS No. : 868691-50-3

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Description

JNJ-26146900 is a potent and orally active androgen receptor antagonist with a Ki value of 400nM for rat AR. JNJ-26146900 is a nonsteroidal androgen receptor (AR) ligand. JNJ-26146900 reduces prostate tumor size and prevents bone loss. JNJ-26146900 can be used in research of cancer[1].

In Vitro

JNJ-26146900 bound to the rat androgen receptor transfected into Cos-7 cells with submicromolar potency[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

JNJ-26146900 (10-100 mg/kg; p.o.; mature male Sprague-Dawley rats) reduces the wet weights of both the ventral prostate and levator ani muscle as effectively[1].
JNJ-26146900 (30-100 mg/kg; p.o.) prevents prostate tumor growth in the Dunning rat model, maximally inhibiting growth at a dose of 10mg/kg. JNJ-26146900 inhibits tumor growth significantly in a CWR22-LD1 mouse xenograft model of human prostate cancer[1].
JNJ-26146900 (30 mg/kg; p.o.; mature male Sprague-Dawley rats) reduces castration-induced tibial bone loss[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: mature male Sprague-Dawley rats[1]
Dosage: 10, 30, 100 mg/kg
Administration: oral gavage; daily, for 6 weeks
Result: Reduced ventral prostate weight.
Animal Model: CWR22-LD1 mouse xenograft model[1]
Dosage: 30, 100 mg/kg
Administration: oral gavage; twice per day for 3 weeks
Result: Inhibited tumor growth at 100 mg/kg, reducing mean tumor weight at Day 21 to about 30% of the intact vehicle tumor weight.
Molecular Weight

360.35

Formula

C15H15F3N2O3S

CAS No.
SMILES

N#CC1=CC2=C(C=C1C(F)(F)F)NC([C@@](O)(CS(=O)(CC)=O)C)=C2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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JNJ-26146900 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
JNJ-26146900
Cat. No.:
HY-123310
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