2. Cell Cycle/DNA Damage TGF-beta/Smad Stem Cell/Wnt Cytoskeleton
  3. LIM Kinase (LIMK) ROCK
  4. LIMK-IN-1

LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK), with IC50s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 can be used for ocular hypertension and associated glaucoma research.

For research use only. We do not sell to patients.

LIMK-IN-1 Chemical Structure

LIMK-IN-1 Chemical Structure

CAS No. : 1116571-01-7

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Based on 1 publication(s) in Google Scholar

LIMK-IN-1 Related Antibodies

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Description

LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK), with IC50s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 can be used for ocular hypertension and associated glaucoma research[1].

IC50 & Target[1]

LIMK1

0.9 nM (IC50)

LIMK2

0.5 nM (IC50)

ROCK1

260 nM (IC50)

ROCK2

2700 nM (IC50)

In Vitro

LIMK-IN-1 (Compound 14) (100 nM) increases outflow facility by about 30% in a pig eye perfusion assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LIMK-IN-1 Related Antibodies
Molecular Weight

453.34

Formula

C20H21BrN8
CAS No.
SMILES

CC1=CNC2=NC=NC(N3C[C@H](C)N(/C(NC4=CC=CC(Br)=C4)=N\C#N)CC3)=C21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LIMK-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LIMK-IN-11116571-01-7LIM Kinase (LIMK)ROCKLIMKsRho-associated protein kinaseRho-associated kinaseRho-kinaseROKLIM-Kinase 2 InhibitorsOcular HypertensionAssociated GlaucomaInhibitorinhibitorinhibit

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HY-14227
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