2. Academic Validation
  3. Anticonvulsant properties of N-salicyloyltryptamine in mice

Anticonvulsant properties of N-salicyloyltryptamine in mice

  • Pharmacol Biochem Behav. 2001 Feb;68(2):199-202. doi: 10.1016/s0091-3057(00)00484-6.
F A Oliveira 1,  R N de Almeida,  M F Sousa,  J M Barbosa-Filho,  S A Diniz,  I A de Medeiros
Affiliations

Affiliation

  • 1 Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Caixa Postal 5009, CEP 58051-970, PB, João Pessoa, Brazil.
PMID: 11267623 DOI: 10.1016/s0091-3057(00)00484-6
Abstract

A new tryptamine analogue, N-salicyloyltryptamine (STP), a potential central nervous system (CNS) depressant, was tested in the pentylenetetrazol (PTZ) and maximal electroshock (MES) models of epilepsy in mice. When administered concurrently, STP (100 mg/kg ip) significantly reduced the number of Animals that exhibited PTZ-induced seizures and eliminated the extensor reflex of maximal electric-induced seizures test in 50% of the experimental Animals. In addition, it showed protection in the PTZ test by diminishing the death rate.

Figures
Products