Bioassay guided isolation of a new C18-polyacetylene, (+)-9(Z),17-octadecadiene-12,14-diyne-1,11,16-triol, from Cassonia barteri

A novel C18-polyacetylene, (+)-9( Z),17-octadecadiene-12,14-diyne-1,11,16-triol, has been isolated from the ethyl acetate extract of Cassonia barteri (Araliaceae) leaves collected in Cameroon. The structure determination was achieved by NMR, mass, IR, and UV spectroscopy. The new polyenyne shows Antibacterial activity against Bacillus subtilis and Pseudomonas fluorescens, Antifungal activity against Cladosporium cucumerinum, moiluscicidal activity against Biomphalaria glabrata at low concentrations, and in addition it possesses haemolytic activity.