2. Academic Validation
  3. Cytotoxic prenylated xanthones from Calophyllum inophyllum

Cytotoxic prenylated xanthones from Calophyllum inophyllum

  • J Asian Nat Prod Res. 2008 Sep-Oct;10(9-10):993-7. doi: 10.1080/10519990802240387.
Qi Xiao 1,  Yan-Bo Zeng,  Wen-Li Mei,  You-Xing Zhao,  Yuan-Yuan Deng,  Hao-Fu Dai
Affiliations

Affiliation

  • 1 Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.
PMID: 19003621 DOI: 10.1080/10519990802240387
Abstract

A new prenylated xanthone (1), named caloxanthone N, together with two known constituents, gerontoxanthone C (2) and 2-hydroxyxanthone (3), was isolated from the ethanolic extract of the twigs of Calophyllum inophyllum. Their structures were completely elucidated using a combination of 1D, 2D NMR techniques (COSY, HMQC, HMBC, and ROESY) and HR-ESI-MS analyses. Compounds 1 and 2 exhibited cytotoxicity against chronic myelogenous leukemia cell line (K562) with IC50 values of 7.2 and 6.3 microg ml(- 1), respectively.

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