2. Academic Validation
  3. Gageotetrins A-C, noncytotoxic antimicrobial linear lipopeptides from a marine bacterium Bacillus subtilis

Gageotetrins A-C, noncytotoxic antimicrobial linear lipopeptides from a marine bacterium Bacillus subtilis

  • Org Lett. 2014 Feb 7;16(3):928-31. doi: 10.1021/ol403657r.
Fakir Shahidullah Tareq 1,  Min Ah Lee,  Hyi-Seung Lee,  Yeon-Ju Lee,  Jong Seok Lee,  Choudhury M Hasan,  Md Tofazzal Islam,  Hee Jae Shin
Affiliations

Affiliation

  • 1 Department of Marine Biotechnology, University of Science and Technology , Republic of Korea.
PMID: 24502521 DOI: 10.1021/ol403657r
Abstract

Gageotetrins A-C (1-3), a unique class of linear lipopeptides, consisting of di- and tetrapeptides and a new fatty acid were isolated from a Marine Bacillus subtilis. The structures of 1-3 were assigned by spectroscopic data and their absolute stereochemistries were ascertained by chemical derivatization. Compounds 1-3 displayed good antimicrobial activities with MIC values of 0.01-0.06 μM. However, these compounds failed to register any cytotoxicity (GI50 > 30 μg/ml) against human Cancer cell lines.

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