2. Academic Validation
  3. GLP-1(28-36)amide, a Long Ignored Peptide Revisited

GLP-1(28-36)amide, a Long Ignored Peptide Revisited

  • Open Biochem J. 2014 Dec 31;8:107-11. doi: 10.2174/1874091X01408010107.
Bilan Zhou 1,  Kaige Ji 1,  Anlin Peng 2,  Xin Yang 1,  Kun Huang 3
Affiliations

Affiliations

  • 1 Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China, 430030.
  • 2 Department of Pharmacy, The Third Hospital of Wuhan, Wuhan, Hubei, P. R. China, 430060.
  • 3 Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, P. R. China, 430030 ; Centre for Biomedicine Research, Wuhan Institute of Biotechnology, Wuhan, Hubei, P. R. China, 430075.
PMID: 25598850 DOI: 10.2174/1874091X01408010107
Abstract

Glucagon-like peptide-1 (GLP-1), which has been extensively applied for treating type 2 diabetes mellitus (T2DM), is an incretin hormone that regulates glucose homeostasis. GLP-1(28-36)amide, a C-terminal nonapeptide (FIAWLVKGRamide) of GLP-1, is a major product derived from the cleavage of GLP-1 by the neutral endopeptidase (NEP). GLP-1(28-36)amide has long been regarded as a metabolically inactive byproduct, however, recent findings reveal that GLP-1(28-36)amide plays multiple novel roles in ameliorating hepatic metabolism, protecting β cells, improving glucose disposal and inhibiting weight gain. Here, we summarize the latest progress on the effects of GLP-1(28-36)amide with a focus on its roles in regulating the Wnt and mitochondrial-mediated signaling pathways.

Keywords

Diabetes; GLP-1(28-36)amide; GLP-1-related peptides..

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