2. Academic Validation
  3. Diterpenoids from Zhumeria majdae roots as potential heat shock protein 90 (HSP90) modulators

Diterpenoids from Zhumeria majdae roots as potential heat shock protein 90 (HSP90) modulators

  • Phytochemistry. 2021 May;185:112685. doi: 10.1016/j.phytochem.2021.112685.
Reza Zadali 1,  Samad Nejad-Ebrahimi 2,  Abbas Hadjiakhoondi 3,  Lorenzo Fiengo 4,  Massimiliano D'Ambola 4,  Simona De Vita 4,  Zahra Tofighi 3,  Maria Giovanna Chini 5,  Giuseppe Bifulco 4,  Nunziatina De Tommasi 6
Affiliations

Affiliations

  • 1 Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano (SA), Italy; Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran; Department of Pharmacognosy, Faculty of Pharmacy, Islamic Azad University-Damghan Branch, Iran.
  • 2 Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran. Electronic address: [email protected].
  • 3 Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran; Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  • 4 Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano (SA), Italy.
  • 5 Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano (SA), Italy; Department of Bioscience and Territory, University of Molise, C.da Fonte Lappone, 86090, Pesche (IS), Italy.
  • 6 Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084, Fisciano (SA), Italy. Electronic address: [email protected].
PMID: 33607577 DOI: 10.1016/j.phytochem.2021.112685
Abstract

Four undescribed and 17 known Diterpenoids were isolated from the roots of Zhumeria majdae Rech.f. & Wendelbo. Using 1D and 2D NMR spectroscopy, ECD spectroscopy, and HRESIMS data analysis, the structures of the undescribed compounds were elucidated. The anti-proliferative activity of isolated compounds was evaluated against HeLa and MCF7 Cancer cell lines. The binding affinity of all compounds to HSP90, one of the targets for the modern Anticancer therapy, was investigated using surface plasmon resonance. The results demonstrated that lanugon Q interacted with the chaperone. To explain its mechanism of action, experimental and computational tests were also conducted.

Keywords

Diterpenoids; Heat shock protein 90; Lamiaceae; Lanugon Q; Molecular modeling; Zhumeria majdae.

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