2. Academic Validation
  3. Unique Cyclized Thiolopyrrolones from the Marine-Derived Streptomyces sp. BTBU20218885

Unique Cyclized Thiolopyrrolones from the Marine-Derived Streptomyces sp. BTBU20218885

  • Mar Drugs. 2022 Mar 18;20(3):214. doi: 10.3390/md20030214.
Fuhang Song 1,  Jiansen Hu 2,  Xinwan Zhang 3,  Wei Xu 3,  Jinpeng Yang 3,  Shaoyong Li 4,  Xiuli Xu 3
Affiliations

Affiliations

  • 1 School of Light Industry, Beijing Technology and Business University, Beijing 100048, China.
  • 2 Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • 3 School of Ocean Sciences, China University of Geosciences, Beijing 100083, China.
  • 4 School of Pharmacy, Tianjin Medical University, Tianjin 300070, China.
PMID: 35323513 DOI: 10.3390/md20030214
Abstract

Two new cyclized thiolopyrrolone derivatives, namely, thiolopyrrolone A (1) and 2,2-dioxidothiolutin (2), together with the kn own compound, thiolutin (3) were identified from a marine-derived Streptomyces sp. BTBU20218885, which was isolated from a mud sample collected from the coastal region of Xiamen, China. Their chemical structures were determined using spectroscopic data, including HRESIMS, 1D and 2D NMR techniques. 1 possessed a unique unsymmetrical sulfur-containing thiolopyrrolone structure. All the compounds were tested for bioactivities against Staphylococcus aureus, Escherichia coli, Bacille Calmette-Guérin (BCG), Mycobacterium tuberculosis, and Candida albicans. 1 displayed Antibacterial activities against BCG, M. tuberculosis, and S. aureus with minimum inhibitory concentration (MIC) values of 10, 10, and 100 μg/mL, respectively. Thiolutin (3) showed Antibacterial activities against E. coli, BCG, M. tuberculosis, and S. aureus with MIC values of 6.25, 0.3125, 0.625, and 3.125 μg/mL, respectively.

Keywords

M. tuberculosis; antibacterial; marine-derived Streptomyces; thiolopyrrolone.

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