2. Academic Validation
  3. Kazusamycin B, a novel antitumor antibiotic

Kazusamycin B, a novel antitumor antibiotic

  • J Antibiot (Tokyo). 1987 Jun;40(6):778-85. doi: 10.7164/antibiotics.40.778.
K Funaishi,  K Kawamura,  Y Sugiura,  N Nakahori,  E Yoshida,  M Okanishi,  I Umezawa,  S Funayama,  K Komiyama
PMID: 3610834 DOI: 10.7164/antibiotics.40.778
Abstract

A novel Antibiotic, kazusamycin B (C32H46O7, MW 542), was isolated from the fermentation broth of Streptomyces sp. No. 81-484 and the structure was established mainly on the basis of its physico-chemical properties. Unambiguous 13C NMR spectral analysis of kazusamycin B has been also accomplished. Kazusamycin B possesses potent cytocidal activities against L1210 (IC50 0.0018 micrograms/ml) and P388 (IC100 0.0016 micrograms/ml) leukemia cells in vitro.

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