Identification of a class of potent USP25/28 inhibitors with broad-spectrum anti-cancer activity

Affiliations

• 1 Zhejiang Provincial Key Laboratory of Pancreatic Diseases, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310003, China.
• 2 Shanghai Institute of Materia Medica, Shanghai, 200216, China.
• 3 Chaser Therapeutics, Inc., Hangzhou, Zhejiang Province, 310018, China.
• 4 Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.
• 5 Zhejiang Provincial Key Laboratory of Pancreatic Diseases, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310003, China. [email protected].
• 6 Shanghai Institute of Materia Medica, Shanghai, 200216, China. [email protected].
• 7 Zhejiang Provincial Key Laboratory of Pancreatic Diseases, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, 310003, China. [email protected].
• # Contributed equally.