1. Academic Validation
  2. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro

Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro

  • J Antimicrob Chemother. 1996 Jan;37(1):145-50. doi: 10.1093/jac/37.1.145.
D Jonkers 1 E Stobberingh R Stockbrügger
Affiliations

Affiliation

  • 1 Department of Gastroenterology, University of Limburg, The Netherlands.
Abstract

The Antibacterial effects of omeprazole (100, 200 and 300 mg/L) were assessed using Bacterial growth curves. A dose-related permanent inhibition was seen with actively growing Gram-positive cocci. A reduced and only temporary effect was observed with Gram-negative bacilli. After 1 day the Bacterial count of Helicobacter pylori in the presence of omeprazole 200 mg/L was reduced from 10(4) cfu/mL for the control to zero. No synergic or antagonistic interaction of omeprazole with amoxycillin or doxycycline was observed for Escherichia coli and Enterococcus faecalis.

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