2. Anti-infection
  3. Antibiotic Orthopoxvirus
  4. Neplanocin A

Neplanocin A ((-)-Neplanocin A) is an antitumor antibiotic with significant antitumor activity against murine L1210 leukemia. Neplanocin A is also an irreversible inhibitor of AdoHcy hydrolase (Ki=8.39 nM). Neplanocin A also has antiviral activity and is effective against vaccinia virus. Neplanocin A is obtained from Ampulariella regularis.

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Neplanocin A Chemical Structure

Neplanocin A Chemical Structure

CAS No. : 72877-50-0

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Neplanocin A Related Antibodies

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Description

Neplanocin A ((-)-Neplanocin A) is an antitumor antibiotic with significant antitumor activity against murine L1210 leukemia. Neplanocin A is also an irreversible inhibitor of AdoHcy hydrolase (Ki=8.39 nM). Neplanocin A also has antiviral activity and is effective against vaccinia virus. Neplanocin A is obtained from Ampulariella regularis[1].

IC50 & Target

AdoHcy hydrolase; vaccinia[1].
In Vitro

Neplanocin A (1 μM; 0-70 h) inhibits the growth of L929 mouse cells[1].
Neplanocin A (1 μM; 72 h) inhibits vaccinia virus plaque formation in monolayer cultures of mouse L-cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Neplanocin A Related Antibodies

Cell Viability Assay[1]

Cell Line: L929 mouse cells
Concentration: 1 μM
Incubation Time: 0-70 h
Result: Slowed the rate of increase in cell number.
Molecular Weight

263.25

Formula

C11H13N5O3
CAS No.
SMILES

O[C@@H]1[C@H](O)C(CO)=C[C@H]1N2C=NC3=C(N)N=CN=C23
Structure Classification
Initial Source

Ampullariella regular
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Neplanocin A Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neplanocin A72877-50-0(-)-Neplanocin AAntibioticOrthopoxvirusvacciniaAmpullariella regulariscancertumorvirusleukemiaInhibitorinhibitorinhibit

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