2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. NPY5RA-972

NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor.

For research use only. We do not sell to patients.

NPY5RA-972 Chemical Structure

NPY5RA-972 Chemical Structure

CAS No. : 439861-56-0

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Based on 1 publication(s) in Google Scholar

NPY5RA-972 Related Antibodies

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Description

NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor[1].

In Vivo

NPY5RA-972(p.o., 10.5 mg/kg) has a Tmax value of 1 hour in rats, a Cmax of 35 μM, a half-life of 6.4 hours, and a total plasma concentration of greater than 3 μM/h even 24 hours after administration[1].
NPY5RA-972 (p.o., 1-10 mg/kg) inhibits food intake elicited by a selective NPY Y5 receptor agonist, but has no effect on food intake or body weight in freely-fed Wistar rats or diet-obese rats Influence[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

351.44

Formula

C21H25N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCOCC1)NC2=C(C)C(C3=CC=CC=C3N4C(C)C)=C4C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (47.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8454 mL 14.2272 mL 28.4544 mL
5 mM 0.5691 mL 2.8454 mL 5.6909 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8454 mL 14.2272 mL 28.4544 mL 71.1359 mL
5 mM 0.5691 mL 2.8454 mL 5.6909 mL 14.2272 mL
10 mM 0.2845 mL 1.4227 mL 2.8454 mL 7.1136 mL
15 mM 0.1897 mL 0.9485 mL 1.8970 mL 4.7424 mL
20 mM 0.1423 mL 0.7114 mL 1.4227 mL 3.5568 mL
25 mM 0.1138 mL 0.5691 mL 1.1382 mL 2.8454 mL
30 mM 0.0948 mL 0.4742 mL 0.9485 mL 2.3712 mL
40 mM 0.0711 mL 0.3557 mL 0.7114 mL 1.7784 mL
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NPY5RA-972 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NPY5RA-972439861-56-0Neuropeptide Y ReceptorNPY receptororally activeCNSfeedingInhibitorinhibitorinhibit

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