Coagulation Factor XIV/PROC Protein, Mouse (HEK293, His)

Factor XIV/PROC protein (or protein C) is an important vitamin K-dependent serine protease that regulates blood clotting. Protein C plays a crucial role in inactivating factors Va and VIIIa and regulating the coagulation cascade in the presence of calcium ions and phospholipids. Coagulation Factor XIV/PROC Protein, Mouse (HEK293, His) is the recombinant mouse-derived Coagulation Factor XIV/PROC protein, expressed by HEK293 , with C-His labeled tag. The total length of Coagulation Factor XIV/PROC Protein, Mouse (HEK293, His) is 442 a.a., with molecular weight of ~63 & 45 kDa, respectively.

Coagulation Factor XIV/PROC Protein, also known as Protein C, emerges as a pivotal vitamin K-dependent serine protease crucial for the regulation of blood coagulation. Functioning in the presence of calcium ions and phospholipids, Protein C plays a key role in the inactivation of factors Va and VIIIa, thereby modulating the coagulation cascade. Beyond its role in hemostasis, Protein C extends its influence to endothelial cell barrier function, exerting a protective effect. This dual functionality underscores the significance of Coagulation Factor XIV/PROC Protein in maintaining the delicate balance of blood coagulation and endothelial integrity, highlighting its intricate involvement in physiological processes.

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Mouse

HEK293

C-His

P33587 (I19-L460)

19123  [NCBI]

Approximately 63&45 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.