TRPV3 Protein, Human (Cell-Free, His, Flag)

The TRPV3 protein is a putative receptor-activated calcium channel that responds to warm temperatures and exhibits increased activity at harmful temperatures above 39 degrees Celsius. It negatively regulates hair growth by inhibiting keratinocyte proliferation, inducing apoptosis, and causing premature degeneration of hair follicles. TRPV3 Protein, Human (Cell-Free, His, Flag) is the recombinant human-derived TRPV3 protein, expressed by E. coli Cell-free , with N-10*His, N-Flag labeled tag. The total length of TRPV3 Protein, Human (Cell-Free, His, Flag) is 790 a.a., with molecular weight of 93.1 kDa.

TRPV3, identified as a putative receptor-activated non-selective calcium-permeant cation channel, responds to innocuous (warm) temperatures and displays heightened activity at noxious temperatures exceeding 39 degrees Celsius. This channel exhibits outward rectification and has been proposed to associate with TRPV1, potentially influencing its activity. Functionally, TRPV3 serves as a negative regulator of hair growth and cycling, as its signaling suppresses keratinocyte proliferation in hair follicles, induces apoptosis, and contributes to premature hair follicle regression (catagen). The possibility of forming a heteromeric channel with TRPV1 further underscores its role in thermosensation and cellular processes. TRPV3's interactions with TRPV1 emphasize its potential involvement in modulating diverse physiological responses.

Human

E. coli Cell-free

N-10*His;N-Flag

Q8NET8 (M1-V790)

162514

MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV

93.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.