ROS-generating agent 1

Cat. No.: HY-149265 Purity: 99.57%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities.

For research use only. We do not sell to patients.

ROS-generating agent 1 Chemical Structure

CAS No. : 2369030-41-9

Size	Price	Stock	Quantity
5 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 750	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

411.34

Formula

C₂₁H₁₅F₆NO

CAS No.

2369030-41-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1/C(CNC/C1=C\C2=CC(C(F)(F)F)=CC=C2)=C/C3=CC=CC(C(F)(F)F)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL (81.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4311 mL	12.1554 mL	24.3108 mL
5 mM	0.4862 mL	2.4311 mL	4.8622 mL
10 mM	0.2431 mL	1.2155 mL	2.4311 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.57%

Select Batch:

Data Sheet (267 KB) SDS (251 KB)

COA (244 KB) HNMR (250 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Liu X, et al. Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition. Eur J Med Chem. 2023 Mar 15;250:115191. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4311 mL	12.1554 mL	24.3108 mL	60.7770 mL
	5 mM	0.4862 mL	2.4311 mL	4.8622 mL	12.1554 mL
	10 mM	0.2431 mL	1.2155 mL	2.4311 mL	6.0777 mL
	15 mM	0.1621 mL	0.8104 mL	1.6207 mL	4.0518 mL
	20 mM	0.1216 mL	0.6078 mL	1.2155 mL	3.0388 mL
	25 mM	0.0972 mL	0.4862 mL	0.9724 mL	2.4311 mL
	30 mM	0.0810 mL	0.4052 mL	0.8104 mL	2.0259 mL
	40 mM	0.0608 mL	0.3039 mL	0.6078 mL	1.5194 mL
	50 mM	0.0486 mL	0.2431 mL	0.4862 mL	1.2155 mL
	60 mM	0.0405 mL	0.2026 mL	0.4052 mL	1.0129 mL
	80 mM	0.0304 mL	0.1519 mL	0.3039 mL	0.7597 mL