2. Stem Cell/Wnt
  3. Smo
  4. SAG-d3

SAG-d3 is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM)[1].

For research use only. We do not sell to patients.

SAG-d<sub>3</sub> Chemical Structure

SAG-d3 Chemical Structure

Size Price Stock Quantity
1 mg USD 220 In-stock
5 mg USD 480 In-stock
10 mg USD 800 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SAG-d3:

SAG-d3 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SAG-d3 is deuterium labeled SAG. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM)[1].

Molecular Weight

493.08

Formula

C28H25D3ClN3OS
Appearance

Solid

Color

White to light yellow

SMILES

ClC1=C(SC2=CC=CC=C21)C(N(CC3=CC=CC(C4=CC=NC=C4)=C3)[C@H]5CC[C@@H](CC5)NC([2H])([2H])[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (202.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0281 mL 10.1403 mL 20.2807 mL
5 mM 0.4056 mL 2.0281 mL 4.0561 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0281 mL 10.1403 mL 20.2807 mL 50.7017 mL
5 mM 0.4056 mL 2.0281 mL 4.0561 mL 10.1403 mL
10 mM 0.2028 mL 1.0140 mL 2.0281 mL 5.0702 mL
15 mM 0.1352 mL 0.6760 mL 1.3520 mL 3.3801 mL
20 mM 0.1014 mL 0.5070 mL 1.0140 mL 2.5351 mL
25 mM 0.0811 mL 0.4056 mL 0.8112 mL 2.0281 mL
30 mM 0.0676 mL 0.3380 mL 0.6760 mL 1.6901 mL
40 mM 0.0507 mL 0.2535 mL 0.5070 mL 1.2675 mL
50 mM 0.0406 mL 0.2028 mL 0.4056 mL 1.0140 mL
60 mM 0.0338 mL 0.1690 mL 0.3380 mL 0.8450 mL
80 mM 0.0254 mL 0.1268 mL 0.2535 mL 0.6338 mL
100 mM 0.0203 mL 0.1014 mL 0.2028 mL 0.5070 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

SAG-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAG-d3SmoSmoothenedInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SAG-d3
Cat. No.:
HY-12848S
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.