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<i>E. coli</i>

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By Targets:	Antibiotic (1) Bacterial (3) Mitochondrial Metabolism (1) Renin (1)
By Research Areas:	Infection (1) Inflammation/Immunology (1)

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2

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

ND-011992	Mitochondrial Metabolism Bacterial	Infection
ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo₃ oxidase in addition to *bd-I* and bd-II oxidases in E. coli strain BL21Δcyo with the IC₅₀* of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study .

Sodium new houttuyfonate SNH	Bacterial Renin	Inflammation/Immunology
Sodium new houttuyfonate (SNH) is a partially reversible NDM-1 inhibitor with an IC₅₀ of 14.2 μM. Sodium new houttuyfonate is an inhibitor against renin and angiotensin I converting enzyme (ACE). Sodium new houttuyfonate can recover the antibacterial activity of Meropenem (HY-13678) against E. coli BL21/pET15b-blaNDM-1 .

Platensimycin	Antibiotic Bacterial
Platensimycin is an antibiotic produced by S. platensis that inhibits gram-positive bacteria by selectively inhibiting cellular lipid biosynthesis (IC₅₀=0.1 μM). Platensimycin targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC₅₀s=48 nM and 160 nM for S.aureus and E.coli enzymes, respectively). Platensimycin is a promising agent for overcoming antibiotic resistance.

Species:	E.coli (2)
Tag:	His (2) SUMO (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	*EXO I Protein, E. coli* (His)**	E.coli	E. coli
	EXO I Protein, documented with high processivity, degrades single-stranded DNA (ssDNA). It also acts as a DNA deoxyribophosphodiesterase, releasing deoxyribose-phosphate moieties post-cleavage at apurinic/apyrimidinic (AP) sites by AP endonuclease or AP lyase. EXO I's dual functionality in ssDNA degradation and deoxyribose-phosphate removal at AP sites underscores its crucial role in DNA repair processes, maintaining genome integrity. EXO I Protein, E. coli (His) is the recombinant E. coli-derived EXO I protein, expressed by E. coli , with N-6*His labeled tag. EXO I Protein, E. coli (His), has molecular weight of ~54.5 kDa.

	Gamma-GCS Protein, E.coli (His-SUMO) gshA; gsh-I; b2688; JW2663Glutamate--cysteine ligase; EC 6.3.2.2; Gamma-ECS; GCS; Gamma-glutamylcysteine synthetase	E.coli	E. coli
	Gamma-GCS protein is a key enzyme in sulfur metabolism and initiates glutathione synthesis by catalyzing the incorporation of L-cysteine and L-glutamic acid. This important molecule critical for cellular antioxidant defense is synthesized through a critical 1/2 step facilitated by γ-GCS. Gamma-GCS Protein, E.coli (His-SUMO) is the recombinant E. coli-derived Gamma-GCS protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

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