α-glucosidase inhibition

By Targets:	Glucosidase (9) Aryl Hydrocarbon Receptor (1) Bacterial (1) Cholinesterase (ChE) (1) Dipeptidyl Peptidase (1) HIV (1) Phosphatase (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (2) Endocrinology (1) Infection (2) Inflammation/Immunology (2) Metabolic Disease (9) Neurological Disease (2)

Targets Recommended: Glucosidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2223

Ganoderol B Ganodermadiol	Glucosidase	Metabolic Disease
Ganoderol B is a potent *α-glucosidase* inhibitor. Ganoderol B has high α-glucosidase inhibition with an IC₅₀ of 48.5 μg/mL (119.8 μM) .

HY-P2802

α-Glucosidase α-D-glucosidase	Glucosidase	Metabolic Disease
α-Glucosidase (α-D-Glucosidase), a carbohydrate hydrolyzing enzyme, catalyzes the liberation of α-glucose from the non-reducing end of the substrate. α-Glucosidase can facilitate the absorption of glucose by the small intestine. Inhibition of α-Glucosidase is an effective management of non-insulin-dependent diabetes mellitus (NIDDM) .

HY-156078

α-Glucosidase-IN-32	Glucosidase	Metabolic Disease
α-Glucosidase-IN-32 (compound f26) is a reversible, noncompetitive and orally active α-glucosidase inhibitor with an IC₅₀ value of 3.07 μM. α-Glucosidase-IN-32 complex with α-glucosidase through hydrogen bonds and hydrophobic interactions, led to changes in the conformation and secondary strictures of α-glucosidase and further the inhibition of the enzymatic activity. α-Glucosidase-IN-32 can be used for diabetic disease research .

HY-148575

α-Glucosidase-IN-23	Glucosidase	Metabolic Disease
α-Glucosidase-IN-23 is an orally active *α-Glucosidase* inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC₅₀ value of 4.48 μM. α-Glucosidase-IN-23 can be used for the research of diabetes .

HY-N10295

Flavipin	Aryl Hydrocarbon Receptor	Inflammation/Immunology
Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4 ⁺ T cells and CD11b ⁺ macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA . Flavipin exhibits the DPPH free radical scavenging ability with IC₅₀ value of 7.2 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 33.8 μM .

HY-161421

α-Glucosidase-IN-61	Glucosidase	Metabolic Disease
α-Glucosidase-IN-61 (Compd 1j), a competitive *α-glucosidase* inhibitor, demonstrates excellent inhibition with an IC₅₀ of 0.73 μM. α-Glucosidase-IN-61 (Compd 1j) is used for the research of type 2 diabetes mellitus .

HY-N12840

Logmalicid B

Others Metabolic Disease

Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

Logmalicid B	Others	Metabolic Disease
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

HY-N10294

Epicoccone B	HIV	Infection Inflammation/Immunology
Epicoccone B, firstly reported from C. globosum, exhibits the DPPH free radical scavenging ability with IC₅₀ value of 10.8 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 27.3 μM. Anti-HIV activity .

HY-N6005

Methyl caffeate	Bacterial	Infection Cancer
Methyl caffeate, an antimicrobial agent, shows moderate antimicrobial and prominent antimycobacterial activities. Methyl caffeate also exhibits α-glucosidase inhibition activity, oxidative stress inhibiting activity, anti-platelet activity, antiproliferative activity in cervix adenocarcinoma and anticancer activity in lung and leukmia cell lines .

HY-N10360

Ellipyrone A	Dipeptidyl Peptidase	Metabolic Disease
Ellipyrone A, a γ-pyrone enclosed macrocyclic poyketide, shows inhibition potential against *dipeptidyl peptidase-4 (IC₅₀=0.35 mM). Ellipyrone A also has anti-carbolytic property against α-glucosidase* (IC₅₀=0.74 mM) and α-amylase (IC₅₀=0.59 mM) .**

HY-150723

PBI-6DNJ	Glucosidase	Metabolic Disease
PBI-6DNJ is an orally active and potent multivalent glycosidase inhibitor. PBI-6DNJ exhibits good inhibition activity against *α-glucosidase* from mice, with a K_i of 0.14 μM. PBI-6DNJ exhibits good hypoglycemic activity. PBI-6DNJ can be used for type 2 diabetes research .

HY-162480

PTP1B-IN-27	Glucosidase Phosphatase	Endocrinology
PTP1B-IN-27 (Compound 7i) is an inhibitor of protein tyrosine phosphatase 1-B (PTP‐1B)(IC₅₀=8.2 µM). PTP1B-IN-27 also inhibits *α-Glucosidase* (IC₅₀=120 µM) and shows competitive inhibition (K_i=118 µM) .

HY-N8161

Kaempferol-3,7-di-O-β-glucoside Kaempferol 3,7-diglucoside	Glucosidase Cholinesterase (ChE)	Neurological Disease
Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside), a flavonol, possesses enzyme inhibition property towards α-amylase, *α-glucosidase* and Acetylcholinesterase. Kaempferol-3,7-di-O-β-glucoside protects differentiating neuronal cells, SH-SY5Y from Amyloid β peptide-induced injury. Kaempferol-3,7-di-O-β-glucoside has the potential for Alzheimer's research .

HY-N2821

(+)-Afzelechin 1 Publications Verification	Glucosidase	Metabolic Disease
(+)-Afzelechin, isolated from rhizomes of Bergenia ligulata, is an *alpha-glucosidase* activity inhibitor with an ID₅₀ (50% inhibition dose) value of 0.13 mM. (+)-Afzelechin can delay the absorption of carbohydrates in food to suppress postprandial hyperglycemia and hyperinsulinemia .

HY-N9283

1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran	Reactive Oxygen Species	Neurological Disease Cancer
1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran, isolated from the edible mushroom Sarcodon leucopus, has antioxidant effects in the DPPH scavenging assay with the IC₅₀ of 28 μM, inhibits malondialdehyde (MDA) with the IC₅₀ of 71 μM, and inhibits α-glucosidase with the IC₅₀ of 6.22 μM .

Cat. No.	Product Name	Type

HY-P2802

α-Glucosidase α-D-glucosidase	Biochemical Assay Reagents
α-Glucosidase (α-D-Glucosidase), a carbohydrate hydrolyzing enzyme, catalyzes the liberation of α-glucose from the non-reducing end of the substrate. α-Glucosidase can facilitate the absorption of glucose by the small intestine. Inhibition of α-Glucosidase is an effective management of non-insulin-dependent diabetes mellitus (NIDDM) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2223

Ganoderol B Ganodermadiol	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polyporaceae Source classification Metabolic Disease Plants Disease Research Fields	Glucosidase
Ganoderol B is a potent *α-glucosidase* inhibitor. Ganoderol B has high α-glucosidase inhibition with an IC₅₀ of 48.5 μg/mL (119.8 μM) .

HY-N6005

Methyl caffeate	Infection Classification of Application Fields Simple Phenylpropanols Source classification Phenols Polyphenols Solanum torvum Swartz Phenylpropanoids Plants Solanaceae Disease Research Fields	Bacterial
Methyl caffeate, an antimicrobial agent, shows moderate antimicrobial and prominent antimycobacterial activities. Methyl caffeate also exhibits α-glucosidase inhibition activity, oxidative stress inhibiting activity, anti-platelet activity, antiproliferative activity in cervix adenocarcinoma and anticancer activity in lung and leukmia cell lines .

HY-N10295

Flavipin	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Disease Research Fields Inflammation/Immunology	Aryl Hydrocarbon Receptor
Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4 ⁺ T cells and CD11b ⁺ macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′UTR, a newly identified target mRNA . Flavipin exhibits the DPPH free radical scavenging ability with IC₅₀ value of 7.2 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 33.8 μM .

HY-N12840

Logmalicid B	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	Others
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

HY-N10294

Epicoccone B	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Disease Research Fields Inflammation/Immunology	HIV
Epicoccone B, firstly reported from C. globosum, exhibits the DPPH free radical scavenging ability with IC₅₀ value of 10.8 μM, and has potent α-glucosidase inhibition with IC₅₀ value of 27.3 μM. Anti-HIV activity .

HY-N10360

Ellipyrone A	Classification of Application Fields Animals Ketones, Aldehydes, Acids Source classification Metabolic Disease Disease Research Fields	Dipeptidyl Peptidase
Ellipyrone A, a γ-pyrone enclosed macrocyclic poyketide, shows inhibition potential against *dipeptidyl peptidase-4 (IC₅₀=0.35 mM). Ellipyrone A also has anti-carbolytic property against α-glucosidase* (IC₅₀=0.74 mM) and α-amylase (IC₅₀=0.59 mM) .**

HY-N8161

Kaempferol-3,7-di-O-β-glucoside Kaempferol 3,7-diglucoside	Flavonols Flavonoids other families Source classification Phenols Polyphenols Plants	Glucosidase Cholinesterase (ChE)
Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside), a flavonol, possesses enzyme inhibition property towards α-amylase, *α-glucosidase* and Acetylcholinesterase. Kaempferol-3,7-di-O-β-glucoside protects differentiating neuronal cells, SH-SY5Y from Amyloid β peptide-induced injury. Kaempferol-3,7-di-O-β-glucoside has the potential for Alzheimer's research .

HY-N2821

(+)-Afzelechin 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Metabolic Disease Plants Saxifragaceae Disease Research Fields	Glucosidase
(+)-Afzelechin, isolated from rhizomes of Bergenia ligulata, is an *alpha-glucosidase* activity inhibitor with an ID₅₀ (50% inhibition dose) value of 0.13 mM. (+)-Afzelechin can delay the absorption of carbohydrates in food to suppress postprandial hyperglycemia and hyperinsulinemia .

HY-N9283

1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran	Microorganisms Source classification Phenols Polyphenols	Reactive Oxygen Species
1,2-Diacetoxy-4,7,8-trihydroxy-3-(4-hydroxyphenyl)dibenzofuran, isolated from the edible mushroom Sarcodon leucopus, has antioxidant effects in the DPPH scavenging assay with the IC₅₀ of 28 μM, inhibits malondialdehyde (MDA) with the IC₅₀ of 71 μM, and inhibits α-glucosidase with the IC₅₀ of 6.22 μM .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Name
Email *

	Sorry, but the email address you supplied was invalid.

α-glucosidase inhibition

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Natural
Products