From 11:00 pm to 12:00 pm EST ( 8:00 pm to 9:00 pm PST ) on January 6th, the website will be under maintenance. We are sorry for the inconvenience. Please arrange your schedule properly.
Adam-20-S is a potent glucosinolate sulfatase inhibitor with an IC50 value of 9.04 μg/mL. Adam-20-S impaires glucosinolate metabolism to produce more toxic isothiocyanates in P. xylostella .
ADAM10 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Adam10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adam10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM10 Rat Pre-designed siRNA Set A contains three designed siRNAs for ADAM10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM11 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM12 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM15 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM17 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM17 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Adam17 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adam17 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Adam17 Rat Pre-designed siRNA Set A contains three designed siRNAs for Adam17 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM18 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM18 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM19 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM19 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM2 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM21 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM21 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM22 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM22 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM23 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM23 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM28 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM28 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM29 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM29 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM30 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM30 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM32 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM32 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM33 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM33 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM7 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM8 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Adam8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Adam8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Adam8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Adam8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
ADAM9 Human Pre-designed siRNA Set A contains three designed siRNAs for ADAM9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
INCB3619 is a selective and orally active ADAM inhibitor with IC50 of 22 nM and 14 nM for ADAM10 and ADAM17, respectively. INCB3619 has anti-tumor activity .
GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor. GW280264X potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively . ADAM10 and 17 modulate the immunogenicity of glioblastoma-initiating cells .
KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE; ADAM17), ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE); ADAM17, ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .
Izeltabart is a high-affinity humanized antibody targeting ADAM9. Izeltabart can be used as ADC Antibody for site-specific conjugation with Maytansinoid-based DM21-C (a Drug-Linker Conjugates for ADC), to synthesize IMGC936 (Antibody-Drug Conjugates (ADCs)) with strong anti-cancer activity. DM21-C is composed of Maytansinoid (microtubule inhibitor) and a stable tripeptide linker. IMGC936 exhibits cytotoxicity against ADAM9-positive human tumor cell lines and potent antitumor activity in xenograft tumor models .
Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17. Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2 + breast cancer, gliomas, et al .
cyclo(RLsKDK) (BK-1361) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) has potential applications in inflammatory diseases and cancer .
cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) (TFA) has potential applications in inflammatory diseases and cancer .
ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC50 of 31.6 μM and a Ki of 26.22 μM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC50 of 5.32 μM .
BMS-561392 is a TNF alpha-converting enzyme (TACE) inhibitor. BMS-561392 is also an ADAM17 blocker. BMS-561392 can be used for research of inflammatory bowel disease .
(S,S)-TAPI-1 is an isomer of TAPI-1. TAPI-1 is a TACE(ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metalloproteinase (MMP) inhibitor .
TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .
BMS-561392 formate is the formate form of BMS-561392 (HY-19667). BMS-561392 is a TNF alpha-converting enzyme (TACE) inhibitor. BMS-561392 is also an ADAM17 blocker. BMS-561392 can be used for research of inflammatory bowel disease .
Vicriviroc maleate (SCH-417690 maleate; SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells, with IC90s of 3.3 nM (JrFL), 2.8 nM (ADA-M), 1.8 nM (301657), 4.9 nM (JV1083) and 10 nM (RU 570).
TMI-1 is a potent inhibitor of disintegrin metalloenzyme 17 (ADAM17) and other MMPs. TMI-1 inhibits LPS-induced TNF-α secretion in human primary monocytes, and human whole blood . TMI-1 selectively induces caspase-dependent apoptosis in triple negative (TN) and ERBB2-overexpressing breast tumor cell lines .
PPNDS tetrasodium is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM). PPNDS tetrasodium is also a P2X1 receptor antagonist. PPNDS is an agonist for the ATP receptor of Paramecium. PPNDS tetrasodium potently inhibits polymerases from viruses. PPNDS tetrasodium can be used in the research of infection and cancers .
(R)-TAPI-2 is the isomer of TAPI-2 (HY-100211A). TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE); ADAM17, ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .
Mca-PLAQAV-Dpa-RSSSR-NH2 is a fluorescent peptide and as one of fluorescent substrates of TNF-α converting enzyme (TACE; ADAM17), ADAM 9 and ADAM 10. Mca-PLAQAV-Dpa-RSSSR-NH2 is a substrate based on fluorescence resonance energy transfer, and its activity can be determined by the change of fluorescence intensity during pyrolysis .
cyclo(RLsKDK) (BK-1361) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) has potential applications in inflammatory diseases and cancer .
cyclo(RLsKDK) (TFA) (BK-1361 (TFA)) is a specific inhibitor of metalloproteinase ADAM8 with an IC50 value of 182 nM. cyclo(RLsKDK) (TFA) has potential applications in inflammatory diseases and cancer .
Izeltabart is a high-affinity humanized antibody targeting ADAM9. Izeltabart can be used as ADC Antibody for site-specific conjugation with Maytansinoid-based DM21-C (a Drug-Linker Conjugates for ADC), to synthesize IMGC936 (Antibody-Drug Conjugates (ADCs)) with strong anti-cancer activity. DM21-C is composed of Maytansinoid (microtubule inhibitor) and a stable tripeptide linker. IMGC936 exhibits cytotoxicity against ADAM9-positive human tumor cell lines and potent antitumor activity in xenograft tumor models .
ADAM8 protein potentially participates in leukocyte extravasation. ADAM8 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ADAM8 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM8 Protein, Mouse (HEK293, His) is 642 a.a., with molecular weight (glycosylation form) of 60-72 & 35-45 kDa (Tris-Bis PAGE), respectively.
ADAM8 protein is suggested to be involved in leukocyte extravasation, indicating its potential role in facilitating the migration of white blood cells from blood vessels into surrounding tissues. This implies ADAM8's contribution to immune responses by regulating leukocyte movement across the endothelial barrier, a crucial step in inflammatory and immune surveillance processes. ADAM8 Protein, Human (HEK293, His) is the recombinant human-derived ADAM8 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM8 Protein, Human (HEK293, His) is 639 a.a., with molecular weight of ~71 kDa.
ADAM8 is a transmembrane glycoprotein containing metalloproteinase and disintegrin domains, belonging to the ADAMs family. It has proteolytic, cell adhesion, cell fusion, and cell signaling properties. It is involved in ectodomain shedding of membrane proteins and is associated with inflammation and neurodegeneration. ADAM8 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived ADAM8 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM8 Protein, Rhesus Macaque (HEK293, His) is 477 a.a., with molecular weight of ~53.4 KDa.
ADAM12 Protein significantly contributes to skeletal muscle regeneration, particularly in initiating cell fusion. Its multifaceted involvement extends to forming macrophage-derived giant cells (MGC) and differentiating osteoclasts from mononuclear precursors, showcasing a broader role beyond muscle regeneration. ADAM12 Protein, Human (HEK293, His) is the recombinant human-derived ADAM12 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM12 Protein, Human (HEK293, His) is 485 a.a., with molecular weight of 27 & 55 & 72 kDa, respectively.
ADAM12 Protein, Mouse (Baculovirus, His-Myc) is a disintegrin and a metalloprotease. ADAM12 is upregulated in epithelial cancers and contributes to increased tumor proliferation, metastasis, and endocrine resistance.
ADAM9, a metalloprotease, cleaves and releases TEK, KDR, EPHB4, CD40, VCAM1, and CDH5, playing a pivotal role in tumorigenesis and angiogenesis. It regulates cell motility through integrin interactions, mediates cell-cell and cell-matrix interactions, and may act as an alpha-secretase for APP, suggesting involvement in neurobiology and neurodegenerative disorders. ADAM9 Protein, Human (HEK293, His) is the recombinant human-derived ADAM9 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM9 Protein, Human (HEK293, His) is 669 a.a., with molecular weight of 40-45 kDa.
ADAM9 protein is a metalloprotease that plays an important role in tumorigenesis and angiogenesis. It cleaves TEK, KDR, EPHB4, CD40, VCAM1 and CDH5, regulating cancer-related signaling pathways and blood vessel formation. ADAM9 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ADAM9 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM9 Protein, Mouse (HEK293, His) is 697 a.a., with molecular weight of ~74.9 kDa.
ADAM15 protein is an active metalloproteinase involved in wound healing, cell interactions, and T-cell aggregation. It inhibits airway smooth muscle cell adhesion and migration mediated by beta-1 integrin. It suppresses cell motility towards fibronectin and cleaves E-cadherin. ADAM15 plays a role in glomerular cell migration, neovascularization, and cartilage remodeling. During sperm maturation, it may undergo proteolytic processing and potentially be involved in sperm-egg binding. ADAM15 Protein, Human (CHO, His) is the recombinant human-derived ADAM15 protein, expressed by CHO, with C-His labeled tag. The total length of ADAM15 Protein, Human (CHO, His) is 490 a.a., with molecular weight of 65-70 kDa.
ADAM15 protein is an active metalloproteinase involved in wound healing, cell interactions, and T-cell aggregation. It inhibits airway smooth muscle cell adhesion and migration mediated by beta-1 integrin. It suppresses cell motility towards fibronectin and cleaves E-cadherin. ADAM15 plays a role in glomerular cell migration, neovascularization, and cartilage remodeling. During sperm maturation, it may undergo proteolytic processing and potentially be involved in sperm-egg binding. ADAM15 Protein, Human (HEK293, His) is the recombinant human-derived ADAM15 protein, expressed by HEK293, with C-His labeled tag. The total length of ADAM15 Protein, Human (HEK293, His) is 490 a.a., with molecular weight of 65-70 kDa.
ADAM15 is an active metalloprotease that plays a crucial role in physiological processes and has gelatin-solubilizing and collagen-solubilizing activities. Notably, it affects wound healing, mediates intraepithelial cell/T cell interactions, and inhibits β-1 integrin-mediated cell adhesion and migration in airway smooth muscle cells. ADAM15 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ADAM15 protein, expressed by HEK293 , with C-His labeled tag. The total length of ADAM15 Protein, Mouse (HEK293, His) is 680 a.a., with molecular weight of 75-110 kDa.
ADAM17/TACE Protein, a pivotal enzyme, cleaves TNF-alpha and activates various cell-surface proteins like p75 TNF-receptor. It also mediates the cleavage of Notch, activates the Notch pathway, and contributes to hemostasis by shedding GP1BA. ADAM17/TACE further facilitates the cleavage of LAG3, IL6R, and FCGR3A, showcasing its significance in diverse cellular functions. ADAM17/TACE Protein, Rat (HEK293, His) is the recombinant rat-derived ADAM17/TACE protein, expressed by HEK293 , with C-10*His labeled tag. The total length of ADAM17/TACE Protein, Rat (HEK293, His) is 546 a.a., with molecular weight of 57 & 20 kDa, respectively.
ADAMDEC1 Protein, Human (HEK293, His) is human recombinant ADAM-like protein decysin-1 (ADAMDEC1) with a 6His tag at the C-terminus. ADAMDEC1 Protein, Human (HEK293, His) is produced by mammalian expression system in human cells and the target gene encoding Ile31-Glu470 is expressed.
A disintegrin and metalloproteinase with thrombospondin motifs 5; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 5; A Disintigrin And Metalloproteinase with ThromboSpondin motif-5; ADAM metallopeptidase with thrombospondin type 1 motif 5; ADAM TS 11; ADAM TS 5; ADAM TS5; ADAMTS 11; ADAMTS 5; ADAMTS11; ADMP 2; ADMP2; Aggrecanase 2; aggrecanase-2; FLJ36738; Implantin; ThromboSpondin motif-5.
ADAMTS5 Antibody is an unconjugated, approximately 102 kDa, rabbit-derived, anti-ADAMTS5 polyclonal antibody. ADAMTS5 Antibody can be used for: WB, ELISA, IHC-P expriments in human, mouse, rat, and predicted: dog, pig, cow, horse, rabbit background without labeling.
Inquiry Online
Your information is safe with us. * Required Fields.