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ALR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldose Reductase (9) Apoptosis (1) FLAP (2) Lipoxygenase (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (3) Metabolic Disease (8)

13

Inhibitors & Agonists

1

Fluorescent Dye

6

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

ALR2-IN-1	Aldose Reductase	Metabolic Disease
ALR2-IN-1 is a potent and selective *ALR2* inhibitor (IC₅₀=1.42 μM). ALR2-IN-1 shows antioxidant and antiglycative properties. ALR2-IN-1 can be used in diabetic complication research .

ALR-38	Lipoxygenase	Inflammation/Immunology
ALR-38 is a 5-lipoxygenase (5-LOX) inhibitor (IC₅₀: 1.1 μM) with anti-inflammatory activity. ALR-38 effectively reduces ROS levels in neutrophils .

ALR2-IN-3	Aldose Reductase	Metabolic Disease
ALR2-IN-2 is a potent inhibitor of aldose reductase (ALR2), with IC₅₀s of 22 nM and 116 nM for rat ALR2 and *ALR1, respectively. ALR*2-IN-2 can be used for the research of diabetic complications .

ALR2-IN-2	Aldose Reductase	Metabolic Disease
ALR2-IN-2 is a potent inhibitor of aldose reductase (ALR2), with IC₅₀s of 27 nM and 228 nM for rat ALR2 and *ALR1, respectively. ALR*2-IN-2 can be used for the research of diabetic complications .

ALR-27	FLAP	Inflammation/Immunology
ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes .

ALR1/2-IN-1	Aldose Reductase	Cancer
ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) and aldose reductase (ALR2) inhibitor with IC₅₀ values of 3.26 μM and 3.06 μM against ALR1 and ALR2, respectively. ALR1/2-IN-1 shows anticancer activity .

ALR-6	FLAP	Inflammation/Immunology
ALR-6 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-6 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM and has no significant effect on direct inhibition of 5-LOX .

MitoBloCK-6	Apoptosis	Metabolic Disease
MitoBloCK-6 is a potent *Erv1/ALR* inhibitor, with an IC₅₀ of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 (IC₅₀=1.4 μM). MitoBloCK-6 can induce apoptosis via cytochrome c release in hESCs .

Ponalrestat 1 Publications Verification ICI 128436	Aldose Reductase	Metabolic Disease
Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (K_i=7.7 nM) over ALR1 (K_i=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol .

IDD388	Aldose Reductase	Metabolic Disease
IDD388 is a selective aldose reductase (ALR2) inhibitor with an IC₅₀ of 30 nM. IDD388 displays selectivity for ALR2 over ALR1 (IC₅₀ of 14 μM) .

Aldose reductase-IN-4	Aldose Reductase	Cancer
Aldose reductase-IN-4 (compund IIc) is an aldose reductase inhibitor with IC₅₀s of 11.70 μM and 0.98 μM for aldehyde reductase 1 (ALR1) and *ALR2*, respectively .

Aldose reductase-IN-5	Aldose Reductase	Metabolic Disease
As an aldose reductase (ALR2) inhibitor, the compound is used to enhance the combination of inhibitory excitability and antioxidant capacity to delay the progress of diabetes complications.

6,7-Dihydroxy-4-coumarinylacetic acid	Aldose Reductase	Metabolic Disease
6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of *ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH* andALR1 with IC₅₀s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation .

Cat. No.	Product Name	Type

6,7-Dihydroxy-4-coumarinylacetic acid	Dyes
6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of *ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH* andALR1 with IC₅₀s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation .

Species:	Human (5) Rat (1)
Tag:	His (6) SUMO (1)
Source:	HEK293 (1) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source

HY-P70953A

GFER Protein, Human (N-His)

FAD-linked sulfhydryl oxidase ALR; GFER; Augmenter of liver regeneration; hERV1; Hepatopoietin; GFER; ALR; HERV1; HPO
Human E. coli

	AKR1A1 Protein, Human (His) Aldo-keto reductase family 1 member A1; Aldehyde reductase; Glucuronate reductase; ALDR1; ALR	Human	E. coli
	The AKR1A1 protein uses NADPH to reduce various carbonyl compounds to alcohols. AKR1A1 Protein, Human (His) is the recombinant human-derived AKR1A1 protein, expressed by E. coli , with N-His labeled tag. The total length of AKR1A1 Protein, Human (His) is 325 a.a., with molecular weight of ~39 KDa.

	GFER Protein, Human (HEK293, His) FAD-linked sulfhydryl oxidase ALR; hERV1; Hepatopoietin; ALR	Human	HEK293
	GFER protein, acting as an autocrine hepatotrophic growth factor, critically promotes liver regeneration. GFER Protein, Human (HEK293, His) is the recombinant human-derived GFER protein, expressed by HEK293 , with C-His labeled tag. The total length of GFER Protein, Human (HEK293, His) is 125 a.a., with molecular weight of ~16.5 kDa.

	GFER Protein, Human (His) 1 Publications Verification FAD-linked sulfhydryl oxidase ALR; GFER; Augmenter of liver regeneration; hERV1; Hepatopoietin; GFER; ALR; HERV1; HPO	Human	E. coli
	GFER protein, acting as an autocrine hepatotrophic growth factor, critically promotes liver regeneration. GFER Protein, Human (His) is the recombinant human-derived GFER protein, expressed by E. coli , with N-6*His labeled tag. The total length of GFER Protein, Human (His) is 125 a.a., with molecular weight of ~15.0 kDa.

	GFER Protein, Rat (His-SUMO) Gfer; ALRFAD-linked sulfhydryl oxidase ALR; EC 1.8.3.2; Augmenter of liver regeneration	Rat	E. coli
	The GFER protein is a FAD-dependent sulfhydryl oxidase that restores redox-active disulfide bonds in CHCHD4/MIA40, an important partner for protein folding in the mitochondrial intermembrane space. GFER Protein, Rat (His-SUMO) is the recombinant rat-derived GFER protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of GFER Protein, Rat (His-SUMO) is 198 a.a., with molecular weight of ~38.8 kDa.

	AKR1B1 Protein, Human (His) Aldo-keto reductase family 1 member B1; AKR1B1; ALDR1; ALR2	Human	E. coli
	The AKR1B1 protein uses NADPH to reduce various carbonyl compounds to alcohols. AKR1B1 Protein, Human (His) is the recombinant human-derived AKR1B1 protein, expressed by E. coli , with N-His, N-10*His labeled tag. The total length of AKR1B1 Protein, Human (His) is 316 a.a., with molecular weight of ~36 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P81338

Aldose Reductase Antibody (YA1083)

AR; ADR; ALR2; ALDR1
WB Human, Mouse, Rat

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