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Results for "

Adenosine A2A receptor agonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (21) Drug Metabolite (1) Endogenous Metabolite (4)
By Research Areas:	Cancer (4) Cardiovascular Disease (6) Infection (1) Inflammation/Immunology (10) Neurological Disease (8)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Adenosine Kinase Adenosine Receptor Adenosine Deaminase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13201A

CGS 21680 Hydrochloride Maximum Cited Publications 7 Publications Verification	Adenosine Receptor	Neurological Disease
CGS 21680 Hydrochloride is a selective **adenosine A2A receptor** agonist with a K_i of 27 nM.

HY-120941

LASSBio-1359

Adenosine Receptor Cardiovascular Disease Inflammation/Immunology

LASSBio-1359 is an adenosine A2A receptor agonist with vasodilatory and anti-inflammatory activities .
HY-13201

CGS 21680

Adenosine Receptor Neurological Disease

CGS 21680 is a selective adenosine A2A receptor agonist, with a K_i of 27 nM.
HY-Z9063

1-epi-Regadenoson

Drug Metabolite Others

1-epi-Regadenoson is an αisomer impurity of Regadenoson which is a highly selective adenosine A2A receptor agonist .

LASSBio-1359	Adenosine Receptor	Cardiovascular Disease Inflammation/Immunology
LASSBio-1359 is an **adenosine A2A receptor** agonist with vasodilatory and anti-inflammatory activities .

CGS 21680	Adenosine Receptor	Neurological Disease
CGS 21680 is a selective **adenosine A2A receptor** agonist, with a K_i of 27 nM.

1-epi-Regadenoson	Drug Metabolite	Others
1-epi-Regadenoson is an αisomer impurity of Regadenoson which is a highly selective adenosine A2A receptor agonist .

HY-A0168S

Regadenoson-d3 CVT-3146-d₃	Adenosine Receptor	Cardiovascular Disease Cancer
Regadenoson-d₃ is the deuterium labeled Regadenoson. Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with Kis of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents[1][2][3].

HY-103183

CV1808 2-PhenylaminoAdenosine	Adenosine Receptor Endogenous Metabolite	Inflammation/Immunology
CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with K_is of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively .

HY-Z9064

1-epi-Regadenoson ethyl ester	Others	Others
1-epi-Regadenoson ethyl ester is an intermediate in the synthesis of αisomer impurity of Regadenoson which is a highly selective adenosine A2A receptor agonist .

HY-Z9065

1-epi-Regadenoson hydrazone	Others	Others
1-epi-Regadenoson hydrazone is an intermediate in the synthesis of αisomer impurity of Regadenoson which is a highly selective adenosine A2A receptor agonist .

HY-147400

Sipagladenant KW-6356	Adenosine Receptor	Neurological Disease
Sipagladenant (Compound I) is an orally active **adenosine receptor A2A** inverse agonist . Sipagladenant can be used in frontal lobe dysfunction research .

HY-103170

LUF5834	Adenosine Receptor	Others
LUF5834 is a selective A_2B adenosine receptor (A2BR) partial agonist (EC₅₀ = 12 nM). LUF5834 is also a partial *A₁/A_2A* adenosine receptor agonist (lacking selectivity) with K_i values of 2.6 and 28 nM, respectively .

HY-103181

N6-Cyclopentyladenosine CPA; UK-80882	Adenosine Receptor	Neurological Disease
N6-Cyclopentyladenosine (CPA) is a selective **Adenosine A₁ receptor** agonist, with K_i values of 2.3 nM, 790 nM and 43 nM for human A₁, A_2A and A₃ receptors, respectively .

HY-N0092

Inosine 5 Publications Verification	Adenosine Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-106450

Binodenoson MRE-0470; WRC 0470	Adenosine Receptor	Cardiovascular Disease
Binodenoson (MRE-0470) is a potent and selective **A2A adenosine receptor** agonist (K_D=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stress imaging .

HY-136233A

PSB 0777 ammonium hydrate	Adenosine Receptor	Inflammation/Immunology
PSB 0777 ammonium hydrate is a potent and selective adenosine *A_2A* receptor full agonist with K_i values of 44.4 nM, 360 nM for rat and human A_2A receptors, respectively. PSB 0777 ammonium hydrate has K_i values of ≥10000 nM, 541 nM for rat and human A₁ receptors, respectively. PSB 0777 ammonium hydrate shows poor brain penetrant and perorally non-absorbable effect. PSB 0777 ammonium hydrate has the potential for inflammatory bowel disease (IBS) research research .

HY-136233

PSB 0777 ammonium	Adenosine Receptor	Inflammation/Immunology
PSB 0777 ammonium is a potent and selective adenosine *A_2A* receptor full agonist with K_i values of 44.4 nM, 360 nM for rat and human A_2A receptors, respectively. PSB 0777 ammonium has K_i values of ≥10000 nM, 541 nM for rat and human A₁ receptors, respectively. PSB 0777 ammonium shows poor brain penetrant and perorally non-absorbable effect. PSB 0777 ammonium has the potential for inflammatory bowel disease (IBS) research research .

HY-12365

Namodenoson CF-102; 2-Cl-IB-MECA	Adenosine Receptor	Cancer
Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (K_i=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively .

HY-103186

MRS-1706 1 Publications Verification	Adenosine Receptor	Inflammation/Immunology
MRS-1706 is a potent and selective **adenosine A_2B receptor** inverse agonist. MRS-1706 has K_i values of 1.39, 112, 157, and 230 nM for human A_2B, A_2A, A₁ and A₃ receptors respectively. MRS-1706 blocks adenosine-mediated cAMP induction .

HY-N0092S

Inosine-2,8-d2	Adenosine Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Inosine-2,8-d₂ is the deuterium labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors[1][2][3].

HY-12365R

Namodenoson (Standard)	Adenosine Receptor	Cancer
Namodenoson (Standard) is the analytical standard of Namodenoson. This product is intended for research and analytical applications. Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (K_i=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively .

HY-105017

Evodenoson ATL 313; DE 112	Adenosine Receptor	Infection Inflammation/Immunology
Evodenoson is a selective agonist of the **A_2A adenosine receptor*. Evodenoson’s primary actions include reducing inflammatory responses, decreasing intestinal fluid secretion, edema, tissue damage, and neutrophil infiltration induced by Clostridium difficile* toxin A. Evodenoson’s protective effect is achieved by reducing myeloperoxidase (MPO) and adenosine deaminase (ADA) activities, and by lowering the production of tumor necrosis factor-alpha (TNF-α) .

HY-A0168

Regadenoson 1 Publications Verification CVT-3146	Adenosine Receptor	Cardiovascular Disease
Regadenoson (CVT-3146) is a selective **A2A adenosine receptor** agonist and vasodilator that increases coronary blood flow, can be used in study of myocardial perfusion imaging. Regadenoson also increases the permeability of the blood-brain barrier (BBB) in rodents, can be used to study increased delivery of agents to the human CNS .

HY-103171

BAY 60-6583 4 Publications Verification	Adenosine Receptor	Cardiovascular Disease Inflammation/Immunology
BAY 60-6583 is a potent and high-affinity agonist of adenosine A_2B receptor (EC₅₀ = 3 nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with K_i values of 750 nM, 340 nM and 330 nM, respectively. BAY 60-6583 has a cardioprotective effect in a myocardial ischemia model .

HY-N0092S3

Inosine-13C10,15N4	Adenosine Receptor Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Inosine-13C10,15N4 is ¹³C and ¹⁵N labeled Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

HY-A0168R

Regadenoson (Standard)		Cardiovascular Disease
Regadenoson (Standard) is the analytical standard of Regadenoson. This product is intended for research and analytical applications. Regadenoson (CVT-3146) is a selective **A2A adenosine receptor** agonist and vasodilator that increases coronary blood flow, can be used in study of myocardial perfusion imaging. Regadenoson also increases the permeability of the blood-brain barrier (BBB) in rodents, can be used to study increased delivery of agents to the human CNS .

HY-109139

Taminadenant 1 Publications Verification NIR178; PBF509	Adenosine Receptor	Neurological Disease Cancer
Taminadenant (NIR178; PBF509) is a highly potent and orally active **adenosine A_2A receptor** (A_2AR) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with K_B values of 72.8 nM and 8.2 nM, respectively. Taminadenant reverses motor impairments in several rat models of movement disorders, including catalepsy, tremor, and hemiparkinsonism. Taminadenant can also inhibit tumor growth when combined with Spartalizumab (HY-P9972). Taminadenant reactivate the antitumor immune response .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-103183

CV1808 2-PhenylaminoAdenosine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Adenosine Receptor Endogenous Metabolite
CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with K_is of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively .

HY-N0092

Inosine 5 Publications Verification	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Adenosine Receptor Endogenous Metabolite
Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

Cat. No.	Product Name	Chemical Structure

HY-A0168S

Regadenoson-d3
Regadenoson-d₃ is the deuterium labeled Regadenoson. Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with Kis of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents[1][2][3].

Regadenoson-d3

Regadenoson-d₃ is the deuterium labeled Regadenoson. Regadenoson (CVT-3146) is a potent and selective A2A adenosine receptor agonist, with Kis of 290 and 1120 nM for rat and pig adenosine A2A receptor, respectively. Regadenoson is selective for the adenosine A2A receptor over adenosine A1 and A2B receptors, and shows 13-fold selectivity over the human adenosine A1 receptor. Regadenoson is a vasodilator stress agent has shifted the landscape of vasodilator myocardial perfusion imaging. Regadenoson increases blood-brain barrier (BBB) permeability in rodents[1][2][3].

HY-N0092S

Inosine-2,8-d2
Inosine-2,8-d₂ is the deuterium labeled Inosine. Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A1 (A1R) and A2A (A2AR) receptors[1][2][3].

HY-N0092S3

Inosine-13C10,15N4
Inosine-13C10,15N4 is ¹³C and ¹⁵N labeled Inosine (HY-N0092). Inosine is an endogenous purine nucleoside produced by catabolism of adenosine. Inosine has anti-inflammatory, antinociceptive, immunomodulatory and neuroprotective effects. Inosine is an agonist for adenosine A₁ (A₁R) and A_2A (A_2AR) receptors .

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