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CBF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (2) HDAC (1) TGF-beta/Smad (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (3) Infection (1) Inflammation/Immunology (3) Neurological Disease (1)

12

Inhibitors & Agonists

3

Recombinant Proteins

3

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Ro5-3335 3 Publications Verification	Others	Cancer
Ro5-3335, a benzodiazepine, acts as an inhibitor of *core binding factor (CBF) leukemia. Ro5-3335 is a RUNX1-CBF*β interaction inhibitor that represses RUNX1/CBFB-dependent transactivation .

AI-10-49	Others	Inflammation/Immunology Cancer
AI-10-49 is an inhibitor of leukemic oncoprotein CBFβ-SMHHC. AI-10-49 inhibits the binding of CBFβ-SMMHCto the RUNX1 Runt domain with IC₅₀ value of 0.26 μM. AI-10-49 can be used for the research of leukemia .

HY-138617

AI-10-47

Others Cancer

AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC₅₀ of 3.2 μM .
HY-124137

Runx1-CBFβ interaction inhibitor 1

Others Cancer

Runx1-CBFβ interaction inhibitor 1 is an allosteric inhibitior of Runt domain-CBFb interaction (IC₅₀=3.2 μM) .

NSC 140873	Others	Infection Cancer
NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335) .

Kartogenin Maximum Cited Publications 21 Publications Verification KGN	TGF-beta/Smad	Inflammation/Immunology
Kartogenin (KGN) is an inducer of chondrogenic tissue formation (EC₅₀: 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research .

Kartogenin sodium Maximum Cited Publications 21 Publications Verification KGN sodium	TGF-beta/Smad	Inflammation/Immunology
Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC₅₀: 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research .

HY-105925

Mefenidil

MCN 2378
Others Cardiovascular Disease

Mefenidil is a selective cerebral vasodilator. Mefenidil can be used in study cardiovascular diseases .

Regadenoson 1 Publications Verification CVT-3146	Adenosine Receptor	Cardiovascular Disease
Regadenoson (CVT-3146) is a selective A2A adenosine receptor agonist and vasodilator that increases coronary blood flow, can be used in study of myocardial perfusion imaging. Regadenoson also increases the permeability of the blood-brain barrier (BBB) in rodents, can be used to study increased delivery of agents to the human CNS .

Regadenoson (Standard)	Adenosine Receptor	Cardiovascular Disease
Regadenoson (Standard) is the analytical standard of Regadenoson. This product is intended for research and analytical applications. Regadenoson (CVT-3146) is a selective A2A adenosine receptor agonist and vasodilator that increases coronary blood flow, can be used in study of myocardial perfusion imaging. Regadenoson also increases the permeability of the blood-brain barrier (BBB) in rodents, can be used to study increased delivery of agents to the human CNS .

HDAC-IN-38	HDAC	Neurological Disease
HDAC-IN-38 (compound 13) is a potent HDAC inhibitor. HDAC-IN-38 shows similar micro-molar inhibitory activity toward HDAC1, 2, 3, 5, 6, and 8. HDAC-IN-38 increases cerebral blood flow (CBF), attenuates cognitive impairment, and improves hippocampal atrophy. HDAC-IN-38 also increases the level of histone acetylation (H3K14 or H4K5) .

AMT-NHS	Others	Others
AMT-NHS is an RNA-protein crosslinker. AMT-NHS is composed of a psoralen derivative and an N-hydroxysuccinimide ester group which react with RNA bases and primary amines of protein, respectively. AMT-NHS can penetrate into living yeast cells and crosslink Cbf5 to H/ACA snoRNAs with high specificity. AMT-NHS induces different crosslinking patterns and targets both single- and double-stranded regions of RNA. AMT-NHS can be used for capturing diverse RNA-protein interactions in cells .

Species:	Human (2) Mouse (1)
Tag:	His (3)
Source:	P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	CBFB Protein, Human (His) Core-binding factor subunit beta; CBF-beta; PEA2-beta; PEBP2-beta	Human	E. coli
	CBFB, forming the heterodimeric complex core-binding factor (CBF) with RUNX family proteins, enhances the DNA-binding capacity of RUNX members like RUNX1, RUNX2, and RUNX3. The heterodimers bind to specific sites in enhancers and promoters, modulating transcription of target genes. CBFB complexes repress ZBTB7B during CD8+ T cell development, acting as a transcriptional silencer and facilitating cytotoxic T cell differentiation. Interactions occur with COPRS and PRMT5 in complexes with RUNX1. CBFB Protein, Human (His) is the recombinant human-derived CBFB protein, expressed by E. coli , with N-6*His labeled tag. The total length of CBFB Protein, Human (His) is 181 a.a., with molecular weight of ~25 kDa.

	YBX1 Protein, Mouse (P.pastoris, His) Ybx1; Msy-1; Msy1; Nsep1; Yb1; Y-box-binding protein 1; YB-1; CCAAT-binding transcription factor I subunit A; CBF-A; DNA-binding protein B; DBPB; Enhancer factor I subunit A; EFI-A; Nuclease-sensitive element-binding protein 1; Y-box transcription factor	Mouse	P. pastoris

	CEBPA Protein, Human (His) Apoptotic cysteine protease; Apoptotic protease Mch 5; C/EBP alpha; C/ebpalpha; CAP4; Caspase 8 precursor; CBF-A; CCAAT Enhancer Binding Protein alpha; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer-binding protein alpha; CEBP; CEBP A; CEBP alpha; Cebpa; CEBPA_HUMAN; FADD homologous; ICE/CED 3 like protease; FADD like ICE; FLICE; ICE like apoptotic protease 5; ICE8; MACH	Human	E. coli
	CEBPA protein, also known as CCAAT/enhancer-binding protein α, is a transcription factor that plays a crucial role in regulating the expression of genes related to cell differentiation, proliferation, and metabolism. The reference paragraph states that CEBPA protein interacts with TAF1A and UBTF. CEBPA Protein, Human (His) is the recombinant human-derived CEBPA protein, expressed by E. coli , with N-His labeled tag. The total length of CEBPA Protein, Human (His) is 358 a.a., with molecular weight of ~44 kDa.

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