Search Result

Results for "

Carcinogenicity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (3) Apoptosis (7) Aryl Hydrocarbon Receptor (1) Autophagy (3) Bacterial (9) Bcl-2 Family (1) Biochemical Assay Reagents (2) Btk (1) Caspase (1) CDK (1) DNA Alkylator/Crosslinker (3) DNA/RNA Synthesis (4) Drug Metabolite (1) Early 2 Factor (E2F) (1) Endogenous Metabolite (15) Estrogen Receptor/ERR (1) Fluorescent Dye (4) Fungal (1) Isotope-Labeled Compounds (12) JAK (1) Keap1-Nrf2 (1) Necroptosis (1) NF-κB (1) Nucleoside Antimetabolite/Analog (1) Parasite (3) PI3K (1) Polo-like Kinase (PLK) (1) PROTAC Linkers (1) RAR/RXR (1) Reactive Oxygen Species (3) STAT (1) YAP (1)
By Research Areas:	Cancer (60) Cardiovascular Disease (2) Endocrinology (1) Infection (10) Inflammation/Immunology (5) Metabolic Disease (5) Neurological Disease (7)

By Targets:

Antibiotic (3)

Apoptosis (7)

Aryl Hydrocarbon Receptor (1)

Autophagy (3)

Bacterial (9)

Bcl-2 Family (1)

Biochemical Assay Reagents (2)

Btk (1)

Caspase (1)

CDK (1)

DNA Alkylator/Crosslinker (3)

DNA/RNA Synthesis (4)

Drug Metabolite (1)

Early 2 Factor (E2F) (1)

Endogenous Metabolite (15)

Estrogen Receptor/ERR (1)

Fluorescent Dye (4)

Fungal (1)

Isotope-Labeled Compounds (12)

JAK (1)

Keap1-Nrf2 (1)

Necroptosis (1)

NF-κB (1)

Nucleoside Antimetabolite/Analog (1)

Parasite (3)

PI3K (1)

Polo-like Kinase (PLK) (1)

PROTAC Linkers (1)

RAR/RXR (1)

Reactive Oxygen Species (3)

STAT (1)

YAP (1)

By Research Areas:

Cancer (60)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (10)

Inflammation/Immunology (5)

Metabolic Disease (5)

Neurological Disease (7)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7027

Macrozamin

Others Neurological Disease Cancer

Macrozamin is a major constituent principle of Cycads. Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties .

Macrozamin	Others	Neurological Disease Cancer
Macrozamin is a major constituent principle of Cycads. Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties .

HY-W543743

1-Ethenylpyrene 1-Vinylpyrene	Others	Cancer
1-Ethenylpyrene (1-Vinylpyrene) is an anti-chemical carcinogen that inhibits the formation of skin tumors initiated by either DMBA (HY-W011845) or Benzo[a]pyrene (HY-107377) .

HY-N7882

Ptaquiloside

Braxin C; Aquilide A
Others Cancer

Ptaquiloside is a sesquiterpene glycoside isolated from Pteridium aquilinum var.latiusculum and has carcinogenic activity .
HY-122927

Symphytine

Others Cancer

Symphytine is a pyrrolizidine alkaloid isolated from Symphytum officinale and has carcinogenicity .

Ptaquiloside Braxin C; Aquilide A	Others	Cancer
Ptaquiloside is a sesquiterpene glycoside isolated from Pteridium aquilinum var.latiusculum and has carcinogenic activity .

Symphytine	Others	Cancer
Symphytine is a pyrrolizidine alkaloid isolated from Symphytum officinale and has carcinogenicity .

HY-106471

Pildralazine Propyldazine	Others	Cardiovascular Disease
Pildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model .

HY-128612

Methylnitronitrosoguanidine 5 Publications Verification MNNG	DNA Alkylator/Crosslinker	Cancer
Methylnitronitrosoguanidine (MNNG) is an orally active alkylating agent with toxic and mutagenic effects. Methylnitronitrosoguanidine can as a carcinogen and mutagen . 50% water content, specifications are based on dry weight.

HY-116108

Musk tibetene Musk tibetine	Others	Cancer
Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line .

HY-W000838

1-Hydroxyanthraquinone	DNA/RNA Synthesis	Cancer
1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect .

HY-W016286

2,6-Dithiopurine 2,6-Dimercaptopurine	Others	Cancer
2,6-Dithiopurine (2,6-Dimercaptopurine) is a nucleophilic scavenger for electrophilic carcinogens. 2,6-Dithiopurine abolishes both DNA adduct formation and the initiation of carcinogenesis .

HY-157030

NIEA

Others Cancer

NIEA is a potent carcinogen that induce pancreatic cancer, esophageal cancer and hepatocellular carcinoma .

NIEA	Others	Cancer
NIEA is a potent carcinogen that induce pancreatic cancer, esophageal cancer and hepatocellular carcinoma .

HY-118547

Clorofene 2-Benzyl-4-chlorophenol	Bacterial	Infection
Clorofene (2-Benzyl-4-chlorophenol) is an aryl halide fungicide widely used in hospitals and homes as a broad-spectrum fungicide in general cleaning and disinfection disinfectant solutions and in soap formulations. Clorofene has antibacterial and carcinogenic activity .

HY-116832

Retrorsine N-oxide	Others	Cancer
Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides .

HY-33354

Nitrochin 4-NQO	Apoptosis	Cancer
Nitrochin (4-NQO) is a chemical carcinogen. Nitrochin induces oncostatin-M (OSM) in esophageal cells. Nitrochin induces DNA damage, and induces apoptosis via a p53-dependent mitochondrial signaling pathway .

HY-141638

Me-IQ Methyl-IQ	Others	Cancer
Me-IQ (Methyl-IQ), an orally active heterocyclic amine, is carcinogenic and mutagenic. Me-IQ is several hundred-fold more mutagenic in liver than in lung microsomal preparations from uninduced mice and rabbits .

HY-137658

Purine riboside triphosphate PTP	Nucleoside Antimetabolite/Analog	Others
Purine riboside triphosphate is a triphosphate derivative of purine riboside. Purine riboside is a naturally occurring base analog which closely resembles adenosine. Purine riboside inhibits carcinogenic growth. Purine riboside strongly inhibits RNA and DNA synthesis in different cancer ascites cells .

HY-D0914

Fast Green FCF FD&C Green No. 3; Food green 3; C.I. 42053	Fluorescent Dye	Others
Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF is carcinogenic and acts as a presynaptic locus by inhibiting the release of neurotransmitters in the nervous system .

HY-34758

N-Nitroso-N-methylurea Maximum Cited Publications 8 Publications Verification NMU; MNU; NMH	DNA Alkylator/Crosslinker	Cancer
N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane .

HY-W271064

1-Methylpyrene	Fluorescent Dye	Others
1-Methylpyrene is a ubiquitous environmental pollutant and rodent carcinogen. Its mutagenic activity depends on sequential activation by various CYP and sulfotransferase (SULT) enzymes. 1-Methylpyrene induces chromosome loss and mitotic disturbance, proba

HY-131123S1

N-Nitrosomorpholine-d8	Isotope-Labeled Compounds	Others
N-Nitrosomorpholine-d₈ is deuterium labeled N-Nitrosomorpholine. N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen[1].

HY-131123S

N-Nitrosomorpholine-d4	Isotope-Labeled Compounds	Others
N-Nitrosomorpholine-d₄ is the deuterium labeled N-Nitrosomorpholine[1]. N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen[2].

HY-Y0946S

Acetamide-15N	Isotope-Labeled Compounds	Cancer
Acetamide- ¹⁵N is the ¹⁵N-labeled Acetamide. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity[1][2].

HY-Y0946S2

Acetamide-d5	Isotope-Labeled Compounds	Cancer
Acetamide-d₅ is the deuterium labeled Acetamide[1]. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity[2][3].

HY-111375

Azoxymethane

5+ Cited Publications

AOM
DNA Alkylator/Crosslinker Cancer

Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts.

Azoxymethane 5+ Cited Publications AOM	DNA Alkylator/Crosslinker	Cancer
Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts.

HY-N0511

Aristolochic acid B 1 Publications Verification	Others	Cancer
Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo .

HY-N12840

Logmalicid B

Others Metabolic Disease

Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

Logmalicid B	Others	Metabolic Disease
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

HY-112085

N-Bis(2-hydroxypropyl)nitrosamine 1 Publications Verification Di(2-hydroxypropyl)nitrosamine; Diisopropanolnitrosamine	Others	Cancer
N-Bis(2-hydroxypropyl)nitrosamine is an agent with carcinogenic activity.

HY-107377

Benzo[a]pyrene 3 Publications Verification 3,4-Benzopyrene	Endogenous Metabolite	Cancer
Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies.

HY-131123

N-Nitrosomorpholine

Others Others

N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen .

N-Nitrosomorpholine	Others	Others
N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen .

HY-34740

Ethylmalonic acid	Endogenous Metabolite	Neurological Disease Metabolic Disease
Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.

HY-N1465

Aristolochic acid D	Others	Cancer
Aristolochic acid D is an aristolochic acid derivative isolated from stems of Aristolochia indica. Aristolochic acid is nephrotoxin and carcinogen .

HY-121107

Chrysene 1 Publications Verification	Others	Cancer
Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties .

HY-131102

Mequindox	Bacterial DNA/RNA Synthesis	Infection
Mequindox is an antimicrobial agent . Mequindox acts as an inhibitor of DNA synthesis. Mequindox induces genotoxicity and carcinogenicity in mice .

HY-N6695

Aflatoxicol

Aflatoxin R0
Others Cancer

Aflatoxin (Aflatoxin R0) is a metabolite of aflatoxin B1 produced from Rhizopus spp , and is mutagenic and carcinogenic mycotoxin .

Aflatoxicol Aflatoxin R0	Others	Cancer
Aflatoxin (Aflatoxin R0) is a metabolite of aflatoxin B1 produced from Rhizopus spp , and is mutagenic and carcinogenic mycotoxin .

HY-W011845

DMBA 7,12-DMBA; 7,12-Dimethylbenzanthracene	Others	Cancer
DMBA has *carcinogenic* activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models .

HY-D0300

Leucomalachite green 1 Publications Verification	Fluorescent Dye	Others
Leucomalachite green is a triphenylmethane dye used to detect blood. Leucomalachite green, a major metabolite of malachite green, is a potential carcinogen, teratogen and mutagen .

HY-N4068

Glucoraphanin 5 Publications Verification	Reactive Oxygen Species Endogenous Metabolite	Cancer
Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects.

HY-34740S

Ethylmalonic acid-d3	Endogenous Metabolite	Neurological Disease Metabolic Disease
Ethylmalonic acid-d₃ is the deuterium labeled Ethylmalonic acid. Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.

HY-34740S1

Ethylmalonic acid-d5	Endogenous Metabolite	Neurological Disease Metabolic Disease
Ethylmalonic acid-d₅ is the deuterium labeled Ethylmalonic acid. Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.

HY-121107S

Chrysene-d12	Isotope-Labeled Compounds	Cancer
Chrysene-d₁₂ is the deuterium labeled Chrysene. Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties[1].

HY-114740

β-Naphthoflavone 1 Publications Verification 5,6-Benzoflavone; beta-NF	Aryl Hydrocarbon Receptor Apoptosis	Neurological Disease Cancer
β-Naphthoflavone is a non-carcinogenic AhR agonist as a positive control for the induction of AhR transcriptional activity . β-Naphthoflavone inhibits hydrogen peroxide-induced apoptosis .

HY-N1376

(20R)-Ginsenoside Rg3 2 Publications Verification (20R)-Propanaxadiol; R-ginsenoside Rg3	Others	Cancer
(20R)-ginsenoside Rg3 ((20R)-Propanaxadiol), one of the active compounds present in ginseng root, inhibits angiogenesis, and has anti-carcinogenic and antimetastatic effects .

HY-107377S

Benzo[a]pyrene-d12	Endogenous Metabolite	Cancer
Benzo[a]pyrene-d₁₂ is the deuterium labeled Benzo[a]pyrene[1]. Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies[2][3].

HY-N6786

Ochratoxin B	Endogenous Metabolite	Cancer
Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents .

HY-Y0946

Acetamide	Biochemical Assay Reagents	Inflammation/Immunology Cancer
Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity. Acetamide derivatives may has antioxidant activity and potential anti-inflammatory activity .

HY-W013075

Rutin trihydrate 5+ Cited Publications Rutoside trihydrate; Quercetin 3-O-rutinoside trihydrate	Apoptosis Endogenous Metabolite	Neurological Disease Cancer
Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities .

HY-N1925

Tea polyphenol	Apoptosis Autophagy	Neurological Disease Inflammation/Immunology Cancer
Tea polyphenol is the floorboard of phenolic compounds in tea. Tea polyphenol exhibits biological activity including antioxidant and anti-cancer activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism .

HY-131120

Bromonitromethane	Others	Cancer
Bromonitromethane is a halonitromethane that can be used in production of various protected α-bromo nitroalkane donors for use in Umpolung Amide Synthesis (UmAS) .

HY-D0300S

Leucomalachite green-d5	Fluorescent Dye Isotope-Labeled Compounds	Others
Leucomalachite green-d₅ is the deuterium labeled Leucomalachite green. Leucomalachite green is a triphenylmethane dye used to detect blood. Leucomalachite green, a major metabolite of malachite green, is a potential carcinogen, teratogen and mutagen[1][2].

HY-W002820

2-Amino-5-phenylpyridine	Endogenous Metabolite	Cancer
2-Amino-5-phenylpyridine is a mutagenic heterocyclic aromatic amine that is formed by pyrolysis of phenylalanine in proteins. 2-Amino-5-phenylpyridine is in broiled sardines and is considered as potentially carcinogenic .

HY-136433

N,N'-Dinitrosopiperazine 1,4-Dinitrosopiperazine; DNP	Others	Cancer
N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is a *carcinogen* with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568 .

Cat. No.	Product Name

HY-L100

Tumorigenesis-Related Compound Library

130 compounds

Cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic or mutagenic properties in experimental systems. Exposure can occur exogenously when these agents are present in food, air or water, and also endogenously when they are products of metabolism or pathophysiologic states such as inflammation. The administration of chemical carcinogens is one of the most commonly used methods to induce tumors in several organs in laboratory animals in order to study oncologic diseases of humans. MCE offers a unique collection of 130 chemical carcinogens which have been identified with carcinogenic activity either in humans or in animal models. MCE Tumorigenesis-Related Compound Library is a powerful tool for studying oncologic diseases of humans. Standard opration based on safety data sheet will not cause harm to the body.

HY-L068

Flavonoids Library

519 compounds

Flavonoids are an important class of natural products; particularly, they belong to a class of plant secondary metabolites having a polyphenolic structure, widely found in fruits, vegetables and certain beverages. Flavonoids can be subdivided into different subgroups depending on the carbon of the C ring on which the B ring is attached and the degree of unsaturation and oxidation of the C ring. These subgroups are: flavones, flavonols, flavanones, flavanonols, flavanols or catechins, anthocyanins and chalcones. Flavonoids are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications. This is attributed to their anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme function. Naturally occurring flavonoids are known to have biological activities for use as drugs, for example, in diseases like cancer, Alzheimer’s disease (AD), atherosclerosis, etc.

MCE offers a unique collection of 519 natural flavonoid compounds which is a useful tool for drug discovery as an important source of lead compounds.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7027

Macrozamin	Liliaceae Source classification Smilacis Glabrae Rhizoma Plants Saccharides	Others
Macrozamin is a major constituent principle of Cycads. Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties .

HY-W000838

1-Hydroxyanthraquinone	Quinones Monophenols other families Classification of Application Fields Anthraquinones Source classification Phenols Plants Disease Research Fields Cancer	DNA/RNA Synthesis
1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect .

HY-N7882

Ptaquiloside Braxin C; Aquilide A	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Pteridium aquilinum Pteridiaceae	Others
Ptaquiloside is a sesquiterpene glycoside isolated from Pteridium aquilinum var.latiusculum and has carcinogenic activity .

HY-116108

Musk tibetene Musk tibetine	Natural Products Classification of Application Fields Animals Source classification Disease Research Fields Cancer	Others
Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line .

HY-116832

Retrorsine N-oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Plants Compositae Baptisia australis (L.) R. Br. Disease Research Fields Cancer	Others
Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides .

HY-N0511

Aristolochic acid B 1 Publications Verification	Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Others
Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo .

HY-N12840

Logmalicid B	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	Others
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

HY-107377

Benzo[a]pyrene 3 Publications Verification 3,4-Benzopyrene	Natural Products Classification of Application Fields Malus pumila Mill. Source classification Rosaceae Plants Disease Research Fields Cancer	Endogenous Metabolite
Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies.

HY-34740

Ethylmalonic acid	Immune System Disorder Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite	Endogenous Metabolite
Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.

HY-N1465

Aristolochic acid D	Structural Classification Monophenols other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Plants Disease Research Fields Cancer	Others
Aristolochic acid D is an aristolochic acid derivative isolated from stems of Aristolochia indica. Aristolochic acid is nephrotoxin and carcinogen .

HY-121107

Chrysene 1 Publications Verification	Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Others
Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties .

HY-N4068

Glucoraphanin 5 Publications Verification	Structural Classification Classification of Application Fields Other Alkaloids Source classification cruciferous vegetables Glucosinolates Plants Brassicaceae Disease Research Fields Cancer	Reactive Oxygen Species Endogenous Metabolite
Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects.

HY-N1376

(20R)-Ginsenoside Rg3 2 Publications Verification (20R)-Propanaxadiol; R-ginsenoside Rg3	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Others
(20R)-ginsenoside Rg3 ((20R)-Propanaxadiol), one of the active compounds present in ginseng root, inhibits angiogenesis, and has anti-carcinogenic and antimetastatic effects .

HY-N6786

Ochratoxin B	Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Disease Research Fields Cancer	Endogenous Metabolite
Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents .

HY-Y0946

Acetamide	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Biochemical Assay Reagents
Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity. Acetamide derivatives may has antioxidant activity and potential anti-inflammatory activity .

HY-W013075

Rutin trihydrate Maximum Cited Publications 7 Publications Verification Rutoside trihydrate; Quercetin 3-O-rutinoside trihydrate	Structural Classification Flavonoids Flavones Combretaceae Combretum micranthum G. Don Source classification Plants	Apoptosis Endogenous Metabolite
Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities .

HY-N1925

Tea polyphenol	Structural Classification Classification of Application Fields Source classification Phenols Plants Camellia sinensis (L.) O. Ktze. Research on Agricultural Breeding Inflammation/Immunology Disease Research Fields Cancer Agricultural Research Theaceae	Apoptosis Autophagy
Tea polyphenol is the floorboard of phenolic compounds in tea. Tea polyphenol exhibits biological activity including antioxidant and anti-cancer activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism .

HY-W002820

2-Amino-5-phenylpyridine	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
2-Amino-5-phenylpyridine is a mutagenic heterocyclic aromatic amine that is formed by pyrolysis of phenylalanine in proteins. 2-Amino-5-phenylpyridine is in broiled sardines and is considered as potentially carcinogenic .

HY-N6697

Aflatoxin G1	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Coumarins Phenylpropanoids Endogenous metabolite Disease Research Fields Cancer	Bacterial Antibiotic Parasite
Aflatoxin G1 is one type of aflatoxins occuring in nature. It is produced by molds, such as Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are hepatogenic, teratogenic, imunosuppressive, and carcinogenic fungal metabolites found in feeds, nuts, wine-grapes, spices, and other grain crops .

HY-N6725

Sterigmatocystine	Infection Structural Classification Monophenols Microorganisms Xanthones Classification of Application Fields Source classification Phenols Disease Research Fields	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Endogenous Metabolite
Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-N10866

Phorbol 12-tiglate	Structural Classification Terpenoids Croton tiglium Linn. Source classification Diterpenoids Euphorbiaceae Plants	Others
Phorbol 12-tiglate is a derivative of Phorbol (HY-N2147). Phorbol, a hydrolyzed product of Croton oil, promotes tumor development by activating protein kinase C. Phorbol and its derivatives can be used to construct carcinogenic models in biomedical research .

HY-N6615

Aflatoxin B1 3 Publications Verification	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Bacterial Endogenous Metabolite Parasite
Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation .

HY-N6678

Zearalanone 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Anticancer Disease Research Fields Endocrinology	Estrogen Receptor/ERR
Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .

HY-N0502

Mogroside V	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Sweeteners Food Research	Reactive Oxygen Species
Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research .

HY-N0828

Pterostilbene 5 Publications Verification	Structural Classification Monophenols other families Stilbenes Classification of Application Fields Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Autophagy
Pterostilbene is a stilbenoid isolated from blueberries and Pterocarpus marsupium . Shows anti-oxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic and anti-obesity properties . Pterostilbene blocks ROS production , also exhibits inhibitory activity against various free radicals such as DPPH, ABTS, hydroxyl, superoxide and hydrogen peroxide .

HY-N6725R

Sterigmatocystine (Standard)	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Endogenous Metabolite
Sterigmatocystine (Standard) is the analytical standard of Sterigmatocystine. This product is intended for research and analytical applications. Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-W024365

3-tert-Butyl-4-methoxyphenol	Structural Classification Monophenols Source classification Jatropha curcas Linn. Phenols Euphorbiaceae Plants	PROTAC Linkers
3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system .

HY-121390

Lasiocarpine	Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Plants Disease Research Fields Boraginaceae Heliotropium europaeum L. Cancer	Endogenous Metabolite
Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide .

HY-N6615R

Aflatoxin B1 (Standard)	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenylpropanoids Endogenous metabolite Disease Research Fields	Bacterial Endogenous Metabolite Parasite
Aflatoxin B1 (Standard) is the analytical standard of Aflatoxin B1. This product is intended for research and analytical applications. Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation .

HY-13755A

(R)-Sulforaphane L-Sulforaphane	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Keap1-Nrf2 Bcl-2 Family Caspase Reactive Oxygen Species NF-κB
(R)-Sulforaphane (L-Sulforaphane) is a orally active, potent inducer of the Keap1/Nrf2/ARE pathway, exhibiting antioxidant and anticancer activities. (R)-Sulforaphane primarily functions by upregulating phase II detoxifying enzymes in cells, aiding in the removal of carcinogens and combating oxidative stress. (R)-Sulforaphane is capable of modulating gene expression, influencing various signaling pathways, including Nrf2, NF-κB, and AP-1. (R)-Sulforaphane can be used in studies of tumor biology, antioxidant defense mechanisms, as well as inflammation and immune responses .

HY-N8380

(-)-Latifolin	Structural Classification Dalbergia hupeana Hance Source classification Phenols Polyphenols Plants Fabaceae	Apoptosis Autophagy PI3K Necroptosis
(-)-Latifolin, a flavonoid, induces apoptotic cell death by targeting PI3K/AKT/mTOR/p70S6K signaling. (-)-Latifolin significantly inhibits the cell proliferation of oral squamous cell carcinoma (OSCC), and causes the anti-metastatic activities by effectively blocking cell migration, invasion, and adhesion via the inactivation of FAK/Src. (-)-Latifolin suppresses autophagic-related proteins and autophagosome formation. (-)-Latifolin inhibits necroptosis by dephosphorylating necroptosis-regulatory proteins (RIP1, RIP3, and MLKL). (-)-Latifolin has beneficial effects on anti-aging, anti-carcinogenic, anti-inflammatory, and cardio-protective activities .

Cat. No.	Product Name	Chemical Structure

HY-131123S1

N-Nitrosomorpholine-d8
N-Nitrosomorpholine-d₈ is deuterium labeled N-Nitrosomorpholine. N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen[1].

HY-Y0946S

Acetamide-15N
Acetamide- ¹⁵N is the ¹⁵N-labeled Acetamide. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity[1][2].

HY-34740S

Ethylmalonic acid-d3
Ethylmalonic acid-d₃ is the deuterium labeled Ethylmalonic acid. Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.

HY-131123S

N-Nitrosomorpholine-d4
N-Nitrosomorpholine-d₄ is the deuterium labeled N-Nitrosomorpholine[1]. N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen[2].

HY-Y0946S2

Acetamide-d5
Acetamide-d₅ is the deuterium labeled Acetamide[1]. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity[2][3].

HY-34740S1

Ethylmalonic acid-d5
Ethylmalonic acid-d₅ is the deuterium labeled Ethylmalonic acid. Ethylmalonic acid is non-carcinogenic potentially toxic and associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency.

HY-121107S

Chrysene-d12
Chrysene-d₁₂ is the deuterium labeled Chrysene. Chrysene is a high molecular weight (HMW), polycyclic aromatic hydrocarbon (PAH) known for its recalcitrance and carcinogenic properties[1].

HY-107377S

Benzo[a]pyrene-d12
Benzo[a]pyrene-d₁₂ is the deuterium labeled Benzo[a]pyrene[1]. Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies[2][3].

HY-D0300S

Leucomalachite green-d5
Leucomalachite green-d₅ is the deuterium labeled Leucomalachite green. Leucomalachite green is a triphenylmethane dye used to detect blood. Leucomalachite green, a major metabolite of malachite green, is a potential carcinogen, teratogen and mutagen[1][2].

HY-I1111S4

Fmoc-L-Val-OH-15N
Fmoc-L-Val-OH- ¹⁵N is a ¹⁵N-labeled Leucomalachite green. Leucomalachite green is a triphenylmethane dye used to detect blood. Leucomalachite green, a major metabolite of malachite green, is a potential carcinogen, teratogen and mutagen[1][2].

HY-136433S

N,N'-Dinitrosopiperazine-d8
N,N'-Dinitrosopiperazine-d₈ is the deuterium labeled N,N'-Dinitrosopiperazine[1]. N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568[2].

HY-N6786S

Ochratoxin B-13C20
Ochratoxin B- ¹³C₂₀ is ¹³C-labeled Ochratoxin B (HY-N6786). Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents .

HY-N1952S

Isoeugenol-d3
Isoeugenol-d₃ is deuterated labeled Sterigmatocystine (HY-N6725). Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-N6697S

Aflatoxin G1-13C17
Aflatoxin G1- ¹³C₁₇ is the ¹³C labeled Aflatoxin G1 (HY-N6697) . Aflatoxin G1 is one type of aflatoxins occuring in nature. It is produced by molds, such as Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are hepatogenic, teratogenic, imunosuppressive, and carcinogenic fungal metabolites found in feeds, nuts, wine-grapes, spices, and other grain crops .

HY-N6615S

Aflatoxin B1-13C17
Aflatoxin B1- ¹³C₁₇ is ¹³C- and ¹⁵N-labeled Aflatoxin B1 (HY-N6615). Aflatoxin B1 (AFB1) is a Class 1A carcinogen, which is a secondary metabolite of Aspergillus flavus and A. parasiticus. Aflatoxin B1 (AFB1) mainly induces the transversion of G-->T in the third position of codon 249 of the p53 tumor suppressor gene, resulting in mutation .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks