DNA polymerase

Pathways Recommended:	Cell Cycle/DNA Damage

By Targets:	DNA Alkylator/Crosslinker (1) DNA Stain (1) DNA/RNA Synthesis (72) PARP (4) Antibiotic (21) Apoptosis (29) Autophagy (10) Bacterial (19) Biochemical Assay Reagents (4) Cathepsin (1) CMV (9) Dengue virus (2) Drug Metabolite (3) Drug-Linker Conjugates for ADC (2) Endogenous Metabolite (18) Flavivirus (2) Fluorescent Dye (1) Fungal (4) G-quadruplex (1) HBV (6) HDAC (2) HIV (15) HIV Protease (2) HSV (18) IKK (4) Influenza Virus (1) Isotope-Labeled Compounds (8) Keap1-Nrf2 (4) Mitophagy (6) Necroptosis (1) Nucleoside Antimetabolite/Analog (17) Orthopoxvirus (8) Parasite (5) Phosphatase (5) PI3K (1) Potassium Channel (2) Reactive Oxygen Species (4) Reverse Transcriptase (9) SARS-CoV (5) Sirtuin (7) STING (1) Telomerase (1) Topoisomerase (6)
By Research Areas:	Cancer (62) Cardiovascular Disease (4) Infection (74) Inflammation/Immunology (12) Metabolic Disease (5) Neurological Disease (2)
Click Chemistry:	Azide (1)

Targets Recommended: DNA-PK DNA Methyltransferase DNA Stain DNA Alkylator/Crosslinker DNA/RNA Synthesis PARP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155094

DNA polymerase-IN-3	DNA/RNA Synthesis	Others
DNA polymerase-IN-3 (Compd 5b) is a coumarin derivative that exhibits inhibitory activity against Taq DNA polymerase and can be used in proliferative disease research .

HY-W560689

DNA polymerase-IN-1

DNA/RNA Synthesis Cancer

DNA polymerase-IN-1 (compound 2d) is a DNA polymerase inhibitor (IC₅₀=20.7 μM) with antiproliferative activity against tumor cells .

DNA polymerase-IN-1	DNA/RNA Synthesis	Cancer
DNA polymerase-IN-1 (compound 2d) is a DNA polymerase inhibitor (IC₅₀=20.7 μM) with antiproliferative activity against tumor cells .

HY-155092

DNA polymerase-IN-2	DNA/RNA Synthesis	Others
DNA polymerase-IN-2 (Compd 3c), a coumarin derivative, exhibits inhibitory activity against Taq DNA polymerase with IC₅₀ of 48.25 μM , which can be used in value-added disease research .

HY-155095

DNA polymerase-IN-4

Others Infection

DNA polymerase-IN-4 (Compd 5c), a coumarin derivative, has antiretroviral activity with IC₅₀ value of 134.22 μM .
HY-E70087

Enhanced Taq DNA polymerase

DNA/RNA Synthesis Others

Enhanced Taq DNA polymerase is a thermostable DNA polymerase that can be used in PCR .

DNA polymerase-IN-4	Others	Infection
DNA polymerase-IN-4 (Compd 5c), a coumarin derivative, has antiretroviral activity with IC₅₀ value of 134.22 μM .

Enhanced Taq DNA polymerase	DNA/RNA Synthesis	Others
Enhanced Taq DNA polymerase is a thermostable DNA polymerase that can be used in PCR .

HY-E70216

*Bsu DNA* polymerase, Large fragment**	Others	Others
Bsu DNA polymerase, Large fragment is a polymerase derived from Bacillus subtilis. Bsu DNA polymerase, Large fragment is a DNA isothermal amplification polymerase with chain replacement activity, which used in RPA recombinase polymerase amplification technology .

HY-E70084

Tth DNA polymerase

Others Others

Tth DNA polymerase is a DNA polymerase from T. thermophilus that can be used for DNA sequencing and polymerase chain reaction (PCR) .
HY-E70086

Taq DNA polymerase

DNA/RNA Synthesis Others

Taq DNA polymerase is a thermostable DNA polymerase that can be used in PCR .
HY-E70086A

Taq DNA Polymerase, Glycerol-free

DNA/RNA Synthesis Others

Taq DNA Polymerase, Glycerol-free is a thermostable DNA polymerase that can be used in PCR .

Tth DNA polymerase	Others	Others
Tth DNA polymerase is a DNA polymerase from T. thermophilus that can be used for DNA sequencing and polymerase chain reaction (PCR) .

Taq DNA polymerase	DNA/RNA Synthesis	Others
Taq DNA polymerase is a thermostable DNA polymerase that can be used in PCR .

*Taq DNA* Polymerase, Glycerol-free**	DNA/RNA Synthesis	Others
Taq DNA Polymerase, Glycerol-free is a thermostable DNA polymerase that can be used in PCR .

HY-156998

Troxacitabine triphosphate TRX-TP	Nucleoside Antimetabolite/Analog	Cancer
Troxacitabine triphosphate (TRX-TP) is a good substrate for replicative and repair DNA polymerases in vitro .

HY-153118

Deoxyribonucleic acid sodium, from calf thymus, Type I, fibers 1 Publications Verification ctDNA sodium, Type I, fibers; DNA sodium, from calf thymus, Type I, fibers; Thymonucleic acid sodium, Type I, fibers	Biochemical Assay Reagents	Others Cancer
Deoxyribonucleic acid sodium, from calf thymus, Type I, fibers is the sodium salts form of Calf thymus DNA (HY-109517). Calf thymus DNA is a double-stranded template DNA isolated from calf thymus. It can be used to study the interaction between DNA and DNA binding agents, as well as the structure and function of DNA, for DNA quantification and used as a substrate for DNA polymerase analysis, etc .

HY-134103A

ddGTP trisodium 2′,3′-Dideoxyguanosine 5′-triphosphate trisodium	DNA/RNA Synthesis	Others
ddGTP (2′,3′-Dideoxyguanosine 5′-triphosphate) trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddGTP trisodium acts as an inhibitor or a substrate for DNA polymerase α .

HY-145330

NSC639828	DNA/RNA Synthesis	Cancer
NSC639828 is a potent inhibitor of DNA polymerase α with an IC₅₀ of 70 μM. NSC639828 has high antitumor activity. NSC639828 has the potential for researching cancer disease .

HY-115528

FF-10502	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Cancer
FF-10502, a structural analog of Gemcitabine, is a pyrimidine nucleoside antimetabolite. FF-10502 inhibits DNA polymerase α and β. FF-10502 shows beneficial anticancer activity via a mechanism of action on dormant cells .

HY-N0872

Isosteviol (-)-Isosteviol; iso-Steviol	Reactive Oxygen Species Topoisomerase	Cardiovascular Disease Cancer
Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-110139

Procaspase-IN-5	Others	Cancer
Procaspase-IN-5 is a human DNA polymerase λ inhibitor. Procaspase-IN-5 has DNA polymerization function and TdT function with an IC₅₀ value of 5.9 μM and 4.5 μM, respectively. Procaspase-IN-5 can be used for the research of cancer .

HY-137697D

ddCTP trisodium	DNA/RNA Synthesis HIV Protease	Infection
ddCTP trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddCTP trisodium is a nucleoside analog that targets the reverse transcriptase of human immunodeficiency virus (HIV). ddCTP trisodium can be used for AIDS research .

HY-136548

Tenofovir diphosphate TFV-DP	Reverse Transcriptase	Infection Inflammation/Immunology
Tenofovir diphosphate (TFV-DP) is a competitive **DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase** (RT) .

HY-12484

BMH-21 5+ Cited Publications	DNA/RNA Synthesis	Cancer
BMH-21 is a first-in-class *DNA* intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity .

HY-136548A

Tenofovir diphosphate triethylamine TFV-DP triethylamine	Reverse Transcriptase	Infection Inflammation/Immunology
Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is a competitive **DNA polymerases inhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1) reverse transcriptase** (RT) .

HY-D1020

7-Aminoactinomycin D 7-AAD	DNA/RNA Synthesis Bacterial DNA Stain Antibiotic	Infection Cancer
7-Aminoactinomycin D (7-AAD) a fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects .

HY-128357

Ibezapolstat ACX-362E; GLS-362E	Bacterial DNA/RNA Synthesis	Infection
Ibezapolstat (ACX-362E) is a first-in-class, orally active DNA polymerase IIIC (pol IIIC) inhibitor, with a K_i of 0.325 μM for the DNA pol IIIC from C. difficile. Ibezapolstat is developed for the research of C. difficile infection(CDI) .

HY-141867

Z-FF-FMK Z-Phe-Phe-FMK	Cathepsin	Neurological Disease
Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation .

HY-136548B

Tenofovir diphosphate disodium 1 Publications Verification TFV-DP disodium	HIV	Infection Inflammation/Immunology
Tenofovir diphosphate disodium is an antiretroviral agent and an inhibitor of **DNA polymerases. Tenofovir diphosphate disodium is a substrate of HIV-1 reverse transcriptase (RT)**. Tenofovir diphosphate disodium can be used for the research of Aids .

HY-137697B

ddCTP trilithium	DNA/RNA Synthesis HIV Protease	Infection
ddCTP trilithium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddCTP trilithium is a nucleoside analog that targets the reverse trsanscriptase of human immunodeficiency virus (HIV). ddCTP trilithium can be used for AIDS research .

HY-141520

ART558 10+ Cited Publications	DNA/RNA Synthesis	Cancer
ART558 is a nanomolar potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC₅₀=7.9 nM). ART558 can be used for the research of cancer .

HY-N3023

3,4-Dihydroxybenzylamine hydrobromide 1 Publications Verification NSC 263475 hydrobromide	DNA/RNA Synthesis	Cancer
3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) is an improved dopamine analog cytotoxic and inhibits **DNA polymerase** activity in melanoma cells . 3,4-Dihydroxybenzylamine hydrobromide (NSC 263475 hydrobromide) displays growth inhibitory activity in melanoma cell lines with varying degrees of tyrosinase activity .

HY-136650

Fludarabine triphosphate F-ara-ATP	Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis	Cancer
Fludarabine triphosphate (F-ara-ATP), the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC₅₀ of 2.3 μM and a K_i of 6.1 μM. Fludarabine triphosphate inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .

HY-136650A

Fludarabine triphosphate trisodium F-ara-ATP trisodium	Nucleoside Antimetabolite/Analog Drug Metabolite DNA/RNA Synthesis Apoptosis	Cancer
Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC₅₀ of 2.3 μM and a K_i of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .

HY-139289

ART812	DNA/RNA Synthesis	Cancer
ART812 is an orally active DNA polymerase Polθ inhibitor with an IC₅₀ value of 7.6 nM. ART812 has an IC₅₀ value of 240 nM for cell based microhomology-mediated end joining (MMEJ) .

HY-130801

5-Hydroxy-2'-deoxyuridine 5-OHdU	Endogenous Metabolite	Metabolic Disease
5-Hydroxy-2'-deoxyuridine (5-OHdU) is a major stable oxidation product of 2'-Deoxycytidine. 5-Hydroxy-2'-deoxyuridine can be incorporated into DNA in vitro by DNA polymerase .

HY-N0720

Neobavaisoflavone 5+ Cited Publications	Apoptosis DNA/RNA Synthesis	Cancer
Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits **DNA polymerase** at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation .

HY-137067

IMT1B 5 Publications Verification LDC203974	DNA/RNA Synthesis	Cancer
IMT1B (LDC203974) is an orally active, noncompetitive and specific allosteric inhibitor of *mitochondrial RNA polymerase* (POLRMT)** and inhibits mitochondrial DNA (mtDNA) expression. IMT1B has anti-tumour effects .

HY-146364

CI-39	HIV	Infection
CI-39 is an antiviral natural product. CI-39 is an NNRTI (non-nucleoside reverse transcriptase inhibit) antiviral agent with an EC₅₀ of 3.40 µM and an CC₅₀ of >30 µM for wild type HIV-1. CI-39 inhibits HIV-1 RT DNA polymerase and ribonuclease H activitiessup .

HY-16740

Eprociclovir A-5021	Others	Infection
Eprociclovir is an antiviral drug with nucleoside analogues. The triphosphate form of Eprociclovir is converted into the active form within virus-infected cells by the virus and possible cellular enzymes, including the viral thymidine kinase, thereby inhibiting the activity of the viral DNA polymerase. The primary activity of Eprociclovir is against herpes viruses, including but not limited to cytomegalovirus (CMV) and herpes simplex virus (HSV). Eprociclovir can be used in studies interfered with by sensitive viruses .

HY-W406070

2'-O,4'-C-Methyleneguanosine LNA-G	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analogue, where LNA (locked nucleic acid) is a nucleic acid analogue. LNA modification can be used in a variety of applications such as effective binding affinity to complementary sequences and greater nuclease resistance than natural nucleotides, offering great potential for applications in disease diagnosis and research. LNA-G is also available via KOD DNA polymerase, which allows the integration of LNA-G nucleotides into the DNA strand .

HY-N6733

Aphidicolin 3 Publications Verification	DNA/RNA Synthesis HSV Apoptosis Antibiotic Orthopoxvirus	Infection Inflammation/Immunology
Aphidicolin is an inhibitor of *DNA* polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line .

HY-B0307A

Idoxuridine hydrate 5-Iodo-2′-deoxyuridine hydrate; 5-IUdR hydrate; IdUrd hydrate	Phosphatase	Infection
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting **DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC₅₀** value of 4.3 μM .

HY-B0307

Idoxuridine 3 Publications Verification 5-Iodo-2′-deoxyuridine; 5-IUdR; IdUrd	Phosphatase Orthopoxvirus	Infection Cancer
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting **DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC₅₀** value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.

HY-N2566

Euscaphic acid	DNA/RNA Synthesis PI3K Apoptosis	Cancer
Euscaphic acid, a **DNA polymerase** inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC₅₀ values of 61 and 108 μM . Euscaphic acid induces apoptosis .

HY-146365

HIV-1 inhibitor-30	HIV	Infection Inflammation/Immunology
HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC₅₀ value of 40 nM and an IC₅₀ value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC₅₀s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS .

HY-163015

RNA polymerase-IN-1

Others Infection

RNA polymerase-IN-1 (compound 4) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-1 inhibits CYP isozymes .
HY-163016

RNA polymerase-IN-2

Others Infection

RNA polymerase-IN-2 (compound 5) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-2 inhibits CYP isozymes .
HY-N1548

Prunasin

DNA/RNA Synthesis Cancer

Prunasin is a inhibitor of DNA Polymerase β .
HY-128917

DNA31

DNA/RNA Synthesis Infection

DNA31 is a potent RNA polymerase inhibitor .

*RNA polymerase-IN-1*	Others	Infection
RNA polymerase-IN-1 (compound 4) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-1 inhibits CYP isozymes .

*RNA polymerase-IN-2*	Others	Infection
RNA polymerase-IN-2 (compound 5) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-2 inhibits CYP isozymes .

Prunasin	DNA/RNA Synthesis	Cancer
Prunasin is a inhibitor of DNA Polymerase β .

DNA31	DNA/RNA Synthesis	Infection
DNA31 is a potent RNA polymerase inhibitor .

HY-E70090

T7 RNA polymerase	DNA/RNA Synthesis	Others
T7 RNA polymerase is a polymerase expressed by Escherichia coli from the RNA polymerase gene of T7 bacteriophage. T7 RNA polymerase is highly specific and involved in in vitro transcription (IVT) of mRNA. In the presence of Mg ²⁺, T7 RNA polymerase only uses the single-stranded or double-stranded DNA containing the T7 promoter sequence as a template, and uses NTP as a substrate to synthesize RNA complementary to the single-stranded DNA downstream of the promoter .

HY-131606

Cidofovir diphosphate	Others	Infection
Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

HY-136648

2'-Deoxyadenosine-5'-triphosphate dATP	Endogenous Metabolite DNA/RNA Synthesis	Others
2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase .

HY-147903

HIV-1 inhibitor-42	HIV	Infection
HIV-1 inhibitor-42 (compound 5b) is a potent HIV-1 inhibitor, with an IC₅₀ of 0.06 μM. HIV-1 inhibitor-42 inhibits HIV-1 RT RNA-dependent DNA polymerase and DNA-dependent DNA polymerase, with IC₅₀ values of 0.518 and 0.072 μM .

HY-131606B

Cidofovir diphosphate tri(triethylamine)	Drug Metabolite	Infection
Cidofovir diphosphate tri triethylamine is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate tri triethylamine is a selective inhibitor of viral DNA polymerases with K_i values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .

Cat. No.	Product Name

HY-L044

Nucleotide Compound Library

497 compounds

Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications.

MCE offers a unique collection of 497 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

HY-L090

Transcription Factor-Targeted Library

1,305 compounds

Transcription is the essential first step in the conversion of the genetic information in the DNA into protein and the major point at which gene expression is controlled. Transcription of protein-coding genes is accomplished by the multi-subunit enzyme RNA polymerase II and an ensemble of ancillary proteins, called transcription factors (TFs). Transcription factors play an important role in the long-term regulation of cell growth, differentiation and responses to environmental cues. Deregulated transcription factors contribute to the pathogenesis of a plethora of human diseases, ranging from diabetes, inflammatory disorders and cardiovascular disease to many cancers, and thus these proteins hold great therapeutic potential.

MCE offers a unique collection of 1,305 compounds with validated transcription factor targets modulating properties. MCE transcription factor-targeted compound library is an effective tool for researching transcription factors as drug targets as well as modulation of TFs for different therapeutic applications.

Cat. No.	Product Name	Type

HY-D1020

7-Aminoactinomycin D 7-AAD	DNA Stain
7-Aminoactinomycin D (7-AAD) a fluorescent DNA stain, is a potent RNA polymerase inhibitor. 7-Aminoactinomycin D selectively binds to GC regions of the DNA. 7-Aminoactinomycin D also has antibacterial effects .

Cat. No.	Product Name	Type

HY-E70090

T7 RNA polymerase

Biochemical Assay Reagents

T7 RNA polymerase is a polymerase expressed by Escherichia coli from the RNA polymerase gene of T7 bacteriophage. T7 RNA polymerase is highly specific and involved in in vitro transcription (IVT) of mRNA. In the presence of Mg ²⁺, T7 RNA polymerase only uses the single-stranded or double-stranded DNA containing the T7 promoter sequence as a template, and uses NTP as a substrate to synthesize RNA complementary to the single-stranded DNA downstream of the promoter .

HY-136648A

2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium	Gene Sequencing and Synthesis
2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase .

HY-137694B

ddTTP trisodium	Gene Sequencing and Synthesis
ddTTP trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing .

HY-P2937

DNA polymerase

Biochemical Assay Reagents

DNA polymerase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
HY-E70087

Enhanced Taq DNA polymerase

Biochemical Assay Reagents

Enhanced Taq DNA polymerase is a thermostable DNA polymerase that can be used in PCR .

HY-W008661

Deoxyguanosine triphosphate trisodium salt dGTP trisodium salt; 2'-Deoxyguanosine-5'-triphosphate trisodium salt	Gene Sequencing and Synthesis
Deoxyguanosine triphosphate (dGTP) trisodium salt is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium salt is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification .

HY-W001952

6-Bromo-2-naphthol

Biochemical Assay Reagents

6-Bromo-2-naphthol is an RTP (real-time polymerase chain reaction) probe capable of real-time monitoring of PCR reactions and quantification of specific nucleic acid sequences. 6-Bromo-2-naphthol phosphoresces at room temperature. RTP probes are a type of small DNA or RNA sequence labeled with fluorescent dyes and quencher molecules and can be widely used for gene expression analysis, SNP genotyping and pathogen detection .

Cat. No.	Product Name	Target	Research Area

HY-141867

Z-FF-FMK Z-Phe-Phe-FMK	Cathepsin	Neurological Disease
Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation .

HY-P2937

DNA polymerase

Peptides Others

DNA polymerase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name

HY-KE8007

DNA Polymerase I(E.coli)

This product is a DNA polymerase obtained by expressing DNA Polymerase I (E. coli) in E. coli and purifying and isolating it multiple times.

HY-KE8006

Terminal Deoxynucleotidyl Transferase (TdT)
Terminal Deoxynucleotidyl Transferase (TdT) is a template-independent DNA polymerase that catalyzes the binding of deoxynucleotides to the 3' hydroxyl end of oligonucleotides, single-stranded DNA, or double-stranded DNA.

HY-KE8001

Phi29 DNA Polymerase

Phi29 DNA Polymerase is a mesophilic DNA polymerase cloned from Bacillus subtilis phage Phi29.
HY-KE8008

T4 DNA Polymerase

T4 DNA polymerase has 5´→3´ DNA polymerase activity and can catalyze the synthesis of DNA along the 5´→3´ direction with the presence of templates and primers.

HY-KE8002

*Bst DNA* Polymerase, Full Length**
Bst DNA Polymerase is derived from Bacillus stearothermophilus and has 5'→3' DNA polymerase activity and double-stranded specific 5'→3' exonuclease activity.

HY-KE8011

*Phi29 DNA* Polymerase（mutant）**
Phi29 DNA polymerase is a protein-engineered Phi29 DNA polymerase expressed in E. coli and then purified and isolated multiple times. Compared with wild-type Phi29 DNA polymerase, it has higher amplification efficiency and sensitivity, and can greatly shorten the reaction time.

HY-KE8003

*Bst DNA* Polymerase, Large Fragment**
Bst DNA Polymerase large fragment is a part of Bacillus stearothermophilus DNA polymerase, which is derived from E. coli strain. It is expressed in E. coli and purified and isolated multiple times.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0872

Isosteviol (-)-Isosteviol; iso-Steviol	other families Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Cancer	Reactive Oxygen Species Topoisomerase
Isosteviol ((-)-Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects .

HY-130801

5-Hydroxy-2'-deoxyuridine 5-OHdU	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Hydroxy-2'-deoxyuridine (5-OHdU) is a major stable oxidation product of 2'-Deoxycytidine. 5-Hydroxy-2'-deoxyuridine can be incorporated into DNA in vitro by DNA polymerase .

HY-N0720

Neobavaisoflavone 5+ Cited Publications	Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields Isoflavones Cancer	Apoptosis DNA/RNA Synthesis
Neobavaisoflavone, a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone inhibits **DNA polymerase** at moderate to high concentrations. Neobavaisoflavone also inhibits platelet aggregation .

HY-N6733

Aphidicolin 3 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Terpenoids Source classification Diterpenoids Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis HSV Apoptosis Antibiotic Orthopoxvirus
Aphidicolin is an inhibitor of *DNA* polymerase α and δ, prevents mitotic cell division by interfering DNA polymerase activity. Aphidicolin is an antibiotic produced by mold Cephalosporium aphidicola, inhibits cellular deoxyribonucleic acid synthesis and the growth of herpes simplex virus. Aphidicolin exhibits anti-orthopoxvirus activity and potentiates apoptosis induced by arabinosyl nucleosides in a human promyelocytic leukemia cell line .

HY-N2566

Euscaphic acid	Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	DNA/RNA Synthesis PI3K Apoptosis
Euscaphic acid, a **DNA polymerase** inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC₅₀ values of 61 and 108 μM . Euscaphic acid induces apoptosis .

HY-N1548

Prunasin	Structural Classification Natural Products Classification of Application Fields Source classification Rosaceae Plants Disease Research Fields Amygdalus persica L. Cancer	DNA/RNA Synthesis
Prunasin is a inhibitor of DNA Polymerase β .

HY-136648

2'-Deoxyadenosine-5'-triphosphate dATP	Structural Classification Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Disease markers Endogenous metabolite Disease Research Fields	Endogenous Metabolite DNA/RNA Synthesis
2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase .

HY-136648A

2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite DNA/RNA Synthesis
2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase .

HY-13605

Cytarabine 35+ Cited Publications Cytosine β-D-arabinofuranoside; Cytosine Arabinoside; Ara-C	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Marine natural products Sponge Endogenous metabolite Disease Research Fields	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus
Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits **DNA polymerase*. Cytarabine inhibits DNA* synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.

HY-W004924

5-Hydroxymethyluracil	Natural Products Classification of Application Fields Other disease Source classification Other Diseases Disease markers Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase.

HY-13605R

Cytarabine (Standard)	Structural Classification Natural Products Microorganisms Marine natural products Source classification Sponge Endogenous metabolite	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HSV Autophagy Apoptosis Endogenous Metabolite Orthopoxvirus
Cytarabine (Standard) is the analytical standard of Cytarabine. This product is intended for research and analytical applications. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits **DNA polymerase*. Cytarabine inhibits DNA* synthesis with an IC₅₀ of 16 nM. Cytarabine has antiviral effects against HSV. Cytarabine shows anti-orthopoxvirus activity.

HY-10571

Delavirdine U 90152; BHAP-U 90152	Infection Classification of Application Fields Disease Research Fields	HIV Reverse Transcriptase
Delavirdine (U 90152) is a potent, highly specific and orally active non-nucleoside reverse transcriptase inhibitor (NNRTI). Delavirdine selectively inhibits HIV-1 reverse transcriptase (RT) (IC₅₀=0.26 μM) over DNA polymerase α (IC₅₀=440 μM) and polymerase δ (IC₅₀>550 μM). Delavirdine is an inhibitor of HIV-1 replication and can can be used for the study of AIDs .

HY-100126

Tubercidin 4 Publications Verification 7-Deazaadenosine	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic
Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC₅₀ of 0.02 μM . Tubercidin inhibits polymerases by incorporating *DNA* or RNA, thereby inhibiting DNA replication, RNA and protein synthesis . Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP . Tubercidin has antiviral activity .

HY-135780

3'-Deoxyuridine-5'-triphosphate 3'-dUTP	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite
3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that inhibits DNA-dependent *RNA polymerases* I and II. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA with a K_i** value of 2.0 μM .

HY-135780A

3'-Deoxyuridine-5'-triphosphate trisodium 3'-dUTP trisodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite
3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent *RNA polymerases* I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into RNA with a K_i** value of 2.0 μM .

HY-17438

Cidofovir 2 Publications Verification GS 0504; HPMPC; (S)-HPMPC	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	CMV Apoptosis DNA/RNA Synthesis Orthopoxvirus Endogenous Metabolite
Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral **DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir also has anti-orthopoxvirus** and anti-variola activities .

HY-17438A

Cidofovir dihydrate GS 0504 dihydrate; HPMPC dihydrate; (S)-HPMPC dihydrate	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	CMV DNA/RNA Synthesis Orthopoxvirus Apoptosis Endogenous Metabolite
Cidofovir (GS 0504; HPMPC; (S)-HPMPC) dihydrate is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir dihydrate inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral **DNA polymerase. Cidofovir dihydrate induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir dihydrate also has anti-orthopoxvirus** and anti-variola activities .

HY-100513A

Dehydroaltenusin	Structural Classification Monophenols Microorganisms Classification of Application Fields Antibiotics Source classification Phenols Disease Research Anticancer Disease Research Fields Other Antibiotics Cancer	Apoptosis DNA/RNA Synthesis Antibiotic
Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC₅₀ value of 0.68 μM. The inhibitory mode of action of dehydroaltenusin against mammalian pol α activity is competitive with respect to the DNA template primer (K_i=0.23 µM) and non-competitive with respect to the 2'-deoxyribonucleoside 5'-triphosphate substrate (K_i=0.18 µM) . Dehydroaltenusin arrests the cancer cell cycle at the S-phase and triggers apoptosis . Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumor in vivo .

HY-17438R

Cidofovir (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	CMV Apoptosis DNA/RNA Synthesis Orthopoxvirus Endogenous Metabolite
Cidofovir (Standard) is the analytical standard of Cidofovir. This product is intended for research and analytical applications. Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral **DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer . Cidofovir also has anti-orthopoxvirus** and anti-variola activities .

HY-N0365

Sennoside A 1 Publications Verification	Infection Quinones Structural Classification Classification of Application Fields Leguminosae Anthraquinones Source classification Folium Sennae Cassia angustifolia Vahl Cassia acutifolia Del. Plants Disease Research Fields	HIV
Sennoside A is an anthraquinone glycoside found in senna (Cassia angustifolia). Sennoside A is an HIV-1 inhibitor (IC₅₀=3.8 μM) that inhibits HIV-1 replication. Sennoside A also inhibits HIV-1 reverse transcriptase (RT)-related DNA polymerase (RDDP) and ribonuclease H (Ribonuclease H) with IC₅₀s of 1.9 μM and 5.3 μM, respectively .

HY-16561

Resveratrol Maximum Cited Publications 81 Publications Verification trans-Resveratrol; SRT501	Structural Classification Classification of Application Fields Anti-aging Source classification Vitis vinifera cv. Zalema Plants Vitaceae Infection Microorganisms Functional Molecules Sunscreen Research of Health Products Phenols Polyphenols Cosmetic Research Inflammation/Immunology Disease Research Fields Cancer	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, **DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2** activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-16561R

Resveratrol (Standard) Maximum Cited Publications 81 Publications Verification trans-Resveratrol (Standard); SRT501 (Standard)	Infection Functional Molecules Classification of Application Fields Sunscreen Anti-aging Source classification Research of Health Products Cosmetic Research Plants Inflammation/Immunology Disease Research Fields Cancer	IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
Resveratrol (Standard) is the analytical standard of Resveratrol. This product is intended for research and analytical applications. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, **DNA polymerase. Resveratrol also is a specific SIRT1 activator . Resveratrol is a potent pregnane X receptor (PXR) inhibitor . Resveratrol is an Nrf2** activator, ameliorates aging-related progressive renal injury in mice model . Resveratrol increases production of NO in endothelial cells .

HY-15310

Ivermectin 15+ Cited Publications MK-933	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Antiviral Anti-parasitic Disease Research Disease Research Fields Cancer	Flavivirus Dengue virus Parasite HIV Mitophagy HSV SARS-CoV Antibiotic Autophagy Bacterial
Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

HY-15310R

Ivermectin (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Antiviral Anti-parasitic Disease Research	Dengue virus Flavivirus Parasite HIV Mitophagy HSV SARS-CoV Antibiotic Autophagy Bacterial
Ivermectin (Standard) is the analytical standard of Ivermectin. This product is intended for research and analytical applications. Ivermectin (MK-933) is a broad-spectrum anti-parasite agent. Ivermectin (MK-933) is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. It is a positive allosteric effector of P2X₄ and the α7 neuronal nicotinic acetylcholine receptor (nAChRs). Ivermectin also inhibits bovine herpesvirus1 (BoHV-1) replication and inhibits BoHV-1 DNA polymerase nuclear import . Ivermectin is a candidate therapeutic against SARS-CoV-2/COVID-19 .

Species:	Human (2)
Tag:	His (4) Fc (1)
Source:	Sf9 insect cells (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P7883

	DNA polymerase beta Protein, Human (His) rHuDNA polymerase beta, His; DNA polymerase Beta; POLB	Human	E. coli
	DNA polymerase beta Protein, Human (His), a DNA repair enzyme, is involved in various types of DNA repair. DNA polymerase beta Protein performs base excision repair (BER) required for DNA maintenance, replication, recombination, and drug resistance.

HY-P78949

	*HIFI Dna* polymerase Protein, Thermococcus kodakarensis**	Others	E. coli
	HIFI DNA polymerase is known for its excellent processivity, rapid polymerization rate, and excellent DNA synthesis fidelity. It also has 3' to 5' exonuclease activity. Related to intein-encoded endonucleases, it suggests a potential role in intein mobility through site-specific recombination. HIFI Dna polymerase Protein, Thermococcus kodakarensis is the recombinant HIFI Dna polymerase protein, expressed by E. coli , with hFc labeled tag. HIFI Dna polymerase Protein, Thermococcus kodakarensis, has molecular weight of ~90 kDa.

HY-P78942

	*Bst DNA* Polymerase Protein, Geobacillus stearothermophilus (His)**	Others	E. coli
	Bst DNA Polymerase protein, featuring polymerase and 5'-3' exonuclease activities, exhibits versatile nucleic acid processing capabilities. Beyond synthesizing DNA strands, it adeptly removes nucleotides from the 5' to 3' direction. These dual functions render Bst DNA Polymerase pivotal in molecular biology applications, ensuring efficient DNA amplification and modification processes. Bst DNA Polymerase Protein, Geobacillus stearothermophilus (His) is the recombinant Bst DNA Polymerase protein, expressed by E. coli , with N-6*His labeled tag. The total length of Bst DNA Polymerase Protein, Geobacillus stearothermophilus (His) is 584 a.a., with molecular weight of ~66.4 kDa.

HY-P78940

	*T4 DNA* Polymerase Protein, T4 phage (His)**	Others	E. coli
	T4 DNA Polymerase, a pivotal enzyme in viral DNA replication, performs dual functions crucial for genome synthesis. As a polymerase, it synthesizes DNA, and with its exonucleolytic activity, it proofreads by degrading single-stranded DNA in the 3'- to 5'-direction, ensuring the accuracy and fidelity of replicated viral genomic DNA. T4 DNA Polymerase Protein, T4 phage (His) is the recombinant T4 DNA Polymerase protein, expressed by E. coli , with N-6*His labeled tag. T4 DNA Polymerase Protein, T4 phage (His), has molecular weight of ~103.6 kDa.

HY-P702585

	PARP2 Protein, Human (sf9, His) Poly [ADP-ribose] polymerase 2; ADP-ribosyltransferase diphtheria toxin-like 2; DNA ADP-ribosyltransferase PARP2; NAD(+) ADP-ribosyltransferase 2; ADPRT-2; pADPRT-2; EC:2.4.2.30; ADPRT2; ADPRTL2	Human	Sf9 insect cells

Cat. No.	Product Name	Chemical Structure

HY-17025S

Rifabutin-d7
Rifabutin-d₇ is the deuterium labeled Rifabutin. Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.

HY-13605S

Cytarabine-d2
Cytarabine-d₂ is the deuterium labeled Cytarabine. Cytarabine, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine has antiviral effects against HSV[1][2].

HY-W004924S

5-Hydroxymethyluracil-d3
5-Hydroxymethyluracil-d₃ is the deuterium labeled 5-Hydroxymethyluracil[1]. 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase[2][3].

HY-136648S4

2'-Deoxyadenosine-5'-triphosphate-15N5 dilithium
2'-Deoxyadenosine-5'-triphosphate- ¹⁵N₅ (dATP- ¹⁵N₅) dilithium is ¹⁵N labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

HY-136648S3

2'-Deoxyadenosine-5'-triphosphate-d14 dilithium
2'-Deoxyadenosine-5'-triphosphate-d₁₄ (dATP-d₁₄) dilithium is deuterium labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

HY-136648S5

2'-Deoxyadenosine-5'-triphosphate-13C10 dilithium
2'-Deoxyadenosine-5'-triphosphate- ¹³C₁₀ (dATP- ¹³C₁₀) dilithium is ¹³C-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

HY-136648S1

2'-Deoxyadenosine-5'-triphosphate-13C10,15N5 dilithium
2'-Deoxyadenosine-5'-triphosphate- ¹³C₁₀, ¹⁵N₅ (dATP- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

HY-136648S2

2'-Deoxyadenosine-5'-triphosphate-15N5,d14 dilithium
2'-Deoxyadenosine-5'-triphosphate- ¹⁵N₅,d₁₄ (dATP- ¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.

HY-B1826S2

Adefovir-d4
Adefovir-d₄ is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses[1][2][3].

HY-16561S1

Resveratrol-13C6

Resveratrol- ¹³C₆ is the ¹³C-labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

HY-16561S

Resveratrol-d4

Resveratrol-d₄ is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83633

DNA Polymerase beta Antibody (YA3378)

POLB; DNA polymerase beta
WB, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P83038

DNA Polymerase gamma Antibody (YA2783)

MDP1; PEO; PolG alpha; POLG; POLG1; POLGA; SANDO; SCAE
WB Human, Mouse, Rat

HY-P80883

	*RNA Polymerase* II Subunit B1 Antibody** POLR2A; POLR2; DNA-directed RNA polymerase II subunit RPB1; RNA polymerase II subunit B1; DNA-directed RNA polymerase II subunit A; DNA-directed RNA polymerase III largest subunit; RNA-directed RNA polymerase II subunit RPB1	WB, IHC-F, IHC-P, ICC/IF, IP	Human
	RNA Polymerase II Subunit B1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 217 kDa, targeting to RNA Polymerase II Subunit B1. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human.

Cat. No.	Product Name		Classification

HY-134320

8-Azido-ATP 8-Azidoadenosine 5'-triphosphate; 8-N3-ATP		Azide
8-Azido-ATP, a photoreactable nucleotide analog, is useful for the identification of proteins, such as DNA-dependent RNA polymerase . 8-Azido-ATP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.


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Remarks

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

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Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

DNA polymerase

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

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Recombinant Proteins

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