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Results for "

E3 ubiquitin ligase binding linker

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

1

Screening Libraries

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-123937
    THAL-SNS-032
    3 Publications Verification

    		 PROTACs CDK Cancer
    THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN) .
    THAL-SNS-032
  • HY-112098
    PROTAC ERα Degrader-1

    		PROTACs Estrogen Receptor/ERR Cancer
    PROTAC ERα Degrader-1 comprises an ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Degrader-1 extracts from patent WO2017201449A1, compound P1. PROTAC ERα Degrader-1 is an estrogen receptor-alpha (ERα) degrader.
    PROTAC ERα Degrader-1
  • HY-153424
    PROTAC SMARCA2 degrader-1

    		Target Protein Ligand-Linker Conjugates Cancer
    PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC50<0.1 μM). PROTAC SMARCA2 degrader-1 is also an E3 ubiquitin ligase binding linker useful in research of cancers. PROTAC SMARCA2 degrader-1 is a target protein ligand-linker conjugate .
    PROTAC SMARCA2 degrader-1
  • HY-145071
    PROTAC ERα Y537S degrader-1

    		PROTACs Estrogen Receptor/ERR Cancer
    PROTAC ERα Y537S degrader-1 comprises a ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Y537S degrader-1 extracts from patent WO2021143822, example 12. PROTAC ERα Y537S degrader-1 is an estrogen receptor-alpha (ERα) Y537S degrader .
    PROTAC ERα Y537S degrader-1
  • HY-158684
    YX-02-030

    		PROTACs MDM-2/p53 Cancer
    YX-02-030M is a PROTAC MDM2 degrader. YX-02-030M inhibits MDM2-p53 binding and VHL-HIF1α binding with IC50s of 63 nM and 1.35 μM respectively. YX-02-030M binds MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, and effectively kills p53 mutant or deleted Triple-negative breast cancers (TNBC) cells. (Blue: VHL ligand; Black: linker; Pink: MDM2 inhibitor) .
    YX-02-030

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