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ENT

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adenosine Receptor (2) Akt (1) Antibiotic (5) Apoptosis (4) Autophagy (1) Bacterial (6) Calcium Channel (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (1) Dopamine Receptor (1) Drug Metabolite (1) Endogenous Metabolite (2) Fungal (1) Glucosidase (1) ICMT (2) Isotope-Labeled Compounds (6) Keap1-Nrf2 (1) Monoamine Transporter (1) NO Synthase (1) Parasite (2) Phosphodiesterase (PDE) (2) PI3K (1) RSV (1) Trk Receptor (1) TRP Channel (1) Tyrosinase (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (2) Endocrinology (2) Infection (12) Inflammation/Immunology (11) Metabolic Disease (4) Neurological Disease (5)

By Targets:

5-HT Receptor (1)

Adenosine Receptor (2)

Akt (1)

Antibiotic (5)

Apoptosis (4)

Autophagy (1)

Bacterial (6)

Calcium Channel (1)

DNA Alkylator/Crosslinker (2)

DNA/RNA Synthesis (1)

Dopamine Receptor (1)

Drug Metabolite (1)

Endogenous Metabolite (2)

Fungal (1)

Glucosidase (1)

ICMT (2)

Isotope-Labeled Compounds (6)

Keap1-Nrf2 (1)

Monoamine Transporter (1)

NO Synthase (1)

Parasite (2)

Phosphodiesterase (PDE) (2)

PI3K (1)

RSV (1)

Trk Receptor (1)

TRP Channel (1)

Tyrosinase (1)

By Research Areas:

Cancer (17)

Cardiovascular Disease (2)

Endocrinology (2)

Infection (12)

Inflammation/Immunology (11)

Metabolic Disease (4)

Neurological Disease (5)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

ent-Tadalafil ENT-IC-351	Phosphodiesterase (PDE)	Cancer
ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC₅₀ of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM .

ent-Ezetimibe ENT-SCH 58235	Drug Metabolite	Cardiovascular Disease
ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator .

ent-Naxagolide hydrochloride ENT-MK-458 hydrochloride; ENT-L-647339 hydrochloride	Dopamine Receptor	Neurological Disease
ent-Naxagolide (ent-MK-458) hydrochloride is a dopamine D2-receptor agonist. ent-Naxagolide hydrochloride can be used in the study of extrapyramidal diseases and Parkinson's syndrome.

ent-Prostaglandin E2 ENT-PGE2	Others	Endocrinology
ent-Prostaglandin E2 (ent-PGE2) is an enantiomer of PGE2 (HY-101952). unlike PGE2, ent-PGE2 is a poor substrate for 15-hydroxyprostaglandin dehydrogenase .

ent-8-iso Prostaglandin F2α ENT-15-F2t-IsoP	Others	Cardiovascular Disease
ent-8-iso Prostaglandin F2α (ent-15-F2t-IsoP) is a potent vasoconstrictor of porcine retina and cerebral microvessels with EC₅₀ values of 30.6 and 53.5 nM, respectively .

ent-Frovatriptan-d3 succinate	5-HT Receptor Isotope-Labeled Compounds	Others
ent-Frovatriptan-d₃ (succinate) is deuterium labeled ent-Frovatriptan.

ent-17-Hydroxykauran-3-one ENT-Kaurane-3-oxo-17β-ol	Others	Others
ent-17-Hydroxykauran-3-one (ent-Kaurane-3-oxo-17β-ol; compound 7) is a kaurane-type diterpenoid that can be found in the roots of Euphorbia fischeriana .

Ent-(+)-Verticilide	Calcium Channel	Cancer
ent-(+)-verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels with antiarrhythmic activity. ent-(+)-verticilide inhibits RyR2-mediated diastolic Ca ²⁺?leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine.?ent-(+)-verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies .

ENT-C225	Trk Receptor	Neurological Disease
ENT-C225 is an effective activator of TrkB neurotrophin receptor. ENT-C225 has high effect on activating TrkB receptor (TrkBR), and has good physicochemical properties and neuroprotective properties .

ent-Prostaglandin F2α	Endogenous Metabolite	Others
ent-Prostaglandin F2α is the opposite enantiomer of PGF2α. ent-Prostaglandin F2α can be found in urine .

ent-17-Hydroxykaur-15-en-19-oic acid	Others	Others
ent-17-Hydroxykaur-15-en-19-oic acid is a ent-kaurene diterpene that can be isolated from the leaves of Laetia thamnia L.. ent-17-Hydroxykaur-15-en-19-oic acid was cytotoxic to human prostate LNCaP2 cells with IC₅₀ 17.63 mg/mL .

Ent-16α,17-dihydroxykauran-3-one ENT-3-oxokaurane-16α,17-diol	Others	Others
Ent-16α,17-dihydroxykauran-3-one is a diterpenoid, which can be isolated from the roots of Euphorbia ebracteolata .

ent-16β,17-Dihydroxykauran-19-oic acid	Others	Inflammation/Immunology
ent-16β,17-Dihydroxykauran-19-oic acid is an anti-inflammatory agent, which can be isolated from Siegesbeckia pubescens herb. ent-16β,17-Dihydroxykauran-19-oic acid inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia .

ent-16-Kaurene-3b,15b,18-triol	Others	Inflammation/Immunology
ent-16-Kaurene-3b,15b,18-triol is a ent-kaurene diterpene. ent-16-Kaurene-3b,15b,18-triol has significant antiallergic activity on β-hexosaminidase release induced by Polyginseng antigen .

ent-Heronamide C	Fungal	Infection
ent-Heronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C .

ent-11β-Hydroxyatis-16-ene-3,14-dione	RSV	Infection
ent-11β-Hydroxyatis-16-ene-3,14-dione (compound 11) is a diterpenoid from the fresh roots of Euphorbia jolkinii. ent-11β-Hydroxyatis-16-ene-3,14-dione has anti-RSV activity .

(7Z)-7-Hexadecen-1-ol ENT-35163	Others	Endocrinology
(7Z)-7-Hexadecen-1-ol (ENT-35163) is a sex pheromone that inhibits male attraction, isolated from female Euxoa tessellata (Harris) .

ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid	Tyrosinase	Others
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis tyrosinase inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds .

ent-8-Iso-15(S)-prostaglandin F2α	Endogenous Metabolite	Metabolic Disease
Ent-8-Iso-15(S)-prostaglandin F2α is an isomer of 8-Isoprostaglandin F2α, with a better inhibiting activity in the whole blood platelet aggregation inhibition assay .

ent-Kaurane-3α,16β,17-triol	Apoptosis	Cancer
ent-Kaurane-3α,16β,17-triol (Compound 3) is an anticancer agent. ent-Kaurane-3α,16β,17-triol induces apoptosis in HCT116 cells .

ent-Atisane-3β,16α,17-triol	Others	Others
ent-Atisane-3β,16α,17-triol is a compound that can be isolated from the acetone extract of roots of Euphorbia sieboldiana. ent-Atisane-3β,16α,17-triol is a natural control product .

ent-11α-Hydroxyabieta-8(14),13(15)-dien-16,12α-olide	Others	Others
ent-11α-Hydroxyabieta-8(14),13(15)-dien-16,12α-olide (compound 12) is a natural bioactive diterpenoid found in the roots of Euphorbia fischeriana .

ent-Florfenicol Amine-d3	Isotope-Labeled Compounds Antibiotic	Infection
ent-Florfenicol Amine-d₃ is the deuterium labeled Florfenicol amine. Florfenicol amine is a metabolite of Florfenicol (HY-B1374). Florfenicol, a veterinary antibiotic, can be used in aquaculture to control susceptible bacterial diseases[1].

ent-Florfenicol-d3	Bacterial Antibiotic	Infection
ent-Florfenicol-d3 is the deuterium labeled Florfenicol. Florfenicol, a commonly used veterinary antibiotic, is currently indicated for the treatment of bovine respiratory disease, and also used in aquaculture for the control of enteric septicemia in catfish. Florfenicol can induce early embryonic death in eggs, with an LC50 of 1.07 μg/g.

Kauran-16,17-diol ENT-Kauran-16β,17-diol	Apoptosis	Inflammation/Immunology Cancer
Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC₅₀ of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages .

ent-Labda-8(17),13Z-diene-15,16,19-triol 19-O-glucoside	Others	Inflammation/Immunology
ent-Labda-8(17),13Z-diene-15,16,19-triol 19-O-glucoside is a natural product derived from the leaves of Andrographis paniculata that has anti-inflammatory and antiviral activity .

MGK-264 N-Octylbicycloheptenedicarboximide; ENT 8184	Others	Infection
MgK-264 (N-octylbicycloheptenedicarboximide) is a synergist enhancing the potency of pyrethroid ingredients. MgK-264 has no intrinsic pesticidal qualities itself .

Piperonyl butoxide ENT-14250	Parasite	Infection
Piperonyl butoxide is a semi-synthetic derivative of safrole used as a component of pesticide formulations. It is a synergist that, although it has no insecticidal activity of its own, enhances certain insecticides such as Carbamates, Pyrethrins, Pyrethroids and Potency of Rotenone.

Altretamine 1 Publications Verification ENT-50852; RB-1515; WR-95704	DNA Alkylator/Crosslinker	Cancer
Altretamine is an alkylating antineoplastic agent.

Altretamine hydrochloride ENT-50852 hydrochloride; RB-1515 hydrochloride; WR-95704 hydrochloride	DNA Alkylator/Crosslinker	Cancer
Altretamine hydrochloride is an alkylating antineoplastic agent.

Ribocil B Ribocil S enantiomer; ENT-Ribocil A	Bacterial	Infection
Ribocil-B is the active S-isomer of ribocil which can inhibit flavin mononucleotide (FMN) with a K_D of 6.6 nM.

Piperonyl butoxide-d9 ENT-14250-d₉	Isotope-Labeled Compounds Parasite	Infection
Piperonyl butoxide-d₉ is the deuterium labeled Piperonyl butoxide. Piperonyl butoxide is a semisynthetic derivative of safrole，used as a component of pesticide formulations. It is a synergist, despite having no pesticidal activity of its own, it enhances the potency of certain pesticides such as Carbamates, Pyrethrins, Pyrethroids, and Rotenone.

*cis-ent-Tadalafil-d3* cis-ENT-IC-351-d₃	Isotope-Labeled Compounds	Others
cis-ent-Tadalafil-d₃ is the deuterium labeled cis-ent-Tadalafil[1].

*L-Ent-oxPt(IV)* L-EOP	Bacterial	Infection
L-Ent-oxPt IV (L-EOP) is a Oxaliplatin (HY-17371)-based siderophore-platinum conjugate. L-Ent-oxPt IV exhibits selectivity towards Escherichia coli and antibacterial activity through DNA damage .

*(1R,3S,4R)-ent-Entecavir* (1R,3S,4R)-ENT-BMS200475; (1R,3S,4R)-ENT-SQ34676	Others	Others
(1R,3S,4R)-ent-Entecavir ((1R,3S,4R)-ent-BMS200475; (1R,3S,4R)-ent-SQ34676) can be used to synthesize PROTAC targets to degrade deoxyribonucleic acid (DNA) polymerase .

*cis-ent-Tadalafil* cis-ENT-IC-351; Tadalafil, (6S,12aR)-	Phosphodiesterase (PDE)	Metabolic Disease
cis-ent-Tadalafil (Tadalafil EP Impurity C) is a highly potent PDE5 inhibitor with an IC₅₀ value of 5 nM and has blood pressure lowering activity .

*(1R,3S,4R)-ent-Entecavir-13C2,15N*	Isotope-Labeled Compounds	Others
(1R,3S,4R)-ent-Entecavir- ¹³C₂, ¹⁵N is the ¹³C and ¹⁵N labeled (1R,3S,4R)-ent-Entecavir[1].

Lomefloxacin (aspartate) SC47111A (aspartate)	Bacterial Antibiotic	Infection
Lomefloxacin (SC47111A) aspartate is a broad-spectrum quinolone antibiotic, with antimicrobial activity. Lomefloxacin aspartate can be used for researching respiratory tract infections, genitourinary infections, gastrointestinal infections, ENT infections, etc. .

*17(13→14)-Abeo-ent-3S,13S,16-trihydroxystrob-8(15)-ene*	Others	Inflammation/Immunology
17(13→14)-Abeo-ent-3S,13S,16-trihydroxystrob-8(15)-ene is a natural sesquiterpene lactone with anti-inflammatory activity .

*19-[(β-D-Glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide*	NO Synthase	Inflammation/Immunology
19-[(β-D-Glucopyranosyl)oxy]-19-oxo-ent-labda-8(17),13-dien-16,15-olide, the metabolite of Neoandrographolide, inhibits nitric oxide (NO) production in lipopolysaccharide-activated macrophages .

*15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide*	Others	Cancer
15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide (compound 2) is an enantio-kaurene diterpenoid (ent -kaurene diterpenoid), which can be isolated from Rubescens rubescens. 15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide has cellular activity against EC-1, U87, A549, MCF-7 and HeLa cell lines Toxicity, IC₅₀s are 37.69 μM, 79.362 μM, 80.07 μM, 197.35 μM, 462.13 μM, and 180.09 μM respectively .

*2β,6β,15α-Trihydroxy-ent-kaur-16-ene* 2β,6β,15α-(-)-Kaur-16-ene	Others	Others
2β,6β,15α-Trihydroxy-ent-kaur-16-ene (compound 19) is a compound isolated from the aerial parts of Pteris cretica .

Pterisolic acid A	Others	Others
Pterisolic acid A is a ent-kaurane diterpenoid, and also is a derivates of ent-15-oxokauran-19-oic acid. Pterisolic acid A can be isolated from the fern Pteris semipinnata (Pteridaceae) .

Pterisolic acid F	Others	Others
Pterisolic acid F is a ent-kaurane diterpenoid, and also is a derivates of ent-15-oxokauran-19-oic acid. Pterisolic acid F can be isolated from the fern Pteris semipinnata (Pteridaceae) .

A2AR-agonist-1 1 Publications Verification	Adenosine Receptor	Neurological Disease
A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of 4.39 and 3.47 for A2AR and ENT1.

Nitrobenzylthioinosine NBMPR	Adenosine Receptor	Neurological Disease
Nitrobenzylthioinosine is an ENT1 transporter inhibitor that binds to ENT1 transporter with high affinity. Nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Nitrobenzylthioinosine can cross the blood-brain barrier .

Cat. No.	Product Name	Target	Research Area

HY-P99803

Clervonafusp alfa VAL-1221	Glucosidase	Others
Clervonafusp alfa (VAL-1221) is a fusion protein targeting both cytosolic and lysosomal glycogen. Clervonafusp alfa is comprised of the Fab portion of a cell-penetrating antibody and recombinant human acid alpha glucosidase (rhGAA), the former utilizing the nucleoside transporter ENT-2 to gain access to the cytosol, and the latter enters lysosomes via mannose-6-phosphate receptors (M6PRs). Clervonafusp alfa can be used for late-onset Pompe disease research .

Species:	Human (2) Mouse (1)
Tag:	His (2) Avi (1) Fc (1)
Source:	HEK293 (2) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71763

	Nidogen-1 Protein, Mouse (P.pastoris, His) Nid1; ENT; Nidogen-1; NID-1; ENTactin	Mouse	P. pastoris
	Nidogen-1 protein is a sulfated glycoprotein that is widely distributed in basement membranes and binds tightly to laminin, type IV collagen, and perlecan, suggesting multiple interactions between cells and the extracellular matrix . Nidogen-1 binds to partners such as FBLN1, LGALS3BP and PLXDC1 and plays a crucial role in the complex molecular network of the extracellular matrix. Nidogen-1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Nidogen-1 protein, expressed by P. pastoris , with N-His labeled tag. The total length of Nidogen-1 Protein, Mouse (P.pastoris, His) is 238 a.a., with molecular weight of ~28.3 kDa.

HY-P74272

	CD73/5'-Nucleotidase Protein, Human (T376A, HEK293, Fc) 5-NT; 5'-Nucleotidase; CD73; E5NT; NT5E; NTE	Human	HEK293
	CD73/5'-Nucleotidase Protein hydrolyzes nucleotide monophosphates, favoring AMP as the primary substrate and showing a preference for ribonucleotide monophosphates. It releases inorganic phosphate and the corresponding nucleoside. CD73 also acts on other substrates, including IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD, and NMN. CD73/5'-Nucleotidase Protein, Human (T376A, HEK293, Fc) is the recombinant human-derived CD73/5'-Nucleotidase protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD73/5'-Nucleotidase Protein, Human (T376A, HEK293, Fc) is 547 a.a., with molecular weight of ~84.5 kDa.

HY-P77534

	CD73/5'-Nucleotidase Protein, Human (Biotinylated, HEK293, His-Avi) 5-NT; 5'-Nucleotidase; CD73; E5NT; NT5E; NTE	Human	HEK293
	CD73/5'-Nucleotidase Protein hydrolyzes nucleotide monophosphates, favoring AMP as the primary substrate and showing a preference for ribonucleotide monophosphates. It releases inorganic phosphate and the corresponding nucleoside. CD73 also acts on other substrates, including IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD, and NMN. CD73/5'-Nucleotidase Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived CD73/5'-Nucleotidase protein, expressed by HEK293 , with C-His labeled tag. The total length of CD73/5'-Nucleotidase Protein, Human (Biotinylated, HEK293, His) is 521 a.a., with molecular weight of ~59.2 KDa.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81506

ENT1 Antibody (YA1251)

SLC29A1; solute carrier family 29 (equilibrative nucleoside transporter); member 1; ENT1
IHC-P Human
HY-P82697

ENT2 Antibody (YA2442)

DER12; ei-type; HNP36; Nucleoside transporter; SLC29A2
WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P83142

Entactin Antibody (YA2887)

Enactin; ENT; ENTactin 1; ENTactin; NID 1; NID; Nid1; Nidogen 1; Nidogen
WB, IHC-P Human

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