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Imiquimod

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Aryl Hydrocarbon Receptor (1) Autophagy (5) Calcium Channel (2) DNA/RNA Synthesis (2) Drug Metabolite (1) HSV (5) Interleukin Related (1) IRAK (1) Isotope-Labeled Compounds (3) Lipoxygenase (1) NOD-like Receptor (NLR) (1) p38 MAPK (1) RIP kinase (1) ROR (2) SARS-CoV (5) STAT (1) Toll-like Receptor (TLR) (6) TRP Channel (2)
By Research Areas:	Cancer (7) Infection (6) Inflammation/Immunology (19) Metabolic Disease (1) Neurological Disease (2)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0180

*Imiquimod* Maximum Cited Publications 33 Publications Verification R 837	Toll-like Receptor (TLR) Autophagy SARS-CoV HSV	Infection Inflammation/Immunology Cancer
Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19 .

HY-B0180B

Imiquimod maleate Maximum Cited Publications 33 Publications Verification R 837 maleate	Toll-like Receptor (TLR) Autophagy SARS-CoV HSV	Infection Inflammation/Immunology Cancer
Imiquimod maleate (R 837 maleate), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod maleate exhibits antiviral and antitumor effects in vivo. Imiquimod maleate can be used for the research of external genital, perianal warts, cancer and COVID-19 .

HY-B0180A

Imiquimod hydrochloride Maximum Cited Publications 33 Publications Verification R 837 hydrochloride	Toll-like Receptor (TLR) Autophagy SARS-CoV HSV	Infection Inflammation/Immunology Cancer
Imiquimod hydrochloride (R 837 hydrochloride), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod hydrochloride exhibits antiviral and antitumor effects in vivo. Imiquimod hydrochloride can be used for the research of external genital, perianal warts, cancer and COVID-19 .

HY-B0180R

Imiquimod (Standard)		Infection Inflammation/Immunology Cancer
Imiquimod (Standard) is the analytical standard of Imiquimod. This product is intended for research and analytical applications. Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19 .

HY-143974S

Imiquimod impurity 1-d6

Drug Metabolite Isotope-Labeled Compounds Others

Imiquimod impurity 1-d₆ is the deuterium labeled Imiquimod impurity 1[1].

Imiquimod impurity 1-d6	Drug Metabolite Isotope-Labeled Compounds	Others
Imiquimod impurity 1-d₆ is the deuterium labeled Imiquimod impurity 1[1].

HY-B0180S

Imiquimod-d6 R 837-d₆	Toll-like Receptor (TLR) Autophagy SARS-CoV HSV	Infection Inflammation/Immunology Cancer
Imiquimod-d₆ is the deuterium labeled Imiquimod. Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].

HY-B0180S1

Imiquimod-d9 R 837-d₉	Isotope-Labeled Compounds Toll-like Receptor (TLR) Autophagy SARS-CoV HSV	Infection Inflammation/Immunology Cancer
Imiquimod-d₉ is deuterium labeled Imiquimod. Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].

HY-143976S

3-Hydroxy imiquimod-d4

Isotope-Labeled Compounds Others

3-Hydroxy imiquimod-d₄ is the deuterium labeled 3-Hydroxy imiquimod.

*3-Hydroxy imiquimod-d4*	Isotope-Labeled Compounds	Others
3-Hydroxy imiquimod-d₄ is the deuterium labeled 3-Hydroxy imiquimod.

HY-155548

RORγt inverse agonist 31	ROR	Inflammation/Immunology
RORγt inverse agonist 31 (14g) is a potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist, with an IC₅₀ of 0.428 μM. RORγt inverse agonist 31 can alleviate the severity of Imiquimod (HY-B0180)-induced psoriasis in mice .

HY-139374

Zabedosertib 1 Publications Verification BAY 1834845	IRAK	Inflammation/Immunology
Zabedosertib (BAY 1834845) is a selective, orally active IRAK4 inhibitor with immunomodulatory potential, IC₅₀ is 3.55 nM. IRAK4 is a protein kinase involved in signaling innate immune responses from Toll-like receptors . Zabedosertib exhibits anti-inflammatory property against IL-β, LPS (HY-D1056) and Imiquimod (HY-B1080) induced inflammation .

HY-136527

BMS-986251	ROR Interleukin Related	Inflammation/Immunology
BMS-986251 is an orally active and selective RORγt inverse agonist with an EC₅₀ of 12 nM for RORγt GAL4. BMS-986251 inhibits IL-17 with an EC₅₀ of 24 nM in human whole blood assay. BMS-986251 demonstrates robust efficacy in mouse acanthosis and Imiquimod-induced (HY-B0180) models (preclinical models of psoriasis) .

HY-157456

RIPK1-IN-19	RIP kinase	Inflammation/Immunology
RIPK1-IN-19 (compound 10b) is a selective RIPK1 inhibitor (IC₅₀=15 nM). RIPK1-IN-19 displays potent protective activity in TNFα-induced systemic inflammatory response syndrome (SIRS) model and Imiquimod (IMQ)-induced psoriasis model. RIPK1-IN-19 can be used in research on inflammation and immune system diseases .

HY-N12840

Logmalicid B

Others Metabolic Disease

Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

Logmalicid B	Others	Metabolic Disease
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

HY-160097

AXC-666	ADC Cytotoxin	Inflammation/Immunology Cancer
AXC-666, an immune agonist, is a Imiquimod (HY-B0180) derivative. AXC-666 can be used for the synthesis of antibody-drug conjugate (ADC) .

HY-120225

NJK14047	p38 MAPK	Inflammation/Immunology
NJK14047 inhibits p38 MAPK and the differentation of naive T-cells to Th1 and Th17 cells. NJK14047 ameliorates the collage-induced rheumatoid arthritis and Imiquimod (HY-B0180)-induced psoriasis in mice .

HY-163176

WB518	STAT	Inflammation/Immunology
WB518 is a potent STAT3 inhibitor. WB518 effectively inhibits STAT3 activation and Keratin 17 expression. WB518 effectively alleviates imiquimod (HY-B0180) and TPA (HY-18739)-induced animal psoriasis by inhibiting STAT3 phosphorylation and Keratin 17 .

HY-150745

ODN 24987	Toll-like Receptor (TLR)	Inflammation/Immunology
ODN 24987 is a Guanine-modified inhibitory oligonucleotides (ODN), targeting TLR9. ODN 24987 can inhibit IL-6 and IFN-α release. ODN 24987 can be used for research immune disorders. ODN 24987 sequence: 5’-C-C-T-G-G-C-c7G-G-G-G-3’ .

HY-155505

AHR agonist 4	Aryl Hydrocarbon Receptor	Inflammation/Immunology
AHR agonist 4 (compound 24e) is an agonist of Aryl hydrocarbon receptor (AHR), assocaited with the immune balance of Th17/22 and Treg cells. AHR agonist 4 serves as a lead compound for anti-psoriasis drug, alleviates imiquimod (IMQ)-induced psoriasis-like skin lesion . AHR agonist 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-131040

NLRP3-IN-NBC6	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC₅₀= 574 nM) that acts independently of Ca ²⁺. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs) .

HY-116330

Hyperforin	Calcium Channel TRP Channel	Neurological Disease Inflammation/Immunology
Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

HY-155244

12R-LOX-IN-2	Lipoxygenase DNA/RNA Synthesis	Inflammation/Immunology
12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases .

HY-116330A

Hyperforin dicyclohexylammonium salt 1 Publications Verification Hyperforin DCHA	TRP Channel Calcium Channel	Neurological Disease
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

HY-155243

12R-LOX-IN-1	DNA/RNA Synthesis	Inflammation/Immunology
12R-LOX-IN-1 (Compound 4a) is a 12R-LOX inhibitor (IC₅₀: 28.25 μM). 12R-LOX-IN-1 inhibits the hyper-proliferative state and colony forming potential of Imiquimod (HY-B0180)-induced psoriatic keratinocytes. 12R-LOX-IN-1 inhibits reactive oxygen species, Ki67, IL-17A, TNF-α and IL-6 production. 12R-LOX-IN-1 can be used for antipsoriatic research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-116330A

Hyperforin dicyclohexylammonium salt 1 Publications Verification Hyperforin DCHA	Structural Classification Natural Products Source classification Guttiferae Hyperlcurn perforatum L. Plants	TRP Channel Calcium Channel
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

HY-N12840

Logmalicid B	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	Others
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

HY-116330

Hyperforin	Structural Classification Anti-inflammation/Immunoregulatory Antibiotics Source classification Guttiferae Hyperlcurn perforatum L. Disease Research Plants Anticancer	Calcium Channel TRP Channel
Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

Cat. No.	Product Name	Chemical Structure

HY-143974S

Imiquimod impurity 1-d6

Imiquimod impurity 1-d₆ is the deuterium labeled Imiquimod impurity 1[1].

Imiquimod impurity 1-d6
Imiquimod impurity 1-d₆ is the deuterium labeled Imiquimod impurity 1[1].

HY-B0180S

Imiquimod-d6
Imiquimod-d₆ is the deuterium labeled Imiquimod. Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].

HY-B0180S1

Imiquimod-d9
Imiquimod-d₉ is deuterium labeled Imiquimod. Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].

HY-143976S

3-Hydroxy imiquimod-d4

3-Hydroxy imiquimod-d₄ is the deuterium labeled 3-Hydroxy imiquimod.

*3-Hydroxy imiquimod-d4*
3-Hydroxy imiquimod-d₄ is the deuterium labeled 3-Hydroxy imiquimod.

AHR agonist 4		Alkynes
AHR agonist 4 (compound 24e) is an agonist of Aryl hydrocarbon receptor (AHR), assocaited with the immune balance of Th17/22 and Treg cells. AHR agonist 4 serves as a lead compound for anti-psoriasis drug, alleviates imiquimod (IMQ)-induced psoriasis-like skin lesion . AHR agonist 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Imiquimod

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products