LXR-α

By Targets:	LXR (15) Apoptosis (2) Bacterial (1) Estrogen Receptor/ERR (1) Free Fatty Acid Receptor (1) FXR (1) Glucocorticoid Receptor (1) Nucleoside Antimetabolite/Analog (1) ROR (1) Sirtuin (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (6) Endocrinology (1) Inflammation/Immunology (2) Metabolic Disease (8)

Targets Recommended: LXR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2509

Iristectorigenin B Iristectrigenin B	LXR	Cardiovascular Disease
Iristectorigenin B (Iristectrigenin B) is a liver X receptor (LXR) modulator. Iristectrigenin B stimulates the transcriptional activity of both LXR-α and LXR-β .

HY-19919

BMS-779788 1 Publications Verification EXEL04286652; XL-652; BMS-788	LXR	Metabolic Disease
BMS-779788 is a *LXR* partial agonist with IC₅₀ values of 68 nM for LXRα and 14 nM for LXRβ.

HY-108688

GSK2033

15+ Cited Publications

LXR Metabolic Disease

GSK2033 is a LXR antagonist with pIC₅₀s of 7 and 7.4 for LXRα or LXRβ, respectively.

GSK2033 15+ Cited Publications	LXR	Metabolic Disease
GSK2033 is a *LXR* antagonist with pIC₅₀s of 7 and 7.4 for *LXRα* or LXRβ, respectively.

HY-N0246

Saikosaponin A 1 Publications Verification	LXR Bacterial	Inflammation/Immunology Cancer
Saikosaponin A is an active component of Bupleurum chinensis, up-regulates *LXRα* expression, with potent anti-inflammatory activity .

HY-144549

LXR agonist 1	LXR	Cardiovascular Disease
LXR (Liver X receptor) agonist 1 is potent *LXR* agonist with AC₅₀s of 1.5 nM and 12 nM for *LXR-α* and *LXR-β, respectively. LXR* agonist 1 has the potential for the research of atherosclerosis .

HY-N12619

12R,13S-Dihydroxyfumitremorgin C

LXR Cancer

12R,13S-Dihydroxyfumitremorgin C (compound 1) is a LXRα agonist .

12R,13S-Dihydroxyfumitremorgin C	LXR	Cancer
12R,13S-Dihydroxyfumitremorgin C (compound 1) is a *LXRα* agonist .

HY-10629

LXR-623 5+ Cited Publications WAY 252623	LXR	Metabolic Disease Cancer
LXR-623 is a brain-penetrant partial *LXRα* and full LXRβ agonist, with IC₅₀s of 24 nM and 179 nM, respectively.

HY-101442

SR9238

LXR Metabolic Disease

SR9238 is a synthetic liver X receptor (LXR) inverse agonist with IC₅₀s of 214 nM and 43 nM for LXRα and LXRβ, respectively.
HY-143259

BE1218

LXR Cancer

BE1218 is a liver X receptor (LXR) inverse agonist with IC₅₀ values of 9 nM and 7 nM against LXRα and LXRβ, respectively .

SR9238	LXR	Metabolic Disease
SR9238 is a synthetic liver X receptor (LXR) inverse agonist with IC₅₀s of 214 nM and 43 nM for *LXRα* and LXRβ, respectively.

BE1218	LXR	Cancer
BE1218 is a liver X receptor (LXR) inverse agonist with IC₅₀ values of 9 nM and 7 nM against LXRα and LXRβ, respectively .

HY-128671

6-Thioinosine 6TI; 6-Mercaptopurine riboside	Nucleoside Antimetabolite/Analog	Metabolic Disease
6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα .

HY-N0835

(20S)-Protopanaxatriol 20(S)-APPT; g-PPT	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis	Cardiovascular Disease Endocrinology
(20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a *LXRα* inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-18282

AZ876

LXR Cancer

AZ876 is a potent and high-affinity LXR agonist. AZ876 displays 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRα and hLXRβ respectively .

AZ876	LXR	Cancer
AZ876 is a potent and high-affinity *LXR* agonist. AZ876 displays 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRα and hLXRβ respectively .

HY-100469

LXRβ agonist-2	LXR	Cardiovascular Disease
LXRβ agonist-2 is a highly potent and β-selective liver X receptor *(LXRβ)* agonist with EC₅₀ of 7 nM, displays 28.5-fold selectivity over LXRα (EC₅₀=200 nM) and used in the treatment of atherosclerosis .

HY-112813

TUG-1375 1 Publications Verification	Free Fatty Acid Receptor	Metabolic Disease
TUG-1375 is an agonist of free fatty acid receptor 2 (FFA2/GPR43), with a pK_i of 6.69. TUG-1375 is inactive on FFA3, FFA4, PPARα, PPARγ, PPARδ, LXRα or LXRβ .

HY-N2273

Gymnestrogenin	LXR	Metabolic Disease
Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br . Gymnestrogenin is a *LXR* antagonist with IC₅₀s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression .

HY-10626

T0901317 Maximum Cited Publications 24 Publications Verification	LXR FXR ROR Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
T0901317 is an orally active and highly selective *LXR* agonist with an EC₅₀ of 20 nM for LXRα . T0901317 activates FXR with an EC₅₀ of 5 μM . T0901317 is RORα and RORγ dual inverse agonist with K_i values of 132 nM and 51 nM, respectively . T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice .

HY-117006

E1231 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one	Sirtuin	Cardiovascular Disease
E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC₅₀=0.83 μM), to modulate cholesterol and lipid metabolism. E1231 interactes with SIRT1 (K_D=9.61 μM) and deacetylated liver X receptor-alpha (LXRα), and increases ATP-binding cassette transporter A1 (ABCA1) expression. E1231 also reduces atherosclerotic plaque development in ApoE ^-/- mice model. E1231 can be used for research in cholesterol and lipid disorder-related diseases .

HY-123148

IMB-808	LXR	Inflammation/Immunology
IMB-808 is a potent LXRα/β dual agonist with EC₅₀ values of 0.53 μM and 0.15 μM (0.15 μM, using GAL4-pGL4-luc reporter plasmid) for LXRβ and LXRα, respectively. IMB-808 promotes expression of genes related to reverse cholesterol transport (ABCA1 and ABCG1). IMB-808 can be used as a promising agent for the prospective treatment of atherosclerosis research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2509

Iristectorigenin B Iristectrigenin B	Cardiovascular Disease Natural Products Iridaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields	LXR
Iristectorigenin B (Iristectrigenin B) is a liver X receptor (LXR) modulator. Iristectrigenin B stimulates the transcriptional activity of both LXR-α and LXR-β .

HY-N0246

Saikosaponin A 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Umbelliferae Disease Research Fields Cancer Carphephorus corymbosus (Nutt.) Torr. & A.Gray	LXR Bacterial
Saikosaponin A is an active component of Bupleurum chinensis, up-regulates *LXRα* expression, with potent anti-inflammatory activity .

HY-N0835

(20S)-Protopanaxatriol 20(S)-APPT; g-PPT	Cardiovascular Disease Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a *LXRα* inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

HY-N2273

Gymnestrogenin	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Asclepiadaceae Metabolic Disease Plants Disease Research Fields Gymnema sylvestre (Retz.) Schult.	LXR
Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br . Gymnestrogenin is a *LXR* antagonist with IC₅₀s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression .

HY-N12619

12R,13S-Dihydroxyfumitremorgin C	Structural Classification Alkaloids Microorganisms Other Alkaloids Source classification	LXR
12R,13S-Dihydroxyfumitremorgin C (compound 1) is a *LXRα* agonist .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701404

	LXR-α Protein, Human NR1H3; Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3	Human	E. coli
	LXR-α protein is a nuclear receptor that activates transcription by interacting with RXR. It regulates cholesterol uptake through MYLIP-dependent ubiquitination and is critical for cholesterol homeostasis. LXR-α Protein, Human is the recombinant human-derived LXR-α protein, expressed by E. coli , with tag free. The total length of LXR-α Protein, Human is 266 a.a., .

HY-P701405

	LXR-α Protein, Human (His) NR1H3; Oxysterols receptor LXR-alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3	Human	E. coli
	LXR-α protein is a nuclear receptor that activates transcription by interacting with RXR. It regulates cholesterol uptake through MYLIP-dependent ubiquitination and is critical for cholesterol homeostasis. LXR-α Protein, Human (His) is the recombinant human-derived LXR-α protein, expressed by E. coli , with N-6*His labeled tag. The total length of LXR-α Protein, Human (His) is 266 a.a., .


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HY-P80423

	LXR alpha Antibody	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	LXR alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 50 kDa, targeting to LXR alpha. It can be used for WB,ICC,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

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