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MDM4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Autophagy (1) Ferroptosis (1) JNK (1) MDM-2/p53 (7) Mixed Lineage Kinase (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (6) Neurological Disease (1)

8

Inhibitors & Agonists

1

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

MDM4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MDM4 Human Pre-designed siRNA Set A contains three designed siRNAs for MDM4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MDM4 Human Pre-designed siRNA Set A MDM4 Human Pre-designed siRNA Set A

MDM2/4-p53-IN-2	MDM-2/p53 Apoptosis	Cancer
MDM2/4-p53-IN-2 (2q) is a potent dual **MDM2/ MDM4 inhibitor and p53 activator with the IC₅₀** values of 70.7 nM for MDM2- p53 and 81.4 nM for MDM4-p53 complexes. MDM2/4-p53-IN-2 regulates the cell cycle, induces cell apoptosis and has anticancer activity .

HY-123544

RDR03871

MDM-2/p53 Cancer

RDR03871 (compound 2) is a potent dual MDM2/MDM4 inhibitor with IC₅₀ values of 35.4 nM and 10.4 nM for MDM2-p53 and MDM4-p53, respectively .

MDM2/4-p53-IN-1	MDM-2/p53	Cancer
MDM2/4-p53-IN-1 is a potent *MDM2-p53* and *MDM4-p53* inhibitor with IC₅₀ values of 35.9, 57.4 nM, respectively. MDM2/4-p53-IN-1 shows antiproliferative activity .

YL93	MDM-2/p53	Cancer
YL93 is a dual inhibitors of *MDM2/4* with K_i values of 0.64 μM and 1.1 nM for MDM4 and MDM2, respectively. YL93 induces cell-cycle arrest and apoptosis. YL93 shows p53-dependent cell growth inhibition .

MDM2/4-p53-IN-3	MDM-2/p53	Cancer
MDM2/4-p53-IN-3 is a *MDM2/4-p53* protein-protein interactions (PPIs) inhibitor (IC₅₀s: 18.5 nM for MDM2-p53, 14.8 nM for MDM4-p53). MDM2/4-p53-IN-3 can be used in the research of cancers, such as colon cancer .

MMRi62	Ferroptosis Apoptosis Autophagy MDM-2/p53	Cancer
MMRi62, a ferroptosis inducer targeting *MDM2-MDM4* (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma (PDAC) cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain (FTH1). MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12 .

CEP-1347 KT7515	JNK Mixed Lineage Kinase MDM-2/p53	Neurological Disease
CEP-1347 is an inhibitor of the JNK/SAPK pathway with neuroprotective effects. CEP-1347 blocks JNK1 activation induced by members of the mixed lineage kinase (MLK) family (MLK3, MLK2, MLK1, dual leucine zipper kinase, and leucine zipper kinase). As an inhibitor of *MDM4, CEP-1347 can more effectively inhibit the growth of glioma cells expressing wild-type p53* ^[4] .

Cat. No.	Compare	Product Name	Species	Source

	MDM4/MDMX Protein, Human (His) Protein MDM4; Protein MDMx; MDM4; MDMX	Human	E. coli
	MDM4/MDMX proteins cooperate with MDM2 to regulate TP53 (p53) and inhibit the transcriptional activation domains of p53 and p73. This hinders their ability to induce cell cycle arrest and apoptosis. MDM4/MDMX Protein, Human (His) is the recombinant human-derived MDM4/MDMX protein, expressed by E. coli , with N-His labeled tag.

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