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Results for "

P.aeruginosa

" in MedChemExpress (MCE) Product Catalog:

89

Inhibitors & Agonists

25

Peptides

1

Inhibitory Antibodies

17

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-129123
    ML318

    		Antibiotic Infection
    ML318 is a biaryl nitrile inhibitor of PvdQ acylase with an IC50 of 20 nM by binding in the acyl-binding site. ML318 inhibits P. aeruginosa (PAO1) with an IC50 of 19 μM. ML318 prevents pyoverdine production and limits the growth of P. aeruginosa under iron-limiting conditions .
    ML318
  • HY-147958
    Antibacterial agent 113

    		Bacterial Infection
    Antibacterial agent 113 (compound 3) is a potent antibacterial agent. Antibacterial agent 113 shows antibacterial activity against P.aeruginosa, S.mutans, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, and S.aureus microorganisms, with MIC values all of 156.25 μM .
    Antibacterial agent 113
  • HY-147957
    Antibacterial agent 112

    		Bacterial Infection
    Antibacterial agent 112 (compound 2) is a potent antibacterial agent. Antibacterial agent 112 shows antibacterial activity against P.aeruginosa, S.mutans, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, and S.aureus microorganisms, with MIC values of 625, 625, 1250, 1250, 1250, 1250 and 1250 μM, respectively .
    Antibacterial agent 112
  • HY-147959
    Antibacterial agent 114

    		Bacterial Infection
    Antibacterial agent 114 (compound 1) is a potent antibacterial agent. Antibacterial agent 114 shows antibacterial activity against P.aeruginosa, B.subtilis, E.coli, E.faecalis, S.typhimuriumand, S.mutans, and S.aureus microorganisms, with MIC values of 625, 625, 625, 625, 625, 1250 and 1250 μM, respectively .
    Antibacterial agent 114
  • HY-P5632
    Bovine tracheal antimicrobial peptide

    		Bacterial Infection
    Bovine tracheal antimicrobial peptide is a kind of comes from the tracheal mucosa of antimicrobial peptides. Bovine tracheal antimicrobial peptide has activity against E.coli D31, K.pneumoniae 13883, S.aureus 25923, P.aeruginosa 27853 and C.albicans 14053, MIC value 12-25, 12-25, 25-50, 25-50, 6-12 μg/ml, respectively .
    Bovine tracheal antimicrobial peptide
  • HY-19806A
    Ceftolozane sulfate

    CXA-101; FR264205

    		 Bacterial Infection
    Ceftolozane (CXA-101) sulfate is an antipseudomonal cephalosporin. Ceftolozane sulfate inhibits P. aeruginosa PAO1 with an MIC of 0.5 μg/mL. Ceftolozane sulfate can also inhibit β-lactam-resistant P. aeruginosa .
    Ceftolozane sulfate
  • HY-114818
    4-(tert-Butyl)-benzhydroxamic Acid

    		Bacterial Infection
    4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively. 4-(tert-Butyl)-benzhydroxamic Acid reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM .
    4-(tert-Butyl)-benzhydroxamic Acid
  • HY-139982
    OX11

    		Bacterial Infection
    OX11 is a selective inhibitor of S. pneumoniae, P. aeruginosa, and E. coli bacterial strains .
    OX11
  • HY-P5556
    KAMP-19

    		Bacterial Infection
    KAMP-19, a keratin-derived antimicrobial peptide, is an antimicrobial peptide against P. aeruginosa. .
    KAMP-19
  • HY-158120
    LasR agonist 1

    		Bacterial Infection Inflammation/Immunology
    LasR agonist 1 (9) is a LasR agonist, with an EC50 of 0.7 μM. Used for P. aeruginosa research .
    LasR agonist 1
  • HY-162475
    Fluorofolin

    		Dihydrofolate reductase (DHFR) Bacterial Infection
    Fluorofolin is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.5 nM. Fluorofolin exhibits significant activity against P. aeruginosa .
    Fluorofolin
  • HY-P5580
    Dermaseptin-B3

    		Bacterial Infection Cancer
    Dermaseptin-B3 inhibits the growth of Gram-positive and Gram-negative bacteria (MIC: 1.3, 2.3, 5.0, 2.6, 2.3 μM for S. aureus, P. aeruginosa, P. aeruginosa, E. (ATCC 25922), E. (54127) respectively). Dermaseptin-B3 also inhibits tumor cell proliferation .
    Dermaseptin-B3
  • HY-A0214
    Colistin methanesulfonate sodium salt
    1 Publications Verification

    		 Bacterial Antibiotic Infection
    Colistin methanesulfonate sodium salt exhibits MIC values ranged from 4 to 16 mg/liter against susceptible strains (P. aeruginosa) .
    Colistin methanesulfonate sodium salt
  • HY-131907
    LpxC-IN-5

    		Bacterial Infection
    LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with an IC50 of 20 nM. LpxC-IN-5 shows antibacterial activity against E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 μg/mL, respectively .
    LpxC-IN-5
  • HY-N5127
    Nonacosane

    		Bacterial Infection
    Nonacosane, isolated from Baphia massaiensis, exhibits weak activities against E. coli, B. subtilis, P. aeruginosa and S. aureus .
    Nonacosane
  • HY-N8281
    Daldinone A

    		Bacterial Infection
    Daldinone A (Compound 4) is an antibacterial agent that can be isolated from Nigrospora oryzae. Daldinone A has antimicrobial potential against P. aeruginosa .
    Daldinone A
  • HY-120659
    Gly-Gly-AMC

    		Fluorescent Dye Others
    Gly-Gly-AMC is a fluorogenic peptide substrate. Gly-Gly-AMC can be used to assess bacterial protease activity of P. aeruginosa and S. aureus .
    Gly-Gly-AMC
  • HY-105180
    Lenapenem

    BO-2727 free acid

    		 Bacterial Infection
    Lenapenem (BO-2727 free acid), a carbapenem antibiotic, has potent antibacterial activity against Gram-positive and Gram-negative bacteria including P. aeruginosa .
    Lenapenem
  • HY-N4136
    Lonicerin

    		Bacterial Apoptosis Endogenous Metabolite Infection
    Lonicerin is an anti-algE (alginate secretion protein) flavonoid with inhibitory activity for P. aeruginosa. Lonicerin prevents inflammation and apoptosis in LPS-induced acute lung injury .
    Lonicerin
  • HY-139746
    FPI-1602

    		Beta-lactamase Bacterial Infection
    FPI-1602 is a β-lactamase inhibitor. FPI-1602 displays marked antimicrobial activity against P. aeruginosa, E. coli, and Enterobacter spp. .
    FPI-1602
  • HY-130055
    HQNO
    1 Publications Verification

    		 Mitochondrial Metabolism Infection
    HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III . HQNO is a potent inhibitor of mitochondrial NDH-2 in many species .
    HQNO
  • HY-P5555
    LMW peptide

    		Bacterial Infection
    LMW peptide is an antimicrobial peptide. LMW peptide is active against Gram-positive and Gram-negative bacterial, such as B. subtilis, L. monocytogenes, E. coli, P. aeruginosa, V. cholera .
    LMW peptide
  • HY-139698
    GT-1

    LCB10-0200

    		 Others Infection
    GT-1 (LCB10-0200), a siderophore-linked cephalosporin, is effective against clinical isolates of P. aeruginosa, Klebsiella oxytoca, Proteus spp., Serratia marcescens, and Enterobacter aerogenes.
    GT-1
  • HY-144071
    MurB-IN-1

    		Others Infection
    MurB-IN-1 (compound 44) is an inhibitor of uridine diphosphate-N-acetylenolpyruvylglucosamine reductase (MurB), with a Kd 3.57 μM. MurB, a target in P. aeruginosa, is an opportunistic infectious agent causing death .
    MurB-IN-1
  • HY-P99214
    Panobacumab

    KBPA101

    		 Bacterial Infection
    Panobacumab (KBPA101) is a fully human IgM/κ monoclonal antibody generated by immortalizing human B lymphocytes against the LPS O polysaccharide of serotype O11 of P. aeruginosa .
    Panobacumab
  • HY-146328
    PqsR/LasR-IN-2

    		Bacterial Antibiotic Infection
    PqsR/LasR-IN-2 (Compound 3) is a potent inhibitor of PqsR and LasR systems in P. aeruginosa. PqsR/LasR-IN-2 also inhibits hERG with the IC50 of 1.408 µM .
    PqsR/LasR-IN-2
  • HY-146329
    PqsR/LasR-IN-3

    		Bacterial Antibiotic Infection
    PqsR/LasR-IN-3 (Compound 7a) is a potent inhibitor of PqsR and LasR systems in P. aeruginosa. PqsR/LasR-IN-3 also inhibits hERG with the IC50 of 109.01 µM .
    PqsR/LasR-IN-3
  • HY-148831
    Antibacterial agent 135

    		Bacterial Infection
    Antibacterial agent 135 (example 7) is a potent antibacterial agent. Antibacterial agent 135 can inhibit P. aeruginosa, A. baumannii, E. coli, and K. pneumoniae, with MIC>64 μg/mL .
    Antibacterial agent 135
  • HY-N6711
    Equisetin

    		HIV Integrase Infection
    Equisetin is an N-methylserine-derived acyl tetramic acid isolated from a terrestrial fungus Fusarium equiseti NRRL 5537 . Equisetin is a tetramate-containing natural product with antibiotic and cytotoxic activity . Equisetin inhibits the growth of Gram-positive bacteria and HIV-1 integrase activity but shows no activity against Gram-negative bacteria . Equisetin is a Quorum-sensing inhibitor (QSI) that attenuates QS-regulated virulence phenotypes in P. aeruginosa without affecting the growth of bacterias, serves as a leading compound for the treatment of P. aeruginosa infections .
    Equisetin
  • HY-N3199
    Neorauflavene

    		Bacterial Infection
    Neorauflavene is a phenolic neorautanenia isoflavanoid isolated from Neorautanenia edulis. Neorauflavene shows antibacterial activities against E. faecalis, S. suis, S. agalactiae, P. aeruginosa, B. subtilis, and R. anatipestifer .
    Neorauflavene
  • HY-131049
    Antimicrobial agent-30

    		Bacterial Infection
    Antimicrobial agent-30 (Compound T10) is an antimicrobial agent, with MIC values of 18.7-21.0 µg/mL for S. aureus, S. epidermidis, E. coli, P. aeruginosa, A. niger, and A. fumigatus .
    Antimicrobial agent-30
  • HY-131337
    RhlR antagonist 1

    		Bacterial Infection
    RhlR antagonist 1 is a potent RhlR antagonist with an IC50 of 26 μM. RhlR antagonist 1 displays selective RhlR antagonism over LasR and PqsR, strong inhibition of biofilm formation in static and dynamic settings, and reduces production of virulence factors such as rhamnolipid and pyocyanin in P. aeruginosa. RhlR antagonist 1 can be utilized for developing QS-modulating molecules in the control of P. aeruginosa infections . RhlR antagonist 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    RhlR antagonist 1
  • HY-P5552
    Melimine

    		Bacterial Parasite Fungal Infection
    Melimine is a hybrid antimicrobial peptide of Melittin (HY-P0233) and Protamine. Melimine is active against P. aeruginosa and S. aureus. Melimine has broad spectrum activity against bacteria, fungi and protozoa .
    Melimine
  • HY-N12182
    Lividomycin A

    		Antibiotic Bacterial Infection
    Lividomycin A is a broad-spectrum aminoglycoside antibiotic. Lividomycin A shows antimicrobial activity. Lividomycin A shows a positive protecting effect for the experimental infections in mice with several bacteria such as S. aureus, P. aeruginosa, Klebsiella pneumoniae and Escherichia coli .
    Lividomycin A
  • HY-W024297
    VP-4509

    		Bacterial Infection
    VP-4509, an anti-methicillin‐resistant Staphylococcus aureus (MRSA) agent, with the MIC of 49.3 µM. VP-4509 also possesses high antibacterial activity towards gram-negative bacteria P. aeruginosa .
    VP-4509
  • HY-144767
    PA3552-IN-1

    		Bacterial Infection
    PA3552-IN-1 (compound 15) is an antibiotic adjuvant that restores sensitivity of MDR P. aeruginosa DK2 strain to Polymyxin B. PA3552-IN-1 can reduce PA3552 expression .
    PA3552-IN-1
  • HY-N10087
    Angustifoline

    		Bacterial Infection
    Angustifoline, an alkaloid, can be isolated from Lupinus angustifolius L. alkaloid extract. Angustifoline exhibits antimicrobial activity. Angustifoline could have bacteriostatic effects against S. aureus, B. subtilis, E. coli, P. aeruginosa and B. thuringiensis .
    Angustifoline
  • HY-N10087A
    Angustifoline hydrochloride

    		Bacterial Infection
    Angustifoline hydrochloride, an alkaloid, can be isolated from Lupinus angustifolius L. alkaloid extract. Angustifoline hydrochloride exhibits antimicrobial activity. Angustifoline hydrochloride could have bacteriostatic effects against S. aureus, B. subtilis, E. coli, P. aeruginosa and B. thuringiensis .
    Angustifoline hydrochloride
  • HY-B1369
    Imipenem monohydrate
    Maximum Cited Publications
    19 Publications Verification

    N-Formimidoyl thienamycin monohydrate; MK0787 monohydrate

    		 Bacterial Antibiotic Infection
    Imipenem monohydrate, a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem monohydrate can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .
    Imipenem monohydrate
  • HY-N10572
    Antibacterial synergist 2

    		Bacterial Infection
    Antibacterial synergist 2 (compound 27) is a biofilm inhibitor. Antibacterial synergist 2 shows inhibitory effects to S. enterica, S. aureus, P. aeruginosa and C. albicans. Antibacterial synergist 2 can be used for the research related to biofilm-forming pathogens .
    Antibacterial synergist 2
  • HY-153576
    Antibacterial agent 143

    		Bacterial Infection
    Antibacterial agent 143 (Compound 5a) is an antibacterial agent with MICs of 25, 25, 50 and 50 μg/mL against B. subtilis ATCC6633, S. aureus ATCC6538, P. aeruginosa ATCC13525 and E. coli ATCC35218, respectively .
    Antibacterial agent 143
  • HY-151160
    LasR-IN-1

    		Bacterial Infection
    LasR-IN-1 (compound 9g) is a potent LasR inhibitor. LasR-IN-1 has good efficacy toward E. coli. LasR-IN-1 shows anti-bacterial activity, with a MIC of 28.13 μM against P. aeruginosa .
    LasR-IN-1
  • HY-P5690
    Distinctin

    		Bacterial Infection
    Distinctin is an antimicrobial peptide. Distinctin can be isolated from frog skin. Distinctin has antibacterial activity against E. faecalis, P. aeruginosa, S. aureus and E. coli (MIC: 14.5, 28.0, 28.0, 14.5 μM) .
    Distinctin
  • HY-162130
    Antibacterial agent 176

    		Bacterial Infection
    Antibacterial agent 176 (Compound 6f) is a potent PqsR antagonist. Antibacterial agent 176 has a good inhibitory effect on P. aeruginosa CF, and a significant inhibitory effect on the production of pyocyanin, 2-alkyl-4 (1H) -quinolones .
    Antibacterial agent 176
  • HY-P10389
    Globomycin derivative G2A

    		Bacterial Infection
    Globomycin derivative G2A (Compound G2A) is an inhibitor for lipoprotein signal peptidase II (LspA), with an IC50 of 604 nM. Globomycin derivative G2A inhibits E. coli, P. aeruginosa and A. baumannii, with MIC ranging from 12.5 to 32 μg/mL .
    Globomycin derivative G2A
  • HY-128384
    Benzyldodecyldimethylammonium chloride dihydrate

    		Bacterial Infection
    Benzyldodecyldimethylammonium chloride dihydrate is a quaternary ammonium compound (QAC) and can be used as a biocide to target antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant (MDR) P. aeruginosa et. al. Benzyldodecyldimethylammonium chloride dihydrate, an antimicrobial agent, bacteriostatic or bactericidal properties depending on the concentration.
    Benzyldodecyldimethylammonium chloride dihydrate
  • HY-B1369A
    Imipenem

    N-Formimidoyl thienamycin; MK0787

    		 Antibiotic Bacterial Infection
    Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections .
    Imipenem
  • HY-P5546
    Lynronne-2

    		Bacterial Infection
    Lynronne-2 is an antimicrobial peptide. Lynronne-1 is active against Gram-positive bacterials, including MDR strains (MIC: 32-256 μg/mL for methicillin-resistant MRSA strains). Lynronne-2 is also effective against P. aeruginosa infection
    Lynronne-2
  • HY-P5547
    Lynronne-3

    		Bacterial Infection
    Lynronne-3 is an antimicrobial peptide. Lynronne-1 is active against Gram-positive bacterials, including MDR strains (MIC: 32-128 μg/mL for methicillin-resistant MRSA strains). Lynronne-3 is also effective against P. aeruginosa infection
    Lynronne-3
  • HY-P5924
    L-K6L9

    		Bacterial Infection
    L-K6L9 shows antimicrobial and antibiofilm activities against P. aeruginosa from cystic fibrosis patients. L-K6L9 is stable and resistant to degradation by cystic fibrosis sputum proteases and will not induce bacterial resistance .
    L-K6L9

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