Phosphatidylserine

By Targets:	Apoptosis (1) Caspase (1) Cathepsin (1) Isotope-Labeled Compounds (1) Liposome (3) PKC (1) SARS-CoV (1)
By Research Areas:	Cancer (6) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0183

*Phosphatidylserine* Phospholipids, Phosphatidylserines; Serine glycerophosphatides	Others	Inflammation/Immunology
Phosphatidylserine is a conserved anti-inflammatory and immunosuppressive signal that is highly dysregulated in the tumor microenvironment and autoimmune diseases. During apoptosis and cellular stress，the related disrupting enzymes Xkr8 and TMEM16 mediate Phosphatidylserine externalization. Phosphatidylserine externalization produces a "eat me" signal that initiates endocytosis and helps clear the body of apoptotic cells. When pathogens use Phosphatidylserine and apoptotic mimicry to evade host immune responses，targeting Phosphatidylserine strategies can stimulate immune activity .

HY-P0109A

Z-FA-FMK 2 Publications Verification (1S)-Z-FA-FMK	SARS-CoV Cathepsin Apoptosis Caspase	Infection Cancer
Z-FA-FMK ((1S)-Z-FA-FMK) is a potent Cathepsin B and L inhibitor. Z-FA-FMK blocks the induction of DEVDase activity, DNA fragmentation, and externalization of phosphatidylserine by selective synthetic retinoid-related molecules (RRMs). Z-FA-FMK inhibits apoptosis. Z-FA-FMK inhibits caspase activity and selectively inhibits recombinant effector caspases 2, -3, -6, and -7. Z-FA-FMK is a viral inhibitor. Z-FA-FMK inhibits reovirus replication in a susceptible host .

HY-N4254

Distearoylphosphatidylserine DSPS	Liposome	Metabolic Disease
Distearoylphosphatidylserine (DSPS) acts as a monolayer. Phosphatidylserine is a phospholipid with a polar serine found in phosphoester linkage to diacylglycerol .

HY-158145

DS55980254

Others Cancer

DS55980254 is a potent and selective phosphatidylserine synthase 1 (PTDSS1) inhibitor .

DS55980254	Others	Cancer
DS55980254 is a potent and selective phosphatidylserine synthase 1 (PTDSS1) inhibitor .

HY-115435

*1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine* sodium** DMPS-Na; Dimyristoyl Phosphatidylserine sodium	Liposome	Cancer
1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine sodium (DMPS-Na; Dimyristoyl phosphatidylserine sodium) is a liposome to simulate biological phospholipid membrane. Liposomes are the main component of vesicles with concentric phospholipid bilayer membranes, which can be used to construct drug delivery systems for anti-cancer and anti-infection fields. Highly polar water-soluble payloads can be trapped in the internal aqueous space of liposomes, while lipophilic payloads can partition into and become part of the lipid bilayer. Especially for delivering antisense oligonucleotides, it can overcome problems such as inefficient cellular uptake and rapid loss in the body .

HY-157562

PTDSS1-IN-1

Others Cancer

PTDSS1-IN-1 is an inhibitor of phosphatidylserine synthase 1 (PTDSS1). PTDSS1-IN-1 can be used in tumor research .

PTDSS1-IN-1	Others	Cancer
PTDSS1-IN-1 is an inhibitor of phosphatidylserine synthase 1 (PTDSS1). PTDSS1-IN-1 can be used in tumor research .

HY-P5988

N-myristoyl-RKRTLRRL	PKC	Cancer
N-myristoyl-RKRTLRRL inhibits binding of PKC substrates. N-myristoyl-RKRTLRRL inhibits Ca ²⁺- and phosphatidylserine (PS)-dependent histone phosphorylation with IC₅₀ of 5 μM.? histone phosphorylation with IC₅₀ of 80 μM .

HY-141613

*1,2-Dioleoyl-sn-glycero-3-phospho-L-serine* sodium** DOPS-NA	Liposome	Others
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium is a ubstitute for Phosphoserine/phosphatidylserine. 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium can be used in lipid mixtures with DOPC and DOPE as effective nontoxic and nonviral DNA vectors .

HY-115435S

*1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine-d54 sodium* DMPS-Na-d₅₄; Dimyristoyl Phosphatidylserine-d₅₄ sodium	Isotope-Labeled Compounds	Others
1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine-d₅₄ (sodium) is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine.

Cat. No.	Product Name	Type

HY-N4254

Distearoylphosphatidylserine DSPS	Drug Delivery
Distearoylphosphatidylserine (DSPS) acts as a monolayer. Phosphatidylserine is a phospholipid with a polar serine found in phosphoester linkage to diacylglycerol .

HY-141613

*1,2-Dioleoyl-sn-glycero-3-phospho-L-serine* sodium** DOPS-NA	Drug Delivery
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium is a ubstitute for Phosphoserine/phosphatidylserine. 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium can be used in lipid mixtures with DOPC and DOPE as effective nontoxic and nonviral DNA vectors .

HY-121892

(Z)-KC02	Drug Delivery
(Z)-KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo .

(Z)-KC02

Drug Delivery

(Z)-KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC). (Z)-KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z)-KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo .

Cat. No.	Product Name	Target	Research Area

HY-P5988

N-myristoyl-RKRTLRRL	PKC	Cancer
N-myristoyl-RKRTLRRL inhibits binding of PKC substrates. N-myristoyl-RKRTLRRL inhibits Ca ²⁺- and phosphatidylserine (PS)-dependent histone phosphorylation with IC₅₀ of 5 μM.? histone phosphorylation with IC₅₀ of 80 μM .

Cat. No.	Product Name	Target	Research Area

HY-P99279

Bavituximab Anti-Human Phosphatidylserine Recombinant Antibody	Inhibitory Antibodies	Cancer
Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a phosphatidylserine (PS)-targeting monoclonal antibody, suppresses tumor growth by targeting tumor vasculature and reactivating antitumor immunity. Bavituximab plus Paclitaxel (HY-B0015) and Carboplatin (HY-17393), have enhanced inhibition on non-small-cell lung cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0183

*Phosphatidylserine* Phospholipids, Phosphatidylserines; Serine glycerophosphatides	Animals Source classification	Others
Phosphatidylserine is a conserved anti-inflammatory and immunosuppressive signal that is highly dysregulated in the tumor microenvironment and autoimmune diseases. During apoptosis and cellular stress，the related disrupting enzymes Xkr8 and TMEM16 mediate Phosphatidylserine externalization. Phosphatidylserine externalization produces a "eat me" signal that initiates endocytosis and helps clear the body of apoptotic cells. When pathogens use Phosphatidylserine and apoptotic mimicry to evade host immune responses，targeting Phosphatidylserine strategies can stimulate immune activity .

Cat. No.	Compare	Product Name	Species	Source

HY-P76637

	SDPR Protein, Mouse (His) Caveolae-associated protein 2; Cavin-2; Phosphatidylserine-binding protein; SDR	Mouse	E. coli
	SDPR proteins complexly regulate caveolae biogenesis and morphology, inducing membrane curvature of specialized caveolae. Tissue-wise, it is critical for caveolae in lung and fat endothelial cells, but not in cardiac endothelial cells. SDPR Protein, Mouse (His) is the recombinant mouse-derived SDPR protein, expressed by E. coli , with N-His labeled tag. The total length of SDPR Protein, Mouse (His) is 179 a.a., with molecular weight of ~28 kDa.


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HY-115435S

1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine-d54 sodium

1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine-d₅₄ (sodium) is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine.

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