Search Result
Results for "
Piperazine
" in MedChemExpress (MCE) Product Catalog:
8
Biochemical Assay Reagents
6
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-100887
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Ferroptosis
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Cancer
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Piperazine erastin is an analog of erastin which induces an iron-dependent form of non-apoptotic cell death, termed ferroptosis. Piperazine erastin can be used in cancer research .
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- HY-B2186
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Parasite
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Infection
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Piperazine adipate is a potent broad spectrum anthelmintic against many common worm infections in mammals.
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- HY-17599
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1,4-Diazacyclohexane citrate
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GABA Receptor
Parasite
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Infection
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Piperazine (1,4-Diazacyclohexane) citrate is a gamma-aminobutyric acid (GABA) agonist . Piperazine citrate is a vital building block and is an essential core in numerous marketed agents with diverse pharmacological activities .
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- HY-161444
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PROTAC Linkers
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Others
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Piperazine-acetyl-PIP-AcOH is a PROTAC linker. Piperazine-acetyl-PIP-AcOH can be used for PROTAC synthesis .
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- HY-148830
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Liposome
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Others
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Piperazine-bis(ethyl octadeca-9,12-dienoate) is a cationic lipid extracted from patent WO2023036148A1, and can be used for the generation of Lipid nanoparticles (LNPs).
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- HY-B1361
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Piperazine estrone sulfate; Estrone sulfate Piperazine salt
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Estrogen Receptor/ERR
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Endocrinology
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Estropipate is a form of estrogen, used to treat symptoms of menopause, also used to prevent osteoporosis.
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- HY-44432
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ABT-263-Piperazine
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Bcl-2 Family
Ligands for Target Protein for PROTAC
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Cancer
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Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604) .
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- HY-161201
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Ligands for E3 Ligase
Autophagy
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Cancer
|
Thalidomide-piperazine-pyrimidine-piperazine-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperazine-pyrimidine-piperazine-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-157760
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Ligands for E3 Ligase
Autophagy
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Cancer
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(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH can serve as a Cereblon ligand to recruit CRBN proteins and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-W259932
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Ligands for E3 Ligase
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Cancer
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Lenalidomide 5'-piperazine is a functionalized cerebellar ligand for PROTAC development that binds an E3 ligand to terminal piperazine for subsequent chemical reactions to produce a protein deactivator with a rigid linker .
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- HY-163233
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Ligands for E3 Ligase
Autophagy
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Cancer
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Phthalimidinoglutarimide-5-piperazine is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Phthalimidinoglutarimide-5-piperazine can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-132971
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Others
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Cancer
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Thalidomide-piperazine hydrochloride has the potential for the research of leprosy and multiple myeloma. Thalidomide-piperazine hydrochloride used as a tool in developmental biology leads to important discoveries in the biochemical pathways of limb development .
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- HY-W797383
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Ligands for E3 Ligase
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Cancer
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Phthalimidinoglutarimide-6-piperazine is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.
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- HY-160244
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Ligands for E3 Ligase
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Cancer
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Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
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- HY-138783A
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .
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- HY-W002603
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Biochemical Assay Reagents
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Others
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Benzyl piperazine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-78871S
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- HY-157759
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Ligands for E3 Ligase
Autophagy
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Cancer
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(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH can serve as a Cereblon ligand to recruit CRBN proteins and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-148834
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-
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- HY-W454945S
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N-Boc-Piperazine-d8
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Isotope-Labeled Compounds
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Others
|
tert-Butyl piperazine-1-carboxylate-2,2,3,3,5,5,6,6-d8 is the deuterium labeled tert-Butyl piperazine-1-carboxylate[1].
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- HY-163223
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Ligands for E3 Ligase
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Cancer
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(S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-CO-CH2-piperazine-C3-piperazine-Boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-163210
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Ligands for E3 Ligase
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Cancer
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Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride (ZJT1) is an E3 ubiquitin ligase cereblon based on Pomalidomide (HY-10984) (CRBN) ligand for recruitment of cereblon protein. Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride can be linked to protein ligand by linker to form PROTAC .
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- HY-157758
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Ligands for E3 Ligase
Autophagy
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Cancer
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(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker . (S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-157566
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Ligands for E3 Ligase
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Cancer
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Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride is a functionalized cerebellar ligand for PROTAC development, combining E3 ligand and terminal piperidine for subsequent chemical reactions. A protein degradant with a rigid connector is generated .
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- HY-163239
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Ligands for E3 Ligase
Autophagy
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Cancer
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(R)-Thalidomide-piperazine-pyrrolidineethanol is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (R)-Thalidomide-piperazine-pyrrolidineethanol can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-134982
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- HY-145766
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Others
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Others
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Anisole-piperazine-methanone-benzothiazole-p-methylpiperidine is an active compound .
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- HY-138783
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- HY-W013249
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PROTAC Linkers
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Cancer
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Boc-piperazine-benzoic acid is a PROTAC linker and can be used in the synthesis of PROTACs, such as PROTAC androgen receptor (AR) degrader ARD-2128 (HY-13229) .
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- HY-20797S
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- HY-41939
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Biochemical Assay Reagents
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Others
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1-(2-Hydroxyethyl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-145755
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Others
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Others
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Benzyl-piperazine-CO-benzothiazole-4-methylpiperidine alters the lifespan of a eukaryotic organism .
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- HY-131184
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PROTAC Linkers
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Inflammation/Immunology
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N-Boc-piperazine-C3-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-N-piperazine-C3-COOH can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183) .
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- HY-134983
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- HY-30105
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PROTAC Linkers
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Cancer
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N-Boc-piperazine is a Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183) .
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- HY-131706A
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Trk Receptor
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Cancer
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GNF-8625 monopyridin-N-piperazine hydrochloride (TRKi-2), a TRK inhibitor, which is from the patent WO 2020038415 A1 .
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- HY-161193
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Ligands for E3 Ligase
Autophagy
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Cancer
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Thalidomide-piperazine-(R)-C-pyrrolidine-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperazine-(R)-C-pyrrolidine-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-161195
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Ligands for E3 Ligase
Autophagy
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Cancer
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Deoxy-thalidomide-piperidine-C-piperazine-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Deoxy-thalidomide-piperidine-C-piperazine-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-161200
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Ligands for E3 Ligase
Autophagy
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Cancer
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Thalidomide-piperazine-C-azetidine-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperazine-C-azetidine-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-W145436
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- HY-W004148S
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2-Piperazinylpyrimidine-d8 dihydrochloride
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Isotope-Labeled Compounds
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Others
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1-(2-Pyrimidinyl)piperazine-d8 (2-Piperazinylpyrimidine-d8) dihydrochloride is deuterium-labeled 1-(2-Pyrimidinyl)piperazine dihydrochloride (HY-W004148) .
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- HY-138780
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- HY-138781
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- HY-138782
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- HY-40041
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Biochemical Assay Reagents
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Others
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(R)-1-Boc-3-methyl-piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-161184
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Ligands for E3 Ligase
Autophagy
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Cancer
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Deoxy-thalidomide-piperidine-C-piperazine-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Deoxy-thalidomide-piperidine-C-piperazine-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-161203
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Ligands for E3 Ligase
Autophagy
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Cancer
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Thalidomide-azetidine-piperazine-C2-O-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-azetidine-piperazine-C2-O-C-boc can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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-
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- HY-161445
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH is a conjugate of the VHL ligand and linker of the E3 ubiquitinase VH032. The Linker of (S,R,S)-AHPC-Me-piperazine-acetyl-PIP-AcOH can further be linked to target protein ligands (such as BCR-ABL1) to form PROTAC molecules .
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- HY-138788
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-
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- HY-138789
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- HY-138787
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- HY-32208S
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Isotope-Labeled Compounds
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Others
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tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate-d4 is the deuterium labeled tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate[1].
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- HY-161191
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Ligands for E3 Ligase
Autophagy
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Cancer
|
Thalidomide-azetidine-piperazine-C2-O-C2-OH is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-azetidine-piperazine-C2-O-C2-OH can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-120220
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A-20968; Ancyte
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Others
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Cancer
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Piposulfan (Ancyte) is a methanesulfonate, alkylating derivative of piperazine. Piposulfan has potential antineoplastic activity. Piposulfan can be used for the research of cancer .
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- HY-138788A
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- HY-138789A
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- HY-131386A
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Target Protein Ligand-Linker Conjugates
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Cancer
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BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM .
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- HY-163225
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Ligands for E3 Ligase
Autophagy
|
Cancer
|
(S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-NH-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-NH-Boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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-
- HY-131386
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Target Protein Ligand-Linker Conjugates
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Cancer
|
BMS-1166-N-piperidine-CO-N-piperazine incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM .
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-
- HY-163221
-
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Ligands for E3 Ligase
Autophagy
|
Cancer
|
(S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-N(Me)-Boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. (S)-Thalidomide-piperazine-(1S,4r)-cyclohexane-N(Me)-Boc can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- HY-125705
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Herqueline A
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Influenza Virus
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Infection
Cardiovascular Disease
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Herquline A (Herqueline A) is a fungal piperazine alkaloid. Herquline A is a fungal metabolite that inhibits platelet aggregation and replication of the influenza virus .
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- HY-131186
-
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E3 Ligase Ligand-Linker Conjugates
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Cancer
|
Pomalidomide-amido-C3-piperazine-N-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in the synthesis of PROTAC PD-1/PD-L1 degrader-1 (HY-131183) .
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-
- HY-66010A
-
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Calcium Channel
|
Cardiovascular Disease
|
Cinepazide is a piperazine derivative and acts as a weak calcium channel blocker. Cinepazide is a potent vasodilator and can be used for the research of cerebrovascular diseases, including ischemic stroke, brain infarct et. al .
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- HY-W140284S
-
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Isotope-Labeled Compounds
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Others
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6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate-d8 (hydrochloride) is the deuterium labeled 6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate hydrochloride[1].
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- HY-157749
-
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Ligands for E3 Ligase
Autophagy
E3 Ligase Ligand-Linker Conjugates
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Cancer
|
Thalidomide-piperazine-(S)-CH2-Pyrrolidine-C2-O-CH2-COO-C (CH3)3 is a synthetic E3 ligase ligand-Linker conjugate. Thalidomide-piperazine-(S)-Ch2-Pyrrolidine-C2-O-CH2-COO-C(CH3)3 includes Thalidomide-based cereblon ligands and linkers. Thalidomide-piperazine-(S)-CH2-Pyrrolidine-C2-O-CH2-COO-C(CH3)3 can be used to synthesize PROTAC BET .
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- HY-163231
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Ligands for E3 Ligase
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Cancer
|
(S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-CO-CH2-azetidine-piperazine-CH2-COOH can be used as a key intermediate for the synthesis of complete PROTAC molecules.
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-
- HY-66010
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MD-67350
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Calcium Channel
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Cardiovascular Disease
|
Cinepazide Maleate (MD-67350) is a piperazine derivative and acts as a weak calcium channel blocker. Cinepazide Maleate is a potent vasodilator and can be used for the research of cerebrovascular diseases, including ischemic stroke, brain infarct et. al .
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-
- HY-130837
-
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Bacterial
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Infection
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JH-LPH-28, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-28 displays outstanding antibiotic activity with a MIC value of 0.83 μg/mL .
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- HY-130838
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Bacterial
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Infection
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JH-LPH-33, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-33 displays outstanding antibiotic activity with a MIC value of 0.66 μg/mL .
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- HY-130836
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Bacterial
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Infection
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LpxH-IN-AZ1, a sulfonyl piperazine compound, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. LpxH-IN-AZ1 is a potent inhibitor of Klebsiella pneumoniae LpxH with IC50 of 0.36 μM .
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- HY-123229
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-
- HY-W031620
-
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Sodium Channel
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Neurological Disease
|
VGSCs-IN-1 (compound 14), a 2-piperazine analog of Riluzole (HY-B0211), is a human voltage-gated sodium channels (VGSCs) inhibitor. VGSCs-IN-1 shows great Nav1.4 blocking activity. VGSCs-IN-1 has a pKa of 7.6 and a cLog P of 2.4. VGSCs-IN-1 can be used for cell excitability disorders research .
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- HY-17550
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DM-235
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iGluR
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Neurological Disease
|
Sunifiram (DM-235) is a piperazine derived ampakine-like drug which has nootropic effects in animal studies with significantly higher potency than piracetam.
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- HY-W414406
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Biochemical Assay Reagents
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Others
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CABS is a zwitterionic piperazine buffer reagent, which can be used as a buffer reagent for wetting agents, pesticide emulsifiers, and dispersants, and has been used in fluorescent dyeing applications .
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- HY-112538
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1-NP hydrochloride; 1-NaphthylPiperazine hydrochloride
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5-HT Receptor
Apoptosis
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Inflammation/Immunology
Cancer
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1-1-Naphthylpiperazine hydrochloride (1-NP hydrochloride; 1-Naphthylpiperazine hydrochloride) is a serotonergic derivative of quipazine, which is both an agonist for 5-HT1A receptor and an antagonist for 5-HT2A receptor. 1-1-Naphthylpiperazine hydrochloride induces cell apoptosis. 1-1-Naphthylpiperazine hydrochloride prevents the immunosuppression and photocarcinogenesis .
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-
- HY-118402
-
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Dopamine Receptor
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Neurological Disease
|
PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis .
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- HY-157588
-
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Ligands for E3 Ligase
Autophagy
|
Cancer
|
E3 ligase Ligand-Linker Conjugate 30 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 30 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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-
- HY-162144
-
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Bacterial
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Infection
|
BDM91288 is an orally active AcrB efflux pump inhibitor of pyridinium piperazine. BDM91288 can enhance the in vivo efficacy of levofloxacin (HY-B0330) in the treatment of Klebsiella pneumoniae pulmonary infection in mouse models .
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- HY-16398
-
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DNA Alkylator/Crosslinker
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Cancer
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Pipobroman is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al .
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- HY-W008865
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Biochemical Assay Reagents
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Others
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PIPES sesquisodium is a pH buffer. PIPES refers to Piperazine N-N’-bis [2 ethanol sulphonic acid, an organic based buffer. PIPES can be used in the preparation of a variety of marine and mammalian tissues for electron microscopic study, with pH range of 6.1-7.5 .
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-
- HY-110191
-
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mGluR
|
Neurological Disease
Cancer
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VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM .
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-
- HY-144320
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HBV
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Infection
|
HBV-IN-17 (compound 8) is a potent HBV capsid assembly modulator with an EC50 of 511 nM .
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-
- HY-155146
-
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Necroptosis
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Cancer
|
Anticancer agent 146 (compound 1.19) is a necroptosis inducer. Anticancer agent 146 has anti-tumor efficacy in the mouse MDA-MB-231 xenograft model .
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- HY-157919
-
N-6-(Biotinylamino)hexanoyl-N'-[2-(N-maleimido)ethyl]Piperazine, hydrochloride
|
Biochemical Assay Reagents
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Others
|
Biotin-PEAC5-maleimide hydrochloride is a biochemical assay reagent, and can be used in biotin-PEAC5-maleimide (BPM)-labeling assay to assess modification of protein thiols by electrophiles .
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-
- HY-148042
-
|
HIV
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Infection
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HIV-1 inhibitor-47 is an inhibitor of HIV-1, and inhibits vif-dependent degradation of human APOBEC3G, with an IC50 value of 14.33 μM. HIV-1 inhibitor-47 also involves in derivatives of 1-(2-pyrimidinyl)piperazine synthesis, with potential antianxiety, antidepressant, and antipsychotic effect .
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-
- HY-160552
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Liposome
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Others
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244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels .
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- HY-W395779
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Filovirus
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Infection
|
EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM .
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-
- HY-146116
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Fungal
|
Infection
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Antifungal agent 32 (compound 1a) is a potent antifungal agent. Antifungal agent 32 inhibits Candida albicans filamentation and biofilm formation. Antifungal agent 32 inhibits the morphological switching of Candida albicans and its adherence to epithelial cells. Antifungal agent 32 can be used for Candida albicans infections research .
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-
- HY-151959
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FXR
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Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
|
FXR agonist 4 (compound 10a) is an agonist of farnesoid X receptor (FXR) with an EC50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of non-alcoholic fatty liver disease (NAFLD) .
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- HY-132994
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Others
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Others
|
TVD-0003510 is a carboxamide derivative, and involves in synthesis of (2-((6-(2-aminopyrimidine-5-carboxamido)-8-methoxy-3,4-dihydro-2H-pyrimido[1,2-c]quinazolin-9-yl)oxy)ethyl)piperazine-l-carboxylate (C51), as a part of tert-butyl2-(4-hydroxyphenyl)acetate .
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-
- HY-161177
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|
PROTACs
Ras
|
Infection
|
PROTAC KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPro). Protac KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPRO). The PROTAC molecule is designed by partially coupling a GC-376-based dipeptidyl 3CLPro ligand with pomadomide via a piperazine-piperidine linker .
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-
- HY-143232
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|
Fungal
Bacterial
|
Infection
Cancer
|
Antibacterial agent 73 (compound 7a) is a potent antimicrobial agent. Antibacterial agent 73 exhibits very good antitubercular activity (MIC=0.65 µg/mL) against Mtb H37Rv. Antibacterial agent 73 shows good activity against fungal and bacterial. Antibacterial agent 73 also shows cytotoxicity in MCF-7 breast cancer cell lines, with IC50 of 8.20 μM .
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-
- HY-147371
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|
Parasite
|
Infection
Neurological Disease
|
Quinoprazine is a potent inhibitor of Vaccinia virus DNA synthesis with an IC50 value of 10 μM. Quinoprazine has antimalarial activity against Plasmodium berghei and also displays antiprion potency, significantly decreases PrP S c levels - .
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Cat. No. |
Product Name |
Type |
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- HY-W002603
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|
Biochemical Assay Reagents
|
Benzyl piperazine-1-carboxylate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-41939
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|
Biochemical Assay Reagents
|
1-(2-Hydroxyethyl)piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-40041
-
|
Biochemical Assay Reagents
|
(R)-1-Boc-3-methyl-piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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-
- HY-148830
-
|
Drug Delivery
|
Piperazine-bis(ethyl octadeca-9,12-dienoate) is a cationic lipid extracted from patent WO2023036148A1, and can be used for the generation of Lipid nanoparticles (LNPs).
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-
- HY-157920
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N-Biotinyl-N'-[2-(N-maleimido)ethyl]Piperazine
|
Biochemical Assay Reagents
|
Biotin-PE-maleimide (N-Biotinyl-N'-[2-(N-maleimido)ethyl]piperazine) is a bulky, membrane-impermeable, sulfhydryl-containing reagent with a relatively large molecular size. Biotin-PE-maleimide can be used for biotin labeling (such as thiol groups) and detection of proteins or other biomolecules .
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-
- HY-W414406
-
|
Buffer Reagents
|
CABS is a zwitterionic piperazine buffer reagent, which can be used as a buffer reagent for wetting agents, pesticide emulsifiers, and dispersants, and has been used in fluorescent dyeing applications .
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-
- HY-W008865
-
|
Buffer Reagents
|
PIPES sesquisodium is a pH buffer. PIPES refers to Piperazine N-N’-bis [2 ethanol sulphonic acid, an organic based buffer. PIPES can be used in the preparation of a variety of marine and mammalian tissues for electron microscopic study, with pH range of 6.1-7.5 .
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-
- HY-157919
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N-6-(Biotinylamino)hexanoyl-N'-[2-(N-maleimido)ethyl]Piperazine, hydrochloride
|
Biochemical Assay Reagents
|
Biotin-PEAC5-maleimide hydrochloride is a biochemical assay reagent, and can be used in biotin-PEAC5-maleimide (BPM)-labeling assay to assess modification of protein thiols by electrophiles .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W454945S
-
|
tert-Butyl piperazine-1-carboxylate-2,2,3,3,5,5,6,6-d8 is the deuterium labeled tert-Butyl piperazine-1-carboxylate[1].
|
-
-
- HY-78871S
-
|
1-(Methyl-d3)piperazine is the deuterium labeled N-Methylpiperazine[1].
|
-
-
- HY-20797S
-
|
1-BOC-4-(2-Hydroxyethyl)piperazine-d4 is the deuterium labeled 1-BOC-4-(2-Hydroxyethyl)piperazine[1].
|
-
-
- HY-W004148S
-
|
1-(2-Pyrimidinyl)piperazine-d8 (2-Piperazinylpyrimidine-d8) dihydrochloride is deuterium-labeled 1-(2-Pyrimidinyl)piperazine dihydrochloride (HY-W004148) .
|
-
-
- HY-32208S
-
|
tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate-d4 is the deuterium labeled tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate[1].
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-
-
- HY-W140284S
-
|
6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate-d8 (hydrochloride) is the deuterium labeled 6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate hydrochloride[1].
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