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Results for "

RUNX

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Endogenous Metabolite (4) Glucosidase (1) HIV (1) NOD-like Receptor (NLR) (1) p38 MAPK (1) Phosphatase (4) Reactive Oxygen Species (5) Small Interfering RNA (siRNA) (4) TGF-beta/Smad (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (12) Infection (2) Inflammation/Immunology (5) Metabolic Disease (6)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151411

RUNX1/ETO tetramerization-IN-1	Others	Cancer
RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor of RUNX1/ETO tetramerization, exhibits anti-leukemic effect. RUNX1/ETO tetramerization-IN-1 specifically targets to NHR2 of *RUNX1/ETO* (EC₅₀=0.25 μM), restores gene expression down-regulated by *RUNX1/ETO. RUNX1/ETO tetramerization-IN-1 inhibits the proliferation of RUNX1/ETO*-depending SKNO-1 cells, and reduces the *RUNX1/ETO*-related tumor growth in a mouse model .

HY-155991

RUNX-IN-2	Apoptosis	Cancer
RUNX-IN-2 (Compound Conjugate 3) covalently binds to the *RUNX*-binding sequences, and inhibits the binding of RUNX proteins to their target sites. RUNX-IN-2 induces the p53-dependent apoptosis and inhibits cancer cell growth. RUNX-IN-2 inhibits tumor growth in PANC-1 xenograft mice. RUNX-IN-2 has high alkylation efficiency and specificity .

HY-124137

Runx1-CBFβ interaction inhibitor 1

Others Cancer

Runx1-CBFβ interaction inhibitor 1 is an allosteric inhibitior of Runt domain-CBFb interaction (IC₅₀=3.2 μM) .

Runx1-CBFβ interaction inhibitor 1	Others	Cancer
Runx1-CBFβ interaction inhibitor 1 is an allosteric inhibitior of Runt domain-CBFb interaction (IC₅₀=3.2 μM) .

HY-RS12349

RUNX1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RUNX1 Human Pre-designed siRNA Set A contains three designed siRNAs for RUNX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RUNX1 Human Pre-designed siRNA Set A RUNX1 Human Pre-designed siRNA Set A

HY-RS12351

RUNX2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RUNX2 Human Pre-designed siRNA Set A contains three designed siRNAs for RUNX2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RUNX2 Human Pre-designed siRNA Set A RUNX2 Human Pre-designed siRNA Set A

HY-RS12352

RUNX3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RUNX3 Human Pre-designed siRNA Set A contains three designed siRNAs for RUNX3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RUNX3 Human Pre-designed siRNA Set A RUNX3 Human Pre-designed siRNA Set A

HY-155990

Chb-M′ RUNX-IN-1	Apoptosis	Cancer
Chb-M′ (Compound Conjugate 1) covalently binds to the *RUNX*-binding sequences, and inhibits the binding of RUNX proteins to their target sites. Chb-M′ induces the p53-dependent apoptosis and inhibits cancer cell growth. Chb-M′ inhibits tumor growth in PANC-1 xenograft mice .

HY-RS12350

RUNX1T1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RUNX1T1 Human Pre-designed siRNA Set A contains three designed siRNAs for RUNX1T1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RUNX1T1 Human Pre-designed siRNA Set A RUNX1T1 Human Pre-designed siRNA Set A

HY-138617

AI-10-47

Others Cancer

AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC₅₀ of 3.2 μM .

AI-10-47	Others	Cancer
AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC₅₀ of 3.2 μM .

HY-108470

Ro5-3335 3 Publications Verification	Others	Cancer
Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. Ro5-3335 is a RUNX1-CBFβ interaction inhibitor that represses RUNX1/CBFB-dependent transactivation .

HY-107999

CADD522 1 Publications Verification	Reactive Oxygen Species	Cancer
CADD522 is a *RUNX2-DNA* binding inhibitor (downregulates *RUNX2*-mediated transcription of downstream target genes), with an IC₅₀ of 10 nM. CADD522 inhibits primary tumor growth and experimental metastasis of tumor cells in the lungs of immune-compromised mice. CADD522 can be used in study of cancer .

HY-118365

NSC 140873	Others	Infection Cancer
NSC 140873 is an inhibitor of the RUNX1-CBFβ interaction. NSC 140873 can be used for research of viral infection and leukemia. NSC 140873 has an unstable structure and can be converted spontaneously in solution to a benzodiazepine (Ro5-3335) .

HY-122657

AI-10-104

Others Cancer

AI-10-104 is an inhibitor for runt-related transcription factor (RUNX), which enhances the cytotoxicity in myeloma cells .

AI-10-104	Others	Cancer
AI-10-104 is an inhibitor for runt-related transcription factor (RUNX), which enhances the cytotoxicity in myeloma cells .

HY-127090

Muramyl dipeptide 2 Publications Verification MDP	p38 MAPK NOD-like Receptor (NLR)	Inflammation/Immunology Cancer
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of *Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK* pathways. Muramyl dipeptide is a NLRP1 agonist .

HY-N2375

L-Quebrachitol	Wnt β-catenin	Metabolic Disease
L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway .

HY-16786

AI-10-49	Others	Inflammation/Immunology Cancer
AI-10-49 is an inhibitor of leukemic oncoprotein CBFβ-SMHHC. AI-10-49 inhibits the binding of CBFβ-SMMHCto the RUNX1 Runt domain with IC₅₀ value of 0.26 μM. AI-10-49 can be used for the research of leukemia .

HY-19149

Ro24-7429	HIV Apoptosis	Infection Inflammation/Immunology Cancer
Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects .

HY-103701

L-Ascorbic acid 2-phosphate 2-Phospho-L-ascorbic acid	Phosphatase Reactive Oxygen Species Endogenous Metabolite	Metabolic Disease
L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .

HY-103701B

L-Ascorbic acid 2-phosphate magnesium hydrate 2-Phospho-L-ascorbic acid magnesium hydrate	Phosphatase Reactive Oxygen Species Endogenous Metabolite	Metabolic Disease
L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) magnesium hydrate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-ascorbic acid 2-phosphate magnesium hydrate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate magnesium hydrate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .

HY-107837

L-Ascorbic acid 2-phosphate trisodium 1 Publications Verification 2-Phospho-L-ascorbic acid trisodium	Phosphatase Reactive Oxygen Species Endogenous Metabolite	Metabolic Disease
L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .

HY-103701A

L-Ascorbic acid 2-phosphate magnesium 1 Publications Verification 2-Phospho-L-ascorbic acid magnesium	Phosphatase Reactive Oxygen Species Endogenous Metabolite	Metabolic Disease
L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .

HY-N0946

(-)-Pinoresinol 4-O-glucoside (-)-Pinoresinol 4-O-β-D-glucopyranoside	Glucosidase	Metabolic Disease
(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC₅₀ value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease .

HY-16268

Kartogenin Maximum Cited Publications 21 Publications Verification KGN	TGF-beta/Smad	Inflammation/Immunology
Kartogenin (KGN) is an inducer of chondrogenic tissue formation (EC₅₀: 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research .

HY-16268A

Kartogenin sodium Maximum Cited Publications 21 Publications Verification KGN sodium	TGF-beta/Smad	Inflammation/Immunology
Kartogenin (KGN) sodium is an inducer of chondrogenic tissue formation (EC₅₀: 100 nM). Kartogenin sodium induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin sodium also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin sodium is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin sodium promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research .

L-Ascorbic acid 2-phosphate magnesium hydrate 2-Phospho-L-ascorbic acid magnesium hydrate	Biochemical Assay Reagents
L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) magnesium hydrate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-ascorbic acid 2-phosphate magnesium hydrate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate magnesium hydrate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .

L-Quebrachitol	Natural Products other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Wnt β-catenin
L-Quebrachitol is a natural product isolated from many plants, promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway .

L-Ascorbic acid 2-phosphate magnesium hydrate 2-Phospho-L-ascorbic acid magnesium hydrate	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Phosphatase Reactive Oxygen Species Endogenous Metabolite
L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) magnesium hydrate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-ascorbic acid 2-phosphate magnesium hydrate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate magnesium hydrate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .

L-Ascorbic acid 2-phosphate trisodium 1 Publications Verification 2-Phospho-L-ascorbic acid trisodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Phosphatase Reactive Oxygen Species Endogenous Metabolite
L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate trisodium (2-Phospho-L-ascorbic acid trisodium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .

L-Ascorbic acid 2-phosphate magnesium 1 Publications Verification 2-Phospho-L-ascorbic acid magnesium	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Phosphatase Reactive Oxygen Species Endogenous Metabolite
L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .

L-Ascorbic acid 2-phosphate 2-Phospho-L-ascorbic acid	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Phosphatase Reactive Oxygen Species Endogenous Metabolite
L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) is a long-acting vitamin C derivative that can stimulate collagen formation and expression . L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation .

(-)-Pinoresinol 4-O-glucoside (-)-Pinoresinol 4-O-β-D-glucopyranoside	Structural Classification Artemisia selengensis Turcz. ex Bess. Source classification Plants Compositae Saccharides Monosaccharides	Glucosidase
(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC₅₀ value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease .

	RUNX2 Antibody 1 Publications Verification	ICC/IF, IHC-P, WB	Human, Mouse
	RUNX2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 57 kDa, targeting to RUNX2. It can be used for ICC/IF,IHC-P,WB assays with tag free, in the background of Human, Mouse.

	RUNX Antibody RUNX1; AML1; RUNX2; OSF2; RUNX3; CBFA3	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	RUNX Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 49 kDa, targeting to RUNX. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.


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