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SCH 56592-d5

" in MedChemExpress (MCE) Product Catalog:

129

Inhibitors & Agonists

3

Inhibitory Antibodies

6

Natural
Products

24

Isotope-Labeled Compounds

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-121852
    SCH 336

    SCH-225336

    		 Cannabinoid Receptor Inflammation/Immunology
    SCH 336 is a potent, selective, inverse and orally active CB2 agonist. SCH 336 inhibits BaF3/CB2 migration. SCH 336 significantly inhibits the migration of leukocytes in vivo. SCH 336 blocks ovalbumin-induced lung eosinophilia in mice .
    <em>SCH</em> 336
  • HY-101682A
    SCH 42495 racemate

    		Neprilysin Cardiovascular Disease
    SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354 .
    <em>SCH</em> 42495 racemate
  • HY-101682
    SCH 42495

    		Neprilysin Cardiovascular Disease
    SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354 .
    <em>SCH</em> 42495
  • HY-101682B
    (R)-SCH 42495

    		Others Others
    (R)-SCH 42495 is the less active enantiomer of SCH 42495 . SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354 .
    (R)-<em>SCH</em> 42495
  • HY-106975
    SCH-42354

    		Neprilysin Cardiovascular Disease
    SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the proagent SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity .
    <em>SCH</em>-42354
  • HY-19545A
    SCH-23390 hydrochloride
    15+ Cited Publications

    R-(+)-SCH-23390 hydrochloride

    		 Dopamine Receptor 5-HT Receptor Potassium Channel Neurological Disease
    SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM .
    <em>SCH</em>-23390 hydrochloride
  • HY-108400
    SCH-23390 maleate

    R-(+)-SCH-23390 maleate

    		 Dopamine Receptor 5-HT Receptor Potassium Channel Neurological Disease
    SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM .
    <em>SCH</em>-23390 maleate
  • HY-N10271
    SCH 38519

    		Bacterial Infection
    SCH 38519 is a platelet aggregation inhibitor. SCH 38519 inhibits thrombin-induced aggregation of human platelets with an IC50 of 68 μg/mL. SCH 38519 is also active against Gram-positive and Gram-negative bacteria .
    <em>SCH</em> 38519
  • HY-111143
    SCH-900271

    		nAChR Metabolic Disease
    SCH-900271 is an orally active, potent nicotinic acid receptor (NAR) agonist with an EC50 of 2 nM in the hu-GPR109a assay. SCH-900271 exhibits dose-dependent inhibition of plasma free fatty acid (FFA). SCH-900271 has an improved therapeutic window to flushing .
    <em>SCH</em>-900271
  • HY-106887
    SCH 32615

    		Others Neurological Disease
    SCH 32615 is an enkephalinase (the enzymes responsible for the degradation of endogenous enkephalins) inhibitor. SCH 32615 can enhance surgery- and pregnancy-induced analgesia in mice .
    <em>SCH</em> 32615
  • HY-107722
    SCH 221510

    		Opioid Receptor Neurological Disease
    SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC50 of 12 nM and Ki of 0.3 nM. SCH 221510 shows an anxiolytic-like effect .
    <em>SCH</em> 221510
  • HY-133862
    SCH-202676

    		Influenza Virus G protein-coupled Bile Acid Receptor 1 Adenosine Receptor Infection
    SCH-202676 is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 has antiviral activity and inhibits 3CL pro in a time-dependent manner with an IC50 value of 0.655 µM .
    <em>SCH</em>-202676
  • HY-10017
    SCH 546738
    10+ Cited Publications

    		 CXCR Inflammation/Immunology Endocrinology
    SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments.
    <em>SCH</em> 546738
  • HY-10483
    SCH-1473759 hydrochloride

    		Aurora Kinase Cancer
    SCH-1473759 hydrochloride is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively.
    <em>SCH</em>-1473759 hydrochloride
  • HY-10482
    SCH-1473759

    		Aurora Kinase Cancer
    SCH-1473759 is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively.
    <em>SCH</em>-1473759
  • HY-17377
    Vicriviroc maleate

    SCH-417690 maleate; SCH-D maleate

    		 CCR HIV Infection Endocrinology
    Vicriviroc maleate (SCH-417690 maleate; SCH-D maleate) is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells, with IC90s of 3.3 nM (JrFL), 2.8 nM (ADA-M), 1.8 nM (301657), 4.9 nM (JV1083) and 10 nM (RU 570).
    Vicriviroc maleate
  • HY-118382
    SCH-451659

    		17β-HSD Cancer
    SCH-451659 is an inhibitor of 17β-hydroxysteroid dehydrogenases (17β-HSDs) for cancer research .
    <em>SCH</em>-451659
  • HY-110012
    SCH-202676 hydrobromide

    		Adenosine Receptor Infection
    SCH-202676 hydrobromide is an allosteric modulator of G protein-coupled receptors (GPCRs) and adenosine receptor (AR). SCH-202676 hydrobromide has antiviral activity and inhibits 3CL pro in a time-dependent manner with an IC50 value of 0.655 μM .
    <em>SCH</em>-202676 hydrobromide
  • HY-121235
    Clonixin

    SCH-10304

    		 Others Inflammation/Immunology
    Clonixin (SCH-10304) is an orally active non-steroidal anti-inflammatory agent in rodents .
    Clonixin
  • HY-14994
    SCH79797 dihydrochloride
    1 Publications Verification

    		 Protease Activated Receptor (PAR) Apoptosis Cardiovascular Disease
    SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes .
    <em>SCH</em>79797 dihydrochloride
  • HY-14993
    SCH79797
    1 Publications Verification

    		 Protease Activated Receptor (PAR) Apoptosis Cardiovascular Disease
    SCH79797 is a highly potent, selective nonpeptide protease activated receptor 1 (PAR1) antagonist. SCH79797 inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. SCH79797 has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes .
    <em>SCH</em>79797
  • HY-116546S
    Sch 40853-d4

    		Isotope-Labeled Compounds Others
    Sch 40853-d4 is deuterium labeled Sch 40853.
    <em>Sch</em> 40853-d4
  • HY-110088
    SCH529074
    1 Publications Verification

    		 MDM-2/p53 Cancer
    SCH529074 is a potent and orally active p53 activator. SCH529074 binds specifically and conformation-dependently to p53 DBD ( DNA binding domain) with a Ki of 1-2 μM in a saturable manner. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. SCH529074 can be used for the study of non-small-cell lung carcinoma (NSCLC) .
    <em>SCH</em>529074
  • HY-125049
    Kijanimicin

    SCH 25663

    		 Endogenous Metabolite Antibiotic Infection
    Kijanimicin (Sch 25663) is an antibiotic produced by Actinomadura kijaniata SCC 1256 .
    Kijanimicin
  • HY-17043
    Loratadine
    4 Publications Verification

    Loratidine; SCH 29851

    		 Flavivirus Dengue virus Histamine Receptor Infection Inflammation/Immunology Endocrinology Cancer
    Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.
    Loratadine
  • HY-103261
    SCH28080

    		Proton Pump Endocrinology
    SCH28080 is a reversible, K +-competitive inhibitor of the gastric H,K-ATPase, with a Ki of 0.12 μM. SCH28080 is an effective inhibitor of acid secretion in vivo and with anti-gastric ulcer activity .
    <em>SCH</em>28080
  • HY-106230A
    Dasantafil

    SCH-446132

    		 Phosphodiesterase (PDE) Others
    Dasantafil (SCH-446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to in genitourinary disorders and study erectile dysfunction .
    Dasantafil
  • HY-10119
    Vorapaxar
    5+ Cited Publications

    SCH 530348

    		 Protease Activated Receptor (PAR) Cardiovascular Disease
    Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .
    Vorapaxar
  • HY-12656
    SCH 51344

    		Ras Cancer
    SCH 51344 inhibits Ras induced malignant transformation and prevents anchorage-independent growth of oncogene transformed fibroblasts .
    <em>SCH</em> 51344
  • HY-B1140
    Diazoxide
    3 Publications Verification

    SCH-6783; SRG-95213

    		 Potassium Channel Autophagy Cardiovascular Disease Cancer
    Diazoxide (Sch-6783) is an ATP-sensitive potassium channel activator, has the potential for hyperinsulinism treatment.
    Diazoxide
  • HY-12783
    SCH 50911 hydrochloride

    		GABA Receptor Neurological Disease
    SCH 50911 hydrochloride, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. SCH 50911 hydrochloride antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM.
    <em>SCH</em> 50911 hydrochloride
  • HY-12783A
    SCH 50911

    		GABA Receptor Neurological Disease
    SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. SCH 50911 antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM .
    <em>SCH</em> 50911
  • HY-U00374
    Sch59498

    		Phosphodiesterase (PDE) Neurological Disease
    Sch59498 is a potent inhibitor of phosphodiesterase 1c (Pde1c).
    <em>Sch</em>59498
  • HY-50846
    SCH772984
    Maximum Cited Publications
    121 Publications Verification

    		 ERK Cancer
    SCH772984 is a highly selective and ATP-competitive ERK inhibitor, with IC50s of 4 and 1 nM for ERK1 and ERK2, respectively. SCH772984 has antitumor activity in MAPK inhibitor-naïve and MAPK inhibitor-resistant cells containing BRAF or RAS mutations .
    <em>SCH</em>772984
  • HY-10011
    SCH 563705
    3 Publications Verification

    		 CXCR Inflammation/Immunology Endocrinology
    SCH 563705 is a potent and orally available CXCR2 and CXCR1 antagonist, with IC50s of 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively.
    <em>SCH</em> 563705
  • HY-106566
    Alclometasone dipropionate

    SCH 22219

    		 Others Inflammation/Immunology
    Alclometasone dipropionate (Sch 22219) is a steroid compound. Alclometasone dipropionate can be used for the research of dermatitis and skin itch .
    Alclometasone dipropionate
  • HY-124161
    SCH54292

    		Ras Cancer
    SCH54292 is a potent Ras-GEF interaction inhibitor with IC50 of 0.7 μM .
    <em>SCH</em>54292
  • HY-103169
    SCH442416
    1 Publications Verification

    		 Adenosine Receptor Neurological Disease
    SCH442416 is a potent, selective and brain-penetrant antagonist of adenosine A2A receptor (A2AR), with Kis of 0.048 and 0.5 nM for human and rat A2AR respectively. SCH442416 displays more than 23000-fold selectivity over A1R, A2BR, and A3R (Ki=1111, 10000, and 10000 nM, respectively). SCH442416 can be used for imaging of adenosine A2A receptors in rat and primate brain .
    <em>SCH</em>442416
  • HY-15532B
    SCH900776 (S-isomer)

    MK-8776 S-isomer

    		 Others Cancer
    SCH900776 S-isomer is the S-isomer of SCH900776. SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with IC50 of 3 nM.
    <em>SCH</em>900776 (S-isomer)
  • HY-A0086
    Netilmicin sulfate

    SCH-20569 sulfate

    		 Bacterial Antibiotic Infection
    Netilmicin (sulfate) (SCH-20569 (sulfate)) is an active aminoglycoside antibiotic against most Gram-negative and some Gram-positive bacteria, including certain strains resistant to gentamicin.
    Netilmicin sulfate
  • HY-116120
    N-Acetyldesloratadine

    SCH-37370

    		 Platelet-activating Factor Receptor (PAFR) Histamine Receptor Inflammation/Immunology
    N-Acetyldesloratadine (SCH-37370) is a potent, orally active dual antagonist of platelet-activating factor (PAF) and histamine. N-Acetyldesloratadine inhibits PAF-induced aggregation of human platelets, with an IC50 of 0.6 µM .
    N-Acetyldesloratadine
  • HY-157743
    SCH 60057

    		Neurokinin Receptor Neurological Disease
    SCH 60057 (Compound 7) is a neurokinin (NK) receptor inhibitor that can be isolated from Acremonium sp., with IC50 values of 6 μM and 12 μM for NK1 and NK2, respectively .
    <em>SCH</em> 60057
  • HY-B0698
    Ceftibuten

    SCH 39720

    		 Beta-lactamase Bacterial Antibiotic Infection
    Ceftibuten (Sch39720), an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens .
    Ceftibuten
  • HY-B0698B
    Ceftibuten hydrate

    SCH 39720 hydrate

    		 Beta-lactamase Bacterial Antibiotic Infection
    Ceftibuten (Sch39720) hydrate, an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens .
    Ceftibuten hydrate
  • HY-B0698A
    Ceftibuten dihydrate
    1 Publications Verification

    SCH-39720 dihydrate

    		 Beta-lactamase Bacterial Antibiotic Infection
    Ceftibuten (Sch-39720) dihydrate, an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens .
    Ceftibuten dihydrate
  • HY-10492
    Dinaciclib
    35+ Cited Publications

    SCH 727965

    		 CDK Apoptosis Cancer
    Dinaciclib (SCH 727965) is a potent inhibitor of CDK, with IC50s of 1 nM, 1 nM, 3 nM, and 4 nM for CDK2, CDK5, CDK1, and CDK9, respectively .
    Dinaciclib
  • HY-17376
    Ezetimibe
    5+ Cited Publications

    SCH 58235

    		 Keap1-Nrf2 Autophagy Cardiovascular Disease Cancer
    Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.
    Ezetimibe
  • HY-104074
    Pocapavir
    3 Publications Verification

    SCH-48973; V-073

    		 Enterovirus Infection
    Pocapavir (SCH-48973) is an orally active capsid inhibitor. Pocapavir prevents virion uncoating upon entry into the cell. Pocapavir has antiviral activity against polioviruses. Pocapavir also inhibits enterovirus infections .
    Pocapavir
  • HY-15532
    SCH900776
    5+ Cited Publications

    MK-8776

    		 Checkpoint Kinase (Chk) Cancer
    SCH900776 (MK-8776) is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with an IC50 of 3 nM. SCH900776 shows 50- and 500-fold selectivity over CDK2 and Chk2, respectively .
    <em>SCH</em>900776
  • HY-14690B
    rel-Ecopipam hydrobromide

    rel-SCH 39166 hydrobromide

    		 Dopamine Receptor Neurological Disease
    rel-Ecopipam (rel-SCH 39166) (Compound 6b) hydrobromide is a D1 receptor antagonist (Ki: 1.30 nM) .
    rel-Ecopipam hydrobromide

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