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Results for "

STAT3-IN-3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Amyloid-β (2) Apoptosis (7) Autophagy (1) Bcr-Abl (1) Cytochrome P450 (1) Ephrin Receptor (1) Fluorescent Dye (1) Formyl Peptide Receptor (FPR) (1) HIV (1) JAK (3) Ligands for Target Protein for PROTAC (1) PROTACs (2) STAT (16)
By Research Areas:	Cancer (16) Infection (1) Inflammation/Immunology (1) Neurological Disease (2)

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Peptides

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Targets Recommended: AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128588

*STAT3-IN-3* 4 Publications Verification	STAT Apoptosis	Cancer
STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research .

HY-N2959

Brevilin A 3 Publications Verification	JAK STAT Apoptosis Autophagy	Cancer
Brevilin A is an orally active *STAT3/JAK* inhibitor (STAT3 IC₅₀= 10.6 µM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce apoptosis and autophagy .

HY-155335

FPR2 agonist 3	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
FPR2 agonist 3 (compound CMC23) can limit the lactate dehydrogenase release in LPS (HY-D1056) -stimulated cultures and decrease the levels of pro-inflammatory IL-1β and IL-6. FPR2 agonist 3 decrease the level of phosphor-STAT3 via the *STAT3/SOCS3* signaling pathway .

HY-153902

DG-8

STAT Fluorescent Dye Others

DG-8 is a potent inhibitor of STAT3-dependent transcription (IC₅₀ 0.98 μM). DG-8 is a fluorescent probe that contains a fluorescent dansyl moiety .

DG-8	STAT Fluorescent Dye	Others
DG-8 is a potent inhibitor of *STAT3*-dependent transcription (IC₅₀ 0.98 μM). DG-8 is a fluorescent probe that contains a fluorescent dansyl moiety .

HY-163526

STAT3-IN-26	Ligands for Target Protein for PROTAC	Cancer
STAT3-IN-26 is the ligand for the target protein STAT3 in PROTAC STAT3 degrader-3 (HY-163502), which can be used for the synthesis of PROTACs .

HY-P2282

APTSTAT3-9R 1 Publications Verification	STAT	Cancer
APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking *STAT3* phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity .

HY-P10115

APT STAT3	STAT	Cancer
APT _STAT3 is a specific STAT3-binding peptide. APT _STAT3 can bind STAT3 with high specificity and affinity (～231 nmol/L). APT _STAT3 is a tractable agent for translation to target the broad array of cancers harboring constitutively activated STAT3 .

HY-163502

PROTAC STAT3 degrader-3	PROTACs STAT	Cancer
PROTAC STAT3 degrader-3 (S3D1) is a STAT3 PROTAC degrader with anticancer activity (Structural notes: (Blue: Cereblon ligand (HY-10984), Black: linker; Pink: Pentafluorobenzenesulfonamide(Me)-CH2-CONH-benzamide (HY-163526)) .

HY-136658

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea 1 Publications Verification	STAT Apoptosis	Cancer
STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of *STAT3*. STAT3-IN-7 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects .

HY-P1061

Colivelin Maximum Cited Publications 37 Publications Verification	STAT Amyloid-β	Neurological Disease
Colivelin is a brain penetrant neuroprotective peptide and a potent activator of *STAT3, suppresses neuronal death by activating STAT3* in vitro . Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury

HY-107460

LDN-211904 oxalate	Ephrin Receptor	Cancer
LDN-211904 oxalate (compound 32) is a potent and selective EphB3 inhibitor with an IC₅₀ of 0.079 µM. LDN-211904 oxalate shows good metabolic stability in mouse liver microsomes. LDN-211904 oxalate with cetuximab could be effective in inhibiting STAT3-activated CSC stemness and cetuximab resistance in CRC .

HY-107595

SD-1008	JAK STAT Apoptosis	Cancer
SD-1008 is a potent JAK inhibitor. SD-1008 inhibits tyrosyl phosphorylation of STAT3, JAK2 and Src. SD-1008 also reduces STAT3-dependent luciferase activity. SD-1008 enhances apoptosis induced by Paclitaxel in ovarian cancer cells via directly blocking the JAK-STAT3 signaling pathway .

HY-112288

C188-9 15+ Cited Publications TTI-101	STAT Apoptosis	Cancer
C188-9 (TTI-101) is a *STAT3* inhibitor, with a K_d of 4.7 nM. C188-9 inhibits G-CSF-induced STAT3 activation and STAT3-dependent gene expression. C188-9 induces apoptosis in AML cell lines and primary samples and inhibits colony formation by primary AML blasts .

HY-P1061A

Colivelin TFA Maximum Cited Publications 37 Publications Verification	STAT Amyloid-β Apoptosis	Neurological Disease
Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of *STAT3, suppresses neuronal death by activating STAT3* in vitro . Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury .

HY-N0751

Scutellarin 5+ Cited Publications	STAT Akt HIV	Infection Cancer
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the *STAT3/Girdin/Akt* signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC₅₀s of 26 μM, 253 μM and 136 μM, respectively.

HY-150251

STAT3 degrader-2	STAT PROTACs	Cancer
STAT3 degrader-2 is a PROTAC-based degrader of *STAT3*. STAT3 degrader-2 can degrade the level of total STAT3 protein. STAT3 degrader-2 can be used for the research of cancer and other diseases . STAT3 degrader-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-108417

Debio 0617B	STAT JAK Bcr-Abl	Cancer
Debio 0617B, a multi-kinase inhibitor, reduces maintenance and self-renewal of primary human AML CD34 ⁺ stem/progenitor cells. Debio 0617B has a unique profile targeting key kinases upstream of STAT3/STAT5 signaling such as JAK, SRC, ABL, and class III/V receptor tyrosine kinases (TKs). Debio 0617B has documented efficacy in STAT3-driven solid tumors .

HY-150084

(±)14,15-Epoxyeicosatrienoic acid (±)14(15)-EET	Cytochrome P450	Cancer
(±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth .

HY-155982

STAT3-IN-20	STAT	Cancer
STAT3-IN-20 (Compound 40) is a selective *STAT3* inhibitor (IC₅₀: 0.65 μM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC₅₀: 2.97 μM and 3.26 μM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis .

HY-151577

STAT3-SH2 domain inhibitor 1	STAT Apoptosis	Cancer
STAT3-SH2 domain inhibitor 1 is a potent *Src Homology 2 (SH2) Domain of STAT3 (STAT3-SH2 domain)* inhibitor with a K_d value of 1.57 μM. STAT3-SH2 domain inhibitor 1 inhibits STAT3 signaling transduction and transcriptional activation. STAT3-SH2 domain inhibitor 1 induces apoptosis in gastric cancer cells. STAT3-SH2 domain inhibitor 1 can be used in research of cancer .

Cat. No.	Product Name	Target	Research Area

HY-P2282

APTSTAT3-9R 1 Publications Verification	STAT	Cancer
APTSTAT3-9R, a specific STAT3-binding peptide, inhibits STAT3 activation and downstream signaling by specifically blocking *STAT3* phosphorylation. APTSTAT3-9R exerts antiproliferative effects and antitumor activity .

HY-P1061

Colivelin Maximum Cited Publications 37 Publications Verification	STAT Amyloid-β	Neurological Disease
Colivelin is a brain penetrant neuroprotective peptide and a potent activator of *STAT3, suppresses neuronal death by activating STAT3* in vitro . Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury

HY-P1061A

Colivelin TFA Maximum Cited Publications 37 Publications Verification	STAT Amyloid-β Apoptosis	Neurological Disease
Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of *STAT3, suppresses neuronal death by activating STAT3* in vitro . Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury .

HY-P10101

*APT STAT3, scrambled* APTscr	Peptides	Others
APT STAT3, scrambled (APTscr), a control peptide of STAT3-specific aptide (APT_STAT3), does not bind STAT3. APT STAT3, scrambled contains the same trpzip scaffold but with a scrambled sequence in the target-binding site .

HY-P10115

APT STAT3	STAT	Cancer
APT _STAT3 is a specific STAT3-binding peptide. APT _STAT3 can bind STAT3 with high specificity and affinity (～231 nmol/L). APT _STAT3 is a tractable agent for translation to target the broad array of cancers harboring constitutively activated STAT3 .

Brevilin A 3 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Euchresta horsfieldii (Lesch.) J. Benn. Plants Compositae Disease Research Fields Cancer	JAK STAT Apoptosis Autophagy
Brevilin A is an orally active *STAT3/JAK* inhibitor (STAT3 IC₅₀= 10.6 µM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce apoptosis and autophagy .

Scutellarin 5+ Cited Publications	Infection Structural Classification Flavonoids Scutellaria baicalensis Georgi Classification of Application Fields Flavones Labiatae Source classification Phenols Polyphenols Plants Disease Research Fields	STAT Akt HIV
Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the *STAT3/Girdin/Akt* signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC₅₀s of 26 μM, 253 μM and 136 μM, respectively.

(±)14,15-Epoxyeicosatrienoic acid (±)14(15)-EET	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Cytochrome P450
(±)14,15-Epoxyeicosatrienoic acid ((±)14(15)-EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±)14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±)14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth .

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STAT3-IN-3

Inhibitors & Agonists

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