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Results for "

TRK degrader

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-157542
    CG428-NEG

    		Others Others
    CG428-NEG is a TRK degrader negative control. CG428-NEG inhibits cell growth and reduce TPM3-TRKA levels .
    CG428-NEG
  • HY-137465
    CG428

    		Trk Receptor Cancer
    CG428 is a potent and selective tropomyosin receptor kinase (TRK) degrader that has anti-tumor activity. CG428 reduces levels of the tropomyosin 3 (TPM3)-TRKA fusion protein in KM12 colorectal carcinoma cells (DC50 = 0.36 nM) and inhibits downstream PLCγ1phosphorylation (IC50 = 0.33 nM). CG428 has a higher binding affinity for TRKA than TRKB and TRKC (Kd = 1 nM, 28 nM and 4.2 nM, respectively). In addition, CG428 effectively inhibits KM12 cell growth (IC50 = 2.9 nM) .
    CG428
  • HY-163208
    VH 032 amide-alkylC9-amine hydrochloride

    (S,R,S)-AHPC-C9-NH2 hydrochloride

    		 PROTAC Linkers Others
    VH 032 amide-alkylC9-amine hydrochloride (Linker 33) is TRK ligand conjugated to the degradation tag .
    VH 032 amide-alkylC9-amine hydrochloride

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