Search Result
Results for "
Trypanosoma
" in MedChemExpress (MCE) Product Catalog:
1
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-147765
-
|
Parasite
|
Infection
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Anti-Trypanosoma cruzi agent-3 (Compound 7c) is an antiprotozoal agent .
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-
-
- HY-115972
-
|
Parasite
|
Infection
Inflammation/Immunology
|
Anti-Trypanosoma cruzi agent-1 (Compd 3b), selective compound against NINOA trypomastigote (IC50 = 0.51 µM) and INC-5 epimastigote form (IC50 = 3.06 µM), posseses anti-T. gondii activity .
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-
-
- HY-148323
-
|
Parasite
|
Infection
|
Anti-Trypanosoma cruzi agent-4 (compound 5c) is an inhibitor of Trypanosoma cruzi. Anti-Trypanosoma cruzi agent-4 can be used for the research of infection .
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-
-
- HY-116004
-
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Parasite
|
Infection
|
Anti-Trypanosoma cruzi agent-5 (compoung 8) is a potent inhibitor of Trypanosoma cruzi proliferation .
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-
-
- HY-115971
-
-
-
- HY-143322
-
|
Parasite
|
Infection
|
CRK12-IN-2 (compound 2) is an inhibitor of CRK12. CRK12-IN-2 shows potency against Trypanosoma congolense and Trypanosoma vivax with EC50 values of 3.2 and 0.08 nM. CRK12-IN-2 can be used for the research of animal trypanosomiasis .
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-
-
- HY-107034
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349C59
|
Parasite
|
Infection
|
Moxipraquine is a potent insecticide against Trypanosoma cruzi. Moxipraquine effectively inhibits Leishmania major, L. mexicana mexicana and L. brasiliensis panamensis but not L.b. brasiliensis .
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-
-
- HY-136200
-
|
Parasite
|
Infection
|
Antitrypanosomal agent 2 is a potent and selective trypanosoma brucei inhibitor .
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-
-
- HY-151943
-
|
Parasite
|
Infection
|
Antitrypanosomal agent 11 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC50 of 0.23 μM .
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-
-
- HY-151942
-
|
Parasite
|
Infection
|
Antitrypanosomal agent 10 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC50 of 0.28 μM .
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-
-
- HY-N2656
-
|
Parasite
|
Infection
|
5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC50s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively .
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-
-
- HY-161299
-
|
Parasite
|
Infection
|
LAPTc-IN-1 (compound 4) is a competitive inhibitor targeting acidic M17 leucinopeptidase (LAPTc) with Ki=0.27 μM. LAPTc-IN-1 is a potential antagonist of the parasite Trypanosoma cruzi .
|
-
-
- HY-N0914
-
Ajugol
2 Publications Verification
|
Parasite
|
Others
|
Ajugol is an iridoid glycoside that can be isolated from Leonurus artemisia. Ajugol has anti-protozoal activity againt Trypanosoma b. rhodesiense with an IC50 of 31.8 μg/mL .
|
-
-
- HY-155655
-
|
Parasite
|
Infection
|
JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) .
|
-
-
- HY-147933
-
|
Parasite
|
Infection
|
Antitrypanosomal agent 8 (compound 3b) has potent antitrypanosomal activity against Trypanosoma brucei with an IC50 value of 0.79 μM and exhibits certain cytotoxicity in L6 cells (IC50=80.95 μM) .
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-
-
- HY-147940
-
|
Parasite
|
Infection
|
TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC50<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC50=0.66 μM) .
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-
-
- HY-103056
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IMP-366
|
DNA/RNA Synthesis
Parasite
|
Infection
|
DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .
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-
-
- HY-103033
-
|
Parasite
|
Infection
|
T.cruzi-IN-1 is a potent Trypanosoma cruzi inhibitor with an IC50 of 8 nM. T.cruzi-IN-1, a 4-trifluoromethyl substituted analog, has the potential for both the acute and chronic stages of Chagas disease .
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-
-
- HY-N10441
-
|
Parasite
|
Infection
|
3β-Hydroxy-hop-22(29)-ene (compound 3) is a potent antiparasitic agent. 3β-Hydroxy-hop-22(29)-ene shows moderate activity against Trypanosoma cruzi and Leishmania mexicana .
|
-
-
- HY-136637
-
|
Phosphodiesterase (PDE)
Parasite
|
Infection
|
NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC50 of 80 nM .
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-
-
- HY-124623
-
|
Parasite
|
Infection
|
DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.
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-
-
- HY-157028
-
|
Others
|
Infection
|
Antiparasitic agent-19 (compound 40) is a compound with broad-spectrum antiparasitic activity. Antiparasitic agent-19 has minimal toxicity against Trypanosoma brucei, Leishmania Infantum, and Trypanosoma cruzi .
|
-
-
- HY-N2970
-
-
-
- HY-155207
-
|
Parasite
|
Infection
|
Antileishmanial agent-23 (compound G1/9) is a potent and selective trypanothione reductase (TR) inhibitor, with an IC50 of 2.24 ± 0.52 μM. Antileishmanial agent-23 inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypanosoma brucei .
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-
-
- HY-N3418
-
|
Parasite
|
Infection
|
Kolavenol is a diterpene, which can be isolated from Entada abyssinica. Kolavenol's diastereoisomer exhibits trypanocidal activity with an IC50 value of 2.5 μg/mL (8.6 μM) against Trypanosoma brucei rhodesiense. While Trypanosoma brucei rhodesiense is the causing factor of the acute form of human African trypanosomiasis .
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-
-
- HY-119938
-
|
Bacterial
|
Infection
|
Tuberculosis inhibitor 1 is a potent and non-cytotoxic trypanosoma brucei growth inhibitor with an EC50 of 5 nM .
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-
-
- HY-N3247
-
|
Parasite
|
Others
|
Monomethyl kolavate is a Trypanosoma brucei GAPDH enzyme (TbGAPDH) inhibitor with theIC50 value of 2 µM .
|
-
-
- HY-145287
-
|
DNA/RNA Synthesis
Parasite
|
Infection
|
S-MGB-234 is a minor groove binder of Animal African Trypanosomiasis (AAT). S-MGB-234 displays excellent in vitro activities against the principal causative organisms of AAT; Trypanosoma congolense, and Trypanosoma vivax. S-MGB-234 does not show cross-resistance with the current diamidine agents and are not internalized via the transporters used by diamidines .
|
-
-
- HY-108938
-
|
Cytochrome P450
Fungal
Parasite
|
Infection
|
SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h) .
|
-
-
- HY-125731
-
-
-
- HY-146049
-
|
Parasite
|
Infection
|
Antitrypanosomal agent 4 (compound 19) is a potent and blood-brain barrier permeable antitrypanosomal agent. Antitrypanosomal agent 4 has good activity against Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei brucei (T. b. brucei) with IC50s of 1.2 μM and 70 nM, respectively . Antitrypanosomal agent 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
-
- HY-W040073
-
|
Parasite
Lactate Dehydrogenase
|
Infection
Cancer
|
Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).
|
-
-
- HY-N7266
-
|
Cytochrome P450
Parasite
|
Infection
Cancer
|
Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with Kd values of 1.2 µM and 1.4 µM for Trypanosoma brucei (TB) and human CYP51, respectively .
|
-
-
- HY-101015A
-
-
-
- HY-144296
-
|
Parasite
|
Infection
|
Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of the Plasmodium falciparum ((Pf)), Plasmodium vivax ((Pv)) and Trypanosoma brucei ((Tbr)) 6-oxopurine phosphoribosyltransferase (PRT), with Kis of 30, 20 and 2 nM, respectively .
|
-
-
- HY-129130
-
Canthin-6-one 3-oxide
|
Parasite
|
Infection
|
Canthin-6-one N-oxide (Canthin-6-one 3-oxide) is an orally active antiparasitic agent with limited activity .
|
-
-
- HY-W040073S
-
|
Isotope-Labeled Compounds
Parasite
Lactate Dehydrogenase
|
Infection
Cancer
|
Nifurtimox-d4 is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).
|
-
-
- HY-N4033
-
7α-Hydroxyroyleanone
|
Bacterial
|
Infection
|
Horminone is an abietan diterpene quinone that can be isolated from Labiatae family. Horminone increases of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum levels in vivo. Horminone inhibits the growth of Trypanosoma cruzi and shows antibacterial activity .
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-
-
- HY-N9179
-
|
Parasite
|
Infection
|
3′,4′,5′,5,6,7-Hexamethoxyflavone is a flavonoid with antiprotozoal activity. 3′,4′,5′,5,6,7-Hexamethoxyflavone inhibits trypanosoma bruceirhodesiense with IC50 of 21.3 μM (8.58 g/mL) .
|
-
-
- HY-12054
-
Hesperadin
Maximum Cited Publications
6 Publications Verification
|
Aurora Kinase
Autophagy
Influenza Virus
Parasite
|
Cancer
|
Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC50 of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral .
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-
-
- HY-142021
-
|
Parasite
|
Infection
|
Z-Leu-Arg-AMC is a 4-methylcoumarinyl-7-amide (Amc) leucine derivative with carboxybenzoyl (Z). Z-Leu-Arg-AMC is the active site of cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei .
|
-
-
- HY-144294
-
|
Parasite
|
Infection
|
Purine phosphoribosyltransferase-IN-1 (Compound (S,R)-48) is a potent inhibitor of the Plasmodium falciparum (Pf), P. vivax (Pv) and Trypanosoma brucei (Tbr) 6-oxopurine purine phosphoribosyltransferases (PRTs), with Ki values of 50, 20, and 2 nM, respectively .
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-
-
- HY-N10547
-
|
Parasite
|
Infection
|
6-O-Methylcatalpol can be isolated from the roots of Scrophularia ningpoensis. 6-O-Methylcatalpol has anti-protozoal activity against Trypanosoma b. rhodesiense and Leishmania donovani (IC50: 32.5 and 8.3 μg/mL) .
|
-
-
- HY-W040073R
-
|
Parasite
Lactate Dehydrogenase
|
Infection
Cancer
|
Nifurtimox (Standard) is the analytical standard of Nifurtimox. This product is intended for research and analytical applications. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).
|
-
-
- HY-151484
-
|
Parasite
|
Infection
|
Anti-infective agent 4 (compound 73) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.016 μM. Anti-infective agent 4 effectively reduces parasite burden in vivo. Anti-infective agent 4 can be used for the research of infection .
|
-
-
- HY-151485
-
|
Parasite
|
Infection
|
Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection .
|
-
-
- HY-W010538
-
|
Parasite
|
Infection
|
trans-4-Methylcyclohexanamine is an intermediate and can be used for the development of T. cruzi enzyme inhibitor .
|
-
-
- HY-W020182
-
Terpilene
|
Fungal
Parasite
|
Infection
|
α-Terpinene (Terpilene) is a monoterpene found in the essential oils of a large variety of foods and aromatic plants such as Mentha piperita. α-Terpinene is active against Trypanosoma evansi and has the potential for trypanosomosis treatment. α-Terpinene has antioxidant and antifungal properties .
|
-
-
- HY-155103
-
|
Proteasome
Parasite
|
Infection
|
Antitrypanosomal agent 15 (compound 26) is an orally active, brain-penetrant, selective inhibitor against Trypanosoma cruzi proteasome, with an pIC50 of 7.4 and <4 for T. cruzi and human proteasome, respectively. Antitrypanosomal agent 15 has favorable ADME properties and can be used for Chagas disease study .
|
-
-
- HY-111759
-
7-CN-7-C-Ino
|
PKA
Parasite
|
Infection
|
Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity .
|
-
- HY-122267
-
-
- HY-101015
-
|
Phospholipase
Apoptosis
|
Inflammation/Immunology
|
(2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM .
|
-
- HY-N1716
-
|
Parasite
|
Infection
|
2’’-Acetylastragalin (Compound 2) is a compound isolated from the aerial parts of Delphinium staphisagria, with an IC50 value of 6.5 μM for Vero cells. 2’’-Acetylastragalin has trypanoidal activity .
|
-
- HY-N10443
-
|
Parasite
Apoptosis
Autophagy
Reactive Oxygen Species
|
Infection
|
Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease .
|
-
- HY-146042
-
|
Parasite
|
Infection
|
Antiparasitic agent-4 (compound 4q) has highly antiparasitic activity against Leishmania infantum (L. infantum) and Trypanosoma cruzi (T. cruzi) with IC50s of 8.51 μM and 2.20 μM, respectively. Antiparasitic agent-4 also has certain cytotoxicity against HepG2 (CC50 = 18.97 μM) .
|
-
- HY-146041
-
|
Parasite
|
Infection
|
Antiparasitic agent-2 (compound 8a) has highly antiparasitic activity against Leishmania infantum (L. infantum) and Trypanosoma cruzi (T. cruzi) with IC50s of 7.28 μM and 2.30 μM, respectively. Antiparasitic agent-2 also has certain cytotoxicity against HepG2 (CC50 = 26.79 μM) .
|
-
- HY-147550
-
|
Parasite
|
Infection
|
Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA .
|
-
- HY-147549
-
|
Parasite
|
Infection
|
Antitrypanosomal agent 6 (compound 18a) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 6 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.47 μM. Antitrypanosomal agent 6 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA .
|
-
- HY-N0389
-
|
COX
Parasite
|
Inflammation/Immunology
|
Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) .
|
-
- HY-N12788
-
|
Parasite
|
Infection
|
T-Cadinol is a sesquiterpene isolated from C. sylvestris that exhibits anti-Trypanosoma cruzi activity, with IC50 values of 18.2 μM and 15.8 μM against trypomastigote and amastigote forms, respectively. T-Cadinol can induce mitochondrial damage in parasites, leading to membrane hyperpolarization and decreased levels of reactive oxygen species. T-Cadinol can be used for the research of Chagas disease .
|
-
- HY-158323
-
|
Parasite
|
Infection
Cancer
|
HGPRT/TBrHGPRT1-IN-1 (Compound 5) is a selective inhibitor targeting human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and Trypanosoma bruce HGPRT1 (TBrHGPRT1) (both Ki=3 nM). HGPRT/TBrHGPRT1-IN-1 ultimately results in decreased cell growth. HGPRT/TBrHGPRT1-IN-1 is primarily used in the research of infectious diseases and cancer .
|
-
- HY-145812
-
|
Parasite
|
Infection
|
CRK12-IN-1 is a potent CRK12 inhibitor. CRK12-IN-1 is extremely potent against T.b. brucei and rapidly cytocidal, as well as equally potent against T. congolense and T. vivax (EC50 of 1.3 and 18 nM, respectively) .
|
-
- HY-126417
-
|
Parasite
|
Infection
|
Methylenetanshinquinone is a natural compound with antiplasmodial, antitrypanosomal and antioxidative activities. Methylenetanshinquinone can be used for the research of parasite infection .
|
-
- HY-126250
-
|
Phosphodiesterase (PDE)
Parasite
|
Infection
Inflammation/Immunology
|
NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. brucei parasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAMP levels and results in the distortion of the cell cycle and cell death . NPD-1335 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-147766
-
|
Parasite
|
Infection
|
Antileishmanial agent-10 (Compound 7h) is an antiprotozoal agent .
|
-
- HY-149079
-
|
Parasite
Necroptosis
|
Infection
|
Antiparasitic agent-15, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-15 has IC50s of 0.9 μM and 0.64 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-15 has IC50s of 42.2 μM and 9.58 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-15 induces parasite cell death through necrosis induction. Antiparasitic agent-15 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes .
|
-
- HY-149080
-
|
Parasite
Necroptosis
|
Infection
|
Antiparasitic agent-16, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-16 has IC50s of 1.0 μM and 0.6 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-16 has IC50s of 150.2 μM and 16.75 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-16 induces parasite cell death through necrosis induction. Antiparasitic agent-16 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes .
|
-
- HY-14932
-
DB289
|
Parasite
Antibiotic
|
Infection
|
Pafuramidine (DB289) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria .
|
-
- HY-14932A
-
DB289 maleate
|
Parasite
Antibiotic
|
Infection
|
Pafuramidine (maleate) (DB289 (maleate)) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine (maleate) (DB289 (maleate)) is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria .
|
-
- HY-119480
-
|
Bacterial
|
Infection
|
Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC50 of 0.01 μg/mL. Megazol can be used for the research of protozoan infections .
|
-
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N0914
-
-
-
- HY-N2656
-
-
-
- HY-N10441
-
-
-
- HY-N2970
-
-
-
- HY-N3418
-
-
-
- HY-N3247
-
-
-
- HY-125731
-
-
-
- HY-N7266
-
-
-
- HY-129130
-
-
-
- HY-N4033
-
-
-
- HY-N9179
-
|
Infection
Flavonoids
Classification of Application Fields
Flavones
Source classification
Lupinus perennis L.
Plants
Compositae
Disease Research Fields
|
Parasite
|
3′,4′,5′,5,6,7-Hexamethoxyflavone is a flavonoid with antiprotozoal activity. 3′,4′,5′,5,6,7-Hexamethoxyflavone inhibits trypanosoma bruceirhodesiense with IC50 of 21.3 μM (8.58 g/mL) .
|
-
-
- HY-N10547
-
-
-
- HY-W020182
-
-
-
- HY-122267
-
-
-
- HY-N1716
-
-
-
- HY-N10443
-
-
-
- HY-N0389
-
-
-
- HY-N12788
-
-
-
- HY-126417
-
-
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W040073S
-
|
Nifurtimox-d4 is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).
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