Unnatural

By Targets:	ADC Linker (3) Amino Acid Derivatives (4) Androgen Receptor (1) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Fluorescent Dye (6) HBV (1) Nucleoside Antimetabolite/Analog (1) Orthopoxvirus (1) Prostaglandin Receptor (1)
By Research Areas:	Cancer (2) Endocrinology (2) Infection (1) Inflammation/Immunology (1) Neurological Disease (2)
Click Chemistry:	Azide (8) Alkynes (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139014

N-ε-propargyloxycarbonyl-L-lysine 1 Publications Verification H-L-Lys(Poc)-OH	Fluorescent Dye	Cancer
N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals . N-ε-propargyloxycarbonyl-L-lysine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B1258

4-(Aminomethyl)benzoic acid Aminomethylbenzoic acid; α-Amino-p-toluic acid	Amino Acid Derivatives	Others
4-(Aminomethyl)benzoic acid is an unnatural amino acid derivative and an antifibrinolytic drug.

HY-101937B

L-ANAP hydrochloride

Fluorescent Dye Others

L-ANAP hydrochloride is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa).

L-ANAP hydrochloride	Fluorescent Dye	Others
L-ANAP hydrochloride is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa).

HY-101937C

(±)-ANAP hydrochloride 1 Publications Verification	Fluorescent Dye	Others
(±)-ANAP hydrochloride is the unnatural amino acid analog of prodan, acts as a fluorescent probes, and enhances environmental sensitivity.

HY-126069

15(R)-Iloprost

15(R)-Ciloprost; 15(R)-ZK 36374
Others Others

15(R)-Iloprost is the unnatural or inverted C-15 epimer of lloprost (HY-A0096) .
HY-101937A

(±)-ANAP

Fluorescent Dye Others

(±)-ANAP is the unnatural amino acid analog of prodan, acts as a fluorescent probes, and enhances environmental sensitivity.
HY-101937

L-ANAP

Fluorescent Dye Others

L-ANAP is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa) .
HY-101937D

L-ANAP TFA

Fluorescent Dye Others

L-ANAP TFA is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa) .

15(R)-Iloprost 15(R)-Ciloprost; 15(R)-ZK 36374	Others	Others
15(R)-Iloprost is the unnatural or inverted C-15 epimer of lloprost (HY-A0096) .

(±)-ANAP	Fluorescent Dye	Others
(±)-ANAP is the unnatural amino acid analog of prodan, acts as a fluorescent probes, and enhances environmental sensitivity.

L-ANAP	Fluorescent Dye	Others
L-ANAP is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa) .

L-ANAP TFA	Fluorescent Dye	Others
L-ANAP TFA is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa) .

HY-W016443

L-m-Tyrosine	Others	Neurological Disease Inflammation/Immunology
L-m-Tyrosine is an unnatural amino acid, that has potential in the research of Parkinsons disease, Alzheimers disease, and arthritis .

HY-100217

DL-3-Indolylglycine	Amino Acid Derivatives	Others
DL-3-Indolylglycine is an unnatural amino acid that is very similar to Tryptophan, with the indole moiety directly attached to the α-position.

HY-W002272

Isocytosine	Nucleoside Antimetabolite/Analog	Others
Isocytosine is a non-natural nucleobase and an isomer of cytosine. It is used in combination with Isoguanine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA and used as a nucleobase of hachimoji RNA .

HY-163485

AR antagonist 8	Androgen Receptor	Endocrinology
AR antagonist 8 (compound 16) is a potent Lupeol-inspired androgen receptor (AR) antagonist with an IC₅₀ of 0.76 μM. AR antagonist 8 is a uniquely substituted unnatural entestrane .

HY-151693A

H-L-Tyr(2-azidoethyl)-OH	ADC Linker	Others
H-L-Tyr(2-azidoethyl)-OH is a unnatural Tyrosine derivative. H-L-Tyr(2-azidoethyl)-OH is a click chemistry reagent containing an azide group .

HY-151693

H-L-Tyr(2-azidoethyl)-OH hydrochloride	ADC Linker	Others
H-L-Tyr(2-azidoethyl)-OH hydrochloride is a unnatural Tyrosine derivative. H-L-Tyr(2-azidoethyl)-OH hydrochloride is a click chemistry reagent containing an azide group .

HY-W002299

Boc-D-Leucine monohydrate Boc-D-Leu-OH hydrate	Amino Acid Derivatives	Neurological Disease
Boc-D-Leucine monohydrate (Boc-D-Leu-OH hydrate) is an N-Boc-protected form of D-Leucine (L330150). D-Leucine is an unnatural isomer of L-Leucine (L330110) that acts as an auto-inhibitor of lactic streptococci. D-Leucine shows potent anti-seizure effect .

HY-13859

Clevudine L-FMAU	HBV DNA/RNA Synthesis Orthopoxvirus	Infection
Clevudine (L-FMAU), a nucleoside analog of the unnatural L-configuration, has potent anti-HBV activity with long half-life, low toxicity. Clevudine is a non-competitive inhibitor that is not incorporated into the viral DNA but rather binds to the polymerase. Clevudine is active against cowpox virus respiratory infection in mice .

HY-114862

13,14-dihydro-15(R)-Prostaglandin E1 13,14-dihydro-15(R)-PGE1	Endogenous Metabolite	Others
13,14-dihydro-15(R)-Prostaglandin E1 (13,14-dihydro-15(R)- PGE1) is an analog of 13,14-dihydro- PGE1 which has the hydroxyl group at C-15 in the unnatural R configuration .

HY-151687

Fmoc-L-Tyr(2-azidoethyl)-OH	ADC Linker	Others
Fmoc-L-Tyr(2-azidoethyl)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Tyr(2-azidoethyl)-OH is unnatural Fmoc-protected Tyrosine derivative bears an azidoethyl substitution as reactive handle e.g. for biorthogonal conjugations, via a Cu(I)-catalyzed 1,3-dipolar Click cycloaddition with alkynes. And azido-UAAs can be employed as IR reporters .

HY-128676

N-ε-propargyloxycarbonyl-L-lysine hydrochloride 1 Publications Verification H-L-Lys(Poc)-OH hydrochloride	Amino Acid Derivatives	Cancer
N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) hydrochloride is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals . N-ε-propargyloxycarbonyl-L-lysine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-139121

15(R)-17-Phenyl trinor Prostaglandin F2α 15-epi Bimatoprost free acid; 15(R)-Bimatoprost free acid; 15(R)-17-phenyl trinor PGF2α	Prostaglandin Receptor	Endocrinology
17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive agent. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hr. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2α is the 15-epi, or “unnatural” isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity, which is generally 1.5 to 2 logs less than the 15(S)-isomer. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.

Cat. No.	Product Name	Type

HY-101937B

L-ANAP hydrochloride

Fluorescent Dyes/Probes

L-ANAP hydrochloride is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa).

L-ANAP hydrochloride	Fluorescent Dyes/Probes
L-ANAP hydrochloride is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa).

HY-101937C

(±)-ANAP hydrochloride 1 Publications Verification	Fluorescent Dyes/Probes
(±)-ANAP hydrochloride is the unnatural amino acid analog of prodan, acts as a fluorescent probes, and enhances environmental sensitivity.

HY-101937A

(±)-ANAP

Fluorescent Dyes/Probes

(±)-ANAP is the unnatural amino acid analog of prodan, acts as a fluorescent probes, and enhances environmental sensitivity.
HY-101937

L-ANAP

Fluorescent Dyes/Probes

L-ANAP is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa) .

(±)-ANAP	Fluorescent Dyes/Probes
(±)-ANAP is the unnatural amino acid analog of prodan, acts as a fluorescent probes, and enhances environmental sensitivity.

L-ANAP	Fluorescent Dyes/Probes
L-ANAP is a genetically encodable and polarity-sensitive fluorescent unnatural amino acid (Uaa) .

Cat. No.	Product Name	Target	Research Area

HY-W002299

Boc-D-Leucine monohydrate Boc-D-Leu-OH hydrate	Amino Acid Derivatives	Neurological Disease
Boc-D-Leucine monohydrate (Boc-D-Leu-OH hydrate) is an N-Boc-protected form of D-Leucine (L330150). D-Leucine is an unnatural isomer of L-Leucine (L330110) that acts as an auto-inhibitor of lactic streptococci. D-Leucine shows potent anti-seizure effect .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W002272

Isocytosine	Classification of Application Fields Other Diseases Disease Research Fields	Nucleoside Antimetabolite/Analog
Isocytosine is a non-natural nucleobase and an isomer of cytosine. It is used in combination with Isoguanine in studies of unnatural nucleic acid analogues of the normal base pairs in DNA and used as a nucleobase of hachimoji RNA .

Cat. No.	Product Name		Classification

HY-131033

L-Azidonorleucine hydrochloride		Azide
L-Azidonorleucine hydrochloride, an unnatural amino acid, is A Methionine surrogate. L-Azidonorleucine hydrochloride can be used to label mammalian cell proteins and identify a diverse set of methionyl-tRNA synthetase (MetRS) mutants . L-Azidonorleucine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-139014

N-ε-propargyloxycarbonyl-L-lysine 1 Publications Verification H-L-Lys(Poc)-OH		Alkynes
N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals . N-ε-propargyloxycarbonyl-L-lysine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-16714

4-Azido-L-phenylalanine Maximum Cited Publications 7 Publications Verification p-Azidophenylalanine; p-Azido-L-phenylalanine		Azide
4-Azido-L-phenylalanine is an unnatural amino acid, which is used as an effective vibrational reporter of local protein environments. 4-Azido-L-phenylalanine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-151693A

H-L-Tyr(2-azidoethyl)-OH

Azide

H-L-Tyr(2-azidoethyl)-OH is a unnatural Tyrosine derivative. H-L-Tyr(2-azidoethyl)-OH is a click chemistry reagent containing an azide group .

H-L-Tyr(2-azidoethyl)-OH		Azide
H-L-Tyr(2-azidoethyl)-OH is a unnatural Tyrosine derivative. H-L-Tyr(2-azidoethyl)-OH is a click chemistry reagent containing an azide group .

HY-151693

H-L-Tyr(2-azidoethyl)-OH hydrochloride		Azide
H-L-Tyr(2-azidoethyl)-OH hydrochloride is a unnatural Tyrosine derivative. H-L-Tyr(2-azidoethyl)-OH hydrochloride is a click chemistry reagent containing an azide group .

HY-16714A

4-Azido-L-phenylalanine hydrochloride Maximum Cited Publications 7 Publications Verification p-Azidophenylalanine hydrochloride; p-Azido-L-phenylalanine hydrochloride		Azide
4-Azido-L-phenylalanine hydrochloride is an unnatural amino acid, which is used as an effective vibrational reporter of local protein environments. 4-Azido-L-phenylalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-151687

Fmoc-L-Tyr(2-azidoethyl)-OH		Azide
Fmoc-L-Tyr(2-azidoethyl)-OH is a click chemistry reagent containing an azide group. Fmoc-L-Tyr(2-azidoethyl)-OH is unnatural Fmoc-protected Tyrosine derivative bears an azidoethyl substitution as reactive handle e.g. for biorthogonal conjugations, via a Cu(I)-catalyzed 1,3-dipolar Click cycloaddition with alkynes. And azido-UAAs can be employed as IR reporters .

HY-148835

AzGGK		Azide
AzGGK is an unnatural amino acid. AzGGK is site-specifically incorporated into proteins via genetic-code expansion. AzGGK can be used as site-specific probe for ubiquitylation and SUMOylation . AzGGK is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-154835

N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine		Azide
N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine is an unnatural amino acid . N6-[[(4-Azidophenyl)methoxy]carbonyl]-L-lysine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

HY-128676

N-ε-propargyloxycarbonyl-L-lysine hydrochloride 1 Publications Verification H-L-Lys(Poc)-OH hydrochloride		Alkynes
N-ε-propargyloxycarbonyl-L-lysine (H-L-Lys(Poc)-OH) hydrochloride is a lysine-based unnatural amino acid (UAA). N-ε-propargyloxycarbonyl-L-lysine is widely used for bio-conjugation of fluorescent probes in diverse organisms from E. coli to mammalian cells even in animals . N-ε-propargyloxycarbonyl-L-lysine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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