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Pathways Recommended: Stem Cell/Wnt
Results for "

Wnt/β-catenin-IN-1

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Peptides

1

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-155391
    hCA/Wnt/β-catenin-IN-1

    		Carbonic Anhydrase P-glycoprotein Wnt β-catenin Cancer
    hCA/Wnt/β-catenin-IN-1 (Compd 15) is an inhibitor of hCA (Ki: 33.6, 24.1, 6.8 nM for hCA II, hCA IX, hCA XII). hCA/Wnt/β-catenin-IN-1 reduces P-gp activity. hCA/Wnt/β-catenin-IN-1 also inhibits Wnt/β-catenin signaling pathway. hCA/Wnt/β-catenin-IN-1 inhibits cancer cell viability, including the NCI/ADR-RES DOX-resistant cell line .
    hCA/<em>Wnt</em>/<em>β-catenin</em>-IN-1
  • HY-114321
    Wnt/β-catenin agonist 1
    4 Publications Verification

    		 Wnt Cancer
    Wnt/β-catenin agonist 1 (compound 3f) is a Wnt/β-catenin signalling pathway agonist, with an EC50 of 0.27 μM .
    <em>Wnt</em>/<em>β-catenin</em> agonist 1
  • HY-121118
    Coronaridine
    1 Publications Verification

    		 Wnt Neurological Disease Cancer
    Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression .
    Coronaridine
  • HY-157990
    Wnt/β-catenin-IN-1

    		Wnt β-catenin Cancer
    Wnt/β-catenin-in-1 (compounds 17) is a Wnt/β-catenin signaling pathway inhibitor. Wnt/β-catenin-IN-1 can induce apoptosis of colon cancer cells, has broad-spectrum anticancer activity, and can be used for the reseach of a variety of solid tumors .
    <em>Wnt/β-catenin</em>-IN-1
  • HY-121540
    IWP-2-V2

    		Wnt Cancer
    IWP-2-V2 is a IWP-2 (HY-13912) analogue that retains activity against the Wnt/β-catenin pathway .
    IWP-2-V2
  • HY-N7507A
    Sempervirine nitrate

    		Wnt β-catenin Cancer
    Sempervirine is an alkaloid derived from Gelsemium elegans Benth.. Sempervirine inhibits the proliferation of hepatocellular carcinoma (HCC) cells and induces apoptosis by regulating Wnt/β-catenin pathway .
    Sempervirine nitrate
  • HY-P5819A
    xStAx-VHLL TFA

    		PROTACs β-catenin Cancer
    xStAx-VHLL TFA, a PROTAC, sustains β-catenin degradation and manifested strong inhibition of Wnt signaling. xStAx-VHLL TFA promotes β-catenin ubiquitination .
    xStAx-VHLL TFA
  • HY-101085
    SKL2001
    Maximum Cited Publications
    38 Publications Verification

    		 Wnt β-catenin Cancer
    SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction .
    SKL2001
  • HY-116553
    FzM1

    		Wnt β-catenin Cancer
    FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the WNT/β-catenin cascade .
    FzM1

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