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Results for "

antiapoptotic

" in MedChemExpress (MCE) Product Catalog:

76

Inhibitors & Agonists

1

Biochemical Assay Reagents

5

Peptides

31

Natural
Products

1

Recombinant Proteins

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-122267A
    cis-Clovamide

    		Apoptosis Inflammation/Immunology
    cis-Clovamide, a natural phenolic compound with antioxidant, anti-inflammatory and antiapoptotic activities .
    cis-Clovamide
  • HY-162137
    Hepatoprotective agent-1

    		Apoptosis Inflammation/Immunology
    Hepatoprotective agent-1 (compound 1b) is a hepatoprotective agenrt. Hepatoprotective agent-1 shows anti-inflammatory, antiapoptotic and antifibrotic effects .
    Hepatoprotective agent-1
  • HY-W027126
    Hepatoprotective agent-2

    		Apoptosis Metabolic Disease
    Hepatoprotective agent-2 (compound 2a), a 4-phenyl-tetrahydroquinoline derivative, displays a remarkable hepatoprotective effect. Hepatoprotective agent-2 has antiapoptotic activity. Hepatoprotective agent-2 notably prevents the chemically induced elevation of hepatic indicators associated with liver injury .
    Hepatoprotective agent-2
  • HY-N7697D
    Chitoheptaose heptahydrochloride

    		Reactive Oxygen Species Cardiovascular Disease Inflammation/Immunology
    Chitoheptaose heptahydrochloride is a chitosan oligosaccharide with antioxidant, anti-inflammatory, antiapoptotic and cardioprotective activities. Chitoheptaose heptahydrochloride significantly enhances the growth and photosynthesis parameters of wheat seedlings .
    Chitoheptaose heptahydrochloride
  • HY-N9933
    Tauro-β-muricholic acid

    TβMCA

    		 FXR Apoptosis Metabolic Disease Cancer
    Tauro-β-muricholic acid (TβMCA) is a trihydroxylated bile acid. Tauro-β-muricholic acid is a competitive and reversible FXR antagonist (IC50 = 40 μM). Tauro-β-muricholic acid has antiapoptotic effect. Tauro-β-muricholic acid inhibits bile acid-induced hepatocellular apoptosis by maintaining the mitochondrial membrane potential .
    Tauro-β-muricholic acid
  • HY-P3600
    FIZZ-1 (32-51) (mouse)

    		Apoptosis Inflammation/Immunology
    FIZZ-1 (32-51) (mouse) is a cysteine-rich secretory protein that is highly expressed by macrophages, bronchial epithelial and type II alveolar epithelial cells (AEC) in allergic airway inflammation. FIZZ1 (32-51) (mouse) also shows an antiapoptotic effect on lung fibroblasts. FIZZ-1 (32-51) (mouse) can be used in the study of allergic pneumonia .
    FIZZ-1 (32-51) (mouse)
  • HY-101083
    BDA-366

    		Bcl-2 Family Cancer
    BDA-366 is a potent Bcl2 antagonist (Ki = 3.3 nM), binding Bcl2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells .
    BDA-366
  • HY-107599
    AEG3482

    		JNK Apoptosis Neurological Disease
    AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25 .
    AEG3482
  • HY-142026
    Vitisin A

    (+)-Vitisin A

    		 NF-κB ERK Inflammation/Immunology
    Vitisin A has antioxidative, anticancer, antiapoptotic, neuroprotective and anti-inflammatory effects. Vitisin A inhibits LPS-induced NO and iNOS production via down-regulation of ERK1/2 and p38 and the NF-κB signal pathway. Vitisin A also inhibits adipocyte differentiation. Vitisin A is a resveratrol tetramer that can be isolated from Vitis vinifera roots .
    Vitisin A
  • HY-15191B
    (S)-Sabutoclax

    (S)-BI-97C1

    		 Bcl-2 Family Cancer
    (S)-Sabutoclax ((S)-BI-97C1), an optically pure apogossypol derivative, is pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. (S)-Sabutoclax (Compound II) inhibits the binding of BH3 peptides to Bcl-XL, Bcl-2, Mcl-1, and Bfl-1 with IC50 values of 0.31, 0.32, 0.20, and 0.62 μM, respectively. (S)-Sabutoclax also potently inhibits cell growth of human prostate cancer, lung cancer, and lymphoma cell lines with EC50 values of 0.13, 0.56, and 0.049 μM, respectively. (S)-Sabutoclax can be used for the research of apoptosis-based therapies against cancer .
    (S)-Sabutoclax
  • HY-N1778
    3,4-Dimethoxycinnamic acid

    O-Methylferulic acid

    		 Reactive Oxygen Species Virus Protease Infection Cancer
    3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .
    3,4-Dimethoxycinnamic acid
  • HY-N1778A
    (E)-3,4-Dimethoxycinnamic acid

    (E)-O-Methylferulic acid

    		 Reactive Oxygen Species Virus Protease Infection Cancer
    (E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway . Anti-apoptotic effects .
    (E)-3,4-Dimethoxycinnamic acid
  • HY-143230
    Custirsen

    OGX-011

    		 Apoptosis Cancer
    Custirsen is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance.
    Custirsen
  • HY-143230A
    Custirsen sodium

    OGX-011 sodium

    		 Apoptosis Cancer
    Custirsen sodium is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance.
    Custirsen sodium
  • HY-138832
    BM-1244

    APG-1252-M1

    		 Bcl-2 Family Cancer
    BM-1244 (APG-1252-M1) is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM. (From patent WO2019033119A1) .
    BM-1244
  • HY-160108
    Bcl-2-IN-17

    		Bcl-2 Family Others
    Bcl-2-IN-17 is a Bcl2 inhibitor and can be used for the research of diseases associated with Bcl anti-apoptotic protein .
    Bcl-2-IN-17
  • HY-N0783
    Eupatilin
    5+ Cited Publications

    		 PPAR Autophagy Neurological Disease Inflammation/Immunology Cancer
    Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.
    Eupatilin
  • HY-12305A
    (R)-Q-VD-OPh

    (R)-QVD-OPH; (R)-Quinoline-Val-Asp-Difluorophenoxymethylketone

    		 Apoptosis Cancer
    (R)-Q-VD-OPh ((R)-QVD-OPH) is the less active enantiomer of Q-VD-OPha. Q-VD-OPha is an irreversible pan-caspase inhibitor with potent antiapoptotic properties.
    (R)-Q-VD-OPh
  • HY-N3204
    Neoechinulin A

    		Apoptosis Neurological Disease
    Neoechinulin A is an isoprenyl indole alkaloid that exhibits scavenging, neurotrophic factor-like, and anti-apoptotic activities. Neoechinulin A induces memory improvements and antidepressant-like effects in mice .
    Neoechinulin A
  • HY-10397A
    MX1013
    2 Publications Verification

    CV1013; Z-VD-FMK

    		 Caspase Cancer
    MX1013 is a potent, irreversible dipeptide caspase inhibitor vith antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC50 of 30 nM .
    MX1013
  • HY-103272
    iMAC2

    		Apoptosis Bacterial Others
    iMAC2 is a potent MAC inhibitor with an IC50 of 28 nM and an LD50 of 15000 nM. iMAC2 shows anti-apoptotic effect. iMAC2 blocks cytochrome c release .
    iMAC2
  • HY-P2804
    GAPDH, rabbit muscle

    GADPH; G3PDH; Glyceraldehyde phosphate dehydrogenase

    		 Others Others
    Glyceraldehyde phosphate dehydrogenase (EC 1.2.1.12) is the target of anti-thymocyte and anti-apoptotic agents. Glyceraldehyde phosphate dehydrogenase catalyzes the chain oxidation of reduced nicotinamide adenine dinucleotide by perhydroxyl radicals .
    GAPDH, rabbit muscle
  • HY-N6850
    Calenduloside E
    1 Publications Verification

    		 HSP Endogenous Metabolite
    Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90) .
    Calenduloside E
  • HY-N6077
    Thalidezine

    		Others Cancer
    Thalidezine is a novel activator of AMP-activated protein kinase (AMPK). Thalidezine can eliminate anti-apoptotic cancer cells through energy-mediated autophagy death. Thalidezine can be used to study apoptosis intervention .
    Thalidezine
  • HY-160006
    PIM-IN-2

    		Pim Cancer
    PIM-IN-2 (Pim-2) is a Pim kinases inhibitor (IC50 = 25 nM). PIM-IN-2 promotes cell survival, is antiapoptotic, and has exhibited an elevated level of expression in a variety of human tumors .
    PIM-IN-2
  • HY-110073
    iMAC2 hydrochloride

    		Apoptosis Inflammation/Immunology Cancer
    iMAC2 hydrochloride is a potent MAC (mitochondrial apoptosis-induced channel) inhibitor, with an IC50 of 28 nM and a LD50 of 15000 nM. iMAC2 hydrochloride shows anti-apoptotic effect. iMAC2 hydrochloride blocks cytochrome c release .
    iMAC2 hydrochloride
  • HY-N6076
    Tenuifoliside A

    		ERK Neurological Disease
    Tenuifoliside A is isolated from Polygala tenuifolia, has anti-apoptotic and antidepressant-like effects. Tenuifoliside A exhibits its neneurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signal pathway in C6 cells .
    Tenuifoliside A
  • HY-134616
    Ulinastatin
    1 Publications Verification

    Uristatin

    		 Ser/Thr Protease Apoptosis Neurological Disease Inflammation/Immunology
    Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects .
    Ulinastatin
  • HY-161254
    ATPase-IN-3

    		Apoptosis MDM-2/p53 Inflammation/Immunology
    ATPase-IN-3 (compound 6) is a ATPase inhibitor. ATPase-IN-3 has Gastroprotective effect in ethanol-induced gastric ulcers by contribution of anti-apoptotic (BCL-2) and tumor suppressor (P53) proteins .
    ATPase-IN-3
  • HY-N0783R
    Eupatilin (Standard)

    		PPAR Autophagy Neurological Disease Inflammation/Immunology Cancer
    Eupatilin (Standard) is the analytical standard of Eupatilin. This product is intended for research and analytical applications. Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi Lévl. et Van., is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.
    Eupatilin (Standard)
  • HY-13264
    Degrasyn
    5+ Cited Publications

    WP1130

    		 Deubiquitinase Bcr-Abl Autophagy Apoptosis Cancer
    Degrasyn (WP1130) is a cell-permeable deubiquitinase (DUB) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37. Degrasyn has been shown to downregulate the antiapoptotic proteins Bcr-Abl and JAK2.
    Degrasyn
  • HY-N2037
    Higenamine

    Norcoclaurine; Demethyl-Coclaurine

    		 Adrenergic Receptor Cardiovascular Disease Endocrinology
    Higenamine (Norcoclaurine), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine (Norcoclaurine) has anti-apoptotic effects .
    Higenamine
  • HY-10087
    Navitoclax
    Maximum Cited Publications
    74 Publications Verification

    ABT-263

    		 Bcl-2 Family Cancer
    Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .
    Navitoclax
  • HY-N0119
    Naringin Dihydrochalcone
    1 Publications Verification

    Naringin DC

    		 NF-κB Cancer
    Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.
    Naringin Dihydrochalcone
  • HY-P3993
    (Gly14)-Humanin (human)

    14-Glycine-Humanin (human)

    		 Apoptosis Neurological Disease
    (Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions .
    (Gly14)-Humanin (human)
  • HY-P3993A
    (Gly14)-Humanin (human) (acetate)

    14-Glycine-Humanin (human) (acetate)

    		 Apoptosis Neurological Disease
    (Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) acetate has anti-apoptotic and neuroprotective functions .
    (Gly14)-Humanin (human) (acetate)
  • HY-149017
    Apoptosis inducer 7

    		Apoptosis Cancer
    Apoptosis inducer 7 (Compound 5I) induces apoptosis in cancer cells. Apoptosis inducer 7 inducrs cleavage of PARP, caspases, down-regulation of anti-apoptotic protein c-Flip and up regulation of pro-apoptotic protein Noxa. Apoptosis inducer 7 exhibits antitumor activity .
    Apoptosis inducer 7
  • HY-N2638
    Ilexsaponin A

    		Apoptosis Cardiovascular Disease
    Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes .
    Ilexsaponin A
  • HY-152193
    ChoKα inhibitor-4

    		Others Cancer
    ChoKα inhibitor-4 is a bioisosteric inhibitor of HChoK α1 (IC50=0.66 μM), with inhibitory and antiproliferative effect on cancer cells. ChoKα inhibitor-4 induces apoptosis via mitochondrial pathway, and reduces anti-apoptotic proteins expression .
    ChoKα inhibitor-4
  • HY-N1485
    Cycloastragenol
    3 Publications Verification

    Astramembrangenin; Cyclosieversigenin

    		 Telomerase Neurological Disease Inflammation/Immunology
    Cycloastragenol (Astramembrangenin), the active form of astragaloside IV, has anti-oxidant, anti-inflammatory, anti-aging, anti-apoptotic, and cardiovascular protective effects. Cycloastragenol is a potent telomerase activator and can lengthen telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties .
    Cycloastragenol
  • HY-N4005
    Isoastilbin

    		Bacterial Tyrosinase Infection Neurological Disease
    Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research .
    Isoastilbin
  • HY-N6959
    Osmundacetone

    		Reactive Oxygen Species Apoptosis Metabolic Disease
    Osmundacetone is a natural product isolated from Osmundae Rhizoma, with neuroprotective and anti-apoptotic effects. Osmundacetone also has DPPH scavenging activity and anti-oxidative stress activity. Osmundacetone inhibits MAPK phosphorylation, including JNK, ERK, and p38 kinase. Osmundacetone can be a potential agent for the research of neurodegenerative diseases .
    Osmundacetone
  • HY-P2343
    BH3 hydrochloride

    		Apoptosis Cancer
    BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian .
    BH3 hydrochloride
  • HY-10930
    UNC0321
    2 Publications Verification

    		 Histone Methyltransferase GCGR Apoptosis Cancer
    UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 63 pM and with assay-dependent IC50 values of 6-9 nM. UNC0321 also inhibits GLP with assay-dependent IC50 values of 15-23 nM. UNC0321 has anti-apoptotic activity and has potential application in diabetic vascular complications .
    UNC0321
  • HY-N0153
    Naringin
    10+ Cited Publications

    Naringoside

    		 Cytochrome P450 Autophagy Mitophagy Endogenous Metabolite Inflammation/Immunology Cancer
    Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin also inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1) .
    Naringin
  • HY-12305
    Q-VD-OPh
    45+ Cited Publications

    QVD-OPH; Quinoline-Val-Asp-Difluorophenoxymethylketone

    		 Caspase HIV Infection Cancer
    Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC50 of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPh can inhibits HIV infection. Q-VD-OPh is able to cross the blood-brain barrier.
    Q-VD-OPh
  • HY-10087S
    Navitoclax-d8

    		Bcl-2 Family Cancer
    Navitoclax-d8 is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM[1].
    Navitoclax-d8
  • HY-155612
    M826

    		Caspase Neurological Disease
    M826 is a potent, selective and reversible non-peptide caspase-3 inhibitor with an IC50 value of 0.005 μM for enzymatic activity against caspase-3. M826 displays potent anti-apoptotic activity in animal models in vitro and in vivo. M826 can be used for nervous system diseases research .
    M826
  • HY-N0153R
    Naringin (Standard)

    Naringoside (Standard)

    		 Endogenous Metabolite Cytochrome P450 Mitophagy Autophagy Inflammation/Immunology Cancer
    Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin also inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1) .
    Naringin (Standard)
  • HY-18628
    UMI-77
    1 Publications Verification

    		 Bcl-2 Family Cancer
    UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.
    UMI-77

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