Search Result

Results for "

chemical synthesis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (10) ADC Cytotoxin (1) Antibiotic (1) Apoptosis (5) Bacterial (4) Beta-lactamase (1) Biochemical Assay Reagents (47) Calcium Channel (1) CRAC Channel (1) E3 Ligase Ligand-Linker Conjugates (3) Endogenous Metabolite (28) Epigenetic Reader Domain (1) Fluorescent Dye (2) Fungal (2) HIV (5) Interleukin Related (1) Isotope-Labeled Compounds (9) Nucleoside Antimetabolite/Analog (5) Parasite (1) PROTAC Linkers (2) Virus Protease (1)
By Research Areas:	Cancer (27) Endocrinology (1) Infection (4) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (2)
Click Chemistry:	TCO (1) PROTAC Synthesis (1) Alkynes (2)

113

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Benzophenonetetracarboxylic dianhydride BTDA	Others	Others
Benzophenonetetracarboxylic dianhydride is widely used in the synthesis of high-performance polyimides and other polymer materials. Benzophenonetetracarboxylic dianhydride reacts with various diamine compounds to form oligoimide chains. These oligimide chains can modify graphene oxide (Go) and enhance its properties .

Tropone	Others	Others
Tropone is a building block in the chemical synthesis .

Alkyne Phosphoramidite, 5'-terminal	Biochemical Assay Reagents	Others
Alkyne Phosphoramidite, 5'-terminal (Compound 2) can be used for synthesis of oligo-nucleotides.

Phidianidine B	Others	Others
Phidianidine B is a highly cytotoxic 1,2,4-oxadiazole marine metabolite. Phidianidine B is a natural product that can be isolated from a marine mollusk .

Acetyl hexapeptide-49	Interleukin Related	Inflammation/Immunology
Acetyl hexapeptide-49 is a bioactive peptide with anti-allergen effect and has been reported used as a cosmetic ingredient .

4-Tolylboronic acid p-Tolylboronic acid	Biochemical Assay Reagents	Others
4-Tolylboronic acid is an organoboron compound with important chemical applications. It can be used as an important intermediate in organic synthesis for the synthesis of organic compounds such as drugs, pesticides, and cosmetics, as well as for the research of coordination chemistry and material science. Due to its high chemical reactivity, 4-Tolylboronic acid has become a widely used reagent in organic synthesis.

3,4-Dimethoxyphenylacetic acid	Endogenous Metabolite	Others
3,4-Dimethoxyphenylacetic acid is a building block in the chemical synthesis.

2'-Deoxyadenosine monohydrate	Endogenous Metabolite	Others
2'-Deoxyadenosine monohydrate is a deoxyribonucleoside. A building block in the chemical synthesis.

Methyl acetylacetate 1 Publications Verification Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl acetoacetate	Endogenous Metabolite	Metabolic Disease
Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives .

3,5-Dimethylbenzaldehyde	Endogenous Metabolite	Others
3,5-Dimethylbenzaldehyde is a building block in the chemical synthesis .

1,3,5-Trimethylpyrazole	Others	Others
1,3,5-Trimethylpyrazole is a compound used for chemical synthesis .

(-)-Corey lactone benzoate	Others	Others
(-)-Corey lactone benzoate is a building block in the chemical synthesis of corey aldehyde .

(-)-Corey lactone diol	Others	Others
(-)-Corey lactone diol is a reduced version of corey aldehyde. A building block in the chemical synthesis.

Tropic acid DL-Tropic acid	Others	Others
Tropic acid (DL-Tropic acid) is a laboratory reagent used in the chemical synthesis of Atropine and Hyoscyamine .

Adamantanone 2-Adamantone; 2-Oxoadamantane	Others	Others
Adamantanone (2-Adamantone) is a bioactive chemical, and can be used for the synthesis of active compound .

3-Methylcatechol	Others	Others
3-Methylcatechol is a building block in the chemical synthesis produced by Pseudomonas putida MC2 .

Benzofuran-3-carbaldehyde	Others	Others
Benzofuran-3-carbaldehyde is a bioactive chemical, and can be used for the synthesis of active compound .

Carboxy-EG6-hexadecanethiol 20-(16-Mercaptohexadecanyloxy)-3,6,9,12,15,18-hexaoxaeicosanoic acid	Biochemical Assay Reagents	Others
Carboxy-EG6-hexadecanethiol is a biochemical assay reagent and can be used for chemical synthesis .

Duostatin 5	ADC Cytotoxin	Cancer
Duostatin 5 is a cytotoxin designed based on dolastatin, can meet the requirement of serving as an effective cytotoxin in ADC, but has the advantages of fewer synthesis steps, easy operation, less difficulty in quality control and more stable chemical synthesis process .

Methyl acetylacetate (Standard) Acetoacetate methyl ester (Standard); Methyl 3-oxobutanoate (Standard); Methyl acetoacetate (Standard)	Endogenous Metabolite	Metabolic Disease
Methyl acetylacetate (Standard) is the analytical standard of Methyl acetylacetate. This product is intended for research and analytical applications. Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives .

1,3-Propanesultam 1,1-Dioxoisothiazolidine	Others	Others
1,3-Propanesultam (1,1-Dioxoisothiazolidine) is a bioactive chemical, and can be used for the synthesis of active compound .

5-Bromoindole	Others	Cancer
5-Bromoindole is a chemical intermediate that can be used for the synthesis of GSK-3 inhibitors and anti-cancer agents .

6-Chloropurine 6-Chloro-9H-purine	Others	Cancer
6-Chloropurine is a building block in chemical synthesis. Intermediate in the preparation of 9-alkylpurines and 6-rnercaptopurine. Antitumor activities .

Acetophenone 1 Publications Verification 1-Phenylethan-1-One	Others	Others
Acetophenone (1-Phenylethan-1-One) is an organic compound with simple structure. Acetophenone can be used in chemical synthesis .

3′,5′-Dimethoxyacetophenone	Others	Others
3′,5′-Dimethoxyacetophenone is a natural ketone compound with antioxidant activities. 3′,5′-Dimethoxyacetophenone is a building block in the chemical synthesis .

Gold(III) chloride trihydrate	Biochemical Assay Reagents	Others
Gold (III) chloride trihydrate is a reducing agent. Gold (III) chromium trihydrate can be used for chemical synthesis of gold nanoparticles (NP) and spirochromene derivatives .

CRAC intermediate 1	CRAC Channel	Inflammation/Immunology
CRAC intermediate 1 is a key intermediate in the chemical synthesis of a series of CRAC channel inhibitors, detailed information can be found in Patent WO 2010122089 A1, intermediate 9.

2,2-Bis(3-phenyl-4-hydroxyphenyl)propane BisOPP-A	Others	Others
2,2-Bis(3-phenyl-4-hydroxyphenyl)propane (BisOPP-A) is a bioactive chemical, and can be used for the synthesis of active compound .

Methyl 3-oxopentanoate	Biochemical Assay Reagents	Others
Methyl 3-oxopentanoate, which is also known as diethyl acetylmalonate or MEAM, Methyl 3-oxopentanoate is commonly used as a building block for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and flavorings, and it can also Used as a reagent in organic chemical reactions, especially the formation of carbon-carbon bonds through malonate synthesis, the researchers also investigated the potential use of Methyl 3-oxopentanoate in the development of chiral auxiliaries that can aid in the selection of Controlling the stereochemistry of chemical reactions.

Aminothiazole 1 Publications Verification 2-Aminothiazole; 2-Thiazolylamine	Bacterial Fungal Virus Protease	Infection
Aminothiazole (2-Aminothiazole), a typical heterocyclic amine, is a precursor for the synthesis of biologically active molecules including sulfur agents, biocides, fungicides, antibiotics, dyes and chemical reaction accelerators .

Sulfo-Cy5 carboxylic acid	Fluorescent Dye	Others
Sulfo-Cy5 carboxylic acid is a Cy5 derivative that can be used for chemical synthesis. Cy5 is a red fluorescent label dye for imaging (Ex/Em=642/670 nm) .

tert-Butyl 3,5-dinitrobenzoate	Others	Cancer
Tert-butyl 3,5-dinitrobenzoate is an intermediate or reactant in organic synthesis and can also play a role in drug synthesis, dye preparation and other chemical fields.The nitro functional group of Tert-butyl 3,5-dinitrobenzoate has certain reactivity in organic chemistry and can participate in various reactions, such as electrophilic substitution, aromatic amine reaction, etc .

Sulfo-Cy5 carboxylic acid TEA	Fluorescent Dye	Others
Sulfo-Cy5 carboxylic acid TEA is a Cy5 derivative that can be used for chemical synthesis. Cy5 is a red fluorescent label dye for imaging (Ex/Em=642/670 nm) .

Copper sulfate pentahydrate, 99.9%	Biochemical Assay Reagents	Others
Copper sulfate pentahydrate, commonly used biochemical reagents. Copper sulfate pentahydrate, 99.9% indicates that it is almost entirely pure, making it suitable for uses in laboratory experiments, chemical synthesis, and some pharmaceutical applications.

Lauric anhydride Bisdodecanoic anhydride	Biochemical Assay Reagents	Others
Lauric anhydride is a white waxy solid used as an intermediate in the production of various chemicals. It is primarily used in the synthesis of surfactants, emulsifiers, and lubricants, and as a raw material for other important industrial chemicals such as plasticizers and flavoring agents. It can be obtained from natural sources such as palm kernel oil and coconut oil, and its unique chemical structure allows it to be used to create compounds with specific surface and interfacial properties.

Tetrabutylammonium hydrogensulfate TBAHS-MB	Biochemical Assay Reagents	Others
Tetrabutylammonium hydrosulfate is a quaternary ammonium salt that is commonly used as a phase transfer catalyst, acid catalyst and reagent in various chemical reactions, especially in organic synthesis. Tetrabutylammonium hydrosulfate has unique chemical properties that allow it to facilitate the transfer of ions or molecules from one phase to another, making it an important ingredient in a variety of industrial processes.

1,3-Dihydroxyacetone Dihydroxyacetone	Endogenous Metabolite	Others
1,3-Dihydroxyacetone (DHA), the main active ingredient in sunless tanning skin-care preparations and an important precursor for the synthesis of various fine chemicals, is produced on an industrial scale by microbial fermentation of glycerol (HY-B1659) in Gluconobacter oxydans. 1,3-Dihydroxyacetone is also used for synthesis of new biodegradable polymers by combining with lactic acid (HY-B2227) .

Methyl trioctyl ammonium chloride	Biochemical Assay Reagents	Others
Methyl trioctyl ammonium chloride is a quaternary ammonium salt commonly used as a surfactant, stabilizer and phase transfer catalyst in various chemical reactions, especially in organic synthesis. Methyl trioctyl ammonium chloride has unique chemical properties that facilitate the transfer of ions or molecules from one phase to another, making it an important ingredient in a variety of industrial processes.

Cat. No.	Product Name

HY-L0103V

UORSY Screening Library	680,000 compounds
UORSY Screening Compounds Library contains about 680,000 compounds. The library has extensively developed a polymerization synthesis method that provides a highly diverse chemical structure. More than 85% of the compounds in the library have drug-like physicochemical properties, and more than 35% of the compounds have lead-like properties.

HY-L0087V

Life Chemicals HTS Compound Collection	494,471 compounds
Life Chemicals Collection of small organic molecules for high-throughput screening currently contains 494 off-the-shelf products. The Collection is being permanently replenished with de novo designed products having optimal physicochemical parameters for drug discovery.

HY-L004

Cell Cycle/DNA Damage Compound Library

2,037 compounds

DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have developed an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division. Cell cycle checkpoints represent integral components of DNA repair that coordinate cooperation between the machinery of the cell cycle and several biochemical pathways that respond to damage and restore DNA structure. By delaying progression through the cell cycle, checkpoints provide more time for repair before the critical phases of DNA replication, when the genome is replicated, and of mitosis, when the genome is segregated. Loss or attenuation of checkpoint function may increase spontaneous and induced gene mutations and chromosomal aberrations by reducing the efficiency of DNA repair.

MCE owns a unique collection of 2,037 cell cycle/DNA damage-related compounds which can be used in the research of the same.

HY-L912V

MegaUni 10M Virtual Diversity Library

10,000,000 compounds

With MCE's 40,662 BBs, covering around 273 reaction types, more than 40 million molecules were generated. Compounds which comply with Ro5 criteria were selected. Inappropriate chemical structures, such as PAINS motifs and synthetically difficult accessible, were removed. Based on Morgan Fingerprint, molecular clustering analysis was carried out, and molecules close to each clustering center were extracted to form this drug-like and synthesizable diversity library. These selected molecules have 805,822 unique Bemis-Murcko Scaffolds (BMS) with diversified chemical space. This library is highly recommended for AI-based lead discovery, ultra-large virtual screening and novel lead discovery.

HY-L910V

MegaUni 50K Virtual Diversity Library

50,000 compounds

MegaUni 50K Virtual Diversity Library consists of 50,000 novel, synthetically accessible, lead-like compounds. With MCE's 40,662 Building Blocks, covering around 273 reaction types, more than 40 million molecules were generated. Based on Morgan Fingerprint and Tanimoto Coefficient, molecular clustering analysis was carried out, and molecules closest to each clustering center were extracted to form a drug-like and synthesizable diversity library. The selected 50,000 drug-like molecules have 46,744 unique Bemis-Murcko Scaffolds (BMS), each containing only 1-3 compounds. This diverse library is highly recommended for virtual screening and novel lead discovery.

HY-L048

Antifungal Compound Library

343 compounds

The high rates of morbidity and mortality caused by fungal infections are associated with the current limited antifungal arsenal and the high toxicity of the compounds. Additionally, identifying novel drug targets is challenging because there are many similarities between fungal and human cells. The most common antifungal targets include fungal RNA synthesis and cell wall and membrane components, though new antifungal targets are being investigated. Nonetheless, fungi have developed resistance mechanisms, such as overexpression of efflux pump proteins, overexpression and changes in drug targets and biofilm formation, emphasizing the importance of discovering new antifungal drugs and therapies. Due to the limited antifungal arsenal, researchers have sought to improve treatment via different approaches, such as the combination of antifungal drugs, development of new formulations for antifungal agents and modifications to the chemical structures of traditional antifungals, etc.

MCE offers a unique collection of 343 compounds with validated antifungal activities. MCE antifungal compound library is an effective tool for drug repurposing screening, combination screening and biological investigation.

HY-L022M

FDA-Approved Drug Library Mini

2,945 compounds

New drug development is a time-consuming and high-cost process. Drug repurposing (also called drug repositioning, reprofiling or re‑tasking) offers various advantages over developing an entirely new drug for a given indication. First, the risk of failure is lower. Second, the time frame for drug development can be reduced. Third, less investment is needed. Approved drugs have identified bioactivities, good pharmacokinetic characteristics and safety which are suitable for drug repurposing.

MCE owns a unique collection of 2,945 approved compounds which have been completed extensive preclinical and clinical studies and have well-characterized bioactivities, safety and bioavailability properties. The package of this library is 96-well microplate with peelable foil seal, which makes the screening process easier and faster.

Cat. No.	Product Name	Type

HY-D1853

Sulfo-Cy5 carboxylic acid

Dyes

Sulfo-Cy5 carboxylic acid is a Cy5 derivative that can be used for chemical synthesis. Cy5 is a red fluorescent label dye for imaging (Ex/Em=642/670 nm) .

HY-D1853A

Sulfo-Cy5 carboxylic acid TEA	Fluorescent Dyes/Probes
Sulfo-Cy5 carboxylic acid TEA is a Cy5 derivative that can be used for chemical synthesis. Cy5 is a red fluorescent label dye for imaging (Ex/Em=642/670 nm) .

Cat. No.	Product Name	Type

HY-W001578

1-Adamantaneacetic acid

Biochemical Assay Reagents

1-Adamantaneacetic acid is an aliphatic carboxylic acid that can be used as an acylating agent, commonly found in chemical synthesis .
HY-W001939

4-Acetylbenzoic acid

4-Acetylbenzoic acid
Biochemical Assay Reagents

4-Acetylbenzoic acid is a derivative of benzoic acid and is commonly used in chemical synthesis .
HY-W001943

3-Benzoylpropionic acid

Biochemical Assay Reagents

3-Benzoylpropionic acid can be used as an intermediate in organic synthesis for the preparation of other organic compounds .

HY-21626

4-Tolylboronic acid

p-Tolylboronic acid