Search Result

Results for "

complex I

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) AMPK (3) Antibiotic (6) Apoptosis (7) Autophagy (6) Bacterial (3) Biochemical Assay Reagents (1) Cuproptosis (1) DNA/RNA Synthesis (6) Fluorescent Dye (1) Fungal (1) HBV (1) HSP (1) IGF-1R (1) IKK (5) Influenza Virus (1) Isotope-Labeled Compounds (2) Ligands for E3 Ligase (1) LRRK2 (2) Mitochondrial Metabolism (20) Orthopoxvirus (2) Oxidative Phosphorylation (7) Paraptosis (1) Parasite (4) Phosphodiesterase (PDE) (3) Proteasome (3) ROS Kinase (1) SARS-CoV (1) Sodium Channel (3) TGF-β Receptor (1) Toll-like Receptor (TLR) (1) Topoisomerase (14)
By Research Areas:	Cancer (43) Cardiovascular Disease (4) Infection (12) Inflammation/Immunology (8) Metabolic Disease (3) Neurological Disease (11)

By Targets:

ADC Cytotoxin (1)

AMPK (3)

Antibiotic (6)

Apoptosis (7)

Autophagy (6)

Bacterial (3)

Biochemical Assay Reagents (1)

Cuproptosis (1)

DNA/RNA Synthesis (6)

Fluorescent Dye (1)

Fungal (1)

HBV (1)

HSP (1)

IGF-1R (1)

IKK (5)

Influenza Virus (1)

Isotope-Labeled Compounds (2)

Ligands for E3 Ligase (1)

LRRK2 (2)

Mitochondrial Metabolism (20)

Orthopoxvirus (2)

Oxidative Phosphorylation (7)

Paraptosis (1)

Parasite (4)

Phosphodiesterase (PDE) (3)

Proteasome (3)

ROS Kinase (1)

SARS-CoV (1)

Sodium Channel (3)

TGF-β Receptor (1)

Toll-like Receptor (TLR) (1)

Topoisomerase (14)

By Research Areas:

Cancer (43)

Cardiovascular Disease (4)

Infection (12)

Inflammation/Immunology (8)

Metabolic Disease (3)

Neurological Disease (11)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Arp2/3 Complex

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145707

BAY-179

Mitochondrial Metabolism Cancer

BAY-179 is a potent, selective, and species cross-reactive complex I inhibitor (IC₅₀=79 µM) .

BAY-179	Mitochondrial Metabolism	Cancer
BAY-179 is a potent, selective, and species cross-reactive complex I inhibitor (IC₅₀=79 µM) .

HY-162515

8-OAc	Mitochondrial Metabolism	Cancer
8-OAc is a potent and selective mitochondrial *electron transport chain (ETC) complex* I** inhibitor. 8-OAc exhibits cytotoxicity against cancer cell lines .

HY-145304

DX3-235	Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
DX3-235 is an oxidative phosphorylation (OXPHOS) inhibitor. DX3-235 shows nanomolar inhibition of complex I function and ATP production in a galactose-containing medium resulting in significant cytotoxicity .

HY-B0825A

Fenpyroximate	Parasite Mitochondrial Metabolism	Infection
Fenpyroximate is an acaricide and insecticide against many mites and insect pests of agricultural crops and ornamentals. Fenpyroximate is also a strong inhibitor of *bovine heart mitochondrial NADH-ubiquinone oxidoreductase (complex* I)**, binds to the ND5 subunit .

HY-162516

DBI-2	AMPK Mitochondrial Metabolism	Cancer
DBI-2 is an AMPK activator targeting mitochondrial complex I. DBI-2 disrupts the OXPHOS process, and reduces ATP generation in mitochondria. DBI-2 inhibits the proliferation of colorectal cancer (CRC) cells .

HY-145303

DX2-201	Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
DX2-201 is a potent and selective *oxidative phosphorylation (OXPHOS) complex* I inhibitor with an IC₅₀** of 312 nM. DX2-201 has anticancer effects .

HY-100777

DACA	Topoisomerase	Cancer
DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells .

HY-W008719

MPP+ iodide 5+ Cited Publications	Mitochondrial Metabolism	Neurological Disease
MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) .

HY-B0817

Pyridaben	Parasite	Infection
Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC₅₀ value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function .

HY-112037

IACS-010759 5+ Cited Publications IACS-10759	Oxidative Phosphorylation Mitochondrial Metabolism Apoptosis	Cancer
IACS-010759 is an orally active, potent *mitochondrial complex* I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 inhibits proliferation and induces apoptosis** in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. IACS-010759 has the potential for relapsed/refractory AML and solid tumors research .

HY-112037A

IACS-010759 hydrochloride 5+ Cited Publications IACS-10759 hydrochloride	Oxidative Phosphorylation Mitochondrial Metabolism Apoptosis	Cancer
IACS-010759 hydrochlorideis an orally active, potent *mitochondrial complex* I of oxidative phosphorylation (OXPHOS) inhibitor. IACS-010759 hydrochlorideinhibits proliferation and induces apoptosis** in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS. IACS-010759 hydrochloride has the potential for relapsed/refractory AML and solid tumors research .

HY-131334

AMPK activator 4	AMPK	Metabolic Disease
AMPK activator 4 is a potent AMPK activator without inhibition of mitochondrial complex I. AMPK activator 4 selectively activates AMPK in the muscle tissues. AMPK activator 4 dose-dependently improves glucose tolerance in normal mice, and significantly lowers fasting blood glucose level and ameliorates insulin resistance in db/db diabetic mice. Anti-hyperglycemic effect .

HY-155107

ND-011992	Mitochondrial Metabolism Bacterial	Infection
ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits *respiratory complex* I and bo₃ oxidase in addition to bd-I and bd-II oxidases** in E. coli strain BL21Δcyo with the IC₅₀* of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study .

HY-155554

SCAL-255	Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
SCAL-255 is a potent *mitochondrial complex* I (CI) inhibitor with IC₅₀** of 1.14 μM. SCAL-255 blocks mitochondrial function, inhibits OCR, induces ROS production, and reduces MMP. SCAL-255 displays a considerable antiproliferation effect against oxidative phosphorylation (OXPHOS)-dependent cancer cells .

HY-155555

SCAL-266	Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
SCAL-266 is a potent *mitochondrial complex* I (CI) inhibitor with IC₅₀** of 0.83 μM. SCAL-266 blocks mitochondrial function, inhibits OCR, induces ROS production, and reduces MMP. SCAL-266 displays a considerable antiproliferation effect against oxidative phosphorylation (OXPHOS)-dependent cancer cells .

HY-144310

DX3-213B	Oxidative Phosphorylation Mitochondrial Metabolism	Cancer
DX3-213B is a highly potent, orally active oxidative phosphorylation (OXPHOS) complex I inhibitor (IC₅₀=3.6 nM). DX3-213B impairs ATP generation (IC₅₀=11 nM), and blocks MIA PaCa-2 cell growth (GI₅₀=11 nM). DX3-213B is used for the research of the pancreatic cancer .

HY-16562S1

Irinotecan-d10 hydrochloride	Isotope-Labeled Compounds Topoisomerase Autophagy	Cancer
Irinotecan-d₁₀ (hydrochloride) is the deuterium labeled Irinotecan. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1][2].

HY-16562S

Irinotecan-d10 (+)-Irinotecan-d₁₀; CPT-11-d₁₀; VAL-413-d₁₀	Topoisomerase Autophagy	Cancer
Irinotecan-d₁₀ is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1].

HY-16562

Irinotecan 40+ Cited Publications (+)-Irinotecan; CPT-11; VAL-413(free base)	Topoisomerase Autophagy	Cancer
Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex .

HY-W194810

MCU-i11	Mitochondrial Metabolism	Neurological Disease Metabolic Disease
MCU-i11 is a negative regulator of the mitochondrial calcium uniporter (MCU) complex. MCU-i11 can reduce mitochondrial Ca ²⁺ uptake. MCU-i11 impairs muscle cell growth .

HY-156237

Beclin1-ATG14L interaction inhibitor 1	Autophagy	Others
Beclin1-ATG14L interaction inhibitor 1 (com 19) is a selective Beclin1-ATG14L interaction inhibitor. This protein interaction mechanism specifically targets complex I of the lipid kinase VPS34 without affecting complex II. Because the integrity of VPS34 complex II depends on the Beclin 1-UVRAG interaction. Beclin1-ATG14L interaction inhibitor 1 can disrupt the formation of VPS34 complex I and inhibit autophagy, but does not affect complex II-related vesicle transport .

HY-N6716

Filipin complex 5+ Cited Publications	Fungal Antibiotic	Infection
Filipin complex is a potent polyene macrolide antifungal antibiotic. Filipin complex inserts into membranes and sequester cholesterol into complexes and inhibits PRRSV entry. The Filipin complex consists of about 75.8% Filipin III (HY-N6718), 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I .

HY-143266

Topoisomerase I inhibitor 3	Topoisomerase Apoptosis	Cancer
Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase .

HY-D0476

C.I. Acid yellow 99

Fluorescent Dye

C.I. Acid yellow 99 is an acidic yellow dye that combines with coconut shell pith through electrostatic and complexing reactions.

C.I. Acid yellow 99	Fluorescent Dye
C.I. Acid yellow 99 is an acidic yellow dye that combines with coconut shell pith through electrostatic and complexing reactions.

HY-161385

Topoisomerase I inhibitor 16	Topoisomerase	Cancer
Topoisomerase I inhibitor 21 (Compound 3e) is an inhibitor for Topoisomerase I through stabilization of enzyme-DNA complex. Topoisomerase I inhibitor 21 exhibits antiproliferative activity in 39 human cancer cells (JFCR39) with mean GI₅₀ 39 nM .

HY-146437

Topoisomerase I inhibitor 6	Topoisomerase	Cancer
Topoisomerase I inhibitor 6 (Compound 3) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 6 is able to trap DNA-Top1 cleavage complex and found to be less cytotoxic in non-cancerous cell line. Topoisomerase I inhibitor 6 has the potential for the research of cancer diseases .

HY-125930

T-2513	Topoisomerase DNA/RNA Synthesis	Cancer
T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death .

HY-125930A

T-2513 hydrochloride	Topoisomerase DNA/RNA Synthesis	Cancer
T-2513 hydrochloride is a selective topoisomerase I inhibitor. T-2513 hydrochloride binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death .

HY-118942

Topovale ARC 111	Topoisomerase	Cancer
Topovale (ARC 111) is a topoisomerase I inhbitor. Topovale is an antitumor agent, and shows low nM cytotoxicity against a panel of cancer cells. Topovale induces reversible topoisomerase I (TOP1) cleavage complexes in tumor cells .

HY-B1756

Rotenone Maximum Cited Publications 61 Publications Verification	Mitochondrial Metabolism Autophagy Apoptosis	Neurological Disease Cancer
Rotenone is a *mitochondrial electron transport chain complex* I** inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

HY-131958

D942

AMPK Cancer

D942 is a cell penetrant AMPK activator and partially inhibits the mitochondrial complex I. In multiple myeloma cells, D942 inhibits cell growth .
HY-P4044

HBV Seq2 aa:28-39

HBV Infection

HBV Seq2 aa:28-39 is a HBsAg peptide, which binds to major histocompatibility complex (MHC) class I molecules .

D942	AMPK	Cancer
D942 is a cell penetrant AMPK activator and partially inhibits the mitochondrial complex I. In multiple myeloma cells, D942 inhibits cell growth .

HBV Seq2 aa:28-39	HBV	Infection
HBV Seq2 aa:28-39 is a HBsAg peptide, which binds to major histocompatibility complex (MHC) class I molecules .

HY-W074006

Tris(2-cyanoethyl)phosphine	Biochemical Assay Reagents	Others
Tris(2-cyanoethyl)phosphine is a protein crosslinker. Tris(2-cyanoethyl)phosphine can be used to synthesis copper(I) complexes which shows antitumour activity .

HY-130278

MitoPQ 2 Publications Verification MitoParaquat	ROS Kinase	Cancer
MitoPQ is a mitochondria-targeted redox cycler. MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ can be used in antioxidant study .

HY-105454

Recainam Wy-42362	Others	Cardiovascular Disease
Recainam (Wy-42362) is an orally active anti-arrhythmic agent with Class I electrophysiological properties. Recainam suppresses complex ventricular arrhythmias. Racainam exhibits a good pharmacokinetic character in Sprague Dawley rats .

HY-N6800A

Netropsin dihydrochloride	DNA/RNA Synthesis Bacterial Influenza Virus Antibiotic Orthopoxvirus	Infection Inflammation/Immunology
Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei . Netropsin dihydrochloride exhibits antiviral activity against the vaccinia virus .

HY-124726

Aumitin	Autophagy	Neurological Disease Cancer
Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC₅₀s of 0.12 μM and 0.24 μM, respectively .

HY-110135A

NBI-31772 hydrate	IGF-1R	Neurological Disease
NBI-31772 hydrate is a potent inhibitor of interaction between insulin-like growth factor (IGF) and IGF-binding proteins (IGFBPs). NBI-31772 hydrate is also a nonpeptide ligand that releases bioactive IGF-I from the IGF-I/IGFBP-3 complex (K_is=1-24 nM for all six human subtypes). Anxiolytic and antidepressant-like effects .

HY-146693

CJJ300	TGF-β Receptor	Cancer
CJJ300 is a transforming growth factor-β (TGF-β) inhibitor with an IC₅₀ of 5.3 µM. CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex .

HY-158152

PROTAC CRBN ligand-2	Ligands for E3 Ligase	Cancer
PROTAC CRBN ligand-2 (12) is a Biguanide-PROTAC derivative, with an EC₅₀ of 0.15 mM in KP4 cells. PROTAC CRBN ligand-2 (12) demonstrates the ability to alter levels of mitochondrial proteins, notably complexes I and IV .

HY-N2306

Aclacinomycin A 3 Publications Verification Aclarubicin	Topoisomerase DNA/RNA Synthesis Proteasome Antibiotic	Cancer
Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

HY-113607

Asimicin Bullatacin	Mitochondrial Metabolism Parasite	Infection Cancer
Asimicin (Bullatacin) is antitumor acetogenin that can be isolated from the bark and seeds of the pawpaw tree, Asimina trilobal Dunal. Asimicin inhibits mitochondrial respiration through the inhibition of complex I. Asimicin shows toxicity to Aphis gossypii, mosquito larvae and mammalian .

HY-N2306A

Aclacinomycin A hydrochloride Aclarubicin hydrochloride	Topoisomerase DNA/RNA Synthesis Proteasome Antibiotic	Cancer
Aclacinomycin A (Aclarubicin) hydrochloride is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A hydrochloride is an inhibitor of topoisomerase I and II. Aclacinomycin A hydrochloride inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A hydrochloride might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

HY-13687

IKK 16 15+ Cited Publications	IKK LRRK2	Inflammation/Immunology
IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC₅₀s of 40 nM, 70 nM and 200 nM, respectively. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC₅₀ of 50 nM.

HY-135748A

Poly (I:C):Kanamycin (1:1) (sodium) 10+ Cited Publications	Toll-like Receptor (TLR) Apoptosis	Infection Cancer
Poly (I:C):Kanamycin (1:1) sodium is an isometric complex of Poly (I:C) (HY-135748) and Kanamycin (HY-16566). Poly(I:C) sodium, a synthetic analog of double-stranded RNA, is a TLR3 and retinoic acid-inducible gene I receptor (RIG-I and b>MDA5) agonist. Poly(I:C) sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and induce apoptosis in cancer cells . Kanamycin is an orally active antibacterial agent (Gram-negative/positive bacteria) that inhibits translocation and causes miscoding by binding to the 70S ribosomal subunit. Kanamycin shows good inhibitory activity against Mycobacterium tuberculosis (susceptible and drug-resistant) and Klebsiella pneumoniae, and can be used in the research of tuberculosis and pneumonia .

HY-149879

Npx-Au	Others	Cancer
Npx-Au is a NSAID–Au(I) complex with antitumor activity. Npx-Au can be used for the research of ovarian cancer . Npx-Au is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-13687A

IKK 16 hydrochloride 15+ Cited Publications	IKK LRRK2	Inflammation/Immunology
IKK 16 hydrochloride is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC₅₀s of 40 nM, 70 nM and 200 nM, respectively . IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC₅₀ of 50 nM .

HY-N2306R

Aclacinomycin A (Standard)	Topoisomerase DNA/RNA Synthesis Proteasome Antibiotic	Cancer
Aclacinomycin A (Standard) is the analytical standard of Aclacinomycin A. This product is intended for research and analytical applications. Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

HY-13295

Vinpocetine 5+ Cited Publications Ethyl apovincaminate	Sodium Channel IKK Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting *IκB kinase complex* (IKK)**, and has been widely used for the treatment of cerebrovascular disorders .

HY-B0817S

Pyridaben-d13	Parasite	Infection
Pyridaben-d₁₃ is the deuterium labeled Pyridaben[1]. Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function[2][3].

Cat. No.	Product Name	Target	Research Area

HY-P5282

ApoA-I mimetic peptide	Peptides	Others
ApoA-I mimetic peptide (PVLDLFRELLNELLEALKQKLK) has good lecithin:cholesterol acyl transferase (LCAT) activation potency. ApoA-I mimetic peptide can be used for synthesis of peptide/lipid complex .

HY-P5411

OVA-T4 Peptide SIITFEKL, OVA (257-264) Variant	Peptides	Others
OVA-T4 Peptide (SIITFEKL, OVA (257-264) Variant) is a biological active peptide. (T4 peptide (SIITFEKL) is a variant of the agonist ovalbumin (OVA) peptide (257-264), SIINFEKL. OVA Peptide is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC).)

HY-P4044

HBV Seq2 aa:28-39

HBV Infection

HBV Seq2 aa:28-39 is a HBsAg peptide, which binds to major histocompatibility complex (MHC) class I molecules .

HY-P3715

OVA peptide	Peptides	Inflammation/Immunology
OVA peptide mainly exists in egg white, it is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC). OVA peptide has been widely studied in allergy research .

HY-P5410

OVA-Q4 Peptide	Peptides	Others
OVA-Q4 Peptide is a biological active peptide. (Q4 Peptide (SIIQFEKL) is a variant of the agonist ovalbumin (OVA) peptide (257-264), SIINFEKL. OVA Peptide is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC).)

HY-P1745

InsB (9-23) Insulin B chain (9-23)	Peptides	Inflammation/Immunology
InsB (9-23) is an insulin B-chain peptide that binds to a class II histocompatibility complex (MHC) allele called I-Ag7. InsB (9-23) can be used to treat a number of autoimmune related diseases like Type 1 diabetes .

HY-P2490

Acetyl-Hirudin (54-65) (sulfated)	Peptides	Metabolic Disease
Acetyl-Hirudin (54-65) (sulfated) is a acetyl-fragment of Hirudin which binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex .

HY-P5412

LLO (190-201) Listeriolysin O 190 peptide	Peptides	Others
LLO (190-201) (Listeriolysin O 190 peptide) is a biological active peptide. (This peptide is a major histocompatibility complex class II (MHC-II)-restricted peptide, LLO190 (NEKYAQAYPNVS), from the listeriolysin O protein of Listeria monocytogenes, which generates an LLO190-specific Th response. This peptide subsequently challenge recombinant L. monocytogenes expressing the MHC-I-restricted epitope of ovalbumin (Ova257, SIINFEKL).)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6716

Filipin complex 5+ Cited Publications	Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Other Diseases Antiviral Disease Research Disease Research Fields Other Antibiotics	Fungal Antibiotic
Filipin complex is a potent polyene macrolide antifungal antibiotic. Filipin complex inserts into membranes and sequester cholesterol into complexes and inhibits PRRSV entry. The Filipin complex consists of about 75.8% Filipin III (HY-N6718), 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I .

HY-B1756

Rotenone Maximum Cited Publications 61 Publications Verification	Structural Classification Flavonoids Neurological Disease Classification of Application Fields Leguminosae Derris trifoliata Lour. Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	Mitochondrial Metabolism Autophagy Apoptosis
Rotenone is a *mitochondrial electron transport chain complex* I** inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.

HY-N6800A

Netropsin dihydrochloride	Classification of Application Fields Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis Bacterial Influenza Virus Antibiotic Orthopoxvirus
Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei . Netropsin dihydrochloride exhibits antiviral activity against the vaccinia virus .

HY-N2306

Aclacinomycin A 3 Publications Verification Aclarubicin	Quinones Structural Classification Microorganisms Anthraquinones	Topoisomerase DNA/RNA Synthesis Proteasome Antibiotic
Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

HY-N2306A

Aclacinomycin A hydrochloride Aclarubicin hydrochloride	Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Source classification Phenols Polyphenols Disease Research Fields Cancer	Topoisomerase DNA/RNA Synthesis Proteasome Antibiotic
Aclacinomycin A (Aclarubicin) hydrochloride is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A hydrochloride is an inhibitor of topoisomerase I and II. Aclacinomycin A hydrochloride inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A hydrochloride might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

HY-N2306R

Aclacinomycin A (Standard)	Quinones Structural Classification Microorganisms Anthraquinones	Topoisomerase DNA/RNA Synthesis Proteasome Antibiotic
Aclacinomycin A (Standard) is the analytical standard of Aclacinomycin A. This product is intended for research and analytical applications. Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis .

HY-13295

Vinpocetine 5+ Cited Publications Ethyl apovincaminate	Cardiovascular Disease Classification of Application Fields Neurological Disease Anti-aging Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don Apocynaceae Alkaloids Piperidine Alkaloids Disease Research Fields Cancer	Sodium Channel IKK Phosphodiesterase (PDE)
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting *IκB kinase complex* (IKK)**, and has been widely used for the treatment of cerebrovascular disorders .

HY-N10661

Ipomoeassin F Ipom-F	Structural Classification Natural Products Ipomoea squamosa Choisy Plants Convolvulaceae	SARS-CoV
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

HY-N12887

Mycothiazole	Structural Classification Natural Products Marine natural products Source classification Sponge	Mitochondrial Metabolism
Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC₅₀ is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans .

HY-114936

Piericidin A 1 Publications Verification AR-054	Structural Classification Neurological Disease Classification of Application Fields Source classification Anti-parasitic Antibacterial Disease Research Other Antibiotics Infection Microorganisms Antibiotics Anticancer Disease Research Fields	Bacterial ADC Cytotoxin Antibiotic Mitochondrial Metabolism
Piericidin A (AR-054) is a natural mitochondrial *NADH-ubiquinone oxidoreductase (complex* I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing** inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity .

HY-13295R

Vinpocetine (Standard)	Apocynaceae Alkaloids Piperidine Alkaloids Structural Classification Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don	Sodium Channel IKK Phosphodiesterase (PDE)
Vinpocetine (Standard) is the analytical standard of Vinpocetine. This product is intended for research and analytical applications. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting *IκB kinase complex* (IKK)**, and has been widely used for the treatment of cerebrovascular disorders .

Species:	Human (25) Rhesus Macaque (1) Mouse (1) Cynomolgus (2)
Tag:	His (29) SUMO (1) Avi (24)
Source:	HEK293 (27) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P75460

	Calnexin Protein, Mouse (HEK293, His) Calnexin; IP90; Major Histocompatibility complex Class I Antigen-Binding Protein p88; CANX	Mouse	HEK293
	Calnexin protein, a calcium-binding chaperone located in the endoplasmic reticulum (ER), plays a pivotal role in interacting with newly synthesized monoglucosylated glycoproteins, contributing to protein assembly and retention of unassembled protein subunits within the ER. With a key function in the ER's quality control apparatus, calnexin participates in the retention of incorrectly folded proteins. Notably, it associates with partial T-cell antigen receptor complexes in immature thymocytes, suggesting a role in signaling and regulation of thymocyte maturation. Additionally, calnexin may be involved in receptor-mediated endocytosis at the synapse. Its interactions extend to various proteins, including MAPK3/ERK1, KCNH2, SERPINA2P/SERPINA2, SGIP1, PPIB, SMIM22, TMX2, TMEM35A/NACHO, CHRNA7, RETREG2, RETREG3, DNM1L, and ADAM7, highlighting its versatility in forming complexes and participating in diverse cellular processes. The palmitoylated form specifically interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins and emphasizing its role in protein maturation within the ER. Calnexin Protein, Mouse (HEK293, His) is the recombinant mouse-derived Calnexin protein, expressed by HEK293 , with C-His labeled tag. The total length of Calnexin Protein, Mouse (HEK293, His) is 482 a.a., with molecular weight of ~53.9 kDa.

HY-P7711

	Calnexin Protein, Human (HEK293, His) rHuCalnexin, His; Calnexin; IP90; Major Histocompatibility complex Class I Antigen-Binding Protein p88; CANX	Human	HEK293
	Calnexin Protein, Human (HEK293, His), a recombinant human Calnexin produced in HEK293 cells, has a His tag at the N-terminus. Calnexin is a 90 kDa type I endoplasmic reticulum (ER) membrane protein.

HY-P75990

	PSME1 Protein, Human (His) Proteasome activator complex subunit 1; REG-alpha; IGUP I-5111; PA28a; IFI5111	Human	E. coli
	The PSME1 protein is critical for immunoproteasome assembly and is essential for efficient antigen processing. As part of the PA28 activator complex, PSME1, together with PSME2, actively enhances the production of class I binding peptides by altering the cleavage pattern of the proteasome. PSME1 Protein, Human (His) is the recombinant human-derived PSME1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PSME1 Protein, Human (His) is 248 a.a., with molecular weight of ~29 kDa.

HY-P71667

	HLA-G Protein, Human (HEK293, His) B2 microglobulin; DADB-15K14.8; HLA 6.0; HLA class I histocompatibility antigen alpha chain G; Major histocompatibility complex class I G; MHC class I antigen; MHC class I antigen G; MHC G; T-cell A locus; TCA	Human	HEK293
	HLA-G is a nonclassical major histocompatibility class Ib molecule that is critical for immune regulation at the maternal-fetal interface. It cooperates with B2M to form a complex that selectively binds self-peptides to promote maternal-fetal tolerance by interacting with KIR2DL4, LILRB1, and LILRB2 receptors. HLA-G Protein, Human (HEK293, His) is the recombinant human-derived HLA-G protein, expressed by HEK293 , with N-His labeled tag. The total length of HLA-G Protein, Human (HEK293, His) is 314 a.a., with molecular weight of ~39.6 kDa.

HY-P72227

	HLA-G Protein, Human (His-SUMO) B2 microglobulin; DADB-15K14.8; HLA 6.0; HLA class I histocompatibility antigen alpha chain G; HLA class I histocompatibility antigen; alpha chain G; HLA class I molecule; HLA G; HLA G antigen; HLA G histocompatibility antigen class I G; HLA G3; HLA-G; HLA-G histocompatibility antigen; class I; HLA60; HLAG; HLAG_HUMAN; Major histocompatibility complex class I G; MHC class I antigen; MHC class I antigen G; MHC G; T-cell A locus; TCA	Human	E. coli
	HLA-G is a nonclassical major histocompatibility class Ib molecule that is critical for immune regulation at the maternal-fetal interface. It cooperates with B2M to form a complex that selectively binds self-peptides to promote maternal-fetal tolerance by interacting with KIR2DL4, LILRB1, and LILRB2 receptors. HLA-G Protein, Human (His-SUMO) is the recombinant human-derived HLA-G protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of HLA-G Protein, Human (His-SUMO) is 314 a.a., with molecular weight of ~51.6 kDa.

HY-P77753

	*HLA-A0201 GP100 Complex Protein, Human (HEK293, His-Avi)** HLA0201; MHC I; gp100; Glycoprotein 100; ME20-M; P100	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 GP100 Complex Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 GP100 Complex protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 GP100 Complex Protein, Human (HEK293, His-Avi), has molecular weight of 52-62 kDa.

HY-P77755

	*HLA-A0201 GP100 Complex Tetramer Protein, Human (HEK293, His-Avi)** HLA0201; MHC I; gp100; Glycoprotein 100; ME20-M; P100	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 GP100 Complex Tetramer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 GP100 Complex Tetramer protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 GP100 Complex Tetramer Protein, Human (HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P77754

	*HLA-A0201 GP100 Complex Protein, Human (Biotinylated, YLEPGPVTA, HEK293, His-Avi)** HLA0201; MHC I; gp100; Glycoprotein 100; ME20-M; P100	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 GP100 Complex Protein, Human (Biotinylated, YLEPGPVTA, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 GP100 Complex protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 GP100 Complex Protein, Human (Biotinylated, YLEPGPVTA, HEK293, His-Avi), has molecular weight of 52-62 kDa.

HY-P77769

	*HLA-A0201 Survivin Complex Protein, Human (HEK293, His-Avi)** Survivin; MHC; MHC I; BIRC5; API4; EPR-1; IAP4; survivin variant 3 alpha	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 Survivin Complex Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 Survivin Complex protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 Survivin Complex Protein, Human (HEK293, His-Avi), has molecular weight of 53-60 kDa.

HY-P72377

	*HLA-A0201 GP100 complex Protein, Human (Biotinylated, HEK293, Avi-His)** Beta-2-microglobulin; B2M; HLA class I histocompatibility antigen, A alpha chain; HLA-A	Human	HEK293
	B2M is a component of MHC class I complexes that present peptide antigens to the immune system. HLA-A0201 GP100 complex Protein, Human (Biotinylated, HEK293, Avi-His) is a recombinant protein dimer complex containing human-derived HLA-A0201 GP100 complex protein, expressed by HEK293 , with C-Avi, C-10His labeled tag. HLA-A0201 GP100 complex Protein, Human (Biotinylated, HEK293, Avi-His), has molecular weight of 55-60 kDa.

HY-P77770

	*HLA-A0201 Survivin Complex Tetramer Protein, Human (HEK293, His-Avi)** Survivin; MHC; MHC I; BIRC5; API4; EPR-1; IAP4; survivin variant 3 alpha	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 Survivin Complex Tetramer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 Survivin Complex Tetramer protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 Survivin Complex Tetramer Protein, Human (HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P700944

	*HLA-A0201 Survivin Complex Protein, Human (Biotinylated, LMLGEFLKL, HEK293, His-Avi)** Survivin; MHC; MHC I; BIRC5; API4; EPR-1; IAP4; survivin variant 3 alpha	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 Survivin Complex Protein, Human (Biotinylated, LMLGEFLKL, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 Survivin Complex protein, expressed by HEK293, with C-Avi, C-His labeled tag. HLA-A*0201 Survivin Complex Protein, Human (Biotinylated, LMLGEFLKL, HEK293, His-Avi), has molecular weight of 55-63 kDa.

HY-P77688

	*HLA-G Complex* Protein, Human (HEK293, His-Avi)** HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Human	HEK293
	HLA-G is a nonclassical major histocompatibility class Ib molecule that is critical for immune regulation at the maternal-fetal interface. It cooperates with B2M to form a complex that selectively binds self-peptides to promote maternal-fetal tolerance by interacting with KIR2DL4, LILRB1, and LILRB2 receptors. HLA-G Complex Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G Protein and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Protein, Human (HEK293, His-Avi), has molecular weight of 51-65 kDa.

HY-P77758

	*HLA-E0103 Complex Protein, Human (HEK293, His-Avi)** HLAE; sHLA-E; HLAE; MHC class I antigen E; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; MHC; QA1	Human	HEK293
	The HLA-E0103 complex is a nonclassical major histocompatibility class Ib molecule that is critical for immune self-non-self discrimination. It selectively binds the VL9 peptide from classical MHC class Ia molecules, forming a complex with B2M. HLA-E0103 Complex Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-E0103 and B2M/Beta-2-microglobulin Protein, expressed by HEK293* , with C-Avi, C-His labeled tag and VMAPRTLVL peptide. HLA-E*0103 Complex Protein, Human (HEK293, His-Avi), has molecular weight of 52-65 kDa.

HY-P700735

	*HLA-G Complex* Protein, Cynomolgus (HEK293, His-Avi)** HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Cynomolgus	HEK293
	HLA-A0201 WT-1 Complex Protein, a member of the MHC class I family, is crucial for immune function, presenting antigenic peptides to cytotoxic T lymphocytes. Associated with the HLA-A0201 allele, this protein contributes to immune surveillance and defense mechanisms. In antigen presentation, HLA-A0201 WT-1 Complex Protein aids in recognizing and eliminating abnormal or infected cells, emphasizing its significance in maintaining immune homeostasis. HLA-G Complex Protein, Cynomolgus (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G and B2M/Beta-2 microglobulin Protein, expressed by HEK293* , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Protein, Cynomolgus (HEK293, His-Avi), has molecular weight of 55-65 kDa.

HY-P77687

	*HLA-G Complex* Tetramer Protein, Cynomolgus (HEK293, His-Avi)** HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Cynomolgus	HEK293
	HLA-A0201 WT-1 Complex Protein, a member of the MHC class I family, is crucial for immune function, presenting antigenic peptides to cytotoxic T lymphocytes. Associated with the HLA-A0201 allele, this protein contributes to immune surveillance and defense mechanisms. In antigen presentation, HLA-A0201 WT-1 Complex Protein aids in recognizing and eliminating abnormal or infected cells, emphasizing its significance in maintaining immune homeostasis. HLA-G Complex Tetramer Protein, Cynomolgus (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G and B2M/Beta-2 microglobulin Protein, expressed by HEK293* , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Tetramer Protein, Cynomolgus (HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P77689

	*HLA-G Complex* Protein, Human (Biotinylated, HEK293, His-Avi)** HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Human	HEK293
	HLA-G, a non-classical major histocompatibility class Ib molecule, crucially regulates immunity at the maternal-fetal interface. Partnered with B2M, it forms a complex selectively binding self-peptides, fostering maternal-fetal tolerance through interactions with KIR2DL4, LILRB1, and LILRB2 receptors. Engagement triggers NK cell senescence, induces regulatory T cell differentiation, and balances tolerance and antiviral immunity. HLA-G actively contributes to immune modulation at the maternal-fetal interface, showcasing its multifaceted role in promoting fetal development while maintaining immune balance. HLA-G Complex Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G Protein and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 51-60 kDa.

HY-P77690

	*HLA-G Complex* Tetramer Protein, Human (HEK293, His-Avi)** HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Human	HEK293
	HLA-G, a non-classical major histocompatibility class Ib molecule, crucially regulates immunity at the maternal-fetal interface. Partnered with B2M, it forms a complex selectively binding self-peptides, fostering maternal-fetal tolerance through interactions with KIR2DL4, LILRB1, and LILRB2 receptors. Engagement triggers NK cell senescence, induces regulatory T cell differentiation, and balances tolerance and antiviral immunity. HLA-G actively contributes to immune modulation at the maternal-fetal interface, showcasing its multifaceted role in promoting fetal development while maintaining immune balance. HLA-G Complex Tetramer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G Protein and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Tetramer Protein, Human (HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P77750

	*HLA-A0201 MAGE-A4 Complex Protein, Human (HEK293, His-Avi)** HLA0201; MHC I; MAGE-A4; CT1.4; MAGE4A; MAGE4B; MAGE-X2; member 4	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 MAGE-A4 Complex Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 MAGE-A4 Complex protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 MAGE-A4 Complex Protein, Human (HEK293, His-Avi), has molecular weight of 52-60 kDa.

HY-P77759

	*HLA-E0103 Complex Protein, Human (Biotinylated, HEK293, His-Avi)** HLAE; sHLA-E; HLAE; MHC class I antigen E; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; MHC; QA1	Human	HEK293
	The HLA-E0103 Complex, a non-classical major histocompatibility class Ib molecule, is crucial for immune self-nonself discrimination. It selectively binds VL9 peptides from classical MHC class Ia molecules, forming a complex with B2M. This complex acts as a ligand for KLRD1-KLRC1 on NK cells, facilitating immune monitoring. Under stress, HLA-E0103 binds stress-induced chaperone peptides and HLA-G peptides, influencing NK cell activation and contributing to adaptive NK cell functions during pregnancy. Additionally, it presents pathogen-derived peptides to CD8-positive T cells, triggering an antimicrobial immune response. HLA-E0103 Complex Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-E0103 and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-His, C-Avi labeled tag and VMAPRTLVL peptide. HLA-E*0103 Complex Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 52-60 kDa.

HY-P77760

	*HLA-E0103 Complex Tetramer Protein, Human (HEK293, His-Avi)** HLAE; sHLA-E; HLAE; MHC class I antigen E; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; MHC; QA1	Human	HEK293
	The HLA-E0103 complex is a nonclassical major histocompatibility class Ib molecule that is critical for immune self-non-self discrimination. It selectively binds the VL9 peptide from classical MHC class Ia molecules, forming a complex with B2M. HLA-E0103 Complex Tetramer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-E0103 and B2M/Beta-2-microglobulin Protein, expressed by HEK293* , with C-Avi, C-His labeled tag and VMAPRTLVL peptide. HLA-E*0103 Complex Tetramer Protein, Human (HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P77691

	*HLA-G Complex* Tetramer Protein, Human (Biotinylated, HEK293, His-Avi)** HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Human	HEK293
	HLA-G, a non-classical major histocompatibility class Ib molecule, crucially regulates immunity at the maternal-fetal interface. Partnered with B2M, it forms a complex selectively binding self-peptides, fostering maternal-fetal tolerance through interactions with KIR2DL4, LILRB1, and LILRB2 receptors. Engagement triggers NK cell senescence, induces regulatory T cell differentiation, and balances tolerance and antiviral immunity. HLA-G actively contributes to immune modulation at the maternal-fetal interface, showcasing its multifaceted role in promoting fetal development while maintaining immune balance. HLA-G Complex Tetramer Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G Protein and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Tetramer Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P77692

	*HLA-G Complex* Tetramer Protein, Rhesus Macaque (HEK293, His-Avi)** HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Rhesus Macaque	HEK293
	The HLA-G, part of the MHC class I family, is pivotal in immune regulation by presenting antigens to cytotoxic T cells and natural killer cells. Distinct from other MHC class I molecules, it shows limited polymorphism and tissue-specific expression, including in immune-privileged sites and the placenta. Linked to immune tolerance, its expression guards against excessive immune responses. Investigating HLA-G mechanisms offers insights into immune-related disorders and potential therapeutic strategies for immune response modulation. HLA-G Complex Tetramer Protein, Rhesus Macaque (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G and B2M/Beta-2 microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Tetramer Protein, Rhesus Macaque (HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P77751

	*HLA-A0201 MAGE-A4 Complex Protein, Human (Biotinylated, HEK293, His-Avi)** HLA0201; MHC I; MAGE-A4; CT1.4; MAGE4A; MAGE4B; MAGE-X2; member 4	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 MAGE-A4 Complex Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 MAGE-A4 Complex protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 MAGE-A4 Complex Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 52-60 kDa.

HY-P77752

	*HLA-A0201 MAGE-A4 Complex Tetramer Protein, Human (HEK293, His-Avi)** HLA0201; MHC I; MAGE-A4; CT1.4; MAGE4A; MAGE4B; MAGE-X2; member 4	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 MAGE-A4 Complex Tetramer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 MAGE-A4 Complex Tetramer protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 MAGE-A4 Complex Tetramer Protein, Human (HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P77761

	*HLA-E0103 Complex Tetramer Protein, Human (Biotinylated, HEK293, His-Avi)** HLAE; sHLA-E; HLAE; MHC class I antigen E; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; MHC; QA1	Human	HEK293
	The HLA-E0103 Complex, a non-classical major histocompatibility class Ib molecule, is crucial for immune self-nonself discrimination. It selectively binds VL9 peptides from classical MHC class Ia molecules, forming a complex with B2M. This complex acts as a ligand for KLRD1-KLRC1 on NK cells, facilitating immune monitoring. Under stress, HLA-E0103 binds stress-induced chaperone peptides and HLA-G peptides, influencing NK cell activation and contributing to adaptive NK cell functions during pregnancy. Additionally, it presents pathogen-derived peptides to CD8-positive T cells, triggering an antimicrobial immune response. HLA-E0103 Complex Tetramer Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-E0103 and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and VMAPRTLVL peptide. HLA-E*0103 Complex Tetramer Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P701002

	*PE-Labeled HLA-G Complex* Tetramer Protein, Human (HEK293, His-Avi)** HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G	Human	HEK293
	HLA-G is a nonclassical major histocompatibility class Ib molecule that is critical for immune regulation at the maternal-fetal interface. It cooperates with B2M to form a complex that selectively binds self-peptides to promote maternal-fetal tolerance by interacting with KIR2DL4, LILRB1, and LILRB2 receptors. PE-Labeled HLA-G Complex Tetramer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G Protein and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. PE-Labeled HLA-G Complex Tetramer Protein, Human (HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P700910

HLA-A*2402 GP100 Intron 4 Complex Protein, Human (VYFFLPDHL, HEK293, His-Avi)

HLA-A*24:02; HLA-A2402; MHC I; gp100; Glycoprotein 100; ME20-M; P100; GP100 Intron 4; Intron 4
Human HEK293

HY-P700909

	*HLA-A2402 GP100 Intron 4 Complex Protein, Human (Biotinylated, VYFFLPDHL, HEK293, His-Avi)** HLA-A*24:02; HLA-A2402; MHC I; gp100; Glycoprotein 100; ME20-M; P100; GP100 Intron 4; Intron 4	Human	HEK293

Cat. No.	Product Name	Chemical Structure

HY-16562S1

Irinotecan-d10 hydrochloride
Irinotecan-d₁₀ (hydrochloride) is the deuterium labeled Irinotecan. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1][2].

HY-W008719S

MPP+-d3(iodide)

MPP+-d₃ (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].

HY-16562S

Irinotecan-d10
Irinotecan-d₁₀ is a deuterium labeled Irinotecan ((+)-Irinotecan). Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1].

HY-B0817S

Pyridaben-d13

Pyridaben-d₁₃ is the deuterium labeled Pyridaben[1]. Pyridaben is a mitochondrial electron transport inhibitor (METI) acaricide that promotes the formation of damaging oxygen and nitrogen radicals. Pyridaben selectively inhibits complex I (NADH dehydrogenase) with an IC50 value of 2.4 nM (assay sites: rat liver and bovine heart mitochondria). Pyridaben also significantly inhibits rat mitochondrial mtNOS function[2][3].

HY-13295S

Vinpocetine-d5

Vinpocetine-d₅ is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders[1][2][3].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80578

	Calnexin Antibody CANX; Calnexin; IP90; Major histocompatibility complex class I antigen-binding protein p88; p90	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Calnexin Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 68 kDa, targeting to Calnexin. It can be used for WB,IHC-F,IHC-P,ICC/IF,ELISA assays with tag free, in the background of Human, Mouse, Rat.

HY-P82790

NDUFS1 Antibody (YA2535)

NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit; mitochondrial; complex I-75kD; CI-75kD
WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

HY-P81585

	NDUFB10 Antibody (YA1330) NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10; complex I-PDSW; CI-PDSW; NADH-ubiquinone oxidoreductase PDSW subunit	WB, IHC-F, IHC-P, ICC/IF, IP	Human

HY-P81601

	NDUFS3 Antibody (YA1346) NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3; mitochondrial; complex I-30kD; CI-30kD; NADH-ubiquinone oxidoreductase 30 kDa subunit	WB	Human, Mouse

HY-P81595

	NDUFB9 Antibody (YA1340) NDUFB9; LYRM3; UQOR22; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; complex I-B22; CI-B22; LYR motif-containing protein 3; NADH-ubiquinone oxidoreductase B22 subunit	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

HY-P80924

	TSG101 Antibody TSG101; Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	TSG101 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 44 kDa, targeting to TSG101. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P80718

	IKB alpha Antibody NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3	WB, IHC-P, IP	Human, Mouse, Rat
	IKB alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to IKB alpha. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80827

	Phospho-IKB alpha (Ser36) Antibody NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3	WB	Human, Mouse
	Phospho-IKB alpha (Ser36) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to Phospho-IKB alpha (Ser36). It can be used for WB assays with tag free, in the background of Human, Mouse.

HY-P80826

	Phospho-IKB alpha (Ser32) Antibody (YA185) NFKBIA; IKBA; MAD3; NFKBI; NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3	WB, IP	Human, Mouse
	Phospho-IKB alpha (Ser32) Antibody (YA185) is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to Phospho-IKB alpha (Ser32). It can be used for WB,IP assays with tag free, in the background of Human, Mouse.

HY-P80876

	Proteasome beta 8 Antibody (YA684) PSMB8; LMP7; PSMB5i; RING10; Y2; Proteasome subunit beta type-8; Low molecular mass protein 7; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; Proteasome component C13; Proteasome subunit beta-5i; Really interesting	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	Proteasome beta 8 Antibody (YA684) is a non-conjugated and Mouse origined monoclonal antibody about 30 kDa, targeting to Proteasome beta 8 (3G3). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Rat.

HY-P80878

	Pyruvate Dehydrogenase E1 alpha Antibody (YA681) mitochondrial; ODPA_HUMAN; PDH; PDHA; PDHA1; PDHCE1A; PDHE1 A type I; PDHE1-A type I; PHE1A; Pyruvate Dehydrogenase (lipoamide) alpha 1; Pyruvate dehydrogenase complex; E1 alpha polypeptide 1; Pyruvate Dehydrogenase E1 alpha; Pyruvate dehydrogenase E1 com	WB, ICC/IF	Human, Mouse
	Pyruvate Dehydrogenase E1 alpha Antibody (YA681) is a non-conjugated and Mouse origined monoclonal antibody about 43 kDa, targeting to Pyruvate Dehydrogenase E1 alpha (3H2). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Mouse.

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