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Results for "

miR-34a

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MicroRNA (17)
By Research Areas:	Cancer (5)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119833

Rubone	MicroRNA	Cancer
Rubone, a chalcone analog, is a modulator of *miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhances the anticancer effect of Paclitaxel (PTX; HY-B0015) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34*a downstream targets .

HY-R00713

*hsa-miR-34a-3p mimic*	MicroRNA	Cancer
hsa-miR-34a-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-34a-3p mimic hsa-miR-34a-3p mimic

HY-R00714

*hsa-miR-34a-5p mimic*	MicroRNA	Cancer
hsa-miR-34a-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-34a-5p mimic hsa-miR-34a-5p mimic

HY-R03076

*mmu-miR-34a-3p mimic*	MicroRNA	Cancer
mmu-miR-34a-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-34a-3p mimic mmu-miR-34a-3p mimic

HY-R04374

*rno-miR-34a-3p mimic*	MicroRNA	Cancer
rno-miR-34a-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

rno-miR-34a-3p mimic rno-miR-34a-3p mimic

HY-R00713A

*hsa-miR-34a-3p agomir*	MicroRNA
hsa-miR-34a-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-34a-3p agomir hsa-miR-34a-3p agomir

HY-R00714A

*hsa-miR-34a-5p agomir*	MicroRNA
hsa-miR-34a-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-34a-5p agomir hsa-miR-34a-5p agomir

HY-R03076A

*mmu-miR-34a-3p agomir*	MicroRNA
mmu-miR-34a-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-34a-3p agomir mmu-miR-34a-3p agomir

HY-R04374A

*rno-miR-34a-3p agomir*	MicroRNA
rno-miR-34a-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

rno-miR-34a-3p agomir rno-miR-34a-3p agomir

HY-RI00713

*hsa-miR-34a-3p inhibitor*	MicroRNA
hsa-miR-34a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-34a-3p inhibitor hsa-miR-34a-3p inhibitor

HY-RI00714

*hsa-miR-34a-5p inhibitor*	MicroRNA
hsa-miR-34a-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-34a-5p inhibitor hsa-miR-34a-5p inhibitor

HY-RI03076

*mmu-miR-34a-3p inhibitor*	MicroRNA
mmu-miR-34a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-34a-3p inhibitor mmu-miR-34a-3p inhibitor

HY-RI04374

*rno-miR-34a-3p inhibitor*	MicroRNA
rno-miR-34a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

rno-miR-34a-3p inhibitor rno-miR-34a-3p inhibitor

HY-RI00713A

*hsa-miR-34a-3p antagomir*	MicroRNA
hsa-miR-34a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-34a-3p antagomir hsa-miR-34a-3p antagomir

HY-RI00714A

*hsa-miR-34a-5p antagomir*	MicroRNA
hsa-miR-34a-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-34a-5p antagomir hsa-miR-34a-5p antagomir

HY-RI04374A

*rno-miR-34a-3p antagomir*	MicroRNA
rno-miR-34a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

rno-miR-34a-3p antagomir rno-miR-34a-3p antagomir

HY-RI03076A

*mmu-miR-34a-3p antagomir*	MicroRNA
mmu-miR-34a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-34a-3p antagomir mmu-miR-34a-3p antagomir

Rubone	Structural Classification Chalcones Flavonoids Leguminosae Source classification Plants Brachypterum robustum (Roxburgh ex Candolle) Dalzell & Gibson	MicroRNA
Rubone, a chalcone analog, is a modulator of *miR-34a. Rubone upregulates miR-34a expression in a p53 dependent manner, downregulates the downstream target Bcl-2 and Cyclin D1 expression, and suppresses hepatocellular carcinoma (HCC) growth in vivo. Rubone enhances the anticancer effect of Paclitaxel (PTX; HY-B0015) in PTX-resistant prostate cancer cell lines by reversing the expression of miR-34*a downstream targets .

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miR-34a

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