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Results for "

pentacyclic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (1) Antibiotic (3) Apoptosis (8) Autophagy (3) Bacterial (4) Caspase (1) COX (1) Endogenous Metabolite (5) ERK (1) Fungal (1) GSK-3 (1) HIV (1) HSP (1) Keap1-Nrf2 (1) Leukotriene Receptor (1) Lipoxygenase (1) Mitophagy (1) NF-κB (2) p38 MAPK (1) Parasite (2) Reactive Oxygen Species (1) Somatostatin Receptor (1) Topoisomerase (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (1) Endocrinology (1) Infection (6) Inflammation/Immunology (17) Metabolic Disease (3) Neurological Disease (6)

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Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N8879

Wilforol A (-)-Wilforol A	Others	Metabolic Disease
Wilforol A ((-)-Wilforol A), plant metabolite, is a pentacyclic triterpenoid. Wilforol A can be used for the research of various biochemical studies .

HY-N6255

Ilexgenin A	Others	Inflammation/Immunology Cancer
Ilexgenin A is a pentacyclic triterpenoid, which extracted from Ilex hainanensis Merr. Ilexgenin A can be used for the research of inflammation and cancer .

HY-N6601

Pomolic acid Randialic acid A	Apoptosis	Cancer
Randialic acid A (Pomolic acid) is a pentacyclic triterpene isolated from Euscaphis japonica (Tunb.). Randialic acid A (Pomolic acid) inhibits tumor cells growth and induces cell apoptosis. Randialic acid A (Pomolic acid) has a potential for the treatment of prostate cancer (PC) .

HY-145869

Anti-inflammatory agent 12	Others	Inflammation/Immunology
Anti-inflammatory agent 12 (Compound 2) is a pentacyclic triterpene compound. Anti-inflammatory agent 12 shows a significant bias in the LPS-induced inflammatory response with an IIC₅₀ value of 2.22 μM. Anti-inflammatory agent 12 has the potential for the research of inflammation disease .

HY-128366

Waltonitone	Apoptosis	Cancer
Waltonitone is a ursane-type pentacyclic triterpene isolated from Gentian waltonii Burkill. Waltonitone significantly inhibits hepatocellular carcinoma cells growth and induces apoptosis in vitro and in vivo .

HY-N8423

α-Amyrin 1 Publications Verification	ERK GSK-3	Neurological Disease Metabolic Disease
α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can be used in the study of metabolic syndrome induced by high fructose diet and cognitive dysfunction caused by low cholinergic neurotransmission .

HY-145870

Anti-inflammatory agent 13	Others	Inflammation/Immunology
Anti-inflammatory agent 13 (Compound 3) is a pentacyclic triterpene compound. Anti-inflammatory agent 13 exhibits a considerable inhibitory effect on inflammation models. Anti-inflammatory agent 13 has the potential for the research of either DAMPs or PAMPs triggered inflammation .

HY-N7652

Terminolic acid	Bacterial	Infection Inflammation/Immunology
Terminolic acid is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum. Terminolic acid can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. Terminolic acid also exhibits moderate antibacterial activity .

HY-125344

Fusarisetin A

Endogenous Metabolite Infection

Fusarisetin A, a pentacyclic fungal metabolite, is an acinar morphogenesis inhibitor .
HY-N8781

Tetrahymanol

Others Others

Tetrahymanol is a pentacyclic triterpenoid that can be found in Tetrahymena pyriformis .
HY-N6983

Licoricesaponin G2

Others Cancer

Licoricesaponin G2 is a pentacyclic triterpenoid isolated from Glycyrrhiza aspera .
HY-N4165

Arnidiol

Others Others

Arnidiol is a pentacyclic triterpene isolated from Barleria Longiflora Linn F. .
HY-128470

Mitoquidone

GR-30921
Others Cancer

Mitoquidone (GR-30921), a pentacyclic pyrroloquinone, is a potent anticancer agent .

Fusarisetin A	Endogenous Metabolite	Infection
Fusarisetin A, a pentacyclic fungal metabolite, is an acinar morphogenesis inhibitor .

Tetrahymanol	Others	Others
Tetrahymanol is a pentacyclic triterpenoid that can be found in Tetrahymena pyriformis .

Licoricesaponin G2	Others	Cancer
Licoricesaponin G2 is a pentacyclic triterpenoid isolated from Glycyrrhiza aspera .

Arnidiol	Others	Others
Arnidiol is a pentacyclic triterpene isolated from Barleria Longiflora Linn F. .

Mitoquidone GR-30921	Others	Cancer
Mitoquidone (GR-30921), a pentacyclic pyrroloquinone, is a potent anticancer agent .

HY-N0271

Echinocystic acid 1 Publications Verification	Reactive Oxygen Species Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Echinocystic acid is a natural pentacyclic triterpene with potent antioxidant, anti-inflammatory and analgesic activities .

HY-N10449

Resistomycin

Antibiotic Apoptosis Bacterial Cancer

Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis .
HY-N12190

Centellasaponin A

Others Others

Centellasaponin A (compound 10) is a pentacyclic triterpene saponin isolated from the methanolic extract of Centella asiatica .

Resistomycin	Antibiotic Apoptosis Bacterial	Cancer
Resistomycin, a pentacyclic polyketide antibiotic, possesses anticancer activity and induces apoptosis .

Centellasaponin A	Others	Others
Centellasaponin A (compound 10) is a pentacyclic triterpene saponin isolated from the methanolic extract of Centella asiatica .

HY-N0140

Ursolic acid 5+ Cited Publications Prunol; Urson; Malol	Autophagy Endogenous Metabolite	Cancer
Ursolic acid (Prunol) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy.

HY-N1037

δ-Amyrenone

Delta-Amyrone
Others Inflammation/Immunology

δ-Amyrenone (Delta-Amyrone) is a pentacyclic triterpene compound from S. lineare, with anti-inflammatory effects .

δ-Amyrenone Delta-Amyrone	Others	Inflammation/Immunology
δ-Amyrenone (Delta-Amyrone) is a pentacyclic triterpene compound from S. lineare, with anti-inflammatory effects .

HY-N1178

Taraxasterol	Others	Inflammation/Immunology
Taraxasterol is a pentacyclic triterpenoid isolated from Taraxacum mongolicum. Taraxasterol has a role as a metabolite and an anti-inflammatory agent .

HY-N6946

Mitraphylline	Others	Inflammation/Immunology
Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils .

HY-N1827

3-epi-Maslinic acid

Others Others

3-epi-Maslinic acid is an acidic pentacyclic triterpene isolated from Hexane and dichloromethane extracts of Platostoma africanum P. Beauv .

3-epi-Maslinic acid	Others	Others
3-epi-Maslinic acid is an acidic pentacyclic triterpene isolated from Hexane and dichloromethane extracts of Platostoma africanum P. Beauv .

HY-N3227

Myricadiol	Others	Cancer
Myricadiol, a pentacyclic triterpenoid compound, is a potential lead compound for anticancer agent. Myricadiol can be isolated from Scaevola spinescens R. Br. (Goodeniaceae) .

HY-N3866

Esculentic acid	COX	Inflammation/Immunology
Esculentic acid is a selective COX-2 inhibitor and has anti-inflammatory effect. Esculentic acid is a pentacyclic triterpenoid that can be extracted from the Chinese herb Phytolacca esculenta .

HY-119784

Eupenifeldin	Others	Cancer
Eupenifeldin is pentacyclic bistropolone isolated from cultures of Eupenicillium brefeldianum ATCC 74184. Eupenifeldin is cytotoxic against the HCT-116 cell line. Eupenifeldin has the potential for the research of leukemia .

HY-N0568

Madecassoside Asiaticoside A	Endogenous Metabolite Apoptosis Autophagy Keap1-Nrf2 p38 MAPK Caspase	Cardiovascular Disease Others Neurological Disease Inflammation/Immunology Endocrinology Cancer
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB ^[5][6], exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity . Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.

HY-10529

Betulinic acid Maximum Cited Publications 22 Publications Verification Lupatic acid; Betulic acid	Apoptosis Topoisomerase HIV Autophagy Mitophagy NF-κB Endogenous Metabolite Parasite	Infection Inflammation/Immunology Cancer
Betulinic acid is a natural pentacyclic triterpenoid, acts as a eukaryotic topoisomerase I inhibitor, with an IC₅₀ of 5 μM, and possesses anti-HIV, anti-malarial, anti-inflammatory and anti-tumor properties .

HY-N6850

Calenduloside E 1 Publications Verification	HSP Endogenous Metabolite
Calenduloside E (CE) is a natural pentacyclic triterpenoid saponin extracted from Aralia elata. Calenduloside E (CE) has anti-apoptotic potent by targeting heat shock protein 90 (Hsp90) .

HY-N1508

Ecliptasaponin A	Others	Inflammation/Immunology
Ecliptasaponin A , a pentacyclic triterpenoid saponin, is one of major compounds separated from Eclipta prostrate . Eclipta prostrate is considered as a nourishing herbal medicine with pleiotropic effects, including anti-inflammatory, hepatoprotective, antioxidant, and immunomodulatory .

HY-N1178R

Taraxasterol (Standard)	Others	Inflammation/Immunology
Taraxasterol (Standard) is the analytical standard of Taraxasterol. This product is intended for research and analytical applications. Taraxasterol is a pentacyclic triterpenoid isolated from Taraxacum mongolicum. Taraxasterol has a role as a metabolite and an anti-inflammatory agent .

HY-N12225

Isoasiaticoside	Others	Neurological Disease
Isoasiaticoside is a pentacyclic triterpene saponin that can be isolated from Centella asiatica. Isoasiaticoside has potential neuroprotective effects in the 6-OHDA (HY-B1081)-induced PC12 cell model .

HY-N0611

alpha-Boswellic acid α-Boswellic acid	Others	Neurological Disease Inflammation/Immunology Cancer
alpha-Boswellic acid (α-Boswellic acid) is an orally active pentacyclic triterpenoid compound that can be extracted from frankincense. alpha-Boswellic acid has anti-inflammatory and antitumor activities. alpha-Boswellic acid can be used in Alzheimer's disease (AD) research .

HY-N0790

Lupeol 3 Publications Verification Clerodol; Monogynol B; Fagarasterol	Androgen Receptor Apoptosis	Cancer
Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent androgen receptor (AR) inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC) .

HY-N12195

Cytochalasin R	Fungal	Infection
Cytochalasin R (compound 17) is a cytochalasin analogue that can be isolated from the endophytic fungus Phomopsis sp. xz-18. Cytochalasin R shows potential antifungal activity .

HY-N2056

11-Keto-beta-boswellic acid 11-Keto-β-boswellic acid	Lipoxygenase Leukotriene Receptor NF-κB	Metabolic Disease Cancer
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production .

HY-P10027

Clovibactin	Antibiotic Bacterial	Infection
Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

HY-P10027A

Clovibactin TFA	Antibiotic Bacterial	Infection
Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

HY-P1206

CH 275	Somatostatin Receptor	Neurological Disease
CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst₁) with a K_i of 52 nM . CH 275 acts as a potent and selective sst₁ agonist (IC₅₀=30.9 nM) and also displays IC₅₀ values of 345 nM, >1 μM, >10 μM, >10 μM for human sst₃, sst₄, sst₂ and sst₅, respectively . CH 275 can be used for the research of alzheimer’s disease .

HY-N0194

Asiatic acid 2 Publications Verification	Apoptosis Parasite	Inflammation/Immunology Cancer
Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model .

HY-143456

Anti-inflammatory agent 18	Others	Inflammation/Immunology
Anti-inflammatory agent 18 (compound 3b) shows NO inhibitory activity, with an IC₅₀ of 15.94 μM. Anti-inflammatory agent 18 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 18 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc .

HY-143457

Anti-inflammatory agent 19	Others	Inflammation/Immunology
Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC₅₀ of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc .

Clovibactin TFA	Antibiotic Bacterial	Infection
Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

Cyclic nona-L-arginine hydrochloride	Peptides	Others
Cyclic nona-L-arginine hydrochloride, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

Cyclic nona-L-arginine TFA	Peptides	Others
Cyclic nona-L-arginine TFA, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .

Cyclic PSAP peptide	Peptides	Cancer
Cyclic PSAP peptide is a cyclic pentapeptide (DWLPK). Cyclic PSAP peptide exhibits agent-like properties and could inhibit metastatic spread and restrain tumor development in general in vivo .

Clovibactin	Antibiotic Bacterial	Infection
Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .

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pentacyclic

Inhibitors & Agonists

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