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Results for "

sialic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Biochemical Assay Reagents (2) Endogenous Metabolite (13) Glycosyltransferase (1) Influenza Virus (3) Sialyltransferase (2)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (3) Metabolic Disease (9) Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112942A

*CMP-Sialic* acid sodium salt** CMP-Neu5Ac sodium salt	Endogenous Metabolite	Metabolic Disease
CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

HY-E70024

*CMP-sialic* acid synthetase (NmCSS)**	Sialyltransferase	Others
CMP-sialic acid synthetase (NmCSS) is an essential enzyme involved in the biosynthesis of carbohydrates and glycoconjugates containing sialic acids. CMP-sialic acid synthetase (NmCSS) activates free Sia, converting it to CMP-Sia, which is the only donor substrate for all sialyltransferases .

HY-P2977

N-Acetylneuraminate lyase (CgNal) sialic acid aldolase (CgNal)	Endogenous Metabolite	Others
N-Acetylneuraminate lyase (CgNal) (Sialic acid aldolase (CgNal)) is a class I aldolase, is often used in biochemical studies. N-Acetylneuraminate lyase (CgNal) catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac) .

HY-112942

*CMP-Sialic* acid** CMP-Neu5Ac	Endogenous Metabolite	Metabolic Disease
CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

HY-160821A

N-Acetylmannosamine 6-phosphate sodium salt ManNAc-6P sodium salt	Endogenous Metabolite	Others
N-Acetylmannosamine 6-phosphate sodium salt is a metabolic intermediate in the breakdown of sialic acid (Neu5Ac) by Staphylococcus aureus. N-Acetylmannosamine 6-phosphate sodium salt reduces the binding ability of transcriptional regulator NanR to DNA, and thus regulates the metabolic pathway of sialic acid .

HY-P2988A

α2-3,6 Neuraminidase, Bifidobacterium infantis	Others	Metabolic Disease
α2-3,6 Neuraminidase, Bifidobacterium infantis is a highly specific exoglycosidase that catalyzes the hydrolysis of non-reducing terminal α2-3 and α2-6 unbranched sialic acid residues from complex carbohydrates and glycoproteins. α2-3,6 Neuraminidase does not exhibit activity on α2-8 or branched sialic acids .

HY-147168

Biocytin hydrazide

Others Metabolic Disease

Biocytin hydrazide is a selective label for sialic acids, galactose, and other sugars in glycoconjugates using avidin-biotin technology .

Biocytin hydrazide	Others	Metabolic Disease
Biocytin hydrazide is a selective label for sialic acids, galactose, and other sugars in glycoconjugates using avidin-biotin technology .

HY-E70073

Ganglioside sialidase (AuSialidase M2) Sialidase isoenzyme M2; AuSialidase M2	Others	Others
Ganglioside sialidase (AuSialidase M2) from Arthrobacter ureafaciens. Ganglioside sialidase is a highly specific N-acetylneuraminidase. Ganglioside sialidase can hydrolyze the internal sialic acid of GM1 under optimal condition with sodium cholate .

HY-161160

Ac4ManNDAz	Others	Others
Ac4ManNDAz is a cell-permeable photocross-linking probe. Ac4ManNDAz can effectively compete with endogenous sialic acid for incorporation into cell surface glycoproteins and form cross-links with glycoprotein ligands under UV light irradiation. Ac4ManNDAz can be used to study interactions between glycoproteins .

HY-110288

3FAx-Neu5Ac	Sialyltransferase	Metabolic Disease
3FAx-Neu5Ac (compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X on myeloid cells .

HY-I0400

N-Acetylneuraminic acid 2 Publications Verification NANA; Lactaminic acid	Influenza Virus Endogenous Metabolite	Cardiovascular Disease
N-Acetylneuraminic acid is a nine-carbon, sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells.

HY-128965

N-Glycolylneuraminic acid NeuGc; GcNeu	Influenza Virus Endogenous Metabolite	Inflammation/Immunology
N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs) .

HY-D0871

CHES N-Cyclohexyltaurine	Biochemical Assay Reagents	Others
CHES (N-Cyclohexyltaurine) is a zwitterionic buffer. CHES can bind to hemagglutinin (HA) emulating with sialic acid (SA) and receptor binding site (RBS)-targeting broadly neutralizing antibodies .

HY-N12756

9-O-Acetylneuraminic acid Neu5,9Ac2	Endogenous Metabolite	Others
9-O-Acetylneuraminic acid (Neu5,9Ac2) is an endogenous metabolite and can bind to lectins and effectively inhibit hemagglutination .

HY-P2988B

Neuraminidase, arthrobacter ureafaciens	Others	Infection
Neuraminidase, arthrobacter ureafaciens is an exosialidase which cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase can facilitate virus release from infected cells .

HY-E70298

ST3 β-Gal α-2,3-Sialyltransferase 1 ST3GAL1	Endogenous Metabolite	Cancer
ST3 β-Gal α-2,3-Sialyltransferase 1 (ST3GAL1) is a sialyltransferase whose overexpression in ovarian cancer cell lines enhances cell growth, migration, and invasion capabilities, as well as increases tumorigenicity and resistance to paclitaxel in vivo. ST3 β-Gal α-2,3-Sialyltransferase 1 catalyzes the transfer of sialic acid from cytidine monophosphate-sialic acid to galactose-containing substrates and can be utilized in studies of cancer progression and chemotherapy resistance .

HY-154790

STn/sialyl-Tn Neu5Aca2-6GalNAc-a-Ser/Thr	Others	Cancer
STn/sialyl-Tn is a sialic acid associated with breast cancer and its expression is closely related to HER2-pos. STn/sialyl-Tn can be used as a marker to count cells in malignant nipple discharge (PND) .

HY-128965R

N-Glycolylneuraminic acid (Standard) NeuGc (Standard); GcNeu (Standard)	Influenza Virus Endogenous Metabolite	Inflammation/Immunology
N-Glycolylneuraminic acid (Standard) is the analytical standard of N-Glycolylneuraminic acid. This product is intended for research and analytical applications. N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs) .

HY-P2988

Neuraminidase, Microorganism Exo-α-sialidase	Endogenous Metabolite	Infection
Neuraminidase, Microorganism (Exo-α-sialidase) is an exosialidase, is often used in biochemical studies. Neuraminidase cleaves α-ketosidic linkage between the sialic (N-acetylneuraminic) acid and an adjacent sugar residue. Neuraminidase, derived from mucosal pathogens, is a virulence factor that modifies the host's response to infection .

HY-E70062

α-2,3-Sialyltransferase, pasteurella multocida Fh8-PmST3	Endogenous Metabolite	Metabolic Disease
alpha-2,3-Sialyltransferase (PmST3) (EC 2.4.99.4) is a beta-galactoside. alpha-2,3-Sialyltransferase (PmST3) catalyzes the transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids .

HY-P99371

Lirentelimab AK002; Anti-Siglec-8 Reference Antibody (lirentelimab)	Apoptosis	Inflammation/Immunology
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .

HY-E70039

alpha-2-3,6,8-Sialidosidase (SpNanA)	Others	Others
alpha-2-3,6,8-Sialidosidase (SpNanA) catalyses hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates .

HY-E70063

alpha-2,3-Sialyltransferase (Phα2,3SiaT)	Endogenous Metabolite	Metabolic Disease
alpha-2,3-Sialyltransferase (Phα2,3SiaT) is a beta-galactoside. alpha-2,3-Sialyltransferase (Phα2,3SiaT) catalyzes the transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids .

HY-W747597

Ganglioside GD1b Disodium Salt (Bovine Brain) Disialoganglioside GD1b; Ganglioside C1; Ganglioside G2	Endogenous Metabolite	Cardiovascular Disease
Ganglioside GD1b is an acidic glycosphingolipid that contains two sialic acid residues linked to an inner galactose unit. It is a component of plasma membranes where it packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events. The concentration of ganglioside GD1b in human brain increases with age, constituting 7.85% of total sialic acid in the brain of 0- to 10-year-old subjects and 20.29% in 11- to 30-year-old subjects.2 Ganglioside GD1b levels are positively correlated with pilocytic astrocytoma tumor grade, and GD1b has been detected in various other gliomas, including primitive neuroectodermal tumors, glioblastomas, and anaplastic astrocytomas.3 This product contains ganglioside GD1b molecular species with primarily C18:0 fatty acyl chain lengths.

HY-E70132

Endo-β-N-acetylglucosaminidase D Endo D	Others	Metabolic Disease
Endo-β-N-acetylglucosaminidase D (Endo D), isolated from Streptococcus pneumoniae. Endo-β-N-acetylglucosaminidase D hydrolyzes Fc N-glycan of intact IgG antibodies after sequential removal of the sialic acid, galactose, and internal GlcNAc residues in the N-glycan. Endo-β-N-acetylglucosaminidase D possesses transglycosylation activity with sugar oxazoline as the donor substrate .

HY-E70097

Sialidase (α2-3-6-8-9)	Others	Others
Sialidase (α2-3-6-8-9) is a broadly specific sialidase that cuts linear and branched non-reducing terminal sialic acid residues from glycoproteins, glycopeptides, and oligosaccharides. Sialidase (α2-3-6-8-9) can be used for in vitro and in vivo polysaccharide analysis and characterization as well as complete glycoprotein remodeling .

HY-E70287

ST6 Sialyltransferase 5 ST6GALNAC5	Glycosyltransferase	Metabolic Disease
ST6 Sialyltransferase 5 (EC:2.4.3.3, ST6GALNAC5, SIAT7E, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5) transfers a sialic acid to N-acetylgalactosamine (GalNAc) residues. ST6 Sialyltransferase 5 is a bio-marker in cervical screening samples .

HY-145533

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid KDN	Others	Others
3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) is a sialic acid. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid protects the oligo/(poly)sialyl chains from exosialidases at nonreducing terminal, and plays a role in egg activation of salmonid fish . 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid is abundant in fetal cord red blood cells and malignant human ovarian cancer cells .

HY-W127461

Ganglioside GM2, Asialo Gangliotriosylceramide	Biochemical Assay Reagents	Others
Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

CHES N-Cyclohexyltaurine	Dyes
CHES (N-Cyclohexyltaurine) is a zwitterionic buffer. CHES can bind to hemagglutinin (HA) emulating with sialic acid (SA) and receptor binding site (RBS)-targeting broadly neutralizing antibodies .

Cat. No.	Product Name	Type

HY-D0871

CHES N-Cyclohexyltaurine	Dyes
CHES (N-Cyclohexyltaurine) is a zwitterionic buffer. CHES can bind to hemagglutinin (HA) emulating with sialic acid (SA) and receptor binding site (RBS)-targeting broadly neutralizing antibodies .

HY-E70148

ST6 Gal Sialyltransferase 1 EC:2.4.3.1; ST6GAL1	Enzyme Substrates
ST6 Gal Sialyltransferase 1 (EC:2.4.3.1, ST6GAL1) catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates .

HY-E70146

ST3 β-Gal α-2,3-Sialyltransferase 2 EC:2.4.3.4; ST3GAL2	Enzyme Substrates
ST3 beta-Gal alpha-2,3-Sialyltransferase 2 (EC:2.4.3.4, ST3GAL2) catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates .

HY-E70152

ST6 Sialyltransferase 4 EC:2.4.3.7; ST6GALNAC4; SIAT3-C	Enzyme Substrates
ST6 Sialyltransferase 4 (EC:2.4.3.7; ST6GALNAC4; SIAT3-C; SIAT3C; SIAT7-D; SIAT7D) catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. ST6 Sialyltransferase 4 promotes hepatocellular carcinogenesis by inducing abnormal glycosylation. .

HY-E70151

ST6 Sialyltransferase 2

ST6GALNAC2
Enzyme Substrates

ST6 Sialyltransferase 2 (EC:2.4.3.3, ST6GALNAC2) add sialic acids to the nonreducing ends of glycoconjugates .

ST6 Sialyltransferase 2 ST6GALNAC2	Enzyme Substrates
ST6 Sialyltransferase 2 (EC:2.4.3.3, ST6GALNAC2) add sialic acids to the nonreducing ends of glycoconjugates .

HY-E70149

ST6 Gal Sialyltransferase 2 EC:2.4.3.1; ST6GAL2	Enzyme Substrates
ST6 Gal Sialyltransferase 2 (EC:2.4.3.1, ST6GAL2) catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. ST6 Gal Sialyltransferase 2 plays an important role in schizophrenic research .

HY-E70150

ST6 Sialyltransferase 1 EC:2.4.3.3; Alpha-N-Acetylgalactosaminide alpha-2,6-sialyltransferase 1	Enzyme Substrates
ST6 Sialyltransferase 1 (EC:2.4.3.3, ST6GALNAC1, SIAT7A, Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1)? transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. ST6 Sialyltransferase 1 plays an important role in cancer .

HY-E70147

ST3 β-Gal α-2,3-Sialyltransferase 6 EC:2.4.99.; ST3GAL6; Type 2 lactosamine α-2,3-sialyltransferase	Enzyme Substrates
ST3 beta-Gal alpha-2,3-Sialyltransferase 6 (EC:2.4.99., ST3GAL6; SIAT10, Type 2 lactosamine alpha-2,3-sialyltransferase) transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. ST3 beta-Gal alpha-2,3-Sialyltransferase 6 play an important role in cancer .

ST3 β-Gal α-2,3-Sialyltransferase 6

EC:2.4.99.; ST3GAL6; Type 2 lactosamine α-2,3-sialyltransferase

Enzyme Substrates

ST3 beta-Gal alpha-2,3-Sialyltransferase 6 (EC:2.4.99., ST3GAL6; SIAT10, Type 2 lactosamine alpha-2,3-sialyltransferase) transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. ST3 beta-Gal alpha-2,3-Sialyltransferase 6 play an important role in cancer .

HY-W127461

Ganglioside GM2, Asialo Gangliotriosylceramide	Biochemical Assay Reagents
Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

Ganglioside GM2, Asialo

Gangliotriosylceramide

Biochemical Assay Reagents

Ganglioside GM2 asialo (asialo-GM2) is a glycosphingolipid containing three monosaccharide residues and one fatty acid of variable chain length, but lacks the sialic acid residue present on ganglioside M2. Asialo-GM2 is found at low or undetectable levels in normal human brains, but it accumulates in the brains of patients with Tay-Sachs disease and Sandhoff disease, which are expressed as lysosomal β- A neurodegenerative disorder characterized by hexosaminidase A and B deficiency. It also binds to various bacteria, including Pseudomonas isolated from cystic fibrosis patients. The Asialo-GM2 mixture contains ganglioside GM2 asialo molecular species with fatty acyl chains of variable length.

Lirentelimab AK002; Anti-Siglec-8 Reference Antibody (lirentelimab)	Apoptosis	Inflammation/Immunology
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .

*CMP-Sialic* acid sodium salt** CMP-Neu5Ac sodium salt	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

N-Acetylneuraminic acid 2 Publications Verification NANA; Lactaminic acid	Cardiovascular Disease Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Monosaccharides	Influenza Virus Endogenous Metabolite
N-Acetylneuraminic acid is a nine-carbon, sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells.

Species:	Human (19) Mouse (5) Cynomolgus (2)
Tag:	His (16) Avi (2) Myc (1) MBP (1) Fc (12) Flag (2)
Source:	HEK293 (22) CHO (1) Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P79127

	Siglec-11 Protein, Human (E84A, K145Q, CHO, hFc) sialic acid-binding Ig-like lectin 11; SIGLEC11; sialic acid-binding lectin 11; Siglec-11; sialic Acid Binding Ig-like Lectin 11	Human	CHO

HY-P71314

	Siglec-E Protein, Mouse (HEK293, Fc) SiglecE; Siglec-E; sialic Acid Binding Ig-like Lectin E	Mouse	HEK293
	Siglec-E Protein is a mouse orthologue of human Siglec-9 and functions as a key immunosuppressive checkpoint molecule. Siglec-E interacts with CD36 to inhibits downstream VAV signaling involved in modified LDL uptake, thereby delaying atherosclerosis. The endogenous inducible Siglec-E plays crucial anti-inflammatory and neuroprotective roles following ischemic stroke. Siglec-E Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Siglec-E protein, expressed by HEK293, with C-hFc labeled tag. The total length of Siglec-E Protein, Mouse (HEK293, Fc) is 336 a.a., with molecular weight of ~95 kDa.

HY-P71309

	SIAE Protein, Human (HEK293, His) Sialate O-Acetylesterase; H-Lse; sialic Acid-Specific 9-O-Acetylesterase; SIAE; YSG2	Human	HEK293
	SIAE proteins play a key role in cellular processes by catalyzing the removal of the O-acetyl ester group specifically from the 9-position of the parent sialic acid N-acetylneuraminic acid. Through this enzymatic activity, SIAE helps regulate sialic acid modifications, affecting various biological functions associated with cell surface glycoconjugates. SIAE Protein, Human (HEK293, His) is the recombinant human-derived SIAE protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P74548

	SIAE Protein, Human (sf9, His) Sialate O-Acetylesterase; H-Lse; sialic Acid-Specific 9-O-Acetylesterase; SIAE; YSG2	Human	Sf9 insect cells
	SIAE proteins play a key role in cellular processes by catalyzing the removal of the O-acetyl ester group specifically from the 9-position of the parent sialic acid N-acetylneuraminic acid. Through this enzymatic activity, SIAE helps regulate sialic acid modifications, affecting various biological functions associated with cell surface glycoconjugates. SIAE Protein, Human (sf9, His) is the recombinant human-derived SIAE protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P70960

	Siglec-5 Protein, Cynomolgus (HEK293, His) sialic acid-binding Ig-like lectin 5; Siglec-5	Cynomolgus	HEK293
	Siglec-5 Protein is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. Siglec-5 is a member of the CD33-related subset of Siglecs and is expressed on myeloid cells of the hemopoietic system. Siglec-5 inhibits the response of innate immune cells, such as monocytes and neutrophils against pathogens. Siglec-5 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Siglec-5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-5 Protein, Cynomolgus (HEK293, His) is 419 a.a., with molecular weight of ~90.0 kDa.

HY-P70959

	NANS Protein, Human (His) sialic Acid Synthase; N-Acetylneuraminate Synthase; N-Acetylneuraminate-9-Phosphate Synthase; N-Acetylneuraminic Acid Phosphate Synthase; N-Acetylneuraminic Acid Synthase; NANS; SAS	Human	E. coli
	NANS Protein is an enzyme that functions in the biosynthetic pathways of sialic acids. NANS protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively. NANS Protein, Human (His) is the recombinant human-derived NANS protein, expressed by E. coli , with N-6*His labeled tag. The total length of NANS Protein, Human (His) is 359 a.a., with molecular weight of ~42.0 kDa.

HY-P72476

	Siglec-10 Protein, Human (HEK293, Fc) sialic acid-binding Ig-like lectin 10; Siglec-10; SIGLEC10; SLG2	Human	HEK293
	Siglec-10 protein is thought to be a putative adhesion molecule that mediates sialic acid-dependent cell binding, preferentially selecting α-2,3- or α-2,6-linked sialic acid. Its sialic acid recognition site may be masked by cis interactions. Siglec-10 Protein, Human (HEK293, Fc) is the recombinant human-derived Siglec-10 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Siglec-10 Protein, Human (HEK293, Fc) is 530 a.a., with molecular weight of 110-130 kDa.

HY-P76642

	Siglec-10 Protein, Human (HEK293, His) sialic acid-binding Ig-like lectin 10; Siglec-10; SIGLEC10; SLG2	Human	HEK293
	Siglec-10 protein is thought to be a putative adhesion molecule that mediates sialic acid-dependent cell binding, preferentially selecting α-2,3- or α-2,6-linked sialic acid. Its sialic acid recognition site may be masked by cis interactions. Siglec-10 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-10 protein, expressed by HEK293 , with C-His labeled tag.

HY-P71311

	Siglec-7 Protein, Human (HEK293, His) sialic acid-binding Ig-like lectin 7; AIRM-1; D-siglec; CD328; SIGLEC7	Human	HEK293
	Siglec-7 protein is a putative adhesion molecule that mediates sialic acid-dependent cell binding with preference for α-2,3- and α-2,6-linked sialic acids. It interacts with disialoganglioside and may be masked by cis interactions. Siglec-7 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-7 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-7 Protein, Human (HEK293, His) is 335 a.a., with molecular weight of 50-70 kDa.

HY-P70739

	Siglec-9 Protein, Human (HEK293, His) sialic acid-binding Ig-like lectin 9; Siglec-9; CDw329; Protein FOAP-9; SIGLEC9	Human	HEK293
	Siglec-9 Protein is a member of the Siglec cell surface immunoglobulin family. Siglec-9 is highly expressed on human neutrophils and monocytes and low on natural killer cells, and sub-populations of T and B lymphocytes. Siglec-9 induces human neutrophil apoptosis and autophagy-like cell death and also inhibits tumor activity. Siglec-9 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-9 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-9 Protein, Human (HEK293, His) is 331 a.a., with molecular weight of 55-90 kDa.

HY-P72470

	Siglec-F Protein, Mouse (HEK293, His) SAF2; sialic acid binding Ig like lectin 8; SIGLEC-8; SIGLEC8L; SiglecF; Siglec-F	Mouse	HEK293
	Siglec-F Protein, a putative adhesion molecule, crucially mediates sialic-acid dependent binding to cells with a preferential affinity for alpha-2,3-linked sialic acid. Notably, its sialic acid recognition site may be concealed through cis interactions with sialic acids on the same cell surface. Siglec-F Protein, Mouse (HEK293, His) is the recombinant mouse-derived Siglec-F protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-F Protein, Mouse (HEK293, His) is 420 a.a., with molecular weight of 55-70 kDa.

HY-P70448

	Siglec-10 Protein, Mouse (HEK293, Fc) SIGLEC10; SiglecG; Siglec-G; MGC126774; PRO940; Siglec10; SLG2; sialic acid-binding Ig-like lectin 10; Siglec-10; siglec-like gene 2; Siglec-like protein 2; SLG2sialic acid binding Ig-like lectin 10 Ig-like lectin 7	Mouse	HEK293
	Siglec-10 protein is an adhesion molecule that mediates sialic acid-dependent cell binding, preferentially selecting α-2,3- or α-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions. Siglec-10 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Siglec-10 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Siglec-10 Protein, Mouse (HEK293, Fc) is 525 a.a., with molecular weight of 110-135 kDa.

HY-P72021

	Siglec-3/CD33 Protein, Human (HEK293, Fc-Myc) sialic acid-binding Ig-like lectin 3 Siglec-3; gp67; CD33; SIGLEC3	Human	HEK293
	Siglec-3/CD33 protein is a sialic acid-binding lectin that mediates cell-cell interactions and maintains immune cell quiescence. It prefers α-2,3- and α-2,6-linked glycans with sialic acid. Siglec-3/CD33 Protein, Human (HEK293, Fc-Myc) is the recombinant human-derived Siglec-3/CD33 protein, expressed by HEK293 , with C-Myc, C-Fc labeled tag. The total length of Siglec-3/CD33 Protein, Human (HEK293, Fc-Myc) is 242 a.a., with molecular weight of ~92 kDa.

HY-P70738

	Siglec-15 Protein, Human (HEK293, mFc) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Human	HEK293
	The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (HEK293, mFc) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of Siglec-15 Protein, Human (HEK293, mFc) is 244 a.a., with molecular weight of 50-70 kDa.

HY-P70742

	Siglec-15 Protein, Human (HEK293, Fc) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Human	HEK293
	The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (HEK293, Fc) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Siglec-15 Protein, Human (HEK293, Fc) is 244 a.a., with molecular weight of ~50-80 kDa.

HY-P70743

	Siglec-15 Protein, Cynomolgus (HEK293, His) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Cynomolgus	HEK293
	Siglec-15 Protein, a Siglec family member and type-1 transmembrane protein, is constitutively expressed in osteoclasts, macrophages and dendritic cells. Siglec-15 plays a pivotal role in the development and differentiation of osteoclastogenesis, inhibiting antigen-specific T cell responses in vitro and in vivo. Siglec-15 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Siglec-15 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-15 Protein, Cynomolgus (HEK293, His) is 244 a.a., with molecular weight of 30-40 kDa.

HY-P70744

	Siglec-15 Protein, Mouse (HEK293, His) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Mouse	HEK293
	Siglec-15 Protein, a Siglec family member and type-1 transmembrane protein, is constitutively expressed in osteoclasts, macrophages and dendritic cells. Siglec-15 plays a pivotal role in the development and differentiation of osteoclastogenesis, inhibiting antigen-specific T cell responses in vitro and in vivo. Siglec-15 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Siglec-15 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-15 Protein, Mouse (HEK293, His) is 239 a.a., with molecular weight of 30-40 kDa.

HY-P72475

	Siglec-15 Protein, Human (HEK293, His) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Human	HEK293
	The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-15 Protein, Human (HEK293, His) is 244 a.a., with molecular weight of 30-40 kDa.

HY-P70767

	Siglec-15 Protein, Human (Biotinylated, HEK293, Fc-Avi) sialic acid-binding Ig-like lectin 15; Siglec-15; CD33 antigen-like 3; CD33L3	Human	HEK293
	The Siglec-15 protein plays a critical role in cellular interactions, selectively binding to sialylated glycoproteins with affinity for sialic acid residues. Binding to TYROBP and HCST suggests involvement in complex signaling pathways. Siglec-15 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived Siglec-15 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of Siglec-15 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 244 a.a., with molecular weight of 58-75 kDa.

HY-P72411

	Siglec-10 Protein, Human (Biotinylated, HEK293, Fc-Avi) MGC126774; PRO940; Siglec10; SLG2; sialic acid-binding Ig-like lectin 10; siglec-like gene 2	Human	HEK293
	Siglec-10 Protein, identified as a putative adhesion molecule, mediates sialic-acid dependent cellular binding, preferring alpha-2,3- or alpha-2,6-linked sialic acid. Its sialic acid recognition site may undergo masking through cis interactions. In immune responses, Siglec-10 acts as an inhibitory receptor, inducing ligand-induced tyrosine phosphorylation, recruiting SH2 domain-containing phosphatases, and negatively regulating B-cell antigen receptor signaling via PTPN6/SHP-1. In collaboration with CD24, it selectively suppresses the immune response to DAMPs, regulates NK cell response, controls autoimmunity, and inhibits cross-presentation during adaptive immune responses by CD8-alpha(+) dendritic cells. Siglec-10 interacts with proteins including PTPN6/SHP-1, NCF1, CD24, HMGB1, RIGI, CBL, and PTPN11. Siglec-10 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived Siglec-10 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of Siglec-10 Protein, Human (Biotinylated, HEK293, Fc-Avi) is 530 a.a., with molecular weight of 100-130 kDa.

HY-P72472

	Siglec-3/CD33 Protein, Human (HEK293, Fc-His) Myeloid Cell Surface Antigen CD33; sialic Acid-Binding Ig-Like Lectin 3; Siglec-3; gp67; CD33; SIGLEC3	Human	HEK293
	Siglec-3/CD33, a sialic-acid-binding lectin, crucially mediates cell-cell interactions and immune cell quiescence. Preferring sialic acid on specific mucins, it forms homodimers, interacting with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. CD33 also engages C1QA through its C-terminus, activating CD33 inhibitory motifs. Siglec-3/CD33 Protein, Human (HEK293, Fc-His) is the recombinant human-derived Siglec-3/CD33 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag. The total length of Siglec-3/CD33 Protein, Human (HEK293, Fc-His) is 242 a.a., with molecular weight of ~80 kDa.

HY-P72473

	Siglec-3/CD33 Protein, Mouse (G236R, HEK293, His) Myeloid Cell Surface Antigen CD33; sialic Acid-Binding Ig-Like Lectin 3; Siglec-3; gp67; CD33; SIGLEC3	Mouse	HEK293
	Siglec-3/CD33, a sialic-acid-binding lectin, crucially mediates cell-cell interactions and immune cell quiescence. Preferring sialic acid on specific mucins, it forms homodimers, interacting with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. CD33 also engages C1QA through its C-terminus, activating CD33 inhibitory motifs. Siglec-3/CD33 Protein, Mouse (G236R, HEK293, His) is the recombinant mouse-derived Siglec-3/CD33 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-3/CD33 Protein, Mouse (G236R, HEK293, His) is 223 a.a., with molecular weight of 30-45 kDa.

HY-P72471

	Siglec-5 Protein, Human (HEK293, Fc) sialic acid-binding Ig-like lectin 5; Siglec-5; CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; CD170	Human	HEK293
	Siglec-5 Protein, a putative adhesion molecule, participates in sialic-acid dependent cellular binding, showing equal affinity for alpha-2,3-linked and alpha-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions with sialic acids on the same cell surface. Siglec-5 Protein, Human (HEK293, Fc) is the recombinant human-derived Siglec-5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Siglec-5 Protein, Human (HEK293, Fc) is 418 a.a., with molecular weight of 90-110 kDa.

HY-P71023

	Siglec-5 Protein, Human (HEK293, His-Flag-Fc) sialic acid-binding Ig-like lectin 5; Siglec-5; CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; CD170	Human	HEK293
	Siglec-5 Protein, a putative adhesion molecule, participates in sialic-acid dependent cellular binding, showing equal affinity for alpha-2,3-linked and alpha-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions with sialic acids on the same cell surface. Siglec-5 Protein, Human (HEK293, His-Flag-Fc) is the recombinant human-derived Siglec-5 protein, expressed by HEK293 , with C-hFc, C-Flag, C-6*His labeled tag. The total length of Siglec-5 Protein, Human (HEK293, His-Flag-Fc) is 418 a.a., with molecular weight of 90-110 kDa.

HY-P70559

	Siglec-2/CD22 Protein, Human (668a.a, HEK293, His) B-cell receptor CD22; BL-CAM; B-lymphocyte cell adhesion molecule; CD22 antigenMGC130020; CD22 molecule; CD22; sialic acid binding Ig-like lectin 2; Siglec-2; SIGLEC2FLJ22814; T-cell surface antigen Leu-14	Human	HEK293
	The Siglec-2/CD22 protein mediates B cell interactions and may direct B cell localization within lymphoid tissues. It recognizes sialylated glycoproteins, especially α-2,6-linked sialic acid, and participates in cis-interactions at the cell surface. Siglec-2/CD22 Protein, Human (668a.a, HEK293, His) is the recombinant human-derived Siglec-2/CD22 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Siglec-2/CD22 Protein, Human (668a.a, HEK293, His) is 668 a.a., with molecular weight of 100-140 kDa.

HY-P702008

	SLC35A1 Protein, Human (Sf9, His, MBP, FLAG) SLC35A1; CMP-sialic acid transporter; CMP-SA-Tr; CMP-Sia-Tr; Solute carrier family 35 member A1	Human	Sf9 insect cells
	SLC35A1 is a key player in intracellular transport, acting as a transporter to transport CMP-sialic acid from the cytoplasm to the Golgi apparatus. As an antiporter, it exchanges CMP-sialic acid for CMP, maintaining cellular homeostasis. SLC35A1 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC35A1 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC35A1 Protein, Human (Sf9, His, MBP, FLAG) is 336 a.a., .

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