Search Result

Pathways Recommended:	Metabolic Enzyme/Protease

Results for "

stable metabolic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adenosine Deaminase (1) Apoptosis (1) Autophagy (1) Bacterial (1) Btk (1) CDK (1) Cholinesterase (ChE) (1) Dopamine Receptor (1) Endogenous Metabolite (6) Epoxide Hydrolase (1) FAAH (1) Ferroptosis (2) Fungal (1) Isocitrate Dehydrogenase (IDH) (1) Keap1-Nrf2 (1) Microtubule/Tubulin (2) Monoamine Oxidase (1) mTOR (1) P2Y Receptor (1) Phospholipase (1) Prostaglandin Receptor (3) Proton Pump (1) RIP kinase (1) ROR (1) Sodium Channel (1) Thyroid Hormone Receptor (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Endocrinology (4) Infection (3) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (12)

By Targets:

5-HT Receptor (1)

Adenosine Deaminase (1)

Apoptosis (1)

Autophagy (1)

Bacterial (1)

Btk (1)

CDK (1)

Cholinesterase (ChE) (1)

Dopamine Receptor (1)

Endogenous Metabolite (6)

Epoxide Hydrolase (1)

FAAH (1)

Ferroptosis (2)

Fungal (1)

Isocitrate Dehydrogenase (IDH) (1)

Keap1-Nrf2 (1)

Microtubule/Tubulin (2)

Monoamine Oxidase (1)

mTOR (1)

P2Y Receptor (1)

Phospholipase (1)

Prostaglandin Receptor (3)

Proton Pump (1)

RIP kinase (1)

ROR (1)

Sodium Channel (1)

Thyroid Hormone Receptor (1)

By Research Areas:

Cancer (9)

Cardiovascular Disease (2)

Endocrinology (4)

Infection (3)

Inflammation/Immunology (4)

Metabolic Disease (4)

Neurological Disease (12)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-121524

DJ101	Microtubule/Tubulin	Cancer
DJ101 is a potent and metabolically stable tubulin inhibitor. DJ101 targets the colchicine binding site and overcomes taxane resistance. DJ101 also inhibits melanoma tumor growth and lung metastasis. DJ101 can be used for prostate cancer research .

HY-143406

Antifungal agent 25	Fungal	Infection
Antifungal agent 25 is a potent broad-spectrum antifungal agent. Antifungal agent 25 shows antifungal effect against Candida albicans and fluconazole-resistant strain of Candida albicans. Antifungal agent 25 stable metabolic property in vivo .

HY-U00271

Pareptide monohydrochloride

Others Neurological Disease

Pareptide monohydrochloride is a melanotropin-inhibiting factor (MIF) metabolically stable analogue.
HY-135880A

OMDM-4

Endogenous Metabolite Neurological Disease

OMDM-4 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i 17.7 μM .
HY-135880

OMDM-3

Endogenous Metabolite Neurological Disease

OMDM-3 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 16.6 μM .
HY-128604

XY101

ROR Cancer

XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC₅₀ of 30 nM and a K_d of 380 nM .
HY-121557

OMDM-1

Endogenous Metabolite Neurological Disease

OMDM-1 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 2.4 μM .
HY-103342

OMDM-2

Endogenous Metabolite Neurological Disease

OMDM-2 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 3.0 μM .
HY-117178

TA 0910 acid-type

Others Metabolic Disease

TA 0910 acid-type is a metabolite of TA 0910. TA-0910 is a metabolically stable analogue of thyrotropin releasing hormone (TRH) .
HY-124175

16-Phenoxy prostaglandin F2α ethyl amide

Others Endocrinology

16-Phenoxy prostaglandin F2α ethyl amide is a metabolically stable PGF2α analogue containing a acetamide structure .

Pareptide monohydrochloride	Others	Neurological Disease
Pareptide monohydrochloride is a melanotropin-inhibiting factor (MIF) metabolically stable analogue.

OMDM-4	Endogenous Metabolite	Neurological Disease
OMDM-4 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i 17.7 μM .

OMDM-3	Endogenous Metabolite	Neurological Disease
OMDM-3 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 16.6 μM .

XY101	ROR	Cancer
XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC₅₀ of 30 nM and a K_d of 380 nM .

OMDM-1	Endogenous Metabolite	Neurological Disease
OMDM-1 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 2.4 μM .

OMDM-2	Endogenous Metabolite	Neurological Disease
OMDM-2 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 3.0 μM .

TA 0910 acid-type	Others	Metabolic Disease
TA 0910 acid-type is a metabolite of TA 0910. TA-0910 is a metabolically stable analogue of thyrotropin releasing hormone (TRH) .

16-Phenoxy prostaglandin F2α ethyl amide	Others	Endocrinology
16-Phenoxy prostaglandin F2α ethyl amide is a metabolically stable PGF2α analogue containing a acetamide structure .

HY-17623S

Tegoprazan-d6 CJ-12420-d₆; RQ-00000004-d₆	Proton Pump	Metabolic Disease
Tegoprazan-d₆ is a stable isotope of Tegoprazan (HY-17623). Tegoprazan-d₆ can be used for the research of metabolic disease[1].

HY-139132

Met-F-AEA

Apoptosis Cancer

Met-F-AEA is a metabolically stable anandamine analogue. Met-F-AEA inhibits cell growth by activating apoptosis. Met-F-AEA has antitumor activity .

Met-F-AEA	Apoptosis	Cancer
Met-F-AEA is a metabolically stable anandamine analogue. Met-F-AEA inhibits cell growth by activating apoptosis. Met-F-AEA has antitumor activity .

HY-102036

G-744	Btk	Inflammation/Immunology
G-744 is a highly potent, selective and orally active Btk inhibitor with an IC₅₀ of 2 nM. G-744 is metabolically stable, well tolerated and efficacious to treat arthritis .

HY-114481

Imidazole ketone erastin Maximum Cited Publications 23 Publications Verification IKE	Ferroptosis	Cancer
Imidazole ketone erastin is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system x_c ^- and an activator of ferroptosis. Imidazole ketone erastin has anti-tumor activity .

HY-101032

RIPA-56 4 Publications Verification	RIP kinase	Inflammation/Immunology
RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC₅₀ of 13 nM. RIPA-56 can be used for the treatment of systemic inflammatory response syndrome .

HY-110092

PSB-1114 tetrasodium	P2Y Receptor	Metabolic Disease
PSB-1114 tetrasodium is a potent, enzymatically stable, and subtype-selective P2Y₂ receptor agonist with an EC₅₀ of 134 nM. PSB-1114 tetrasodium displays >50-fold selectivity versus the P2Y₄ (EC₅₀ of 9.3 μM) and P2Y₆ (EC₅₀ of 7.0 μM) receptors .

HY-151879

Tubulin inhibitor 30	Microtubule/Tubulin Ferroptosis	Cancer
Tubulin inhibitor 30 (Compound 15) is a tubulin assembly inhibitor with an IC₅₀ of 0.52 μM. Tubulin inhibitor 30 can induce ferroptosis .

HY-103237

L-Adenosine	Adenosine Deaminase	Neurological Disease
L-Adenosine is a metabolically stable enantiomeric analog and also is a potential probe. L-Adenosine has weakly inhibitory adenosine deaminase (ADA) activity with an K_i value of 385 μM. L-Adenosine can be used for the research of adenosine uptake and accumulation .

HY-136059

Desfluoro-ezetimibe	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator .

HY-13847

GNE-555	mTOR	Cancer
GNE-555 is a selective, metabolically stable mTOR inhibitor (K_i=1.5 nM) that also has good oral bioavailability. GNE-555 exhibits antiproliferative activity on PC3 and MCF-7 cells and can be used in cancer research .

HY-118520

16-Phenoxy tetranor prostaglandin F2α methyl ester	Prostaglandin Receptor	Endocrinology
16-Phenoxy tetranor Prostaglandin F2α methyl ester is a metabolically stable form of Prostaglandin F2α that can binds to FP receptor. 16-Phenoxy tetranor Prostaglandin F2α methyl ester serves as prodrug that can be hydrolyzed to generate bioactive free acid .

HY-B0389A

D-Glucose-13C6 4 Publications Verification Glucose-¹³C₆; D-(+)-Glucose-¹³C₆; Dextrose-¹³C₆	Endogenous Metabolite	Others Metabolic Disease
D-Glucose- ¹³C₆ is a stable isotope-labeled counterpart of D-glucose (HY-B0389). D-Glucose- ¹³C₆ can be used as a metabolic tracer to trace glucose-related synthetic catabolism or as synthesis ingredient, minimal media reagent, and internal standard .

HY-128428

Carboprost 15(S)-15-Methyl Prostaglandin F2α; 15-Methyl-PGF2α	Prostaglandin Receptor	Endocrinology
Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a metabolically stable synthetic analog of prostaglandin F2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester .

HY-149481

D4R agonist-1	Dopamine Receptor	Neurological Disease
D4R agonist-1 (Compound 16f) is a D4R partial agonist (K_i: 2.2 nM). D4R agonist-1 is metabolically stable in rat and human liver microsomes. D4R agonist-1 can be used for research of neuropsychiatric disorders .

HY-152219

CLK1-IN-2	CDK	Infection Cancer
CLK1-IN-2 is metabolically stable Clk1 inhibitor. CLK1-IN-2 has selectivity for Clk1 with an IC₅₀ value of 1.7 nM. CLK1-IN-2 can be used for the research of tumour, Duchenne's muscular dystrophy and viral infections such as HIV-1 and influenza .

HY-143326

Antibacterial agent 83	Bacterial	Infection
Antibacterial agent 83 (compound 17h) displays potent antibacterial activity against various vancomycin-resistant Enterococcus faecalis (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). Antibacterial agent 83 can significantly reduce the biofilm formation of MRSA and exhibited promising selectivity. Antibacterial agent 83 is metabolically stable in human liver microsomes .

HY-14921

Elsibucol	Others	Cardiovascular Disease Inflammation/Immunology
Elsibucol is a VCAM1 inhibitor for the study of organ transplant rejection. Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. Elsibucol lowers blood cholesterol levels and reduces oxidative stress and inflammatory responses in injured arteries, thereby inhibiting atherosclerosis and protecting endothelial healing after arterial injury .

HY-117507

U92016A hydrochloride	5-HT Receptor	Neurological Disease
U92016A hydrochloride is a potent, metabolically stable, orally acitive 5-HT1A receptor agonist with an exceptionally high degree of intrinsic activity . U92016A hydrochloride binds with high affinity to human 5-HT1A receptors expressed in Chinese hamster ovary cells (K_i=0.2 nM) .

HY-145695

Dual AChE-MAO B-IN-1	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
Dual AChE-MAO B-IN-1 (compound 15) is an orally bioavailable CNS-permeant potent inhibitor of both human AChE (IC₅₀=550 nM) and MAO B (IC₅₀=8.2 nM). Dual AChE-MAO B-IN-1 behaves as a safe and metabolically stable neuroprotective agent, devoid of cytochrome liability .

HY-155111

nSMase2-IN-1	Phospholipase	Neurological Disease
nSMase2-IN-1 is an orally active Neutral sphingomyelinase 2 (nSMase2) inhibitor with an IC₅₀ value of 0.13 ± 0.06 μM. nSMase2-IN-1 is metabolically stable in liver microsomes and orally available with a favorable brain-to-plasma ratio. nSMase2-IN-1 can be used for nervous system disease research .

HY-128428R

Carboprost (Standard)	Prostaglandin Receptor	Endocrinology
Carboprost (Standard) is the analytical standard of Carboprost. This product is intended for research and analytical applications. Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a metabolically stable synthetic analog of prostaglandin F2α. Carboprost stimulates uterine contractions and induces abortion. Carboprost is used for postpartum hemorrhage due to uterine atony and for the termination of pregnancy in the second trimester .

HY-144738

Dual FAAH/sEH-IN-1	Epoxide Hydrolase FAAH	Inflammation/Immunology
Dual FAAH/sEH-IN-1 (compound 3) is a high affinity dual sEH (soluble epoxide hydrolase) and FAAH (fatty acid amide hydrolase) inhibitor, with IC₅₀ values of 9.6 and 7 nM, respectively. Dual FAAH/sEH-IN-1 shows antinociception against the inflammatory phase .

HY-P3960

(Glu2)-TRH	Thyroid Hormone Receptor Endogenous Metabolite	Neurological Disease
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS .

HY-120181

AGI-14100	Isocitrate Dehydrogenase (IDH)	Cancer
AGI-14100 is a metabolically stable and orally available mIDH1 inhibitor (IC₅₀=6 nM). The pharmacochemical optimization of AGI-14100 is aimed at eliminating hPXR activation, resulting in the final drug candidate AG-120. AG-120 can be used in the study of cancers carrying IDH1 mutations. The discovery and development of AGI-14100 can be used for further studies of mutant isocitrate dehydrogenase 1 (mIDH1) inhibitors .

HY-126291

GNE-616	Sodium Channel	Neurological Disease
GNE-616 is a highly potent, metabolically stable, orally bioavailable, and subtype selective Nav1.7 inhibitor (K_i of 0.79 nM and K_d of 0.38 nM for hNav1.7) for the treatment of chronic pain. GNE-616 shows >1000 nM K_d and >2500-fold selectivity over hNav1.1, hNav1.3, hNav1.4, and hNav1.5. Selectivity over hNav1.2 and hNav1.6 is more modest at 31- and 73-fold, respectively .

(Glu2)-TRH	Thyroid Hormone Receptor Endogenous Metabolite	Neurological Disease
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-121557

OMDM-1	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
OMDM-1 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 2.4 μM .

HY-135880A

OMDM-4	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
OMDM-4 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i 17.7 μM .

HY-135880

OMDM-3	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
OMDM-3 is a selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 16.6 μM .

HY-103342

OMDM-2	Structural Classification Alkaloids Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
OMDM-2 is a potent, selective and metabolically stable inhibitor of anandamide cellular uptake (ACU), with a K_i of 3.0 μM .

Cat. No.	Product Name	Chemical Structure

HY-B0389A

D-Glucose-13C6 4 Publications Verification
D-Glucose- ¹³C₆ is a stable isotope-labeled counterpart of D-glucose (HY-B0389). D-Glucose- ¹³C₆ can be used as a metabolic tracer to trace glucose-related synthetic catabolism or as synthesis ingredient, minimal media reagent, and internal standard .

HY-17623S

Tegoprazan-d6

Tegoprazan-d₆ is a stable isotope of Tegoprazan (HY-17623). Tegoprazan-d₆ can be used for the research of metabolic disease[1].

Tegoprazan-d6
Tegoprazan-d₆ is a stable isotope of Tegoprazan (HY-17623). Tegoprazan-d₆ can be used for the research of metabolic disease[1].

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks