triphenylphosphonium

By Targets:	AMPK (1) Bacterial (2) Biochemical Assay Reagents (1) Endothelin Receptor (1) Fungal (2) HSP (1) Isotope-Labeled Compounds (2) Mitochondrial Metabolism (2) Reactive Oxygen Species (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Infection (4) Metabolic Disease (1) Neurological Disease (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1033S

Methyl-triphenylphosphonium-d3 bromide

Isotope-Labeled Compounds Others

Methyl-triphenylphosphonium-d₃ (bromide) is the deuterium labeled Methyl-triphenylphosphonium bromide[1].

*Methyl-triphenylphosphonium-d3 bromide*	Isotope-Labeled Compounds	Others
Methyl-triphenylphosphonium-d₃ (bromide) is the deuterium labeled Methyl-triphenylphosphonium bromide[1].

HY-135868

Mito-apocynin (C2)	Mitochondrial Metabolism	Neurological Disease
Mito-apocynin (C2), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP ⁺ cation. Mito-apocynin (C2) exhibits antineuroinflammatory effect .

HY-135869

Mito-apocynin (C11) 2 Publications Verification	Mitochondrial Metabolism	Neurological Disease
Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP ⁺ cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function .

HY-W010882S

*(4-Carboxybutyl-d4)triphenylphosphonium* bromide**	Isotope-Labeled Compounds	Others
(4-Carboxybutyl-d₄)triphenylphosphonium (bromide) is the deuterium labeled (4-Carboxybutyl)triphenylphosphonium bromide[1].

HY-N12840

Logmalicid B

Others Metabolic Disease

Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

Logmalicid B	Others	Metabolic Disease
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

HY-126124

AP39 2 Publications Verification	Others	Cardiovascular Disease Neurological Disease
AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H₂S) donor. AP39 increases intracellular H₂S levels. AP39 exerts cytoprotective effects and maintains mitochondrial DNA integrity under oxidative stress conditions. AP39 protects against myocardial reperfusion injury in mice model and has the potential for Alzheimer's disease research .

HY-163073

Anti-MRSA agent 9	Bacterial	Infection
Anti-MRSA agent 9 (compound 39) shows antibacterial effects against clinically isolated methicillin-resistant Staphylococcus aureus (MRSA) with MIC values of 1 μg/ml. Anti-MRSA agent 9 also shows anti-MRSA efficacy in vivo .

HY-W111141

BCN-OH endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne	Biochemical Assay Reagents	Others
BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is a mitochondrial probe based on the lyophilic bidentate bicyclic ligand BCN and is a control reagent for BCN-TPP. The TPP group is a reactive sulfenic acid probe that targets mitochondria. BCN-TPP is known to affect mitochondrial energy, causing a sharp decrease in basal respiration, causing it to exhibit faster reaction kinetics with sulfonated proteins. BCN-OH does not contain hydrophobic triphenylphosphonium (TPP) ions. Using BCN-OH as a control allows the TPP group to be safely introduced when designing sulfenic acid traps .

HY-147696

SMTIN-T140	HSP AMPK Reactive Oxygen Species	Cancer
SMTIN-T140 (compound 6a) is a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor, with an IC₅₀ of 1.646 μM. SMTIN-T140 shows anticancer activity. SMTIN-T140 leads to mitochondrial dysfunction, increases mitochondrial ROS production and activates AMPK. SMTIN-T140 potently suppressed tumor growth without any noticeable in vivo toxicity in a mouse model xenografted with PC3 prostate cancer cells .

HY-149067

Antifungal agent 47	Fungal	Infection
Antifungal agent 47 (compound 3b) shows the highest and broad-spectrum fungicidal activity, strong respiratory inhibition activity, and adenosine 5′-triphosphate synthesis inhibition activity. Antifungal agent 47 is potential as a fungicide .

HY-151556

Antifungal agent 45	Fungal	Infection
Antifungal agent 45 is with fungicidal activities. Antifungal agent 45 shows excellent characteristics superior to Kresoxim-methyl (HY-125776), in which the activity enhancement against Phytophthora capsici was the most remarkable, with an EC₅₀ value of about 5 μM .

HY-105168

TAK 044	Endothelin Receptor	Cardiovascular Disease
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .

Cat. No.	Product Name	Type

HY-W111141

BCN-OH endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne	Biochemical Assay Reagents
BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is a mitochondrial probe based on the lyophilic bidentate bicyclic ligand BCN and is a control reagent for BCN-TPP. The TPP group is a reactive sulfenic acid probe that targets mitochondria. BCN-TPP is known to affect mitochondrial energy, causing a sharp decrease in basal respiration, causing it to exhibit faster reaction kinetics with sulfonated proteins. BCN-OH does not contain hydrophobic triphenylphosphonium (TPP) ions. Using BCN-OH as a control allows the TPP group to be safely introduced when designing sulfenic acid traps .

BCN-OH

endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne

Biochemical Assay Reagents

BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is a mitochondrial probe based on the lyophilic bidentate bicyclic ligand BCN and is a control reagent for BCN-TPP. The TPP group is a reactive sulfenic acid probe that targets mitochondria. BCN-TPP is known to affect mitochondrial energy, causing a sharp decrease in basal respiration, causing it to exhibit faster reaction kinetics with sulfonated proteins. BCN-OH does not contain hydrophobic triphenylphosphonium (TPP) ions. Using BCN-OH as a control allows the TPP group to be safely introduced when designing sulfenic acid traps .

Cat. No.	Product Name	Target	Research Area

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

HY-105168

TAK 044	Endothelin Receptor	Cardiovascular Disease
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N12840

Logmalicid B	Structural Classification Iridoids Cornaceae Cornus officinalis Sieb. et Zucc. Terpenoids Source classification Plants	Others
Logmalicid B is an iridoid glycoside compound that can be isolated from Cornus officinalis and can be used in diabetes research .

Cat. No.	Product Name	Chemical Structure

HY-Y1033S

Methyl-triphenylphosphonium-d3 bromide

Methyl-triphenylphosphonium-d₃ (bromide) is the deuterium labeled Methyl-triphenylphosphonium bromide[1].
HY-W010882S

(4-Carboxybutyl-d4)triphenylphosphonium bromide

(4-Carboxybutyl-d₄)triphenylphosphonium (bromide) is the deuterium labeled (4-Carboxybutyl)triphenylphosphonium bromide[1].

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triphenylphosphonium

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