2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. Selnoflast

Selnoflast  (Synonyms: RO-7486967)

Cat. No.: HY-132831 Purity: 98.58%
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Selnoflast (RO-7486967) Formerly known as Somalix/RG6418/IZD334, Selnoflast is an orally available inhibitor of NLRP3. Selnoflast is used in research into systemic inflammation, such as ulcerative colitis and chronic obstructive pulmonary disease.

For research use only. We do not sell to patients.

Selnoflast Chemical Structure

Selnoflast Chemical Structure

CAS No. : 2260969-36-4

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5 mg USD 390 In-stock
10 mg USD 650 In-stock
25 mg USD 1250 In-stock
50 mg USD 2000 In-stock
100 mg USD 3300 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Selnoflast:

Selnoflast Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Selnoflast

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  • Purity & Documentation

  • References

  • Customer Review

Description

Selnoflast (RO-7486967) Formerly known as Somalix/RG6418/IZD334, Selnoflast is an orally available inhibitor of NLRP3. Selnoflast is used in research into systemic inflammation, such as ulcerative colitis and chronic obstructive pulmonary disease[1][2].

IC50 & Target

NLRP3

 

Molecular Weight

391.53

Formula

C20H29N3O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NS(=O)(C1CCN(CC1)CC)=O)NC2=C(CCC3)C3=CC4=C2CCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (12.77 mM; ultrasonic and adjust pH to 8 with 1M NaOH; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

1M NaOH : 3.33 mg/mL (8.51 mM; adjust pH to 12 with 1M NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5541 mL 12.7704 mL 25.5408 mL
5 mM 0.5108 mL 2.5541 mL 5.1082 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1M NaOH / DMSO 1 mM 2.5541 mL 12.7704 mL 25.5408 mL 63.8521 mL
5 mM 0.5108 mL 2.5541 mL 5.1082 mL 12.7704 mL
DMSO 10 mM 0.2554 mL 1.2770 mL 2.5541 mL 6.3852 mL
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Selnoflast Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Selnoflast2260969-36-4RO-7486967RO7486967RO 7486967NOD-like Receptor (NLR)NLRInhibitorAnti-inflammatoryinhibitorinhibit

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